Pyridones as herbicides

ABSTRACT

Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, 
                         
wherein
         A, R 1 , R 4 , Z and q are as defined in the disclosure.
 
Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.

FIELD OF THE INVENTION

This invention relates to certain pyridones, their N-oxides, salts and compositions, and methods of their use for controlling undesirable vegetation.

BACKGROUND OF THE INVENTION

The control of undesired vegetation is extremely important in achieving high crop efficiency. Achievement of selective control of the growth of weeds especially in such useful crops as rice, soybean, sugar beet, maize, potato, wheat, barley, tomato and plantation crops, among others, is very desirable. Unchecked weed growth in such useful crops can cause significant reduction in productivity and thereby result in increased costs to the consumer. The control of undesired vegetation in noncrop areas is also important. Many products are commercially available for these purposes, but the need continues for new compounds that are more effective, less costly, less toxic, environmentally safer or have different sites of action.

SUMMARY OF THE INVENTION

This invention is directed to compounds of Formula 1 (including all stereoisomers), N-oxides, and salts thereof, agricultural compositions containing them and their use as herbicides:

wherein

-   -   A is phenyl optionally substituted with up to 4 R²; or a 5- or         6-membered heteroaromatic ring, the ring bonded to the remainder         of Formula 1 through a carbon atom, and optionally substituted         with up to 4 R²;     -   Z is O or SO_(m);     -   R¹ is halogen, cyano, nitro, C₁-C₄ alkoxy, C₁-C₄ alkyl, C₂-C₆         alkenyl, C₂-C₆ alkynyl, SO_(n)R³ or C₁-C₄ haloalkyl;     -   each R² is halogen, cyano, CHO, nitro, C₁-C₄ alkyl, C₂-C₄         alkenyl, C₂-C₄ alkynyl, C₁-C₄ alkoxy, C₃-C₄ alkenyloxy, C₃-C₄         alkynyloxy, C₁-C₄ haloalkyl, C₁-C₄ haloalkoxy, C₂-C₄         alkoxyalkyl, C₂-C₄ alkylthioalkyl, SO_(n)R³, C₂-C₆ dialkylamino,         C₁-C₄ cyanoalkyl, C₁-C₄ hydroxyalkyl, CH(═NOH), C₃-C₆         cycloalkyl, phenyl or pyridyl;     -   each R³ is independently C₁-C₄ alkyl, C₁-C₄ haloalkyl, C₁-C₄         alkylamino or C₂-C₆ dialkylamino;     -   each R⁴ is independently halogen, cyano, hydroxy, nitro, amino,         CHO, C₁-C₄ alkyl, C₂-C₄ alkenyl, C₂-C₄ alkynyl,         C(═O)N(R^(4A))(R^(4B)), C(═NOR^(4C))H, C(═N)(R^(4D))H, C₁-C₄         alkoxy, C₂-C₄ cyanoalkoxy, C₂-C₄ alkylcarbonyl, C₂-C₄         alkoxycarbonyl, C₂-C₄ alkylcarbonyloxy, C₂-C₄ alkoxyalkyl, C₁-C₄         haloalkyl, C₁-C₄ haloalkoxy, SO_(n)R³ or C₃-C₆ cycloalkyl; or         phenyl optionally substituted with cyano, halogen or C₁-C₄         alkyl;     -   R^(4A) is C₁-C₄ alkyl or C₁-C₄ haloalkyl;     -   R^(4B) is H, C₁-C₄ alkyl or C₁-C₄ haloalkyl;     -   R^(4C) is H or C₁-C₄ alkyl;     -   R^(4D) is H or C₁-C₄ alkyl;     -   q is 0, 1, 2 or 3;     -   m is 0, 1 or 2; and     -   each n is independently 0, 1 or 2.

More particularly, this invention pertains to a compound of Formula 1 (including all stereoisomers), an N-oxide or a salt thereof. This invention also relates to a herbicidal composition comprising a compound of the invention (i.e. in a herbicidally effective amount) and at least one component selected from the group consisting of surfactants, solid diluents and liquid diluents. This invention further relates to a method for controlling the growth of undesired vegetation comprising contacting the vegetation or its environment with a herbicidally effective amount of a compound of the invention (e.g., as a composition described herein).

This invention also includes a herbicidal mixture comprising (a) a compound selected from Formula 1, N-oxides, and salts thereof, and (b) at least one additional active ingredient selected from (b1) through (b16); and salts of compounds of (b1) through (b16), as described below.

DETAILS OF THE INVENTION

As used herein, the terms “comprises,” “comprising,” “includes,” “including,” “has,” “having,” “contains”, “containing,” “characterized by” or any other variation thereof, are intended to cover a non-exclusive inclusion, subject to any limitation explicitly indicated. For example, a composition, mixture, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, mixture, process, method, article, or apparatus.

The transitional phrase “consisting of” excludes any element, step, or ingredient not specified. If in the claim, such would close the claim to the inclusion of materials other than those recited except for impurities ordinarily associated therewith. When the phrase “consisting of” appears in a clause of the body of a claim, rather than immediately following the preamble, it limits only the element set forth in that clause; other elements are not excluded from the claim as a whole.

The transitional phrase “consisting essentially of” is used to define a composition, method or apparatus that includes materials, steps, features, components, or elements, in addition to those literally disclosed, provided that these additional materials, steps, features, components, or elements do not materially affect the basic and novel characteristic(s) of the claimed invention. The term “consisting essentially of” occupies a middle ground between “comprising” and “consisting of”.

Where applicants have defined an invention or a portion thereof with an open-ended term such as “comprising,” it should be readily understood that (unless otherwise stated) the description should be interpreted to also describe such an invention using the terms “consisting essentially of” or “consisting of.”

Further, unless expressly stated to the contrary, “or” refers to an inclusive or and not to an exclusive or. For example, a condition A or B is satisfied by any one of the following: A is true (or present) and B is false (or not present), A is false (or not present) and B is true (or present), and both A and B are true (or present).

Also, the indefinite articles “a” and “an” preceding an element or component of the invention are intended to be nonrestrictive regarding the number of instances (i.e. occurrences) of the element or component. Therefore “a” or “an” should be read to include one or at least one, and the singular word form of the element or component also includes the plural unless the number is obviously meant to be singular.

As referred to herein, the term “seedling”, used either alone or in a combination of words means a young plant developing from the embryo of a seed.

As referred to herein, the term “broadleaf” used either alone or in words such as “broadleaf weed” means dicot or dicotyledon, a term used to describe a group of angiosperms characterized by embryos having two cotyledons.

In the above recitations, the term “alkyl”, used either alone or in compound words such as “alkylthio” or “haloalkyl” includes straight-chain or branched alkyl, such as, methyl, ethyl, n-propyl, i-propyl, or the different butyl, pentyl or hexyl isomers. “Alkenyl” includes straight-chain or branched alkenes such as ethenyl, 1-propenyl, 2-propenyl, and the different butenyl, pentenyl and hexenyl isomers. “Alkenyl” also includes polyenes such as 1,2-propadienyl and 2,4-hexadienyl. “Alkynyl” includes straight-chain or branched alkynes such as ethynyl, 1-propynyl, 2-propynyl and the different butynyl, pentynyl and hexynyl isomers. “Alkynyl” can also include moieties comprised of multiple triple bonds such as 2,5-hexadiynyl.

“Alkoxy” includes, for example, methoxy, ethoxy, n-propyloxy, isopropyloxy and the different butoxy isomers. “Alkoxyalkyl” denotes alkoxy substitution on alkyl. Examples of “alkoxyalkyl” include CH₃OCH₂, CH₃OCH₂CH₂, CH₃CH₂OCH₂ and CH₃CH₂OCH₂CH₂. “Alkenyloxy” includes straight-chain or branched alkenyloxy moieties. Examples of “alkenyloxy” include H₂C═CHCH₂O, (CH₃)₂C═CHCH₂O, (CH₃)CH═CHCH₂O and CH₂═CHCH₂CH₂O. “Alkynyloxy” includes straight-chain or branched alkynyloxy moieties. Examples of “alkynyloxy” include HC≡CCH₂O and CH₃C≡CCH₂O. “Alkylthio” includes branched or straight-chain alkylthio moieties such as methylthio, ethylthio, and the different propylthio, butylthio, pentylthio and hexylthio isomers. “Alkylthioalkyl” denotes alkylthio substitution on alkyl. Examples of “alkylthioalkyl” include CH₃SCH₂, CH₃SCH₂CH₂, CH₃CH₂SCH₂ and CH₃CH₂SCH₂CH₂. “Cyanoalkyl” denotes an alkyl group substituted with one cyano group. Examples of “cyanoalkyl” include NCCH₂, NCCH₂CH₂ and CH₃CH(CN)CH₂. “Alkylamino”, “dialkylamino” and the like, are defined analogously to the above examples.

“Cycloalkyl” includes, for example, cyclopropyl. The term “halogen”, either alone or in compound words such as “haloalkyl”, or when used in descriptions such as “alkyl substituted with halogen” includes fluorine, chlorine, bromine or iodine. Further, when used in compound words such as “haloalkyl”, or when used in descriptions such as “alkyl substituted with halogen” said alkyl may be partially or fully substituted with halogen atoms which may be the same or different. Examples of “haloalkyl” or “alkyl substituted with halogen” include F₃C, ClCH₂, CF₃CH₂ and CF₃CCl₂. Examples of “haloalkoxy” include CF₃O—, CCl₃CH₂O—, HCF₂CH₂CH₂O— and CF₃CH₂O—. “Alkylcarbonyl” denotes a straight-chain or branched alkyl moieties bonded to a C(═O) moiety. Examples of “alkylcarbonyl” include CH₃C(═O)—, CH₃CH₂CH₂C(═O)— and (CH₃)₂CHC(═O)—. Examples of “alkoxycarbonyl” include CH₃OC(═O)—, CH₃CH₂OC(═O)—, CH₃CH₂CH₂OC(═O)—, (CH₃)₂CHOC(═O)— and the different butoxycarbonyl isomers.

The total number of carbon atoms in a substituent group is indicated by the “C_(i)-C_(j)” prefix where i and j are numbers from 1 to 6. For example, C₁-C₄ alkyl designates methyl through butyl; C₂ alkoxyalkyl designates CH₃OCH₂—; C₃ alkoxyalkyl designates, for example, CH₃CH(OCH₃)—, CH₃OCH₂CH₂— or CH₃CH₂OCH₂—; and C₄ alkoxyalkyl designates the various isomers of an alkyl group substituted with an alkoxy group containing a total of four carbon atoms, examples including CH₃CH₂CH₂OCH₂— and CH₃CH₂OCH₂CH₂—.

When a compound is substituted with a substituent bearing a subscript that indicates the number of said substituents can exceed 1, said substituents (when they exceed 1) are independently selected from the group of defined substituents, e.g., [(R⁴)_(q)], q is 0, 1, 2 or 3. When a variable group is shown to be optionally attached to a position, for example (R⁴)_(q) in Formula 1 wherein q may be 0, then hydrogen may be at the position even if not recited in the variable group definition. When one or more positions on a group are said to be “not substituted” or “unsubstituted”, then hydrogen atoms are attached to take up any free valency.

When a fully unsaturated carbocyclic ring satisfies Hückel's rule, then said ring is also called an “aromatic ring”.

The terms “heterocyclic ring”, “heterocycle” or “heterocyclic ring system” denote a ring or ring system in which at least one atom forming the ring backbone is not carbon, e.g., nitrogen, oxygen or sulfur. Typically a heterocyclic ring contains no more than 4 nitrogens, no more than 2 oxygens and no more than 2 sulfurs. Unless otherwise indicated, a heterocyclic ring can be a saturated, partially unsaturated, or fully unsaturated ring. When a fully unsaturated heterocyclic ring satisfies Hückel's rule, then said ring is also called a “heteroaromatic ring”. Unless otherwise indicated, heterocyclic rings and ring systems can be attached through any available carbon or nitrogen by replacement of a hydrogen on said carbon or nitrogen.

“Aromatic” indicates that each of the ring atoms is essentially in the same plane and has a p-orbital perpendicular to the ring plane, and that (4n+2) π electrons, where n is a positive integer, are associated with the ring to comply with Hückel's rule.

The term “optionally substituted” in connection with the heterocyclic rings refers to groups which are unsubstituted or have at least one non-hydrogen substituent that does not extinguish the biological activity possessed by the unsubstituted analog. As used herein, the following definitions shall apply unless otherwise indicated. The term “optionally substituted” is used interchangeably with the phrase “substituted or unsubstituted” or with the term “(un)substituted.” Unless otherwise indicated, an optionally substituted group may have a substituent at each substitutable position of the group, and each substitution is independent of the other.

As noted above, A can be (among others) phenyl optionally substituted with one or more substituents selected from a group of substituents as defined in the Summary of the Invention. An example of phenyl optionally substituted with one to five substituents is the ring illustrated as U-1 in Exhibit 1, wherein R^(v) is R² as defined in the Summary of the Invention for A and r is an integer (from 0 to 4).

As noted above, A can be (among others) 5- or 6-membered heteroaromatic ring, optionally substituted with one or more substituents selected from a group of substituents as defined in the Summary of the Invention. Examples of a 5- or 6-membered unsaturated aromatic heterocyclic ring optionally substituted with from one or more substituents include the rings U-2 through U-61 illustrated in Exhibit 1 wherein R^(v) is any substituent as defined in the Summary of the Invention for A (i.e. R²) and r is an integer from 0 to 4, limited by the number of available positions on each U group. As U-29, U-30, U-36, U-37, U-38, U-39, U-40, U-41, U-42 and U-43 have only one available position, for these U groups r is limited to the integers 0 or 1, and r being 0 means that the U group is unsubstituted and a hydrogen is present at the position indicated by (R^(v))_(r).

Although R^(v) groups are shown in the structures U-1 through U-61, it is noted that they do not need to be present since they are optional substituents. Note that when R^(v) is H when attached to an atom, this is the same as if said atom is unsubstituted. The nitrogen atoms that require substitution to fill their valence are substituted with H or R^(v). Note that when the attachment point between (R^(v))_(r) and the U group is illustrated as floating, (R^(v))_(r) can be attached to any available carbon atom or nitrogen atom of the U group. Note that some U groups can only be substituted with less than 4 R^(v) groups (e.g., U-2 through U-5, U-7 through U-48, and U-52 through U-61).

A wide variety of synthetic methods are known in the art to enable preparation of aromatic and nonaromatic heterocyclic rings and ring systems; for extensive reviews see the eight volume set of Comprehensive Heterocyclic Chemistry, A. R. Katritzky and C. W. Rees editors-in-chief, Pergamon Press, Oxford, 1984 and the twelve volume set of Comprehensive Heterocyclic Chemistry II, A. R. Katritzky, C. W. Rees and E. F. V. Scriven editors-in-chief, Pergamon Press, Oxford, 1996.

Compounds of this invention can exist as one or more stereoisomers. The various stereoisomers include enantiomers, diastereomers, atropisomers and geometric isomers. Stereoisomers are isomers of identical constitution but differing in the arrangement of their atoms in space and include enantiomers, diastereomers, cis-trans isomers (also known as geometric isomers) and atropisomers. Atropisomers result from restricted rotation about single bonds where the rotational barrier is high enough to permit isolation of the isomeric species. One skilled in the art will appreciate that one stereoisomer may be more active and/or may exhibit beneficial effects when enriched relative to the other stereoisomer(s) or when separated from the other stereoisomer(s). Additionally, the skilled artisan knows how to separate, enrich, and/or to selectively prepare said stereoisomers. The compounds of the invention may be present as a mixture of stereoisomers, individual stereoisomers or as an optically active form.

Compounds of Formula 1 typically exist in more than one form, and Formula 1 thus include all crystalline and non-crystalline forms of the compounds they represent. Non-crystalline forms include embodiments which are solids such as waxes and gums as well as embodiments which are liquids such as solutions and melts. Crystalline forms include embodiments which represent essentially a single crystal type and embodiments which represent a mixture of polymorphs (i.e. different crystalline types). The term “polymorph” refers to a particular crystalline form of a chemical compound that can crystallize in different crystalline forms, these forms having different arrangements and/or conformations of the molecules in the crystal lattice. Although polymorphs can have the same chemical composition, they can also differ in composition due the presence or absence of co-crystallized water or other molecules, which can be weakly or strongly bound in the lattice. Polymorphs can differ in such chemical, physical and biological properties as crystal shape, density, hardness, color, chemical stability, melting point, hygroscopicity, suspensibility, dissolution rate and biological availability. One skilled in the art will appreciate that a polymorph of a compound of Formula 1 can exhibit beneficial effects (e.g., suitability for preparation of useful formulations, improved biological performance) relative to another polymorph or a mixture of polymorphs of the same compound of Formula 1. Preparation and isolation of a particular polymorph of a compound of Formula 1 can be achieved by methods known to those skilled in the art including, for example, crystallization using selected solvents and temperatures. For a comprehensive discussion of polymorphism see R. Hilfiker, Ed., Polymorphism in the Pharmaceutical Industry, Wiley-VCH, Weinheim, 2006.

One skilled in the art will appreciate that not all nitrogen-containing heterocycles can form N-oxides since the nitrogen requires an available lone pair for oxidation to the oxide; one skilled in the art will recognize those nitrogen-containing heterocycles which can form N-oxides. One skilled in the art will also recognize that tertiary amines can form N-oxides. Synthetic methods for the preparation of N-oxides of heterocycles and tertiary amines are very well known by one skilled in the art including the oxidation of heterocycles and tertiary amines with peroxy acids such as peracetic and m-chloroperbenzoic acid (MCPBA), hydrogen peroxide, alkyl hydroperoxides such as t-butyl hydroperoxide, sodium perborate, and dioxiranes such as dimethyldioxirane. These methods for the preparation of N-oxides have been extensively described and reviewed in the literature, see for example: T. L. Gilchrist in Comprehensive Organic Synthesis, vol. 7, pp 748-750, S. V. Ley, Ed., Pergamon Press; M. Tisler and B. Stanovnik in Comprehensive Heterocyclic Chemistry, vol. 3, pp 18-20, A. J. Boulton and A. McKillop, Eds., Pergamon Press; M. R. Grimmett and B. R. T. Keene in Advances in Heterocyclic Chemistry, vol. 43, pp 149-161, A. R. Katritzky, Ed., Academic Press; M. Tisler and B. Stanovnik in Advances in Heterocyclic Chemistry, vol. 9, pp 285-291, A. R. Katritzky and A. J. Boulton, Eds., Academic Press; and G. W. H. Cheeseman and E. S. G. Werstiuk in Advances in Heterocyclic Chemistry, vol. 22, pp 390-392, A. R. Katritzky and A. J. Boulton, Eds., Academic Press.

One skilled in the art recognizes that because in the environment and under physiological conditions salts of chemical compounds are in equilibrium with their corresponding nonsalt forms, salts share the biological utility of the nonsalt forms. Thus a wide variety of salts of a compound of Formula 1 are useful for control of undesired vegetation (i.e. are agriculturally suitable). The salts of a compound of Formula 1 include acid-addition salts with inorganic or organic acids such as hydrobromic, hydrochloric, nitric, phosphoric, sulfuric, acetic, butyric, fumaric, lactic, maleic, malonic, oxalic, propionic, salicylic, tartaric, 4-toluenesulfonic or valeric acids. When a compound of Formula 1 contains an acidic moiety such as a carboxylic acid or phenol, salts also include those formed with organic or inorganic bases such as pyridine, triethylamine or ammonia, or amides, hydrides, hydroxides or carbonates of sodium, potassium, lithium, calcium, magnesium or barium. Accordingly, the present invention comprises compounds selected from Formula 1, N-oxides and agriculturally suitable salts thereof.

Embodiments of the present invention as described in the Summary of the Invention include (where Formula 1 as used in the following Embodiments includes N-oxides and salts thereof):

Embodiment 1

-   A compound of Formula 1 wherein A is a 5- or 6-membered     nitrogen-containing heteroaromatic ring, the ring bonded to the     remainder of Formula 1 through a carbon atom, and optionally     substituted with up to 3 R².

Embodiment 2

-   A compound of Embodiment 1 wherein A is selected from

and r is 0, 1, 2 or 3.

Embodiment 3

-   A compound of Embodiment 2 wherein A is selected from A-1 through     A-13.

Embodiment 3a

-   A compound of Embodiment 3 wherein A is selected from A-1, A-2, A-4,     A-6, A-9, A-10, A-11 and A-12.

Embodiment 4

-   A compound of Embodiment 3 wherein A is selected from A-1, A-2 and     A-6.

Embodiment 5

-   A compound of Embodiment 4 wherein A is A-1.

Embodiment 6

-   A compound of Embodiment 4 wherein A is A-2.

Embodiment 7

-   A compound of Embodiment 4 wherein A is A-6.

Embodiment 8

-   A compound of Embodiment 4 wherein A is selected from

Embodiment 9

-   A compound of Formula 1 wherein A is phenyl optionally substituted     with up to 3 R².

Embodiment 10

-   A compound of Embodiment 9 wherein A is phenyl optionally     substituted with up to 2 R².

Embodiment 11

-   A compound of Embodiment 10 wherein A is phenyl optionally     substituted with one R².

Embodiment 11a

-   A compound of Formula 1 wherein Z is O.

Embodiment 12

-   A compound of Formula 1 or any one of Embodiments 1 through 11     wherein R¹ is halogen, C₁-C₄ alkyl or C₁-C₄ haloalkyl.

Embodiment 13

-   A compound of Embodiment 12 wherein R¹ is halogen.

Embodiment 14

-   A compound of Embodiment 13 wherein R¹ is chlorine.

Embodiment 15

-   A compound of Formula 1 or any one of Embodiments 1 through 14     wherein each R² is independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy,     C₁-C₄ haloalkyl or C₁-C₄ haloalkoxy.

Embodiment 16

-   A compound of Embodiment 15 wherein each R² is independently Cl, CF₃     or OCF₃.

Embodiment 17

-   A compound of Formula 1 or any one of Embodiments 9 through 16     wherein A is substituted with one R² at the position meta or para to     the connection of the phenyl ring to the remainder of Formula 1.

Embodiment 18

-   A compound of Embodiment 17 wherein R² is Cl, CF₃ or OCF₃.

Embodiment 19

-   A compound of Embodiment 17 wherein A is substituted with one R² at     the position para to the connection of the phenyl ring to the     remainder of Formula 1.

Embodiment 20

-   A compound of Embodiment 19 wherein R² is halogen.

Embodiment 21

-   A compound of Embodiment 19 wherein R² is Cl.

Embodiment 22

-   A compound of Formula 1 or any one of Embodiments 1 through 21     wherein q is 0, 1 or 2.

Embodiment 23

-   A compound of Embodiment 22 wherein q is 0 or 1.

Embodiment 24

-   A compound of Embodiment 23 wherein q is 1.

Embodiment 25

-   A compound of Embodiment 23 wherein q is 0 (i.e. the 3-, 4- and     5-positions of the benzene ring are unsubstituted by R⁴).

Embodiment 26

-   A compound of Formula 1 or any one of Embodiments 1 through 24     wherein each R⁴ is independently halogen, cyano, hydroxy, nitro,     amino, CHO, C₁-C₄ alkyl, C₂-C₄ alkenyl, C₂-C₄ alkynyl,     C(═O)N(R^(4A))(R^(4B))C(═NOR⁴C)H, C(═N)(R^(4D))H, C₁-C₄ alkoxy,     C₂-C₄ cyanoalkoxy, C₂-C₄ alkylcarbonyl, C₂-C₄ alkoxycarbonyl, C₂-C₄     alkylcarbonyloxy, C₂-C₄ alkoxyalkyl, C₁-C₄ haloalkyl, C₁-C₄     haloalkoxy, SO_(n)R³ or C₃-C₆ cycloalkyl.

Embodiment 27

-   A compound of Embodiment 26 wherein each R⁴ is independently     halogen, cyano, amino, C₁-C₄ alkyl, C₂-C₄ alkenyl, C₂-C₄ alkynyl,     C₁-C₄ alkoxy, C₂-C₄ alkoxycarbonyl, C₂-C₄ alkylcarbonyloxy, C₂-C₄     alkoxyalkyl or C₁-C₄ haloalkyl.

Embodiment 28

-   A compound of Embodiment 27 wherein each R⁴ is independently     halogen, cyano, amino or C₁-C₄ alkyl.

Embodiment 29

-   A compound of Embodiment 28 wherein each R⁴ is independently cyano.

Embodiment 30

-   A compound of Embodiment 26 wherein each R⁴ is attached to the     remainder of Formula 1 at the 3- or 4-position.

Embodiment 31

-   A compound of Embodiment 30 wherein R⁴ is attached to the remainder     of Formula 1 at the 3-position.

Embodiment 32

-   A compound of Embodiment 26 wherein R^(4A) is C₁-C₄ alkyl.

Embodiment 33

-   A compound of Embodiment 26 wherein R^(4B) is C₁-C₄ alkyl.

Embodiment 34

-   A compound of Embodiment 26 wherein R^(4C) is H or CH₃.

Embodiment 35

-   A compound of Embodiment 26 wherein R^(4D) is H or CH₃.

Embodiments of this invention, including Embodiments 1-35 above as well as any other embodiments described herein, can be combined in any manner, and the descriptions of variables in the embodiments pertain not only to the compounds of Formula 1 but also to the starting compounds and intermediate compounds useful for preparing the compounds of Formula 1. In addition, embodiments of this invention, including Embodiments 1-35 above as well as any other embodiments described herein, and any combination thereof, pertain to the compositions and methods of the present invention.

Combinations of Embodiments 1-35 are illustrated by:

Embodiment A

A compound of the Summary of the Invention wherein

-   -   A is a 5- or 6-membered nitrogen-containing heteroaromatic ring,         the ring bonded to the remainder of Formula 1 through a carbon         atom, and optionally substituted with up to 3 R²; or     -   A is phenyl optionally substituted with up to 3 R².

Embodiment B

A compound of Embodiment A wherein

-   -   A is selected from A-1 through A-20;

Z is O;

-   -   R¹ is halogen, C₁-C₄ alkyl or C₁-C₄ haloalkyl;     -   each R² is independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy,         C₁-C₄ haloalkyl or C₁-C₄ haloalkoxy;     -   q is 0, 1 or 2; and     -   each R⁴ is independently halogen, cyano, amino, C₁-C₄ alkyl,         C₂-C₄ alkenyl, C₂-C₄ alkynyl, C₁-C₄ alkoxy, C₂-C₄         alkoxycarbonyl, C₂-C₄ alkylcarbonyloxy, C₂-C₄ alkoxyalkyl or         C₁-C₄ haloalkyl.

Embodiment C

A compound of Embodiment B wherein

-   -   A is selected from A-1 through A-13;     -   R¹ is halogen;     -   each R² is independently Cl, CF₃ or OCF₃;     -   q is 0 or 1; and     -   R⁴ is halogen, cyano, amino or C₁-C₄ alkyl.

Embodiment D

A compound of Embodiment C wherein

-   -   A is selected from A-1a, A-2a and A-6a;     -   R² is halogen; and     -   q is 0 (i.e. the 3-, 4- and 5-positions of the benzene ring are         unsubstituted by R⁴).

Embodiment E

A compound of Embodiment A wherein

-   -   A is phenyl optionally substituted with up to 2 R²;     -   Z is O;     -   R¹ is halogen, C₁-C₄ alkyl or C₁-C₄ haloalkyl;     -   each R² is independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy,         C₁-C₄ haloalkyl or C₁-C₄ haloalkoxy;     -   q is 0, 1 or 2; and     -   each R⁴ is independently halogen, cyano, amino, C₁-C₄ alkyl,         C₂-C₄ alkenyl, C₂-C₄ alkynyl, C₁-C₄ alkoxy, C₂-C₄         alkoxycarbonyl, C₂-C₄ alkylcarbonyloxy, C₂-C₄ alkoxyalkyl or         C₁-C₄ haloalkyl.

Embodiment F

A compound of Embodiment E wherein

-   -   A is phenyl optionally substituted with one R²;     -   R¹ is halogen;     -   R² is independently Cl, CF₃ or OCF₃; and     -   q is 0 (i.e. the 3-, 4- and 5-positions of the benzene ring are         unsubstituted by R⁴).

Embodiment G

A compound of Embodiment F wherein

-   -   R¹ is chlorine.         Specific embodiments include compounds of Formula 1 selected         from the group consisting of:

-   1-(4-chlorophenyl)-6-[(5-chloro-2-pyrimidinyl)oxy]-2(1H)-pyridinone     (Compound 1);

-   6-[(5-chloro-2-pyrimidinyl)oxy]-1-[3-(trifluoromethyl)phenyl]-2(1H)-pyridinone     (Compound 2);

-   6-[(5-chloro-2-pyrimidinyl)oxy]-1-[3-(trifluoromethoxy)phenyl]-2(1H)-pyridinone     (Compound 3);

This invention also relates to a method for controlling undesired vegetation comprising applying to the locus of the vegetation herbicidally effective amounts of the compounds of the invention (e.g., as a composition described herein). Of note as embodiments relating to methods of use are those involving the compounds of embodiments described above. Compounds of the invention are particularly useful for selective control of weeds in crops such as wheat, barley, maize, soybean, sunflower, cotton, oilseed rape and rice, and specialty crops such as sugarcane, citrus, fruit and nut crops.

Also noteworthy as embodiments are herbicidal compositions of the present invention comprising the compounds of embodiments described above.

This invention also includes a herbicidal mixture comprising (a) a compound selected from Formula 1, N-oxides, and salts thereof, and (b) at least one additional active ingredient selected from (b1) photosystem II inhibitors, (b2) acetohydroxy acid synthase (AHAS) inhibitors, (b3) acetyl-CoA carboxylase (ACCase) inhibitors, (b4) auxin mimics, (b5) 5-enol-pyruvylshikimate-3-phosphate (EPSP) synthase inhibitors, (b6) photosystem I electron diverters, (b7) protoporphyrinogen oxidase (PPO) inhibitors, (b8) glutamine synthetase (GS) inhibitors, (b9) very long chain fatty acid (VLCFA) elongase inhibitors, (b10) auxin transport inhibitors, (b11) phytoene desaturase (PDS) inhibitors, (b12) 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) inhibitors, (b13) homogentisate solenesyltransererase (HST) inhibitors, (b14) cellulose biosynthesis inhibitors, (b15) other herbicides including mitotic disruptors, organic arsenicals, asulam, bromobutide, cinmethylin, cumyluron, dazomet, difenzoquat, dymron, etobenzanid, flurenol, fosamine, fosamine-ammonium, metam, methyldymron, oleic acid, oxaziclomefone, pelargonic acid and pyributicarb, and (b16) herbicide safeners; and salts of compounds of (b1) through (b16).

“Photosystem II inhibitors” (b1) are chemical compounds that bind to the D-1 protein at the Q_(B)-binding niche and thus block electron transport from Q_(A) to Q_(B) in the chloroplast thylakoid membranes. The electrons blocked from passing through photosystem II are transferred through a series of reactions to form toxic compounds that disrupt cell membranes and cause chloroplast swelling, membrane leakage, and ultimately cellular destruction. The Q_(B)-binding niche has three different binding sites: binding site A binds the triazines such as atrazine, triazinones such as hexazinone, and uracils such as bromacil, binding site B binds the phenylureas such as diuron, and binding site C binds benzothiadiazoles such as bentazon, nitriles such as bromoxynil and phenyl-pyridazines such as pyridate. Examples of photosystem II inhibitors include ametryn, amicarbazone, atrazine, bentazon, bromacil, bromofenoxim, bromoxynil, chlorbromuron, chloridazon, chlorotoluron, chloroxuron, cumyluron, cyanazine, daimuron, desmedipham, desmetryn, dimefuron, dimethametryn, diuron, ethidimuron, fenuron, fluometuron, hexazinone, ioxynil, isoproturon, isouron, lenacil, linuron, metamitron, methabenzthiazuron, metobromuron, metoxuron, metribuzin, monolinuron, neburon, pentanochlor, phenmedipham, prometon, prometryn, propanil, propazine, pyridafol, pyridate, siduron, simazine, simetryn, tebuthiuron, terbacil, terbumeton, terbuthylazine, terbutryn and trietazine.

“AHAS inhibitors” (b2) are chemical compounds that inhibit acetohydroxy acid synthase (AHAS), also known as acetolactate synthase (ALS), and thus kill plants by inhibiting the production of the branched-chain aliphatic amino acids such as valine, leucine and isoleucine, which are required for protein synthesis and cell growth. Examples of AHAS inhibitors include amidosulfuron, azimsulfuron, bensulfuron-methyl, bispyribac-sodium, cloransulam-methyl, chlorimuron-ethyl, chlorsulfuron, cinosulfuron, cyclosulfamuron, diclosulam, ethametsulfuron-methyl, ethoxysulfuron, flazasulfuron, florasulam, flucarbazone-sodium, flumetsulam, flupyrsulfuron-methyl, flupyrsulfuron-sodium, foramsulfuron, halosulfuron-methyl, imazamethabenz-methyl, imazamox, imazapic, imazapyr, imazaquin, imazethapyr, imazosulfuron, iodosulfuron-methyl (including sodium salt), iofensulfuron (2-iodo-N-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]benzenesulfonamide), mesosulfuron-methyl, metazosulfuron (3-chloro-4-(5,6-dihydro-5-methyl-1,4,2-dioxazin-3-yl)-N-[ [(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-1-methyl-1H-pyrazole-5-sulfonamide), metosulam, metsulfuron-methyl, nicosulfuron, oxasulfuron, penoxsulam, primisulfuron-methyl, propoxycarbazone-sodium, propyrisulfuron (2-chloro-N-[[(4, 6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-6-propylimidazo[1,2-b]pyridazine-3-sulfonamide), prosulfuron, pyrazosulfuron-ethyl, pyribenzoxim, pyriftalid, pyriminobac-methyl, pyrithiobac-sodium, rimsulfuron, sulfometuron-methyl, sulfosulfuron, thiencarbazone, thifensulfuron-methyl, triafamone (N-[2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)carbonyl]-6-fluorophenyl]-1,1-difluoro-N-methylmethanesulfonamide), triasulfuron, tribenuron-methyl, trifloxysulfuron (including sodium salt), triflusulfuron-methyl and tritosulfuron.

“ACCase inhibitors” (b3) are chemical compounds that inhibit the acetyl-CoA carboxylase enzyme, which is responsible for catalyzing an early step in lipid and fatty acid synthesis in plants. Lipids are essential components of cell membranes, and without them, new cells cannot be produced. The inhibition of acetyl CoA carboxylase and the subsequent lack of lipid production leads to losses in cell membrane integrity, especially in regions of active growth such as meristems. Eventually shoot and rhizome growth ceases, and shoot meristems and rhizome buds begin to die back. Examples of ACCase inhibitors include alloxydim, butroxydim, clethodim, clodinafop, cycloxydim, cyhalofop, diclofop, fenoxaprop, fluazifop, haloxyfop, pinoxaden, profoxydim, propaquizafop, quizalofop, sethoxydim, tepraloxydim and tralkoxydim, including resolved forms such as fenoxaprop-P, fluazifop-P, haloxyfop-P and quizalofop-P and ester forms such as clodinafop-propargyl, cyhalofop-butyl, diclofop-methyl and fenoxaprop-P-ethyl.

Auxin is a plant hormone that regulates growth in many plant tissues. “Auxin mimics” (b4) are chemical compounds mimicking the plant growth hormone auxin, thus causing uncontrolled and disorganized growth leading to plant death in susceptible species. Examples of auxin mimics include aminocyclopyrachlor (6-amino-5-chloro-2-cyclopropyl-4-pyrimidinecarboxylic acid) and its methyl and ethyl esters and its sodium and potassium salts, aminopyralid, benazolin-ethyl, chloramben, clacyfos, clomeprop, clopyralid, dicamba, 2,4-D, 2,4-DB, dichlorprop, fluroxypyr, halauxifen (4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-2-pyridinecarboxylic acid), halauxifen-methyl (methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-2-pyridinecarboxylate), MCPA, MCPB, mecoprop, picloram, quinclorac, quinmerac, 2,3,6-TBA, triclopyr, and methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-2-pyridinecarboxylate.

“EPSP synthase inhibitors” (b5) are chemical compounds that inhibit the enzyme, 5-enol-pyruvylshikimate-3-phosphate synthase, which is involved in the synthesis of aromatic amino acids such as tyrosine, tryptophan and phenylalanine. EPSP inhibitor herbicides are readily absorbed through plant foliage and translocated in the phloem to the growing points. Glyphosate is a relatively nonselective postemergence herbicide that belongs to this group. Glyphosate includes esters and salts such as ammonium, isopropylammonium, potassium, sodium (including sesquisodium) and trimesium (alternatively named sulfosate).

“Photosystem I electron diverters” (b6) are chemical compounds that accept electrons from Photosystem I, and after several cycles, generate hydroxyl radicals. These radicals are extremely reactive and readily destroy unsaturated lipids, including membrane fatty acids and chlorophyll. This destroys cell membrane integrity, so that cells and organelles “leak”, leading to rapid leaf wilting and desiccation, and eventually to plant death. Examples of this second type of photosynthesis inhibitor include diquat and paraquat.

“PPO inhibitors” (b7) are chemical compounds that inhibit the enzyme protoporphyrinogen oxidase, quickly resulting in formation of highly reactive compounds in plants that rupture cell membranes, causing cell fluids to leak out. Examples of PPO inhibitors include acifluorfen-sodium, azafenidin, benzfendizone, bifenox, butafenacil, carfentrazone, carfentrazone-ethyl, chlomethoxyfen, cinidon-ethyl, fluazolate, flufenpyr-ethyl, flumiclorac-pentyl, flumioxazin, fluoroglycofen-ethyl, fluthiacet-methyl, fomesafen, halosafen, lactofen, oxadiargyl, oxadiazon, oxyfluorfen, pentoxazone, profluazol, pyraclonil, pyraflufen-ethyl, saflufenacil, sulfentrazone, thidiazimin, tiafenacil (methyl N-[2-[[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenyl]thio]-1-oxopropyl]-β-alaninate) and 3-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propyn-1-yl)-2H-1,4-benzoxazin-6-yl]dihydro-1,5-dimethyl-6-thioxo-1,3,5-triazine-2,4(1H,3H)-dione.

“GS inhibitors” (b8) are chemical compounds that inhibit the activity of the glutamine synthetase enzyme, which plants use to convert ammonia into glutamine. Consequently, ammonia accumulates and glutamine levels decrease. Plant damage probably occurs due to the combined effects of ammonia toxicity and deficiency of amino acids required for other metabolic processes. The GS inhibitors include glufosinate and its esters and salts such as glufosinate-ammonium and other phosphinothricin derivatives, glufosinate-P ((2S)-2-amino-4-(hydroxymethylphosphinyl)butanoic acid) and bilanaphos.

“VLCFA elongase inhibitors” (b9) are herbicides having a wide variety of chemical structures, which inhibit the elongase. Elongase is one of the enzymes located in or near chloroplasts which are involved in biosynthesis of VLCFAs. In plants, very-long-chain fatty acids are the main constituents of hydrophobic polymers that prevent desiccation at the leaf surface and provide stability to pollen grains. Such herbicides include acetochlor, alachlor, anilofos, butachlor, cafenstrole, dimethachlor, dimethenamid, diphenamid, fenoxasulfone (3-[[(2,5-dichloro-4-ethoxyphenyl)methyl]sulfonyl]-4,5-dihydro-5,5-dimethylisoxazole), fentrazamide, flufenacet, indanofan, mefenacet, metazachlor, metolachlor, naproanilide, napropamide, napropamide-M ((2R)—N,N-diethyl-2-(1-naphthalenyloxy)propanamide), pethoxamid, piperophos, pretilachlor, propachlor, propisochlor, pyroxasulfone, and thenylchlor, including resolved forms such as S-metolachlor and chloroacetamides and oxyacetamides.

“Auxin transport inhibitors” (b10) are chemical substances that inhibit auxin transport in plants, such as by binding with an auxin-carrier protein. Examples of auxin transport inhibitors include diflufenzopyr, naptalam (also known as N-(1-naphthyl)phthalamic acid and 2-[(1-naphthalenylamino)carbonyl]benzoic acid).

“PDS inhibitors” (b11) are chemical compounds that inhibit carotenoid biosynthesis pathway at the phytoene desaturase step. Examples of PDS inhibitors include beflubutamid, diflufenican, fluridone, flurochloridone, flurtamone norflurzon and picolinafen.

“HPPD inhibitors” (b12) are chemical substances that inhibit the biosynthesis of synthesis of 4-hydroxyphenyl-pyruvate dioxygenase. Examples of HPPD inhibitors include benzobicyclon, benzofenap, bicyclopyrone (4-hydroxy-3-[[2-[(2-methoxyethoxy)methyl]-6-(trifluoromethyl)-3-pyridinyl]carbonyl]bicyclo[3.2.1]oct-3-en-2-one), fenquinotrione (2-[ [8-chloro-3,4-dihydro-4-(4-methoxyphenyl)-3-oxo-2-quinoxalinyl]carbonyl]-1,3-cyclohexanedione), isoxachlortole, isoxaflutole, mesotrione, pyrasulfotole, pyrazolynate, pyrazoxyfen, sulcotrione, tefuryltrione, tembotrione, topramezone, 5-chloro-3-[(2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl]-1-(4-methoxyphenyl)-2(1H)-quinoxalinone, 4-(2,6-diethyl-4-methylphenyl)-5-hydroxy-2, 6-dimethyl-3 (2H)-pyridazinone, 4-(4-fluorophenyl)-6-[(2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl]-2-methyl-1,2,4-triazine-3,5(2H,4H)-dione, 5-[(2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl]-2-(3-methoxyphenyl)-3-(3-methoxypropyl)-4(3H)-pyrimidinone, 2-methyl-N-(4-methyl-1,2,5-oxadiazol-3-yl)-3-(methylsulfinyl)-4-(trifluoromethyl)benzamide and 2-methyl-3-(methylsulfonyl)-N-(1-methyl-1H-tetrazol-5-yl)-4-(trifluoromethyl)benzamide.

HST inhibitors (b13) disrupt a plant's ability to convert homogentisate to 2-methyl-6-solanyl-1,4-benzoquinone, thereby disrupting carotenoid biosynthesis. Examples of HST inhibitors include haloxydine, pyriclor, 3-(2-chloro-3,6-difluorophenyl)-4-hydroxy-1-methyl-1,5-naphthyridin-2 (1H)-one, 7-(3,5-dichloro-4-pyridinyl)-5-(2,2-difluoroethyl)-8-hydroxypyrido[2,3-b]pyrazin-6(5H)-one and 4-(2,6-diethyl-4-methylphenyl)-5-hydroxy-2,6-dimethyl-3(2H)-pyridazinone.

HST inhibitors also include compounds of Formulae A and B.

-   wherein R^(d1) is H, Cl or CF₃; R^(d2) is H, Cl or Br; R^(d3) is H     or Cl; R^(d4) is H, Cl or CF₃; R^(d5) is CH₃, CH₂CH₃ or CH₂CHF₂; and     R^(d6) is OH, or —OC(═O)-i-Pr; and E^(e1) is H, F, Cl, CH₃ or     CH₂CH₃; R^(e2) is H or CF₃; R^(e3) is H, CH₃ or CH₂CH₃; R^(e4) is H,     F or Br; R^(e5) is Cl, CH₃, CF₃, OCF₃ or CH₂CH₃; R^(e6) is H, CH₃,     CH₂CHF₂ or C≡CH; R^(e7) is OH, —OC(═O)Et, —OC(═O)-i-Pr or     —OC(═O)-t-Bu; and A^(e8) is N or CH.

Cellulose biosynthesis inhibitors (b14) inhibit the biosynthesis of cellulose in certain plants. They are most effective when applied preemergence or early postemergence on young or rapidly growing plants. Examples of cellulose biosynthesis inhibitors include chlorthiamid, dichlobenil, flupoxam, indaziflam (N²-[(1R,2S)-2,3-dihydro-2,6-dimethyl-1H-inden-1-yl]-6-(1-fluoroethyl)-1,3, 5-triazine-2,4-diamine), isoxaben and triaziflam.

Other herbicides (b15) include herbicides that act through a variety of different modes of action such as mitotic disruptors (e.g., flamprop-M-methyl and flamprop-M-isopropyl), organic arsenicals (e.g., DSMA, and MSMA), 7,8-dihydropteroate synthase inhibitors, chloroplast isoprenoid synthesis inhibitors and cell-wall biosynthesis inhibitors. Other herbicides include those herbicides having unknown modes of action or do not fall into a specific category listed in (b1) through (b14) or act through a combination of modes of action listed above. Examples of other herbicides include aclonifen, asulam, amitrole, bromobutide, cinmethylin, clomazone, cumyluron, cyclopyrimorate (6-chloro-3-(2-cyclopropyl-6-methylphenoxy)-4-pyridazinyl 4-morpholinecarboxylate), daimuron, difenzoquat, etobenzanid, fluometuron, flurenol, fosamine, fosamine-ammonium, dazomet, dymron, ipfencarbazone (1-(2,4-dichlorophenyl)-N-(2,4-difluorophenyl)-1,5-dihydro-N-(1-methylethyl)-5-oxo-4H-1,2,4-triazole-4-carboxamide), metam, methyldymron, oleic acid, oxaziclomefone, pelargonic acid, pyributicarb and 5-[[(2,6-difluorophenyl)methoxy]methyl]-4,5-dihydro-5-methyl-3-(3-methyl-2-thienyl)isoxazole.

“Herbicide safeners” (b16) are substances added to a herbicide formulation to eliminate or reduce phytotoxic effects of the herbicide to certain crops. These compounds protect crops from injury by herbicides but typically do not prevent the herbicide from controlling undesired vegetation. Examples of herbicide safeners include but are not limited to benoxacor, cloquintocet-mexyl, cumyluron, cyometrinil, cyprosulfamide, daimuron, dichlormid, dicyclonon, dimepiperate, fenchlorazole-ethyl, fenclorim, flurazole, fluxofenim, furilazole, isoxadifen-ethyl, mefenpyr-diethyl, mephenate, methoxyphenone, naphthalic anhydride, oxabetrinil, N-(aminocarbonyl)-2-methylbenzenesulfonamide and N-(aminocarbonyl)-2-fluorobenzenesulfonamide, 1-bromo-4-[(chloromethyl)sulfonyl]benzene, 2-(dichloromethyl)-2-methyl-1,3-dioxolane (MG 191), 4-(dichloroacetyl)-1-oxa-4-azospiro[4.5]decane (MON 4660).

The compounds of Formula 1 can be prepared by general methods known in the art of synthetic organic chemistry. One or more of the following methods and variations as described in Schemes 1-6 can be used to prepare the compounds of Formula 1. The definitions of A, Z, R¹, R⁴ and q in the compounds of Formulae 1-9 below are as defined above in the Summary of the Invention unless otherwise noted. Compounds of Formulae 1a, 1b, 2a and 2b are various subsets of the compounds of Formula 1 and 2 and all substituents for Formulae 1, 1a, 1b, 2, 2a, 2b, 3, 5, 6, 7, 8, 9, 10 and 11 are as defined above for Formula 1 unless otherwise noted.

As shown in Scheme 1, a compound of Formula 1 can be prepared by nucleophilic substitution by heating a compound of Formula 2 in a suitable solvent such as acetonitrile, tetrahydrofuran or N,N-dimethylformamide in the presence of a base such as potassium or cesium carbonate, with a compound of Formula 3 (where LG is a nucleophilic reaction leaving group such as halogen or S(O)₂Me). The reaction is typically conducted at temperatures ranging from 50 to 110° C.

As shown in Scheme 2, a compound of Formula 2 can be prepared by deprotection of a compound of Formula 2a (i.e. a compound of Formula 2 wherein Z is O and R^(a) is CH₃) with a suitable deprotecting agent. Suitable methoxy deprotecting reagents such as BBr₃, AlCl₃ and HBr in acetic acid can be used in the presence of solvents such as toluene, dichloromethane and dichloroethane at a temperature of from −80 to 120° C. Other useful phenolic protecting groups suitable for use in preparing the compound of Formula 2 can be found in Greene, T. W.; Wuts, P. G. M. Protective Groups in Organic Synthesis, 4th ed.; Wiley: Hoboken, N.J., 1991.

As shown in Scheme 3, a compound of Formula 5 or 6 can be coupled with an intermediate of Formula 4 under modified Chan-Lam conditions to give the compound of Formula 2a. Chan-Lam couplings typically are conducted in the presence of a copper salt, oxygen and a base at temperatures ranging from ambient to reflux for 24 to 72 h. Reactivity can be improved with additional additives. Examples of Cu(II) salts which can be used are Cu(OAc)₂, CuBr₂ and CuI₂. Suitable bases include pyridine, quinolone and triethylamine. Suitable additives include pyridine-N-oxide and 4 Å moleculuar sieves. Suitable solvents include dichloromethane, chloroform, diethyl ether and tetrahydrofuran. For representative conditions, see Eur. J. Med. Chem. 2013, 613-620; Tetrahedron Lett. 1998, 38, 2941 and PCT publication WO2003/072547. Boron intermediates of Formula 5 are commercially available or can be prepared from the corresponding halides or trifluoromethanesulfonates by methods known in the literature (see for example, PCT publication WO 2007/043278, U.S. Pat. No. 8,080,566, Org. Lett. 2011, 13(6), 1366 and Org. Lett. 2012, 14(2), 600).

Alternatively, as shown in Scheme 4, a compound of Formula 7 can be coupled with an aryl halide of Formula 4 under Ullman conditions to give the compound of Formula 2a. Ullman couplings typically are conducted in the presence of a copper salt, a ligand and a base at a temperature ranging from ambient to reflux for 24 to 72 h. Examples of copper catalysts which can be used include CuI, CuBr, Cu₂O or Copper powder. Suitable bases include potassium phosphate, potassium carbonate and cesium carbonate. Suitable ligands include N,N-dimethylcyclohexane-1,2-diamine and other N,N-dimethylethylenediamines. Suitable solvents include 1,4-dioxane, toluene, dimethyl formamide and dimethylsulfoxide. For representative conditions, see Chem. Pharm. Bull. 1997, 45, 719-721, Tet. Lett. 2004, 45, 4257-4260 and Tetrahedron 2005, 61, 2931-2939. Halide intermediates of Formula 7 are commercially available or can be prepared by methods known in the literature.

As shown in Scheme 5, a compound of Formula 4 can be made by deprotection of a compound of Formula 8. The deprotection is typically conducted by hydrogenation in the presence of a metal catalyst in a solvent at a temperature ranging from ambient to reflux for 24 to 72 h. The pressure of hydrogen gas is ranges from atmospheric to 800 bar. An example of a metal catalyst which can be used is palladium on carbon. Suitable solvents include ethyl acetate, ethanol and methanol. For representative conditions see Chemical and Pharmaceutical Bulletin, 1986, 34, 3658-3671. For alternative deprotection conditions, see Greene, T. W.; Wuts, P. G. M. Protective Groups in Organic Synthesis, 4th ed.; Wiley: Hoboken, N.J., 1991.

As shown in Scheme 6, a compound of Formula 8 can be prepared by nucleophilic substitution by heating a compound of Formula 9 with benzyl alcohol in the presence of a base. Reactions are typically conducted in benzyl alcohol at reflux. Suitable bases include sodium benzoxide formed from reaction of sodium with benzyl alcohol. For representative conditions see Chemical and Pharmaceutical Bulletin, 1986, 34, 3658-3671. Compounds of Formula 9 are commercially available or can be prepared by methods known in the literature.

As shown in Scheme 7, Formula 1b (i.e. a compound of Formula 1 wherein Z is S) can be prepared by nucleophilic substitution by heating Formula 2b (i.e. a compound of Formula 2 wherein R^(a) is H and Z is S) with a compound of Formula 3 using the method as described in Scheme 1.

As shown in Scheme 8, a compound of Formula 2b can be prepared by copper mediated cross-coupling reaction of a compound of Formula 10 with thiourea, followed by deprotection as described in Chin. J. Chem. 2010, 28, 1441-1443. Alternatively, Formula 2b can also be prepared by palladium coupling of a compound of Formula 10 with triisopropylsilane thiol (TIPS thiol), followed by deprotection as described in Angew. Chem. Int. Ed. 2012, 51, 3314-3322.

As shown in Scheme 9, a compound of Formula 5 or 6 can be coupled with an intermediate of Formula 11 using the method as described in Scheme 3 to give the compound of Formula 10. For representative conditions, see Eur. J. Med. Chem. 2013, 613-620; Tetrahedron Lett. 1998, 38, 2941 and PCT publication WO2003/072547.

As shown in Scheme 10, a compound of 1b can be converted into a compound of 1c (i.e a compound of Formula 1 wherein Z is SO) or 1d (i.e a compound of Formula 1 wherein Z is SO₂) using oxidizing conditions.

The compounds of Formula 11 are known in the literature and can be prepared easily from commercial materials. For representative methods, see Tetrahedron 1996, 52, 35, 11385-11404.

It is recognized by one skilled in the art that various functional groups can be converted into others to provide different compounds of Formula 1. For a valuable resource that illustrates the interconversion of functional groups in a simple and straightforward fashion, see Larock, R. C., Comprehensive Organic Transformations: A Guide to Functional Group Preparations, 2nd Ed., Wiley-VCH, New York, 1999. For example, intermediates for the preparation of compounds of Formula 1 may contain aromatic nitro groups, which can be reduced to amino groups, and then be converted via reactions well known in the art such as the Sandmeyer reaction, to various halides, providing compounds of Formula 1. The above reactions can also in many cases be performed in alternate order.

It is recognized that some reagents and reaction conditions described above for preparing compounds of Formula 1 may not be compatible with certain functionalities present in the intermediates. In these instances, the incorporation of protection/deprotection sequences or functional group interconversions into the synthesis will aid in obtaining the desired products. The use and choice of the protecting groups will be apparent to one skilled in chemical synthesis (see, for example, Greene, T. W.; Wuts, P. G. M. Protective Groups in Organic Synthesis, 2nd ed.; Wiley: New York, 1991). One skilled in the art will recognize that, in some cases, after the introduction of a given reagent as depicted in any individual scheme, it may be necessary to perform additional routine synthetic steps not described in detail to complete the synthesis of compounds of Formula 1. One skilled in the art will also recognize that it may be necessary to perform a combination of the steps illustrated in the above schemes in an order other than that implied by the particular presented to prepare the compounds of Formula 1.

One skilled in the art will also recognize that compounds of Formula 1 and the intermediates described herein can be subjected to various electrophilic, nucleophilic, radical, organometallic, oxidation, and reduction reactions to add substituents or modify existing substituents.

Without further elaboration, it is believed that one skilled in the art using the preceding description can utilize the present invention to its fullest extent. The following non-limiting Examples are illustrative of the invention. Steps in the following Examples illustrate a procedure for each step in an overall synthetic transformation, and the starting material for each step may not have necessarily been prepared by a particular preparative run whose procedure is described in other Examples or Steps. Percentages are by weight except for chromatographic solvent mixtures or where otherwise indicated. Parts and percentages for chromatographic solvent mixtures are by volume unless otherwise indicated. ¹H NMR spectra are reported in ppm downfield from tetramethylsilane in CDCl₃ unless otherwise noted; “s” means singlet, “d” means doublet, “t” means triplet, “m” means multiplet and “br s” means broad singlet.

Synthesis Example 1 Preparation of 1-(4-chlorophenyl)-6-[(5-chloro-2-pyrimidinyl)oxy]-2(1H)-pyridinone (Compound 1) Step A: Preparation of 2-(benzyloxy)-6-methoxypyridine

To a one liter three-neck round bottom flask containing benzyl alcohol (60.25 g, 557.2 mmol) was added sodium metal (3.56 g, 154.6 mmol) slowly in small pieces. The mixture was stirred for 1 h at room temperature. 2-Chloro-6-methoxy pyridine (20.0 g, 139.3 mmol) was added slowly and the reaction mixture was stirred and heated at 120° C. for 2 h, and monitored by TLC analysis. After completion, the reaction mixture was concentrated and the residue was diluted with water and extracted with EtOAc (3×300 mL). The combined organic layers were washed with water, dried over anhydrous Na₂SO₄ and concentrated under reduced pressure and the residue was purified by a short column. ¹HNMR showed residual peak of the title product along with a small trace of un-reacted benzyl alcohol. The product was used for the next reaction without further purification.

¹H NMR (400 MHz) δ 7.50-7.24 (m, 6H), 6.37-6.34 (m, 1H), 6.29 (d, 1H, J=8.0 Hz), 5.36 (s, 2H), 3.89 (s, 3H).

Step B: Preparation of 6-methoxy-2(1H)-pyridinone

To a solution of 2-(benzyloxy)-6-methoxypyridine (i.e. the product of Step A) (6.3 g, 29.3 mmol) in MeOH (60 mL) was added 10% Pd/C (1.0 g) and the reaction mixture was stirred under a balloon of H₂ (gas) at ambient temperature for 2 h, monitored by TLC analysis. After completion, the reaction mixture was filtered through a bed of Celite® diatomaceous earth filter aid and washed with methanol (20 mL). The filtrate was concentrated under reduced pressure. The residue was purified by column chromatography, eluting with ethyl acetate in petroleum ether 1:19 to afford the title compound (800 mg) as an off white solid.

¹H NMR (300 MHz) δ 11.44 (br s, 1H), 7.43 (t, 1H, J=8.4 Hz), 6.23 (d, 1H, J=8.7 Hz), 5.70 (d, 1H, J=7.8 Hz), 3.86 (s, 3H).

Step C: Preparation of 1-(4-chlorophenyl)-6-methoxy-2(1H)-pyridinone

To a solution of 6-methoxy-2(1H)-pyridinone (i.e. the product of Step B) (1.0 g, 8.0 mmol) in dichloromethane (10 mL) was added 4-chlorophenylboronic acid (2.5 g, 16.0 mmol), Cu(OAc)₂ (160 mg, 0.88 mmol), pyridine (1.26 g, 16.0 mmol), pyridine N-oxide (840 mg, 8.80 mmol) and molecular sieves (150 mg) and the reaction mixture was stirred at room temperature for 12 h, and monitored by TLC analysis. After completion, the reaction mixture was diluted with dichloromethan (30 mL) and ammonium hydroxide (10 mL) was added. The resulting mixture was filtered through a bed of Celite® diatomaceous earth filter aid and washed with water (10 mL). From the filtrate, the organic layer was separated, dried over anhydrous Na₂SO₄ and concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluting with ethyl acetate in petroleum ether 1:9 to afford the title compound (320 mg) as a pale green liquid.

¹H NMR (400 MHz) δ 7.56 (t, 1H, J=8.0 Hz), 7.35-7.32 (m, 2H), 7.10-7.08 (m, 2H), 6.45 (d, 1H, J=8.0 Hz), 6.35 (d, 1H, J=8.0 Hz), 3.78 (s, 3H).

Step D: Preparation of 1-(4-chlorophenyl)-6-hydroxy-2(1H)-pyridinone

A solution of 1-(4-chlorophenyl)-6-methoxy-2(1H)-pyridinone (i.e. the product of Step C) (300 mg, 1.27 mmol) in 33% HBr in acetic acid (10 mL) was stirred at 80° C. for 12 h and monitored by TLC analysis. After completion, the reaction mixture was poured into saturated aqueous NaHCO₃ solution (15 mL) and extracted with dichloromethane (3×20 mL). The combined organic layers were dried over anhydrous Na₂SO₄ and concentrated under reduced pressure. The residue was purified by column chromatography, eluted with 1:9 of ethyl acetate in petroleum ether to afford the title compound (150 mg) as an off white solid.

¹H NMR (400 MHz, DMSO-d₆) δ 10.77 (br s, 1H), 7.66 (t, 1H, J=7.8 Hz), 7.46-7.43 (m, 2H), 7.16-7.12 (m, 2H), 6.41 (s, 1H), 6.36 (d, 1H, J=8.4 Hz).

Step E: Preparation of 1-(4-Chlorophenyl)-6-[(5-chloro-2-pyrimidinyl)oxy]-2(1H)-pyridinone (Compound 1)

To a solution of 1-(4-Chlorophenyl)-6-hydroxy-2-(1H)-pyridinone (i.e. the product of Step D) (120 mg, 0.541 mmol) in N,N-dimethylformamide (5 mL) was added 2,5-dichloropyrimidine (80 mg, 0.541 mmol) and K₂CO₃ (225 mg, 1.62 mmol) and the reaction mixture was stirred at 80° C. for 2 h. After completion, the reaction mixture was poured into water (15 mL) and extracted with dicholormethane (3×10 mL). The combined organic layers were washed with water, followed by brine solution, dried over anhydrous Na₂SO₄ and concentrated under reduced pressure. The residue was purified by column chromatography, eluting with ethyl acetate in petroleum ether 1:4 to afford the title compound (100 mg) as an off white solid.

¹H NMR (300 MHz) δ 8.50 (s, 2H), 7.80 (t, 1H, J=7.8 Hz), 7.28 (m, 2H), 7.05-7.02 (m, 2H), 6.82 (d, 1H, J=7.5 Hz), 6.74 (d, 1H, J=8.1 Hz).

Synthesis Example 2 Preparation of 6-[(5-Chloro-2-pyrimidinyl)oxy]-1-[3-(trifluoromethyl)phenyl]-2(1H)-pyridinone (Compound 2) Step A: Preparation of 6-methoxy-1-[3-(trifluoromethyl)phenyl]-2(1H)-pyridinone

To a solution of 6-methoxy-2(1H)-pyridinone (i.e. the product of Step B in Synthesis Example 1) (1.00 g, 8.0 mmol) in dichloromethane (20 mL) was added 3-(trifluoromethyl)phenylboronic acid (3.03 g, 16.0 mmol), Cu(OAc)₂ (160 mg, 0.88 mmol), pyridine (1.26 g, 16.0 mmol), pyridine N-oxide (840 mg, 8.80 mmol) and molecular sieves (150 mg) and the reaction mixture was stirred at room temperature for 12 h and monitored by TLC analysis. After completion, the reaction mixture was diluted with dichloromethane (20 mL) and ammonium hydroxide solution (10 mL) was added. Then the resulting mixture was filtered through a short celite bed and washed with water (10 mL). From the filtrate, the organic layer was separated, dried over anhydrous Na₂SO₄ and concentrated under reduced pressure. The residue was purified by column chromatography eluting with ethyl acetate in petroleum ether 1:19 to afford the title compound (630 mg) as a pale yellow liquid.

¹H NMR (400 MHz) δ7.59 (t, 1H, J=8.0 Hz), 7.51-7.42 (m, 3H), 7.33 (d, 1H, J=8.0 Hz), 6.48 (d, 1H, J=8.0 Hz), 6.43 (d, 1H, J=8.0 Hz), 3.74 (s, 3H).

Step B: Preparation of 6-hydroxy-1-[3-(trifluoromethyl)phenyl]-2(1H)-pyridinone

A solution of 6-methoxy-1-[3-(trifluoromethyl)phenyl]-2(1H)-pyridinone (i.e. the product of Step A) (600 mg, 2.23 mmol) in 33% HBr in acetic acid (15 mL) was stirred at 80° C. for 12 h. The progress of the reaction was monitored by TLC analysis. After completion, the reaction mixture was poured into saturated aqueous NaHCO₃ solution (20 mL) and extracted with dichloromethane (3×25 mL). The combined organic layers were dried over anhydrous Na₂SO₄ and concentrated under reduced pressure. The residue was purified by column chromatography, eluting with ethyl acetate in petroleum ether 1:4 to afford the title compound (370 mg) as an off white solid.

¹H NMR (400 MHz) δ 10.70 (br s, 1H), 7.55-7.44 (m, 3H), 7.34 (t, 1H, J=2.0 Hz), 7.28 (t, 1H, J=2.0 Hz), 6.44 (d, 1H, J=8.3 Hz), 5.99 (d, 1H, J=7.9 Hz).

Step C: Preparation of 6-[(5-chloro-2-pyrimidinyl)oxy]-1-[3-(trifluoromethyl)phenyl]-2(1H)-pyridinone

To a solution of 6-hydroxy-1-[3-(trifluoromethyl)phenyl]-2(1H)-pyridinone (i.e. the product of Step B) (150 mg, 0.587 mmol) in N,N-dimethylformamide (8 mL) was added 2,5-dichloropyrimidine (87 mg, 0.587 mmol) and K₂CO₃ (245 mg, 1.76 mmol) and the reaction was stirred at 80° C. for 2 h. The progress of the reaction was monitored by TLC analysis. After completion, the reaction mixture was poured into water (15 mL) and extracted with CH₂Cl₂ (3×10 mL). The combined organic layers were washed with water, followed by brine solution, dried over anhydrous Na₂SO₄ and concentrated under reduced pressure. The residue was purified by column chromatography, eluting with ethyl acetate in petroleum ether 1:4 to afford the title compound (110 mg) as a pale yellow liquid.

¹H NMR (400 MHz) δ 8.48 (s, 2H), 7.84 (t, 1H, J=7.8 Hz), 7.43-7.37 (m, 3H), 7.28 (s, 1H), 6.86 (d, 1H, J=7.3 Hz), 6.82 (d, 1H, J=8.3 Hz).

Synthesis Example 3 Preparation of 6-[(5-Chloro-2-pyrimidinyl)oxy]-1-[3-(trifluoromethoxy)phenyl]-2(1H)-pyridinone (Compound 3) Step A: Preparation of 6-methoxy-1-[3-(trifluoromethoxy)phenyl]-2(1H)-pyridinone

To a solution of 6-methoxy-2(1H)-pyridinone (i.e. the product of Step B in Synthesis Example 1) (1.0 g, 8.0 mmol) in dichloromethane (20 mL) was added 3-(trifluoromethoxy)phenylboronic acid (3.29 g, 16.0 mmol), Cu(OAc)₂ (160 mg, 0.88 mmol), pyridine (1.26 g, 16.0 mmol), pyridine N-oxide (840 mg, 8.80 mmol) and molecular sieves (150 mg) and the reaction mixture was stirred at room temperature for 12 h, and monitored by TLC analysis. After completion, the reaction mixture was diluted with dichloromethane (20 mL) and ammonium hydroxide solution (10 mL) was added. Then the reaction mixture was filtered through a short celite bed and washed with water (10 mL). From the filtrate, the organic layer was separated, dried over anhydrous Na₂SO₄ and concentrated under reduced pressure. The resulting residue was purified by column chromatography, eluting with ethyl acetate in petroleum ether 1:9 to afford the title compound (450 mg) as a pale green liquid.

¹H NMR (400 MHz) δ7.58 (t, 1H, J=8.0 Hz), 7.38 (t, 1H, J=8.0 Hz), 7.10-7.03 (m, 3H), 6.48 (d, 1H, J=8.0 Hz), 6.42 (d, 1H, J=7.8 Hz), 3.76 (s, 3H).

Step B: Preparation of 6-hydroxy-1-[3-(trifluoromethoxy)phenyl]-2(1H)-pyridinone

A solution of 6-methoxy-1-[3-(trifluoromethoxy)phenyl]-2(1H)-pyridinone (i.e. the product of Step A) (500 mg, 1.27 mmol) in 33% HBr in acetic acid (10 mL) was stirred at 80° C. for 12 h and monitored by TLC analysis. After completion, the reaction mixture was poured into saturated aqueous NaHCO₃ solution (20 mL) and extracted with dichloromethane (3×20 mL). The combined organic layers were dried over anhydrous Na₂SO₄ and concentrated under reduced pressure. The resulting residue was purified by column chromatography, eluting with ethyl acetate in petroleum ether 1:9 to afford the title compound (250 mg) as an off white solid.

¹H NMR (400 MHz) δ9.64 (br s, 1H), 7.53 (t, 1H, J=8.0 Hz), 7.39 (t, 1H, J=8.3 Hz), 7.08-6.99 (m, 3H), 6.43 (d, 1H, J=8.0 Hz), 6.03 (d, 1H, J=8.0 Hz).

Step C: Preparation of 6-[(5-Chloro-2-pyrimidinyl)oxy]-1-[3-(trifluoromethoxy)phenyl]-2(1H)-pyridinone

To a solution of 6-hydroxy-1-[3-(trifluoromethoxy)phenyl]-2(1H)-pyridinone (i.e. the product of Step B) (70 mg, 0.26 mmol) in N,N-dimethylformamide (5 mL) was added 2.5-dichloropyrimidine (38 mg, 0.26 mmol) and K₂CO₃ (107 mg, 0.774 mmol) and the reaction was stirred at 80° C. for 2 h and monitored by TLC analysis. After the reaction was completed, the reaction mixture was poured into water (10 mL) and extracted with CH₂Cl₂ (3×10 mL). The combined organic layers were washed with water, followed by brine solution, dried over anhydrous Na₂SO₄ and concentrated under reduced pressure. The residue was purified by column chromatography, eluted with 1:9 of ethyl acetate in petroleum ether to afford the title compound (70 mg) as a pale green liquid.

¹H NMR (300 MHz) δ 8.50 (s, 2H), 7.83 (t, 1H, J=8.0 Hz), 7.31 (t, 1H, J=8.0 Hz), 7.05-6.98 (m, 3H), 6.86 (t, 1H, J=8.0 Hz), 6.80 (d, 1H, J=8.0 Hz).

By the procedures described herein together with methods known in the art, the following compounds of Tables 1 to 13,712 can be prepared. The following abbreviations are used in the Tables which follow: Ph means phenyl, OTFE means OCH₂CF₃, ODFM means OCF₂H, DFM means CF₂H, TFE means CH₂CF₃, OEt means ethoxy, CN means cyano, NO₂ means nitro, TMS means trimethylsilyl, S(O)Me means methylsulfinyl, and S(O)₂Me means methylsulfonyl.

TABLE 1

R^(2a) R^(2b) W R^(2a) R^(2b) W R^(2a) R^(2b) W H H O H Br O H OTFE O H F O H I O H CN O H Cl O H CF₃ O H ODFM O H OCF₃ O Br OTFE O CN Br O H DFM O Br CN O CN I O F H O Br ODFM O CN CF₃ O Cl H O Br OCF₃ O CN OTFE O Br H O Br DFM O CN CN O I H O I F O CN ODFM O CF₃ H O I Cl O CN OCF₃ O OTFE H O I Br O CN DFM O CN H O I I O ODFM F O ODFM H O I CF₃ O ODFM Cl O OCF₃ H O I OTFE O ODFM Br O DFM H O I CN O ODFM I O F F O I ODFM O ODFM CF₃ O F Cl O I OCF₃ O ODFM OTFE O F Br O I DFM O ODFM CN O F I O CF₃ F O ODFM ODFM O F CF₃ O CF₃ Cl O ODFM OCF₃ O F OTFE O CF₃ Br O ODFM DFM O F CN O CF₃ I O OCF₃ F O F ODFM O CF₃ CF₃ O OCF₃ Cl O F OCF₃ O CF₃ OTFE O OCF₃ Br O F DFM O CF₃ CN O OCF₃ I O Cl F O CF₃ ODFM O OCF₃ CF₃ O Cl Cl O CF₃ OCF₃ O OCF₃ OTFE O Cl Br O CF₃ DFM O OCF₃ CN O Cl I O OTFE F O OCF₃ ODFM O Cl CF₃ O OTFE Cl O OCF₃ OCF₃ O Cl OTFE O OTFE Br O OCF₃ DFM O Cl CN O OTFE I O DFM F O Cl ODFM O OTFE CF₃ O DFM Cl O Cl OCF₃ O OTFE OTFE O DFM Br O Cl DFM O OTFE CN O DFM I O Br F O OTFE ODFM O DFM CF₃ O Br Cl O OTFE OCF₃ O DFM OTFE O Br Br O OTFE DFM O DFM CN O Br I O CN F O DFM ODFM O Br CF₃ O CN Cl O DFM OCF₃ O DFM DFM O Cl OTFE S OTFE Br S H H S Cl CN S OTFE I S H F S Cl ODFM S OTFE CF₃ S H Cl S Cl OCF₃ S OTFE OTFE S H Br S Cl DFM S OTFE CN S H I S Br F S OTFE ODFM S H CF₃ S Br Cl S OTFE OCF₃ S H OTFE S Br Br S OTFE DFM S H CN S Br I S CN F S H ODFM S Br CF₃ S CN Cl S H OCF₃ S Br OTFE S CN Br S H DFM S Br CN S CN I S F H S Br ODFM S CN CF₃ S Cl H S Br OCF₃ S CN OTFE S Br H S Br DFM S CN CN S I H S I F S CN ODFM S CF₃ H S I Cl S CN OCF₃ S OTFE H S I Br S CN DFM S CN H S I I S ODFM F S ODFM H S I CF₃ S ODFM Cl S OCF₃ H S I OTFE S ODFM Br S DFM H S I CN S ODFM I S F F S I ODFM S ODFM CF₃ S F Cl S I OCF₃ S ODFM OTFE S F Br S I DFM S ODFM CN S F I S CF₃ F S ODFM ODFM S F CF₃ S CF₃ Cl S ODFM OCF₃ S F OTFE S CF₃ Br S ODFM DFM S F CN S CF₃ I S OCF₃ F S F ODFM S CF₃ CF₃ S OCF₃ Cl S F OCF₃ S CF₃ OTFE S OCF₃ Br S F DFM S CF₃ CN S OCF₃ I S Cl F S CF₃ ODFM S OCF₃ CF₃ S Cl Cl S CF₃ OCF₃ S OCF₃ OTFE S Cl Br S CF₃ DFM S OCF₃ CN S Cl I S OTFE F S OCF₃ ODFM S Cl CF₃ S OTFE Cl S OCF₃ OCF₃ S OCF₃ DFM S F OTFE NH CF₃ Br NH DFM F S F CN NH CF₃ I NH DFM Cl S F ODFM NH CF₃ CF₃ NH DFM Br S F OCF₃ NH CF₃ OTFE NH DFM I S F DFM NH CF₃ CN NH DFM CF₃ S Cl F NH CF₃ ODFM NH DFM OTFE S Cl Cl NH CF₃ OCF₃ NH DFM CN S Cl Br NH CF₃ DFM NH DFM ODFM S Cl I NH OTFE F NH DFM OCF₃ S Cl CF₃ NH OTFE Cl NH DFM DFM S Cl OTFE NH OTFE Br NH H H NH Cl CN NH OTFE I NH H F NH Cl ODFM NH OTFE CF₃ NH H Cl NH Cl OCF₃ NH OTFE OTFE NH H Br NH Cl DFM NH OTFE CN NH H I NH Br F NH OTFE ODFM NH H CF₃ NH Br Cl NH OTFE OCF₃ NH H OTFE NH Br Br NH OTFE DFM NH H CN NH Br I NH CN F NH H ODFM NH Br CF₃ NH CN Cl NH H OCF₃ NH Br OTFE NH CN Br NH H DFM NH Br CN NH CN I NH F H NH Br ODFM NH CN CF₃ NH Cl H NH Br OCF₃ NH CN OTFE NH Br H NH Br DFM NH CN CN NH I H NH I F NH CN ODFM NH CF₃ H NH I Cl NH CN OCF₃ NH OTFE H NH I Br NH CN DFM NH CN H NH I I NH ODFM F NH ODFM H NH I CF₃ NH ODFM Cl NH OCF₃ H NH I OTFE NH ODFM Br NH DFM H NH I CN NH ODFM I NH F F NH I ODFM NH ODFM CF₃ NH F Cl NH I OCF₃ NH ODFM OTFE NH F Br NH I DFM NH ODFM CN NH F I NH CF₃ F NH ODFM ODFM NH F CF₃ NH CF₃ Cl NH ODFM OCF₃ NH ODFM DFM NH OTFE H NMe I Br NMe OCF₃ F NH CN H NMe I I NMe OCF₃ Cl NH ODFM H NMe I CF₃ NMe OCF₃ Br NH OCF₃ H NMe I OTFE NMe OCF₃ I NH DFM H NMe I CN NMe OCF₃ CF₃ NH F F NMe I ODFM NMe OCF₃ OTFE NH F Cl NMe I OCF₃ NMe OCF₃ CN NH F Br NMe I DFM NMe OCF₃ ODFM NH F I NMe CF₃ F NMe OCF₃ OCF₃ NH F CF₃ NMe CF₃ Cl NMe OCF₃ DFM NH F OTFE NMe CF₃ Br NMe DFM F NH F CN NMe CF₃ I NMe DFM Cl NH F ODFM NMe CF₃ CF₃ NMe DFM Br NH F OCF₃ NMe CF₃ OTFE NMe DFM I NH F DFM NMe CF₃ CN NMe DFM CF₃ NH Cl F NMe CF₃ ODFM NMe DFM OTFE NH Cl Cl NMe CF₃ OCF₃ NMe DFM CN NH Cl Br NMe CF₃ DFM NMe DFM ODFM NH Cl I NMe OTFE F NMe DFM OCF₃ NH Cl CF₃ NMe OTFE Cl NMe DFM DFM NH Cl OTFE NMe OTFE Br NMe H H NMe Cl CN NMe OTFE I NMe H F NMe Cl ODFM NMe OTFE CF₃ NMe H Cl NMe Cl OCF₃ NMe OTFE OTFE NMe H Br NMe Cl DFM NMe OTFE CN NMe H I NMe Br F NMe OTFE ODFM NMe H CF₃ NMe Br Cl NMe OTFE OCF₃ NMe H OTFE NMe Br Br NMe OTFE DFM NMe H CN NMe Br I NMe CN F NMe H ODFM NMe Br CF₃ NMe CN Cl NMe H OCF₃ NMe Br OTFE NMe CN Br NMe H DFM NMe Br CN NMe CN I NMe F H NMe Br ODFM NMe CN CF₃ NMe Cl H NMe Br OCF₃ NMe CN OTFE NMe Br H NMe Br DFM NMe CN CN NMe I H NMe I F NMe CN ODFM NMe CF₃ H NMe I Cl NMe CN OCF₃ NMe CN DFM NMe H OTFE NDFM Br Br NDFM ODFM F NMe H CN NDFM Br I NDFM ODFM Cl NMe H ODFM NDFM Br CF₃ NDFM ODFM Br NMe H OCF₃ NDFM Br OTFE NDFM ODFM I NMe H DFM NDFM Br CN NDFM ODFM CF₃ NMe F H NDFM Br ODFM NDFM ODFM OTFE NMe Cl H NDFM Br OCF₃ NDFM ODFM CN NMe Br H NDFM Br DFM NDFM ODFM ODFM NMe I H NDFM I F NDFM ODFM OCF₃ NMe CF₃ H NDFM I Cl NDFM ODFM DFM NMe OTFE H NDFM I Br NDFM OCF₃ F NMe CN H NDFM I I NDFM OCF₃ Cl NMe ODFM H NDFM I CF₃ NDFM OCF₃ Br NMe OCF₃ H NDFM I OTFE NDFM OCF₃ I NMe DFM H NDFM I CN NDFM OCF₃ CF₃ NMe F F NDFM I ODFM NDFM OCF₃ OTFE NMe F Cl NDFM I OCF₃ NDFM OCF₃ CN NMe F Br NDFM I DFM NDFM OCF₃ ODFM NMe F I NDFM CF₃ F NDFM OCF₃ OCF₃ NMe F CF₃ NDFM CF₃ Cl NDFM OCF₃ DFM NMe F OTFE NDFM CF₃ Br NDFM DFM F NMe F CN NDFM CF₃ I NDFM DFM Cl NMe F ODFM NDFM CF₃ CF₃ NDFM DFM Br NMe F OCF₃ NDFM CF₃ OTFE NDFM DFM I NMe F DFM NDFM CF₃ CN NDFM DFM CF₃ NMe Cl F NDFM CF₃ ODFM NDFM DFM OTFE NMe Cl Cl NDFM CF₃ OCF₃ NDFM DFM CN NMe Cl Br NDFM CF₃ DFM NDFM DFM ODFM NMe Cl I NDFM OTFE F NDFM DFM OCF₃ NMe Cl CF₃ NDFM OTFE Cl NDFM DFM DFM NMe Cl OTFE NDFM OTFE Br NDFM H H NDFM Cl CN NDFM OTFE I NDFM H F NDFM Cl ODFM NDFM OTFE CF₃ NDFM H Cl NDFM Cl OCF₃ NDFM OTFE OTFE NDFM H Br NDFM Cl DFM NDFM OTFE CN NDFM H I NDFM Br F NDFM OTFE ODFM NDFM H CF₃ NDFM Br Cl NDFM OTFE OCF₃ NDFM OTFE DFM NDFM DFM CN NDFM Cl Br NCF₃ CN F NDFM DFM ODFM NDFM Cl I NCF₃ CN Cl NDFM DFM OCF₃ NDFM Cl CF₃ NCF₃ CN Br NDFM DFM DFM NDFM Cl OTFE NCF₃ CN I NDFM H H NCF₃ Cl CN NCF₃ CN CF₃ NDFM H F NCF₃ Cl ODFM NCF₃ CN OTFE NDFM H Cl NCF₃ Cl OCF₃ NCF₃ CN CN NDFM H Br NCF₃ Cl DFM NCF₃ CN ODFM NDFM H I NCF₃ Br F NCF₃ CN OCF₃ NDFM H CF₃ NCF₃ Br Cl NCF₃ CN DFM NDFM H OTFE NCF₃ Br Br NCF₃ ODFM F NDFM H CN NCF₃ Br I NCF₃ ODFM Cl NDFM H ODFM NCF₃ Br CF₃ NCF₃ ODFM Br NDFM H OCF₃ NCF₃ Br OTFE NCF₃ ODFM I NDFM H DFM NCF₃ Br CN NCF₃ ODFM CF₃ NDFM F H NCF₃ Br ODFM NCF₃ ODFM OTFE NDFM Cl H NCF₃ Br OCF₃ NCF₃ ODFM CN NDFM Br H NCF₃ Br DFM NCF₃ ODFM ODFM NDFM I H NCF₃ I F NCF₃ ODFM OCF₃ NDFM CF₃ H NCF₃ I Cl NCF₃ ODFM DFM NDFM OTFE H NCF₃ I Br NCF₃ OCF₃ F NDFM CN H NCF₃ I I NCF₃ OCF₃ Cl NDFM ODFM H NCF₃ I CF₃ NCF₃ OCF₃ Br NDFM OCF₃ H NCF₃ I OTFE NCF₃ OCF₃ I NDFM DFM H NCF₃ I CN NCF₃ OCF₃ CF₃ NDFM F F NCF₃ I ODFM NCF₃ OCF₃ OTFE NDFM F Cl NCF₃ I OCF₃ NCF₃ OCF₃ CN NDFM F Br NCF₃ I DFM NCF₃ OCF₃ ODFM NDFM F I NCF₃ CF₃ F NCF₃ OCF₃ OCF₃ NDFM F CF₃ NCF₃ CF₃ Cl NCF₃ OCF₃ DFM NDFM F OTFE NCF₃ CF₃ Br NCF₃ DFM F NDFM F CN NCF₃ CF₃ I NCF₃ DFM Cl NDFM F ODFM NCF₃ CF₃ CF₃ NCF₃ DFM Br NDFM F OCF₃ NCF₃ CF₃ OTFE NCF₃ DFM I NDFM F DFM NCF₃ CF₃ CN NCF₃ DFM CF₃ NDFM Cl F NCF₃ CF₃ ODFM NCF₃ DFM OTFE NDFM Cl Cl NCF₃ CF₃ OCF₃ NCF₃ CF₃ DFM NCF₃ OCF₃ CN NCF₃ F Br NTFE OTFE F NCF₃ OCF₃ ODFM NCF₃ F I NTFE OTFE Cl NCF₃ OCF₃ OCF₃ NCF₃ F CF₃ NTFE OTFE Br NCF₃ OCF₃ DFM NCF₃ F OTFE NTFE OTFE I NCF₃ DFM F NCF₃ F CN NTFE OTFE CF₃ NCF₃ DFM Cl NCF₃ F ODFM NTFE OTFE OTFE NCF₃ DFM Br NCF₃ F OCF₃ NTFE OTFE CN NCF₃ DFM I NCF₃ F DFM NTFE OTFE ODFM NCF₃ DFM CF₃ NCF₃ Cl F NTFE OTFE OCF₃ NCF₃ DFM OTFE NCF₃ Cl Cl NTFE OTFE DFM NCF₃ DFM CN NCF₃ Cl Br NTFE CN F NCF₃ DFM ODFM NCF₃ Cl I NTFE CN Cl NCF₃ DFM OCF₃ NCF₃ Cl CF₃ NTFE CN Br NCF₃ DFM DFM NCF₃ Cl OTFE NTFE CN I NCF₃ H H NTFE Cl CN NTFE CN CF₃ NCF₃ H F NTFE Cl ODFM NTFE CN OTFE NCF₃ H Cl NTFE Cl OCF₃ NTFE CN CN NCF₃ H Br NTFE Cl DFM NTFE CN ODFM NCF₃ H I NTFE Br F NTFE CN OCF₃ NCF₃ H CF₃ NTFE Br Cl NTFE CN DFM NCF₃ H OTFE NTFE Br Br NTFE ODFM F NCF₃ H CN NTFE Br I NTFE ODFM Cl NCF₃ H ODFM NTFE Br CF₃ NTFE ODFM Br NCF₃ H OCF₃ NTFE Br OTFE NTFE ODFM I NCF₃ H DFM NTFE Br CN NTFE ODFM CF₃ NCF₃ F H NTFE Br ODFM NTFE ODFM OTFE NCF₃ Cl H NTFE Br OCF₃ NTFE ODFM CN NCF₃ Br H NTFE Br DFM NTFE ODFM ODFM NCF₃ I H NTFE I F NTFE ODFM OCF₃ NCF₃ CF₃ H NTFE I Cl NTFE ODFM DFM NCF₃ OTFE H NTFE I Br NTFE OCF₃ F NCF₃ CN H NTFE I I NTFE OCF₃ Cl NCF₃ ODFM H NTFE I CF₃ NTFE OCF₃ Br NCF₃ OCF₃ H NTFE I OTFE NTFE OCF₃ I NCF₃ DFM H NTFE I CN NTFE OCF₃ CF₃ NCF₃ F F NTFE I ODFM NTFE OCF₃ OTFE NCF₃ F Cl NTFE I OCF₃ NTFE I DFM NTFE CN F NTFE OCF₃ Cl NTFE CF₃ F NTFE CN Cl NTFE OCF₃ Br NTFE CF₃ Cl NTFE CN Br NTFE OCF₃ I NTFE CF₃ Br NTFE CN I NTFE OCF₃ CF₃ NTFE CF₃ I NTFE CN CF₃ NTFE OCF₃ OTFE NTFE CF₃ CF₃ NTFE CN OTFE NTFE OCF₃ CN NTFE CF₃ OTFE NTFE CN CN NTFE OCF₃ ODFM NTFE CF₃ CN NTFE CN ODFM NTFE OCF₃ OCF₃ NTFE CF₃ ODFM NTFE CN OCF₃ NTFE OCF₃ DFM NTFE CF₃ OCF₃ NTFE CN DFM NTFE DFM F NTFE CF₃ DFM NTFE ODFM F NTFE DFM Cl NTFE OTFE F NTFE ODFM Cl NTFE DFM Br NTFE OTFE Cl NTFE ODFM Br NTFE DFM I NTFE OTFE Br NTFE ODFM I NTFE DFM CF₃ NTFE OTFE I NTFE ODFM CF₃ NTFE DFM OTFE NTFE OTFE CF₃ NTFE ODFM OTFE NTFE DFM CN NTFE OTFE OTFE NTFE ODFM CN NTFE DFM ODFM NTFE OTFE CN NTFE ODFM ODFM NTFE DFM OCF₃ NTFE OTFE ODFM NTFE ODFM OCF₃ NTFE DFM DFM NTFE OTFE OCF₃ NTFE ODFM DFM NTFE OTFE DFM NTFE OCF₃ F NTFE The present disclosure also includes Tables 2 through 319, each of which is constructed the same as Table 1 above, except that the row heading in Table 1 (i.e. “Z═O, R¹═Cl, R^(4a)═H, R^(4b)═H R^(4c)═H”) is replaced with the respective row heading shown below. For Example, in Table 2 the row heading is “Z═O, R¹═F, R^(4a)═H, R^(4b)═H R^(4c)═H” and R^(2a), R^(2b), and W are as defined in Table 1 above.

Table Table Heading 2 Z = O, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = H 3 Z = O, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = H 4 Z = O, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = H 5 Z = O, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = H 6 Z = O, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = H 7 Z = O, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = H 8 Z = O, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = H 9 Z = S, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = H 10 Z = S, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = H 11 Z = S, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = H 12 Z = S, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = H 13 Z = S, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = H 14 Z = S, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = H 15 Z = S, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = H 16 Z = S, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = H 17 Z = SO, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = H 18 Z = SO, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = H 19 Z = SO, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = H 20 Z = SO, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = H 21 Z = SO, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = H 22 Z = SO, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = H 23 Z = SO, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = H 24 Z = SO, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = H 25 Z = SO₂, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = H 26 Z = SO₂, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = H 27 Z = SO₂, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = H 28 Z = SO₂, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = H 29 Z = SO₂, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = H 30 Z = SO₂, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = H 31 Z = SO₂, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = H 32 Z = SO₂, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = H 33 Z = O, R¹ = F, R^(4a) = Cl, R^(4b) = H R^(4c) = H 34 Z = O, R¹ = Cl, R^(4a) = Cl, R^(4b) = H R^(4c) = H 35 Z = O, R¹ = Br, R^(4a) = Cl, R^(4b) = H R^(4c) = H 36 Z = O, R¹ = I, R^(4a) = Cl, R^(4b) = H R^(4c) = H 37 Z = O, R¹ = F, R^(4a) = Cl, R^(4b) = H R^(4c) = H 38 Z = O, R¹ = Cl, R^(4a) = Cl, R^(4b) = H R^(4c) = H 39 Z = O, R¹ = Br, R^(4a) = Cl, R^(4b) = H R^(4c) = H 40 Z = O, R¹ = I, R^(4a) = Cl, R^(4b) = H R^(4c) = H 41 Z = S, R¹ = F, R^(4a) = Cl, R^(4b) = H R^(4c) = H 42 Z = S, R¹ = Cl, R^(4a) = Cl, R^(4b) = H R^(4c) = H 43 Z = S, R¹ = Br, R^(4a) = Cl, R^(4b) = H R^(4c) = H 44 Z = S, R¹ = I, R^(4a) = Cl, R^(4b) = H R^(4c) = H 45 Z = S, R¹ = F, R^(4a) = Cl, R^(4b) = H R^(4c) = H 46 Z = S, R¹ = Cl, R^(4a) = Cl, R^(4b) = H R^(4c) = H 47 Z = S, R¹ = Br, R^(4a) = Cl, R^(4b) = H R^(4c) = H 48 Z = S, R¹ = I, R^(4a) = Cl, R^(4b) = H R^(4c) = H 49 Z = SO, R¹ = F, R^(4a) = Cl, R^(4b) = H R^(4c) = H 50 Z = SO, R¹ = Cl, R^(4a) = Cl, R^(4b) = H R^(4c) = H 51 Z = SO, R¹ = Br, R^(4a) = Cl, R^(4b) = H R^(4c) = H 52 Z = SO, R¹ = I, R^(4a) = Cl, R^(4b) = H R^(4c) = H 53 Z = SO, R¹ = F, R^(4a) = Cl, R^(4b) = H R^(4c) = H 54 Z = SO, R¹ = Cl, R^(4a) = Cl, R^(4b) = H R^(4c) = H 55 Z = SO, R¹ = Br, R^(4a) = Cl, R^(4b) = H R^(4c) = H 56 Z = SO, R¹ = I, R^(4a) = Cl, R^(4b) = H R^(4c) = H 57 Z = SO₂, R¹ = F, R^(4a) = Cl, R^(4b) = H R^(4c) = H 58 Z = SO₂, R¹ = Cl, R^(4a) = Cl, R^(4b) = H R^(4c) = H 59 Z = SO₂, R¹ = Br, R^(4a) = Cl, R^(4b) = H R^(4c) = H 60 Z = SO₂, R¹ = I, R^(4a) = Cl, R^(4b) = H R^(4c) = H 61 Z = SO₂, R¹ = F, R^(4a) = Cl, R^(4b) = H R^(4c) = H 62 Z = SO₂, R¹ = Cl, R^(4a) = Cl, R^(4b) = H R^(4c) = H 63 Z = SO₂, R¹ = Br, R^(4a) = Cl, R^(4b) = H R^(4c) = H 64 Z = SO₂, R¹ = I, R^(4a) = Cl, R^(4b) = H R^(4c) = H 65 Z = O, R¹ = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 66 Z = O, R¹ = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 67 Z = O, R¹ = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 68 Z = O, R¹ = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 69 Z = O, R¹ = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 70 Z = O, R¹ = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 71 Z = O, R¹ = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 72 Z = O, R¹ = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 73 Z = S, R¹ = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 74 Z = S, R¹ = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 75 Z = S, R¹ = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 76 Z = S, R¹ = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 77 Z = S, R¹ = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 78 Z = S, R¹ = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 79 Z = S, R¹ = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 80 Z = S, R¹ = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 81 Z = SO, R¹ = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 82 Z = SO, R¹ = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 83 Z = SO, R¹ = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 84 Z = SO, R¹ = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 85 Z = SO, R¹ = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 86 Z = SO, R¹ = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 87 Z = SO, R¹ = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 88 Z = SO, R¹ = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 89 Z = SO₂, R¹ = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 90 Z = SO₂, R¹ = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 91 Z = SO₂, R¹ = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 92 Z = SO₂, R¹ = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 93 Z = SO₂, R¹ = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 94 Z = SO₂, R¹ = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 95 Z = SO₂, R¹ = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 96 Z = SO₂, R¹ = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 97 Z = O, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = Cl 98 Z = O, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = Cl 99 Z = O, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = Cl 100 Z = O, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = Cl 101 Z = O, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = Cl 102 Z = O, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = Cl 103 Z = O, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = Cl 104 Z = O, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = Cl 105 Z = S, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = Cl 106 Z = S, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = Cl 107 Z = S, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = Cl 108 Z = S, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = Cl 109 Z = S, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = Cl 110 Z = S, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = Cl 111 Z = S, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = Cl 112 Z = S, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = Cl 113 Z = SO, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = Cl 114 Z = SO, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = Cl 115 Z = SO, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = Cl 116 Z = SO, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = Cl 117 Z = SO, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = Cl 118 Z = SO, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = Cl 119 Z = SO, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = Cl 120 Z = SO, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = Cl 121 Z = SO₂, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = Cl 122 Z = SO₂, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = Cl 123 Z = SO₂, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = Cl 124 Z = SO₂, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = Cl 125 Z = SO₂, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = Cl 126 Z = SO₂, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = Cl 127 Z = SO₂, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = Cl 128 Z = SO₂, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = Cl 129 Z = O, R¹ = F, R^(4a) = F, R^(4b) = H R^(4c) = H 130 Z = O, R¹ = Cl, R^(4a) = F, R^(4b) = H R^(4c) = H 131 Z = O, R¹ = Br, R^(4a) = F, R^(4b) = H R^(4c) = H 132 Z = O, R¹ = I, R^(4a) = F, R^(4b) = H R^(4c) = H 133 Z = O, R¹ = F, R^(4a) = F, R^(4b) = H R^(4c) = H 134 Z = O, R¹ = Cl, R^(4a) = F, R^(4b) = H R^(4c) = H 135 Z = O, R¹ = Br, R^(4a) = F, R^(4b) = H R^(4c) = H 136 Z = O, R¹ = I, R^(4a) = F, R^(4b) = H R^(4c) = H 137 Z = S, R¹ = F, R^(4a) = F, R^(4b) = H R^(4c) = H 138 Z = S, R¹ = Cl, R^(4a) = F, R^(4b) = H R^(4c) = H 139 Z = S, R¹ = Br, R^(4a) = F, R^(4b) = H R^(4c) = H 140 Z = S, R¹ = I, R^(4a) = F, R^(4b) = H R^(4c) = H 141 Z = S, R¹ = F, R^(4a) = F, R^(4b) = H R^(4c) = H 142 Z = S, R¹ = Cl, R^(4a) = F, R^(4b) = H R^(4c) = H 143 Z = S, R¹ = Br, R^(4a) = F, R^(4b) = H R^(4c) = H 144 Z = S, R¹ = I, R^(4a) = F, R^(4b) = H R^(4c) = H 145 Z = SO, R¹ = F, R^(4a) = F, R^(4b) = H R^(4c) = H 146 Z = SO, R¹ = Cl, R^(4a) = F, R^(4b) = H R^(4c) = H 147 Z = SO, R¹ = Br, R^(4a) = F, R^(4b) = H R^(4c) = H 148 Z = SO, R¹ = I, R^(4a) = F, R^(4b) = H R^(4c) = H 149 Z = SO, R¹ = F, R^(4a) = F, R^(4b) = H R^(4c) = H 150 Z = SO, R¹ = Cl, R^(4a) = F, R^(4b) = H R^(4c) = H 151 Z = SO, R¹ = Br, R^(4a) = F, R^(4b) = H R^(4c) = H 152 Z = SO, R¹ = I, R^(4a) = F, R^(4b) = H R^(4c) = H 153 Z = SO₂, R¹ = F, R^(4a) = F, R^(4b) = H R^(4c) = H 154 Z = SO₂, R¹ = Cl, R^(4a) = F, R^(4b) = H R^(4c) = H 155 Z = SO₂, R¹ = Br, R^(4a) = F, R^(4b) = H R^(4c) = H 156 Z = SO₂, R¹ = I, R^(4a) = F, R^(4b) = H R^(4c) = H 157 Z = SO₂, R¹ = F, R^(4a) = F, R^(4b) = H R^(4c) = H 158 Z = SO₂, R¹ = Cl, R^(4a) = F, R^(4b) = H R^(4c) = H 159 Z = SO₂, R¹ = Br, R^(4a) = F, R^(4b) = H R^(4c) = H 160 Z = SO₂, R¹ = I, R^(4a) = F, R^(4b) = H R^(4c) = H 161 Z = O, R¹ = F, R^(4a) = H, R^(4b) = F R^(4c) = H 162 Z = O, R¹ = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 163 Z = O, R¹ = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 164 Z = O, R¹ = I, R^(4a) = H, R^(4b) = F R^(4c) = H 165 Z = O, R¹ = F, R^(4a) = H, R^(4b) = F R^(4c) = H 166 Z = O, R¹ = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 167 Z = O, R¹ = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 168 Z = O, R¹ = I, R^(4a) = H, R^(4b) = F R^(4c) = H 169 Z = S, R¹ = F, R^(4a) = H, R^(4b) = F R^(4c) = H 170 Z = S, R¹ = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 171 Z = S, R¹ = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 172 Z = S, R¹ = I, R^(4a) = H, R^(4b) = F R^(4c) = H 173 Z = S, R¹ = F, R^(4a) = H, R^(4b) = F R^(4c) = H 174 Z = S, R¹ = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 175 Z = S, R¹ = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 176 Z = S, R¹ = I, R^(4a) = H, R^(4b) = F R^(4c) = H 177 Z = SO, R¹ = F, R^(4a) = H, R^(4b) = F R^(4c) = H 178 Z = SO, R¹ = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 179 Z = SO, R¹ = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 180 Z = SO, R¹ = I, R^(4a) = H, R^(4b) = F R^(4c) = H 181 Z = SO, R¹ = F, R^(4a) = H, R^(4b) = F R^(4c) = H 182 Z = SO, R¹ = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 183 Z = SO, R¹ = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 184 Z = SO, R¹ = I, R^(4a) = H, R^(4b) = F R^(4c) = H 185 Z = SO₂, R¹ = F, R^(4a) = H, R^(4b) = F R^(4c) = H 186 Z = SO₂, R¹ = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 187 Z = SO₂, R¹ = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 188 Z = SO₂, R¹ = I, R^(4a) = H, R^(4b) = F R^(4c) = H 189 Z = SO₂, R¹ = F, R^(4a) = H, R^(4b) = F R^(4c) = H 190 Z = SO₂, R¹ = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 191 Z = SO₂, R¹ = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 192 Z = SO₂, R¹ = I, R^(4a) = H, R^(4b) = F R^(4c) = H 193 Z = O, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = F 194 Z = O, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = F 195 Z = O, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = F 196 Z = O, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = F 197 Z = O, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = F 198 Z = O, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = F 199 Z = O, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = F 200 Z = O, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = F 201 Z = S, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = F 202 Z = S, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = F 203 Z = S, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = F 204 Z = S, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = F 205 Z = S, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = F 206 Z = S, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = F 207 Z = S, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = F 208 Z = S, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = F 209 Z = SO, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = F 210 Z = SO, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = F 211 Z = SO, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = F 212 Z = SO, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = F 213 Z = SO, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = F 214 Z = SO, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = F 215 Z = SO, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = F 216 Z = SO, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = F 217 Z = SO₂, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = F 218 Z = SO₂, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = F 219 Z = SO₂, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = F 220 Z = SO₂, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = F 221 Z = SO₂, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = F 222 Z = SO₂, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = F 223 Z = SO₂, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = F 224 Z = SO₂, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = F 225 Z = O, R¹ = F, R^(4a) = CN, R^(4b) = H R^(4c) = H 226 Z = O, R¹ = Cl, R^(4a) = CN, R^(4b) = H R^(4c) = H 227 Z = O, R¹ = Br, R^(4a) = CN, R^(4b) = H R^(4c) = H 228 Z = O, R¹ = I, R^(4a) = CN, R^(4b) = H R^(4c) = H 229 Z = O, R¹ = F, R^(4a) = CN, R^(4b) = H R^(4c) = H 230 Z = O, R¹ = Cl, R^(4a) = CN, R^(4b) = H R^(4c) = H 231 Z = O, R¹ = Br, R^(4a) = CN, R^(4b) = H R^(4c) = H 232 Z = O, R¹ = I, R^(4a) = CN, R^(4b) = H R^(4c) = H 233 Z = S, R¹ = F, R^(4a) = CN, R^(4b) = H R^(4c) = H 234 Z = S, R¹ = Cl, R^(4a) = CN, R^(4b) = H R^(4c) = H 235 Z = S, R¹ = Br, R^(4a) = CN, R^(4b) = H R^(4c) = H 236 Z = S, R¹ = I, R^(4a) = CN, R^(4b) = H R^(4c) = H 237 Z = S, R¹ = F, R^(4a) = CN, R^(4b) = H R^(4c) = H 238 Z = S, R¹ = Cl, R^(4a) = CN, R^(4b) = H R^(4c) = H 239 Z = S, R¹ = Br, R^(4a) = CN, R^(4b) = H R^(4c) = H 240 Z = S, R¹ = I, R^(4a) = CN, R^(4b) = H R^(4c) = H 241 Z = SO, R¹ = F, R^(4a) = CN, R^(4b) = H R^(4c) = H 242 Z = SO, R¹ = Cl, R^(4a) = CN, R^(4b) = H R^(4c) = H 243 Z = SO, R¹ = Br, R^(4a) = CN, R^(4b) = H R^(4c) = H 244 Z = SO, R¹ = I, R^(4a) = CN, R^(4b) = H R^(4c) = H 245 Z = SO, R¹ = F, R^(4a) = CN, R^(4b) = H R^(4c) = H 246 Z = SO, R¹ = Cl, R^(4a) = CN, R^(4b) = H R^(4c) = H 247 Z = SO, R¹ = Br, R^(4a) = CN, R^(4b) = H R^(4c) = H 248 Z = SO, R¹ = I, R^(4a) = CN, R^(4b) = H R^(4c) = H 249 Z = SO₂, R¹ = F, R^(4a) = CN, R^(4b) = H R^(4c) = H 250 Z = SO₂, R¹ = Cl, R^(4a) = CN, R^(4b) = H R^(4c) = H 251 Z = SO₂, R¹ = Br, R^(4a) = CN, R^(4b) = H R^(4c) = H 252 Z = SO₂, R¹ = I, R^(4a) = CN, R^(4b) = H R^(4c) = H 253 Z = SO₂, R¹ = F, R^(4a) = CN, R^(4b) = H R^(4c) = H 254 Z = SO₂, R¹ = Cl, R^(4a) = CN, R^(4b) = H R^(4c) = H 255 Z = SO₂, R¹ = Br, R^(4a) = CN, R^(4b) = H R^(4c) = H 256 Z = SO₂, R¹ = I, R^(4a) = CN, R^(4b) = H R^(4c) = H 257 Z = O, R¹ = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 258 Z = O, R¹ = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 259 Z = O, R¹ = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 260 Z = O, R¹ = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 261 Z = O, R¹ = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 262 Z = O, R¹ = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 263 Z = O, R¹ = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 264 Z = O, R¹ = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 265 Z = S, R¹ = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 266 Z = S, R¹ = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 267 Z = S, R¹ = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 268 Z = S, R¹ = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 269 Z = S, R¹ = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 270 Z = S, R¹ = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 271 Z = S, R¹ = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 272 Z = S, R¹ = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 273 Z = SO, R¹ = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 274 Z = SO, R¹ = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 275 Z = SO, R¹ = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 276 Z = SO, R¹ = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 277 Z = SO, R¹ = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 278 Z = SO, R¹ = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 279 Z = SO, R¹ = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 280 Z = SO, R¹ = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 281 Z = SO₂, R¹ = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 282 Z = SO₂, R¹ = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 283 Z = SO₂, R¹ = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 284 Z = SO₂, R¹ = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 285 Z = SO₂, R¹ = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 286 Z = SO₂, R¹ = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 287 Z = SO₂, R¹ = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 288 Z = SO₂, R¹ = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 289 Z = O, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = CN 290 Z = O, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = CN 291 Z = O, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = CN 292 Z = O, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = CN 293 Z = O, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = CN 294 Z = O, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = CN 295 Z = O, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = CN 296 Z = O, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = CN 297 Z = S, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = CN 298 Z = S, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = CN 299 Z = S, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = CN 300 Z = S, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = CN 301 Z = S, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = CN 302 Z = S, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = CN 303 Z = S, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = CN 304 Z = S, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = CN 305 Z = SO, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = CN 306 Z = SO, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = CN 307 Z = SO, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = CN 308 Z = SO, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = CN 309 Z = SO, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = CN 310 Z = SO, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = CN 311 Z = SO, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = CN 312 Z = SO, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = CN 313 Z = SO₂, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = CN 314 Z = SO₂, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = CN 315 Z = SO₂, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = CN 316 Z = SO₂, R¹ = I, R^(4a) = H, R^(4b) = H R^(4c) = CN 317 Z = SO₂, R¹ = F, R^(4a) = H, R^(4b) = H R^(4c) = CN 318 Z = SO₂, R¹ = Cl, R^(4a) = H, R^(4b) = H R^(4c) = CN 319 Z = SO₂, R¹ = Br, R^(4a) = H, R^(4b) = H R^(4c) = CN

Table 320

Table 320 is constructed the same way as Table 1 above except that the structure is replaced with the structure below.

The disclosure also includes Tables 321-638 which are constructed the same as Table 320 except that the header row is replaced with the header row shown in Tables 2-319.

Table 639

Table 639 is constructed the same way as Table 1 except that the structure is replaced with the structure below.

The disclosure also includes Tables 640-958 which are constructed the same as Table 639 except that the header row is replaced with the header row shown in Tables 2-319.

Table 959

Table 959 is constructed the same way as Table 1 except that the structure is replaced with the structure below.

The disclosure also includes Tables 960-1278 which are constructed the same as Table 959 except that the header row is replaced with the header row shown in Tables 2-319.

Table 1279

Table 1279 is constructed the same way as Table 1 except that the structure is replaced with the structure below.

The disclosure also includes Tables 1280-1598 which are constructed the same as Table 1279 except that the header row is replaced with the header row shown in Tables 2-319.

Table 1599

Table 1599 is constructed the same way as Table 1 except that the structure is replaced with the structure below.

The disclosure also includes Tables 1600-1918 which are constructed the same as Table 1599 except that the header row is replaced with the header row shown in Tables 2-319.

TABLE 1919

R^(2a) W H O H S H NH H NDFM H NCF₃ H NTFE F O F S F NH F NDFM F NCF₃ F NTFE Cl O Cl S Cl NH Cl NDFM Cl NCF₃ Cl NTFE Br O Br S Br NH Br NDFM Br NCF₃ Br NTFE I O I S I NH I NDFM I NCF₃ I NTFE CF₃ O CF₃ S CF₃ NH CF₃ NDFM CF₃ NCF₃ CF₃ NTFE OTFE O OTFE S OTFE NH OTFE NDFM OTFE NCF₃ OTFE NTFE CN O CN S CN NH CN NDFM CN NCF₃ CN NTFE OCF₂H O OCF₂H S OCF₂H NH OCF₂H NDFM OCF₂H NCF₃ OCF₂H NTFE OCF₃ O OCF₃ S OCF₃ NH OCF₃ NDFM OCF₃ NCF₃ OCF₃ NTFE CF₂H O CF₂H S CF₂H NH CF₂H NDFM CF₂H NCF₃ CF₂H NTFE

The disclosure also includes Tables 1920-2238 which are constructed the same as Table 1919 except that the header row is replaced with the header row shown in Tables 2-319.

Table 2239

Table 2239 is constructed the same way as Table 1919 except that the structure is replaced with the structure below.

The disclosure also includes Tables 2400-2718 which are constructed the same as Table 2239 except that the header row is replaced with the header row shown in Tables 2-319.

Table 2719

Table 2719 is constructed the same way as Table 1919 except that the structure is replaced with the structure below.

The disclosure also includes Tables 2720-3038 which are constructed the same as Table 2719 except that the header row is replaced with the header row shown in Tables 2-319.

Table 3039

Table 3039 is constructed the same way as Table 1919 except that the structure is replaced with the structure below.

The disclosure also includes Tables 3040-3358 which are constructed the same as Table 3039 except that the header row is replaced with the header row shown in Tables 2-319.

Table 3359

Table 3359 is constructed the same way as Table 1919 except that the structure is replaced with the structure below.

The disclosure also includes Tables 3360-3678 which are constructed the same as Table 3359 except that the header row is replaced with the header row shown in Tables 2-319.

Table 3679

Table 3679 is constructed the same way as Table 1919 except that the structure is replaced with the structure below.

The disclosure also includes Tables 3680-3998 which are constructed the same as Table 3679 except that the header row is replaced with the header row shown in Tables 2-319.

TABLE 3999

R2a CF₂H CF₃ CH₂CF₃ H Me

The disclosure also includes Tables 4000-4318 which are constructed the same as Table 3999 except that the header row is replaced with the header row shown in Tables 2-319.

Table 4319

Table 4319 is constructed the same way as Table 3999 except that the structure is replaced with the structure below.

The disclosure also includes Tables 4320-4638 which are constructed the same as Table 4319 except that the header row is replaced with the header row shown in Tables 2-319.

TABLE 4639

R^(2a) R^(2b) W H H O F H O Cl H O Br H O I H O CF₃ H O OTFE H O CN H O ODFM H O OCF₃ H O CF₂H H O H F O F F O Cl F O Br F O I F O CF₃ F O OTFE F O CN F O ODFM F O OCF₃ F O CF₂H F O H Cl O F Cl O Cl Cl O Br Cl O I Cl O CF₃ Cl O OTFE Cl O CN Cl O ODFM Cl O OCF₃ Cl O CF₂H Cl O H Br O F Br O Cl Br O Br Br O I Br O CF₃ Br O OTFE Br O CN Br O ODFM Br O OCF₃ Br O CF₂H Br O H I O F I O Cl I O Br I O I I O CF₃ I O OTFE I O CN I O ODFM I O OCF₃ I O CF₂H I O H CF₃ O F CF₃ O Cl CF₃ O Br CF₃ O I CF₃ O CF₃ CF₃ O OTFE CF₃ O CN CF₃ O ODFM CF₃ O OCF₃ CF₃ O CF₂H CF₃ O H OTFE O F OTFE O Cl OTFE O Br OTFE O I OTFE O CF₃ OTFE O OTFE OTFE O CN OTFE O ODFM OTFE O OCF₃ OTFE O CF₂H OTFE O H CN O F CN O Cl CN O Br CN O I CN O CF₃ CN O OTFE CN O CN CN O ODFM CN O OCF₃ CN O CF₂H CN O H ODFM O F ODFM O Cl ODFM O Br ODFM O I ODFM O CF₃ ODFM O OTFE ODFM O CN ODFM O ODFM ODFM O OCF₃ ODFM O CF₂H ODFM O H OCF₃ O F OCF₃ O Cl OCF₃ O Br OCF₃ O I OCF₃ O CF₃ OCF₃ O OTFE OCF₃ O CN OCF₃ O ODFM OCF₃ O OCF₃ OCF₃ O CF₂H OCF₃ O H CF₂H O F CF₂H O Cl CF₂H O Br CF₂H O I CF₂H O CF₃ CF₂H O OTFE CF₂H O CN CF₂H O ODFM CF₂H O OCF₃ CF₂H O CF₂H CF₂H O H H S F H S Cl H S Br H S I H S CF₃ H S OTFE H S CN H S ODFM H S OCF₃ H S CF₂H H S H F S F F S Cl F S Br F S I F S CF₃ F S OTFE F S CN F S ODFM F S OCF₃ F S CF₂H F S H Cl S F Cl S Cl Cl S Br Cl S I Cl S CF₃ Cl S OTFE Cl S CN Cl S ODFM Cl S OCF₃ Cl S CF₂H Cl S H Br S F Br S Cl Br S Br Br S I Br S CF₃ Br S OTFE Br S CN Br S ODFM Br S OCF₃ Br S CF₂H Br S H I S F I S Cl I S Br I S I I S CF₃ I S OTFE I S CN I S ODFM I S OCF₃ I S CF₂H I S H CF₃ S F CF₃ S Cl CF₃ S Br CF₃ S I CF₃ S CF₃ CF₃ S OTFE CF₃ S CN CF₃ S ODFM CF₃ S OCF₃ CF₃ S CF₂H CF₃ S H OTFE S F OTFE S Cl OTFE S Br OTFE S I OTFE S CF₃ OTFE S OTFE OTFE S CN OTFE S ODFM OTFE S OCF₃ OTFE S CF₂H OTFE S H CN S F CN S Cl CN S Br CN S I CN S CF₃ CN S OTFE CN S CN CN S ODFM CN S OCF₃ CN S CF₂H CN S H ODFM S F ODFM S Cl ODFM S Br ODFM S I ODFM S CF₃ ODFM S OTFE ODFM S CN ODFM S ODFM ODFM S OCF₃ ODFM S CF₂H ODFM S H OCF₃ S F OCF₃ S Cl OCF₃ S Br OCF₃ S I OCF₃ S CF₃ OCF₃ S OTFE OCF₃ S CN OCF₃ S ODFM OCF₃ S OCF₃ OCF₃ S CF₂H OCF₃ S H CF₂H S F CF₂H S Cl CF₂H S Br CF₂H S I CF₂H S CF₃ CF₂H S OTFE CF₂H S CN CF₂H S ODFM CF₂H S OCF₃ CF₂H S CF₂H CF₂H S H H NH F H NH Cl H NH Br H NH I H NH CF₃ H NH OTFE H NH CN H NH ODFM H NH OCF₃ H NH CF₂H H NH H F NH F F NH Cl F NH Br F NH I F NH CF₃ F NH OTFE F NH CN F NH ODFM F NH OCF₃ F NH CF₂H F NH H Cl NH F Cl NH Cl Cl NH Br Cl NH I Cl NH CF₃ Cl NH OTFE Cl NH CN Cl NH ODFM Cl NH OCF₃ Cl NH CF₂H Cl NH H Br NH F Br NH Cl Br NH Br Br NH I Br NH CF₃ Br NH OTFE Br NH CN Br NH ODFM Br NH OCF₃ Br NH CF₂H Br NH H I NH F I NH Cl I NH Br I NH I I NH CF₃ I NH OTFE I NH CN I NH ODFM I NH OCF₃ I NH CF₂H I NH H CF₃ NH F CF₃ NH Cl CF₃ NH Br CF₃ NH I CF₃ NH CF₃ CF₃ NH OTFE CF₃ NH CN CF₃ NH ODFM CF₃ NH OCF₃ CF₃ NH CF₂H CF₃ NH H OTFE NH F OTFE NH Cl OTFE NH Br OTFE NH I OTFE NH CF₃ OTFE NH OTFE OTFE NH CN OTFE NH ODFM OTFE NH OCF₃ OTFE NH CF₂H OTFE NH H CN NH F CN NH Cl CN NH Br CN NH I CN NH CF₃ CN NH OTFE CN NH CN CN NH ODFM CN NH OCF₃ CN NH CF₂H CN NH H ODFM NH F ODFM NH Cl ODFM NH Br ODFM NH I ODFM NH CF₃ ODFM NH OTFE ODFM NH CN ODFM NH ODFM ODFM NH OCF₃ ODFM NH CF₂H ODFM NH H OCF₃ NH F OCF₃ NH Cl OCF₃ NH Br OCF₃ NH I OCF₃ NH CF₃ OCF₃ NH OTFE OCF₃ NH CN OCF₃ NH ODFM OCF₃ NH OCF₃ OCF₃ NH CF₂H OCF₃ NH H CF₂H NH F CF₂H NH Cl CF₂H NH Br CF₂H NH I CF₂H NH CF₃ CF₂H NH OTFE CF₂H NH CN CF₂H NH ODFM CF₂H NH OCF₃ CF₂H NH CF₂H CF₂H NH H H NCF₃ F H NCF₃ Cl H NCF₃ Br H NCF₃ I H NCF₃ CF₃ H NCF₃ OTFE H NCF₃ CN H NCF₃ ODFM H NCF₃ OCF₃ H NCF₃ CF₂H H NCF₃ H F NCF₃ F F NCF₃ Cl F NCF₃ Br F NCF₃ I F NCF₃ CF₃ F NCF₃ OTFE F NCF₃ CN F NCF₃ ODFM F NCF₃ OCF₃ F NCF₃ CF₂H F NCF₃ H Cl NCF₃ F Cl NCF₃ Cl Cl NCF₃ Br Cl NCF₃ I Cl NCF₃ CF₃ Cl NCF₃ OTFE Cl NCF₃ CN Cl NCF₃ ODFM Cl NCF₃ OCF₃ Cl NCF₃ CF₂H Cl NCF₃ H Br NCF₃ F Br NCF₃ Cl Br NCF₃ Br Br NCF₃ I Br NCF₃ CF₃ Br NCF₃ OTFE Br NCF₃ CN Br NCF₃ ODFM Br NCF₃ OCF₃ Br NCF₃ CF₂H Br NCF₃ H I NCF₃ F I NCF₃ Cl I NCF₃ Br I NCF₃ I I NCF₃ CF₃ I NCF₃ OTFE I NCF₃ CN I NCF₃ ODFM I NCF₃ OCF₃ I NCF₃ CF₂H I NCF₃ H CF₃ NCF₃ F CF₃ NCF₃ Cl CF₃ NCF₃ Br CF₃ NCF₃ I CF₃ NCF₃ CF₃ CF₃ NCF₃ OTFE CF₃ NCF₃ CN CF₃ NCF₃ ODFM CF₃ NCF₃ OCF₃ CF₃ NCF₃ CF₂H CF₃ NCF₃ H OTFE NCF₃ F OTFE NCF₃ Cl OTFE NCF₃ Br OTFE NCF₃ I OTFE NCF₃ CF₃ OTFE NCF₃ OTFE OTFE NCF₃ CN OTFE NCF₃ ODFM OTFE NCF₃ OCF₃ OTFE NCF₃ CF₂H OTFE NCF₃ H CN NCF₃ F CN NCF₃ Cl CN NCF₃ Br CN NCF₃ I CN NCF₃ CF₃ CN NCF₃ OTFE CN NCF₃ CN CN NCF₃ ODFM CN NCF₃ OCF₃ CN NCF₃ CF₂H CN NCF₃ H ODFM NCF₃ F ODFM NCF₃ Cl ODFM NCF₃ Br ODFM NCF₃ I ODFM NCF₃ CF₃ ODFM NCF₃ OTFE ODFM NCF₃ CN ODFM NCF₃ ODFM ODFM NCF₃ OCF₃ ODFM NCF₃ CF₂H ODFM NCF₃ H OCF₃ NCF₃ F OCF₃ NCF₃ Cl OCF₃ NCF₃ Br OCF₃ NCF₃ I OCF₃ NCF₃ CF₃ OCF₃ NCF₃ OTFE OCF₃ NCF₃ CN OCF₃ NCF₃ ODFM OCF₃ NCF₃ OCF₃ OCF₃ NCF₃ CF₂H OCF₃ NCF₃ H CF₂H NCF₃ F CF₂H NCF₃ Cl CF₂H NCF₃ Br CF₂H NCF₃ I CF₂H NCF₃ CF₃ CF₂H NCF₃ OTFE CF₂H NCF₃ CN CF₂H NCF₃ ODFM CF₂H NCF₃ OCF₃ CF₂H NCF₃ CF₂H CF₂H NCF₃ H H NCF₂H F H NCF₂H Cl H NCF₂H Br H NCF₂H I H NCF₂H CF₃ H NCF₂H OTFE H NCF₂H CN H NCF₂H ODFM H NCF₂H OCF₃ H NCF₂H CF₂H H NCF₂H H F NCF₂H F F NCF₂H Cl F NCF₂H Br F NCF₂H I F NCF₂H CF₃ F NCF₂H OTFE F NCF₂H CN F NCF₂H ODFM F NCF₂H OCF₃ F NCF₂H CF₂H F NCF₂H H Cl NCF₂H F Cl NCF₂H Cl Cl NCF₂H Br Cl NCF₂H I Cl NCF₂H CF₃ Cl NCF₂H OTFE Cl NCF₂H CN Cl NCF₂H ODFM Cl NCF₂H OCF₃ Cl NCF₂H CF₂H Cl NCF₂H H Br NCF₂H F Br NCF₂H Cl Br NCF₂H Br Br NCF₂H I Br NCF₂H CF₃ Br NCF₂H OTFE Br NCF₂H CN Br NCF₂H ODFM Br NCF₂H OCF₃ Br NCF₂H CF₂H Br NCF₂H H I NCF₂H F I NCF₂H Cl I NCF₂H Br I NCF₂H I I NCF₂H CF₃ I NCF₂H OTFE I NCF₂H CN I NCF₂H ODFM I NCF₂H OCF₃ I NCF₂H CF₂H I NCF₂H H CF₃ NCF₂H F CF₃ NCF₂H Cl CF₃ NCF₂H Br CF₃ NCF₂H I CF₃ NCF₂H CF₃ CF₃ NCF₂H OTFE CF₃ NCF₂H CN CF₃ NCF₂H ODFM CF₃ NCF₂H OCF₃ CF₃ NCF₂H CF₂H CF₃ NCF₂H H OTFE NCF₂H F OTFE NCF₂H Cl OTFE NCF₂H Br OTFE NCF₂H I OTFE NCF₂H CF₃ OTFE NCF₂H OTFE OTFE NCF₂H CN OTFE NCF₂H ODFM OTFE NCF₂H OCF₃ OTFE NCF₂H CF₂H OTFE NCF₂H H CN NCF₂H F CN NCF₂H Cl CN NCF₂H Br CN NCF₂H I CN NCF₂H CF₃ CN NCF₂H OTFE CN NCF₂H CN CN NCF₂H ODFM CN NCF₂H OCF₃ CN NCF₂H CF₂H CN NCF₂H H ODFM NCF₂H F ODFM NCF₂H Cl ODFM NCF₂H Br ODFM NCF₂H I ODFM NCF₂H CF₃ ODFM NCF₂H OTFE ODFM NCF₂H CN ODFM NCF₂H ODFM ODFM NCF₂H OCF₃ ODFM NCF₂H CF₂H ODFM NCF₂H H OCF₃ NCF₂H F OCF₃ NCF₂H Cl OCF₃ NCF₂H Br OCF₃ NCF₂H I OCF₃ NCF₂H CF₃ OCF₃ NCF₂H OTFE OCF₃ NCF₂H CN OCF₃ NCF₂H ODFM OCF₃ NCF₂H OCF₃ OCF₃ NCF₂H CF₂H OCF₃ NCF₂H H CF₂H NCF₂H F CF₂H NCF₂H Cl CF₂H NCF₂H Br CF₂H NCF₂H I CF₂H NCF₂H CF₃ CF₂H NCF₂H OTFE CF₂H NCF₂H CN CF₂H NCF₂H ODFM CF₂H NCF₂H OCF₃ CF₂H NCF₂H CF₂H CF₂H NCF₂H H H NCH₂CF₃ F H NCH₂CF₃ Cl H NCH₂CF₃ Br H NCH₂CF₃ I H NCH₂CF₃ CF₃ H NCH₂CF₃ OTFE H NCH₂CF₃ CN H NCH₂CF₃ ODFM H NCH₂CF₃ OCF₃ H NCH₂CF₃ CF₂H H NCH₂CF₃ H F NCH₂CF₃ F F NCH₂CF₃ Cl F NCH₂CF₃ Br F NCH₂CF₃ I F NCH₂CF₃ CF₃ F NCH₂CF₃ OTFE F NCH₂CF₃ CN F NCH₂CF₃ ODFM F NCH₂CF₃ OCF₃ F NCH₂CF₃ CF₂H F NCH₂CF₃ H Cl NCH₂CF₃ F Cl NCH₂CF₃ Cl Cl NCH₂CF₃ Br Cl NCH₂CF₃ I Cl NCH₂CF₃ CF₃ Cl NCH₂CF₃ OTFE Cl NCH₂CF₃ CN Cl NCH₂CF₃ ODFM Cl NCH₂CF₃ OCF₃ Cl NCH₂CF₃ CF₂H Cl NCH₂CF₃ H Br NCH₂CF₃ F Br NCH₂CF₃ Cl Br NCH₂CF₃ Br Br NCH₂CF₃ I Br NCH₂CF₃ CF₃ Br NCH₂CF₃ OTFE Br NCH₂CF₃ CN Br NCH₂CF₃ ODFM Br NCH₂CF₃ OCF₃ Br NCH₂CF₃ CF₂H Br NCH₂CF₃ H I NCH₂CF₃ F I NCH₂CF₃ Cl I NCH₂CF₃ Br I NCH₂CF₃ I I NCH₂CF₃ CF₃ I NCH₂CF₃ OTFE I NCH₂CF₃ CN I NCH₂CF₃ ODFM I NCH₂CF₃ OCF₃ I NCH₂CF₃ CF₂H I NCH₂CF₃ H CF₃ NCH₂CF₃ F CF₃ NCH₂CF₃ Cl CF₃ NCH₂CF₃ Br CF₃ NCH₂CF₃ I CF₃ NCH₂CF₃ CF₃ CF₃ NCH₂CF₃ OTFE CF₃ NCH₂CF₃ CN CF₃ NCH₂CF₃ ODFM CF₃ NCH₂CF₃ OCF₃ CF₃ NCH₂CF₃ CF₂H CF₃ NCH₂CF₃ H OTFE NCH₂CF₃ F OTFE NCH₂CF₃ Cl OTFE NCH₂CF₃ Br OTFE NCH₂CF₃ I OTFE NCH₂CF₃ CF₃ OTFE NCH₂CF₃ OTFE OTFE NCH₂CF₃ CN OTFE NCH₂CF₃ ODFM OTFE NCH₂CF₃ OCF₃ OTFE NCH₂CF₃ CF₂H OTFE NCH₂CF₃ H CN NCH₂CF₃ F CN NCH₂CF₃ Cl CN NCH₂CF₃ Br CN NCH₂CF₃ I CN NCH₂CF₃ CF₃ CN NCH₂CF₃ OTFE CN NCH₂CF₃ CN CN NCH₂CF₃ ODFM CN NCH₂CF₃ OCF₃ CN NCH₂CF₃ CF₂H CN NCH₂CF₃ H ODFM NCH₂CF₃ F ODFM NCH₂CF₃ Cl ODFM NCH₂CF₃ Br ODFM NCH₂CF₃ I ODFM NCH₂CF₃ CF₃ ODFM NCH₂CF₃ OTFE ODFM NCH₂CF₃ CN ODFM NCH₂CF₃ ODFM ODFM NCH₂CF₃ OCF₃ ODFM NCH₂CF₃ CF₂H ODFM NCH₂CF₃ H OCF₃ NCH₂CF₃ F OCF₃ NCH₂CF₃ Cl OCF₃ NCH₂CF₃ Br OCF₃ NCH₂CF₃ I OCF₃ NCH₂CF₃ CF₃ OCF₃ NCH₂CF₃ OTFE OCF₃ NCH₂CF₃ CN OCF₃ NCH₂CF₃ ODFM OCF₃ NCH₂CF₃ OCF₃ OCF₃ NCH₂CF₃ CF₂H OCF₃ NCH₂CF₃ H CF₂H NCH₂CF₃ F CF₂H NCH₂CF₃ Cl CF₂H NCH₂CF₃ Br CF₂H NCH₂CF₃ I CF₂H NCH₂CF₃ CF₃ CF₂H NCH₂CF₃ OTFE CF₂H NCH₂CF₃ CN CF₂H NCH₂CF₃ ODFM CF₂H NCH₂CF₃ OCF₃ CF₂H NCH₂CF₃ CF₂H CF₂H NCH₂CF₃

The present disclosure also includes Tables 4640-6389, each of which is constructed the same as Table 4639 above, except that the row heading in Table 4639 (i.e. “Z═O, R¹═Cl, R^(2c)═H, R^(4a)═H, R^(4b)═H R^(4c)═H”) is replaced with the respective row heading shown below. For Example, in Table 4640 the row heading is “Z═O, R¹═F, R^(2c)═H, R^(4a)═H, R^(4b)═H R^(4c)═H” and Z and R¹ are as defined in Table 4639 above.

Table Table Heading 4640 Z = O, R¹ = F, R^(2c) = H, R^(4a) = H, R^(4b) = R^(4c) = H 4641 Z = O, R¹ = Br, R^(2c) = H, R^(4a) = H, R^(4b) = R^(4c) = H 4642 Z = O, R¹ = I, R^(2c) = H, R^(4a) = H, R^(4b) = R^(4c) = H 4643 Z = S, R¹ = F, R^(2c) = H, R^(4a) = H, R^(4b) = R^(4c) = H 4644 Z = S, R¹ = Cl, R^(2c) = H, R^(4a) = H, R^(4b) = R^(4c) = H 4645 Z = S, R¹ = Br, R^(2c) = H, R^(4a) = H, R^(4b) = R^(4c) = H 4646 Z = S, R¹ = I, R^(2c) = H, R^(4a) = H, R^(4b) = R^(4c) = H 4647 Z = SO, R¹ = F, R^(2c) = H, R^(4a) = H, R^(4b) = R^(4c) = H 4648 Z = SO, R¹ = Cl, R^(2c) = H, R^(4a) = H, R^(4b) = R^(4c) = H 4649 Z = SO, R¹ = Br, R^(2c) = H, R^(4a) = H, R^(4b) = R^(4c) = H 4650 Z = SO, R¹ = I, R^(2c) = H, R^(4a) = H, R^(4b) = R^(4c) = H 4651 Z = SO₂, R¹ = F, R^(2c) = H, R^(4a) = H, R^(4b) = R^(4c) = H 4652 Z = SO₂, R¹ = Cl, R^(2c) = H, R^(4a) = H, R^(4b) = R^(4c) = H 4653 Z = SO₂, R¹ = Br, R^(2c) = H, R^(4a) = H, R^(4b) = R^(4c) = H 4654 Z = SO₂, R¹ = I, R^(2c) = H, R^(4a) = R^(4b) = R^(4c) = H 4655 Z = O, R¹ = F, R^(2c) = F, R^(4a) = R^(4b) = R^(4c) = H 4656 Z = O, R¹ = Cl, R^(2c) = F, R^(4a) = R^(4b) = R^(4c) = H 4657 Z = O, R¹ = Br, R^(2c) = F, R^(4a) = R^(4b) = R^(4c) = H 4658 Z = O, R¹ = I, R^(2c) = F, R^(4a) = R^(4b) = R^(4c) = H 4659 Z = S, R¹ = F, R^(2c) = F, R^(4a) = R^(4b) = R^(4c) = H 4660 Z = S, R¹ = Cl, R^(2c) = F, R^(4a) = R^(4b) = R^(4c) = H 4661 Z = S, R¹ = Br, R^(2c) = F, R^(4a) = R^(4b) = R^(4c) = H 4662 Z = S, R¹ = I, R^(2c) = F, R^(4a) = R^(4b) = R^(4c) = H 4663 Z = SO, R¹ = F, R^(2c) = F, R^(4a) = R^(4b) = R^(4c) = H 4664 Z = SO, R¹ = Cl, R^(2c) = F, R^(4a) = R^(4b) = R^(4c) = H 4665 Z = SO, R¹ = Br, R^(2c) = F, R^(4a) = R^(4b) = R^(4c) = H 4666 Z = SO, R¹ = I, R^(2c) = F, R^(4a) = R^(4b) = R^(4c) = H 4667 Z = SO₂, R¹ = F, R^(2c) = F, R^(4a) = R^(4b) = R^(4c) = H 4668 Z = SO₂, R¹ = Cl, R^(2c) = F, R^(4a) = R^(4b) = R^(4c) = H 4669 Z = SO₂, R¹ = Br, R^(2c) = F, R^(4a) = R^(4b) = R^(4c) = H 4670 Z = SO₂, R¹ = I, R^(2c) = F, R^(4a) = R^(4b) = R^(4c) = H 4671 Z = O, R¹ = F, R^(2c) = Cl, R^(4a) = R^(4b) = R^(4c) = H 4672 Z = O, R¹ = Cl, R^(2c) = Cl, R^(4a) = R^(4b) = R^(4c) = H 4673 Z = O, R¹ = Br, R^(2c) = Cl, R^(4a) = R^(4b) = R^(4c) = H 4674 Z = O, R¹ = I, R^(2c) = Cl, R^(4a) = R^(4b) = R^(4c) = H 4675 Z = S, R¹ = F, R^(2c) = Cl, R^(4a) = R^(4b) = R^(4c) = H 4676 Z = S, R¹ = Cl, R^(2c) = Cl, R^(4a) = R^(4b) = R^(4c) = H 4677 Z = S, R¹ = Br, R^(2c) = Cl, R^(4a) = R^(4b) = R^(4c) = H 4678 Z = S, R¹ = I, R^(2c) = Cl, R^(4a) = R^(4b) = R^(4c) = H 4679 Z = SO, R¹ = F, R^(2c) = Cl, R^(4a) = R^(4b) = R^(4c) = H 4680 Z = SO, R¹ = Cl, R^(2c) = Cl, R^(4a) = R^(4b) = R^(4c) = H 4681 Z = SO, R¹ = Br, R^(2c) = Cl, R^(4a) = R 4b = R^(4c) = H 4682 Z = SO, R¹ = I, R^(2c) = Cl, R^(4a) = R^(4b) = R^(4c) = H 4683 Z = SO₂, R¹ = F, R^(2c) = Cl, R^(4a) = R^(4b) = R^(4c) = H 4684 Z = SO₂, R¹ = Cl, R^(2c) = Cl, R^(4a) = R^(4b) = R^(4c) = H 4685 Z = SO₂, R¹ = Br, R^(2c) = Cl, R^(4a) = R^(4b) = R^(4c) = H 4686 Z = SO₂, R¹ = I, R^(2c) = Cl, R^(4a) = R^(4b) = R^(4c) = H 4687 Z = O, R¹ = F, R^(2c) = Br, R^(4a) = R^(4b) = R^(4c) = H 4688 Z = O, R¹ = Cl, R^(2c) = Br, R^(4a) = R^(4b) = R^(4c) = H 4689 Z = O, R¹ = Br, R^(2c) = Br, R^(4a) = R^(4b) = R^(4c) = H 4690 Z = O, R¹ = I, R^(2c) = Br, R^(4a) = R^(4b) = R^(4c) = H 4691 Z = S, R¹ = F, R^(2c) = Br, R^(4a) = R^(4b) = R^(4c) = H 4692 Z = S, R¹ = Cl, R^(2c) = Br, R^(4a) = R^(4b) = R^(4c) = H 4693 Z = S, R¹ = Br, R^(2c) = Br, R^(4a) = R^(4b) = R^(4c) = H 4694 Z = S, R¹ = I, R^(2c) = Br, R^(4a) = R^(4b) = R^(4c) = H 4695 Z = SO, R¹ = F, R^(2c) = Br, R^(4a) = R^(4b) = R^(4c) = H 4696 Z = SO, R¹ = Cl, R^(2c) = Br, R^(4a) = R^(4b) = R^(4c) = H 4697 Z = SO, R¹ = Br, R^(2c) = Br, R^(4a) = R^(4b) = R^(4c) = H 4698 Z = SO, R¹ = I, R^(2c) = Br, R^(4a) = R^(4b) = R^(4c) = H 4699 Z = SO₂, R¹ = F, R^(2c) = Br, R^(4a) = R^(4b) = R^(4c) = H 4700 Z = SO₂, R¹ = Cl, R^(2c) = Br, R^(4a) = R^(4b) = R^(4c) = H 4701 Z = SO₂, R¹ = Br, R^(2c) = Br, R^(4a) = R^(4b) = R^(4c) = H 4702 Z = SO₂, R¹ = I, R^(2c) = Br, R^(4a) = R^(4b) = R^(4c) = H 4703 Z = O, R¹ = F, R^(2c) = I, R^(4a) = R^(4b) = R^(4c) = H 4704 Z = O, R¹ = Cl, R^(2c) = I, R^(4a) = R^(4b) = R^(4c) = H 4705 Z = O, R¹ = Br, R^(2c) = I, R^(4a) = R^(4b) = R^(4c) = H 4706 Z = O, R¹ = I, R^(2c) = I, R^(4a) = R^(4b) = R^(4c) = H 4707 Z = S, R¹ = F, R^(2c) = I, R^(4a) = R^(4b) = R^(4c) = H 4708 Z = S, R¹ = Cl, R^(2c) = I, R^(4a) = R^(4b) = R^(4c) = H 4709 Z = S, R¹ = Br, R^(2c) = I, R^(4a) = R^(4b) = R^(4c) = H 4710 Z = S, R¹ = I, R^(2c) = I, R^(4a) = R^(4b) = R^(4c) = H 4711 Z = SO, R¹ = F, R^(2c) = I, R^(4a) = R^(4b) = R^(4c) = H 4712 Z = SO, R¹ = Cl, R^(2c) = I, R^(4a) = R^(4b) = R^(4c) = H 4713 Z = SO, R¹ = Br, R^(2c) = I, R^(4a) = R^(4b) = R^(4c) = H 4714 Z = SO, R¹ = I, R^(2c) = I, R^(4a) = R^(4b) = R^(4c) = H 4715 Z = SO₂, R¹ = F, R^(2c) = I, R^(4a) = R^(4b) = R^(4c) = H 4716 Z = SO₂, R¹ = Cl, R^(2c) = I, R^(4a) = R^(4b) = R^(4c) = H 4717 Z = SO₂, R¹ = Br, R^(2c) = I, R^(4a) = R^(4b) = R^(4c) = H 4718 Z = SO₂, R¹ = I, R^(2c) = I, R^(4a) = R^(4b) = R^(4c) = H 4719 Z = O, R¹ = F, R^(2c) = CF₃, R^(4a) = R^(4b) = R^(4c) = H 4720 Z = O, R¹ = Cl, R^(2c) = CF₃, R^(4a) = R^(4b) = R^(4c) = H 4721 Z = O, R¹ = Br, R^(2c) = CF₃, R^(4a) = R^(4b) = R^(4c) = H 4722 Z = O, R¹ = I, R^(2c) = CF₃, R^(4a) = R^(4b) = R^(4c) = H 4723 Z = S, R¹ = F, R^(2c) = CF₃, R^(4a) = R^(4b) = R^(4c) = H 4724 Z = S, R¹ = Cl, R^(2c) = CF₃, R^(4a) = R^(4b) = R^(4c) = H 4725 Z = S, R¹ = Br, R^(2c) = CF₃, R^(4a) = R^(4b) = R^(4c) = H 4726 Z = S, R¹ = I, R^(2c) = CF₃, R^(4a) = R^(4b) = R^(4c) = H 4727 Z = SO, R¹ = F, R^(2c) = CF₃, R^(4a) = R^(4b) = R^(4c) = H 4728 Z = SO, R¹ = Cl, R^(2c) = CF₃, R^(4a) = R^(4b) = R^(4c) = H 4729 Z = SO, R¹ = Br, R^(2c) = CF₃, R^(4a) = R^(4b) = R^(4c) = H 4730 Z = SO, R¹ = I, R^(2c) = CF₃, R^(4a) = R^(4b) = R^(4c) = H 4731 Z = SO₂, R¹ = F, R^(2c) = CF₃, R^(4a) = R^(4b) = R^(4c) = H 4732 Z = SO₂, R¹ = Cl, R^(2c) = CF₃, R^(4a) = R^(4b) = R^(4c) = H 4733 Z = SO₂, R¹ = Br, R^(2c) = CF₃, R^(4a) = R^(4b) = R^(4c) = H 4734 Z = SO₂, R¹ = I, R^(2c) = CF₃, R^(4a) = R^(4b) = R^(4c) = H 4735 Z = O, R¹ = F, R^(2c) = OTFE, R^(4a) = R^(4b) = R^(4c) = H 4736 Z = O, R¹ = Cl, R^(2c) = OTFE, R^(4a) = R^(4b) = R^(4c) = H 4737 Z = O, R¹ = Br, R^(2c) = OTFE, R^(4a) = R^(4b) = R^(4c) = H 4738 Z = O, R¹ = I, R^(2c) = OTFE, R^(4a) = R^(4b) = R^(4c) = H 4739 Z = S, R¹ = F, R^(2c) = OTFE, R^(4a) = R^(4b) = R^(4c) = H 4740 Z = S, R¹ = Cl, R^(2c) = OTFE, R^(4a) = R^(4b) = R^(4c) = H 4741 Z = S, R¹ = Br, R^(2c) = OTFE, R^(4a) = R^(4b) = R^(4c) = H 4742 Z = S, R¹ = I, R^(2c) = OTFE, R^(4a) = R^(4b) = R^(4c) = H 4743 Z = SO, R¹ = F, R^(2c) = OTFE, R^(4a) = R^(4b) = R^(4c) = H 4744 Z = SO, R¹ = Cl, R^(2c) = OTFE, R^(4a) = R^(4b) = R^(4c) = H 4745 Z = SO, R¹ = Br, R^(2c) = OTFE, R^(4a) = R^(4b) = R^(4c) = H 4746 Z = SO, R¹ = I, R^(2c) = OTFE, R^(4a) = R^(4b) = R^(4c) = H 4747 Z = SO₂, R¹ = F, R^(2c) = OTFE, R^(4a) = R^(4b) = R^(4c) = H 4748 Z = SO₂, R¹ = Cl, R^(2c) = OTFE, R^(4a) = R^(4b) = R^(4c) = H 4749 Z = SO₂, R¹ = Br, R^(2c) = OTFE, R^(4a) = R^(4b) = R^(4c) = H 4750 Z = SO₂, R¹ = I, R^(2c) = OTFE, R^(4a) = R^(4b) = R^(4c) = H 4751 Z = O, R¹ = F, R^(2c) = CN, R^(4a) = R^(4b) = R^(4c) = H 4752 Z = O, R¹ = Cl, R^(2c) = CN, R^(4a) = R^(4b) = R^(4c) = H 4753 Z = O, R¹ = Br, R^(2c) = CN, R^(4a) = R^(4b) = R^(4c) = H 4754 Z = O, R¹ = I, R^(2c) = CN, R^(4a) = R^(4b) = R^(4c) = H 4755 Z = S, R¹ = F, R^(2c) = CN, R^(4a) = R^(4b) = R^(4c) = H 4756 Z = S, R¹ = Cl, R^(2c) = CN, R^(4a) = R^(4b) = R^(4c) = H 4757 Z = S, R¹ = Br, R^(2c) = CN, R^(4a) = R^(4b) = R^(4c) = H 4758 Z = S, R¹ = I, R^(2c) = CN, R^(4a) = R^(4b) = R^(4c) = H 4759 Z = SO, R¹ = F, R^(2c) = CN, R^(4a) = R^(4b) = R^(4c) = H 4760 Z = SO, R¹ = Cl, R^(2c) = CN, R^(4a) = R^(4b) = R^(4c) = H 4761 Z = SO, R¹ = Br, R^(2c) = CN, R^(4a) = R^(4b) = R^(4c) = H 4762 Z = SO, R¹ = I, R^(2c) = CN, R^(4a) = R^(4b) = R^(4c) = H 4763 Z = SO₂, R¹ = F, R^(2c) = CN, R^(4a) = R^(4b) = R^(4c) = H 4764 Z = SO₂, R¹ = Cl, R^(2c) = CN, R^(4a) = R^(4b) = R^(4c) = H 4765 Z = SO₂, R¹ = Br, R^(2c) = CN, R^(4a) = R^(4b) = R^(4c) = H 4766 Z = SO₂, R¹ = I, R^(2c) = CN, R^(4a) = R^(4b) = R^(4c) = H 4767 Z = O, R¹ = F, R^(2c) = ODFM, R^(4a) = R^(4b) = R^(4c) = H 4768 Z = O, R¹ = Cl, R^(2c) = ODFM, R^(4a) = R^(4b) = R^(4c) = H 4769 Z = O, R¹ = Br, R^(2c) = ODFM, R^(4a) = R^(4b) = R^(4c) = H 4770 Z = O, R¹ = I, R^(2c) = ODFM, R^(4a) = R^(4b) = R^(4c) = H 4771 Z = S, R¹ = F, R^(2c) = ODFM, R^(4a) = R^(4b) = R^(4c) = H 4772 Z = S, R¹ = Cl, R^(2c) = ODFM, R^(4a) = R^(4b) = R^(4c) = H 4773 Z = S, R¹ = Br, R^(2c) = ODFM, R^(4a) = R^(4b) = R^(4c) = H 4774 Z = S, R¹ = I, R^(2c) = ODFM, R^(4a) = R^(4b) = R^(4c) = H 4775 Z = SO, R¹ = F, R^(2c) = ODFM, R^(4a) = R^(4b) = R^(4c) = H 4776 Z = SO, R¹ = Cl, R^(2c) = ODFM, R^(4a) = R^(4b) = R^(4c) = H 4777 Z = SO, R¹ = Br, R^(2c) = ODFM, R^(4a) = R^(4b) = R^(4c) = H 4778 Z = SO, R¹ = I, R^(2c) = ODFM, R^(4a) = R^(4b) = R^(4c) = H 4779 Z = SO₂, R¹ = F, R^(2c) = ODFM, R^(4a) = R^(4b) = R^(4c) = H 4780 Z = SO₂, R¹ = Cl, R^(2c) = ODFM, R^(4a) = R^(4b) = R^(4c) = H 4781 Z = SO₂, R¹ = Br, R^(2c) = ODFM, R^(4a) = R^(4b) = R^(4c) = H 4782 Z = SO₂, R¹ = I, R^(2c) = ODFM, R^(4a) = R^(4b) = R^(4c) = H 4783 Z = O, R¹ = F, R^(2c) = OCF₃, R^(4a) = R^(4b) = R^(4c) = H 4784 Z = O, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = R^(4b) = R^(4c) = H 4785 Z = O, R¹ = Br, R^(2c) = OCF₃, R^(4a) = R^(4b) = R^(4c) = H 4786 Z = O, R¹ = I, R^(2c) = OCF₃, R^(4a) = R^(4b) = R^(4c) = H 4787 Z = S, R¹ = F, R^(2c) = OCF₃, R^(4a) = R^(4b) = R^(4c) = H 4788 Z = S, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = R^(4b) = R^(4c) = H 4789 Z = S, R¹ = Br, R^(2c) = OCF₃, R^(4a) = R^(4b) = R^(4c) = H 4790 Z = S, R¹ = I, R^(2c) = OCF₃, R^(4a) = R^(4b) = R^(4c) = H 4791 Z = SO, R¹ = F, R^(2c) = OCF₃, R^(4a) = R^(4b) = R^(4c) = H 4792 Z = SO, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = R^(4b) = R^(4c) = H 4793 Z = SO, R¹ = Br, R^(2c) = OCF₃, R^(4a) = R^(4b) = R^(4c) = H 4794 Z = SO, R¹ = I, R^(2c) = OCF₃, R^(4a) = R^(4b) = R^(4c) = H 4795 Z = SO₂, R¹ = F, R^(2c) = OCF₃, R^(4a) = R^(4b) = R^(4c) = H 4796 Z = SO₂, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = R^(4b) = R^(4c) = H 4797 Z = SO₂, R¹ = Br, R^(2c) = OCF₃, R^(4a) = R^(4b) = R^(4c) = H 4798 Z = SO₂, R¹ = I, R^(2c) = OCF₃, R^(4a) = R^(4b) = R^(4c) = H 4799 Z = O, R¹ = F, R^(2c) = CF₂H, R^(4a) = R^(4b) = R^(4c) = H 4800 Z = O, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = R^(4b) = R^(4c) = H 4801 Z = O, R¹ = Br, R^(2c) = CF₂H, R^(4a) = R^(4b) = R^(4c) = H 4802 Z = O, R¹ = I, R^(2c) = CF₂H, R^(4a) = R^(4b) = R^(4c) = H 4803 Z = S, R¹ = F, R^(2c) = CF₂H, R^(4a) = R^(4b) = R^(4c) = H 4804 Z = S, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = R^(4b) = R^(4c) = H 4805 Z = S, R¹ = Br, R^(2c) = CF₂H, R^(4a) = R^(4b) = R^(4c) = H 4806 Z = S, R¹ = I, R^(2c) = CF₂H, R^(4a) = R^(4b) = R^(4c) = H 4807 Z = SO, R¹ = F, R^(2c) = CF₂H, R^(4a) = R^(4b) = R^(4c) = H 4808 Z = SO, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = R^(4b) = R^(4c) = H 4809 Z = SO, R¹ = Br, R^(2c) = CF₂H, R^(4a) = R^(4b) = R^(4c) = H 4810 Z = SO, R¹ = I, R^(2c) = CF₂H, R^(4a) = R^(4b) = R^(4c) = H 4811 Z = SO₂, R¹ = F, R^(2c) = CF₂H, R^(4a) = R^(4b) = R^(4c) = H 4812 Z = SO₂, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = R^(4b) = R^(4c) = H 4813 Z = SO₂, R¹ = Br, R^(2c) = CF₂H, R^(4a) = R^(4b) = R^(4c) = H 4814 Z = SO₂, R¹ = I, R^(2c) = CF₂H, R^(4a) = R^(4b) = R^(4c) = H 4815 Z = O, R¹ = F, R^(2c) = H, R^(4a) = F, R^(4b) = R^(4c) = H 4816 Z = O, R¹ = Br, R^(2c) = H, R^(4a) = F, R^(4b) = R^(4c) = H 4817 Z = O, R¹ = I, R^(2c) = H, R^(4a) = F, R^(4b) = R^(4c) = H 4818 Z = S, R¹ = F, R^(2c) = H, R^(4a) = F, R^(4b) = R^(4c) = H 4819 Z = S, R¹ = Cl, R^(2c) = H, R^(4a) = F, R^(4b) = R^(4c) = H 4820 Z = S, R¹ = Br, R^(2c) = H, R^(4a) = F, R^(4b) = R^(4c) = H 4821 Z = S, R¹ = I, R^(2c) = H, R^(4a) = F, R^(4b) = R^(4c) = H 4822 Z = SO, R¹ = F, R^(2c) = H, R^(4a) = F, R^(4b) = R^(4c) = H 4823 Z = SO, R¹ = Cl, R^(2c) = H, R^(4a) = F, R^(4b) = R^(4c) = H 4824 Z = SO, R¹ = Br, R^(2c) = H, R^(4a) = F, R^(4b) = R^(4c) = H 4825 Z = SO, R¹ = I, R^(2c) = H, R^(4a) = F, R^(4b) = R^(4c) = H 4826 Z = SO₂, R¹ = F, R^(2c) = H, R^(4a) = F, R^(4b) = R^(4c) = H 4827 Z = SO₂, R¹ = Cl, R^(2c) = H, R^(4a) = F, R^(4b) = R^(4c) = H 4828 Z = SO₂, R¹ = Br, R^(2c) = H, R^(4a) = F, R^(4b) = R^(4c) = H 4829 Z = SO₂, R¹ = I, R^(2c) = H, R^(4a) = F, R^(4b) = R^(4c) = H 4830 Z = O, R¹ = F, R^(2c) = F, R^(4a) = F, R^(4b) = R^(4c) = H 4831 Z = O, R¹ = Cl, R^(2c) = F, R^(4a) = F, R^(4b) = R^(4c) = H 4832 Z = O, R¹ = Br, R^(2c) = F, R^(4a) = F, R^(4b) = R^(4c) = H 4833 Z = O, R¹ = I, R^(2c) = F, R^(4a) = F, R^(4b) = R^(4c) = H 4834 Z = S, R¹ = F, R^(2c) = F, R^(4a) = F, R^(4b) = R^(4c) = H 4835 Z = S, R¹ = Cl, R^(2c) = F, R^(4a) = F, R^(4b) = R^(4c) = H 4836 Z = S, R¹ = Br, R^(2c) = F, R^(4a) = F, R^(4b) = R^(4c) = H 4837 Z = S, R¹ = I, R^(2c) = F, R^(4a) = F, R^(4b) = R^(4c) = H 4838 Z = SO, R¹ = F, R^(2c) = F, R^(4a) = F, R^(4b) = R^(4c) = H 4839 Z = SO, R¹ = Cl, R^(2c) = F, R^(4a) = F, R^(4b) = R^(4c) = H 4840 Z = SO, R¹ = Br, R^(2c) = F, R^(4a) = F, R^(4b) = R^(4c) = H 4841 Z = SO, R¹ = I, R^(2c) = F, R^(4a) = F, R^(4b) = R^(4c) = H 4842 Z = SO₂, R¹ = F, R^(2c) = F, R^(4a) = F, R^(4b) = R^(4c) = H 4843 Z = SO₂, R¹ = Cl, R^(2c) = F, R^(4a) = F, R^(4b) = R^(4c) = H 4844 Z = SO₂, R¹ = Br, R^(2c) = F, R^(4a) = F, R^(4b) = R^(4c) = H 4845 Z = SO₂, R¹ = I, R^(2c) = F, R^(4a) = F, R^(4b) = R^(4c) = H 4846 Z = O, R¹ = F, R^(2c) = Cl, R^(4a) = F, R^(4b) = R^(4c) = H 4847 Z = O, R¹ = Cl, R^(2c) = Cl, R^(4a) = F, R^(4b) = R^(4c) = H 4848 Z = O, R¹ = Br, R^(2c) = Cl, R^(4a) = F, R^(4b) = R^(4c) = H 4849 Z = O, R¹ = I, R^(2c) = Cl, R^(4a) = F, R^(4b) = R^(4c) = H 4850 Z = S, R¹ = F, R^(2c) = Cl, R^(4a) = F, R^(4b) = R^(4c) = H 4851 Z = S, R¹ = Cl, R^(2c) = Cl, R^(4a) = F, R^(4b) = R^(4c) = H 4852 Z = S, R¹ = Br, R^(2c) = Cl, R^(4a) = F, R^(4b) = R^(4c) = H 4853 Z = S, R¹ = I, R^(2c) = Cl, R^(4a) = F, R^(4b) = R^(4c) = H 4854 Z = SO, R¹ = F, R^(2c) = Cl, R^(4a) = F, R^(4b) = R^(4c) = H 4855 Z = SO, R¹ = Cl, R^(2c) = Cl, R^(4a) = F, R^(4b) = R^(4c) = H 4856 Z = SO, R¹ = Br, R^(2c) = Cl, R^(4a) = F, R^(4b) = R^(4c) = H 4857 Z = SO, R¹ = I, R^(2c) = Cl, R^(4a) = F, R^(4b) = R^(4c) = H 4858 Z = SO₂, R¹ = F, R^(2c) = Cl, R^(4a) = F, R^(4b) = R^(4c) = H 4859 Z = SO₂, R¹ = Cl, R^(2c) = Cl, R^(4a) = F, R^(4b) = R^(4c) = H 4860 Z = SO₂, R¹ = Br, R^(2c) = Cl, R^(4a) = F, R^(4b) = R^(4c) = H 4861 Z = SO₂, R¹ = I, R^(2c) = Cl, R^(4a) = F, R^(4b) = R^(4c) = H 4862 Z = O, R¹ = F, R^(2c) = Br, R^(4a) = F, R^(4b) = R^(4c) = H 4863 Z = O, R¹ = Cl, R^(2c) = Br, R^(4a) = F, R^(4b) = R^(4c) = H 4864 Z = O, R¹ = Br, R^(2c) = Br, R^(4a) = F, R^(4b) = R^(4c) = H 4865 Z = O, R¹ = I, R^(2c) = Br, R^(4a) = F, R^(4b) = R^(4c) = H 4866 Z = S, R¹ = F, R^(2c) = Br, R^(4a) = F, R^(4b) = R^(4c) = H 4867 Z = S, R¹ = Cl, R^(2c) = Br, R^(4a) = F, R^(4b) = R^(4c) = H 4868 Z = S, R¹ = Br, R^(2c) = Br, R^(4a) = F, R^(4b) = R^(4c) = H 4869 Z = S, R¹ = I, R^(2c) = Br, R^(4a) = F, R^(4b) = R^(4c) = H 4870 Z = SO, R¹ = F, R^(2c) = Br, R^(4a) = F, R^(4b) = R^(4c) = H 4871 Z = SO, R¹ = Cl, R^(2c) = Br, R^(4a) = F, R^(4b) = R^(4c) = H 4872 Z = SO, R¹ = Br, R^(2c) = Br, R^(4a) = F, R^(4b) = R^(4c) = H 4873 Z = SO, R¹ = I, R^(2c) = Br, R^(4a) = F, R^(4b) = R^(4c) = H 4874 Z = SO₂, R¹ = F, R^(2c) = Br, R^(4a) = F, R^(4b) = R^(4c) = H 4875 Z = SO₂, R¹ = Cl, R^(2c) = Br, R^(4a) = F, R^(4b) = R^(4c) = H 4876 Z = SO₂, R¹ = Br, R^(2c) = Br, R^(4a) = F, R^(4b) = R^(4c) = H 4877 Z = SO₂, R¹ = I, R^(2c) = Br, R^(4a) = F, R^(4b) = R^(4c) = H 4878 Z = O, R¹ = F, R^(2c) = I, R^(4a) = F, R^(4b) = R^(4c) = H 4879 Z = O, R¹ = Cl, R^(2c) = I, R^(4a) = F, R^(4b) = R^(4c) = H 4880 Z = O, R¹ = Br, R^(2c) = I, R^(4a) = F, R^(4b) = R^(4c) = H 4881 Z = O, R¹ = I, R^(2c) = I, R^(4a) = F, R^(4b) = R^(4c) = H 4882 Z = S, R¹ = F, R^(2c) = I, R^(4a) = F, R^(4b) = R^(4c) = H 4883 Z = S, R¹ = Cl, R^(2c) = I, R^(4a) = F, R^(4b) = R^(4c) = H 4884 Z = S, R¹ = Br, R^(2c) = I, R^(4a) = F, R^(4b) = R^(4c) = H 4885 Z = S, R¹ = I, R^(2c) = I, R^(4a) = F, R^(4b) = R^(4c) = H 4886 Z = SO, R¹ = F, R^(2c) = I, R^(4a) = F, R^(4b) = R^(4c) = H 4887 Z = SO, R¹ = Cl, R^(2c) = I, R^(4a) = F, R^(4b) = R^(4c) = H 4888 Z = SO, R¹ = Br, R^(2c) = I, R^(4a) = F, R^(4b) = R^(4c) = H 4889 Z = SO, R¹ = I, R^(2c) = I, R^(4a) = F, R^(4b) = R^(4c) = H 4890 Z = SO₂, R¹ = F, R^(2c) = I, R^(4a) = F, R^(4b) = R^(4c) = H 4891 Z = SO₂, R¹ = Cl, R^(2c) = I, R^(4a) = F, R^(4b) = R^(4c) = H 4892 Z = SO₂, R¹ = Br, R^(2c) = I, R^(4a) = F, R^(4b) = R^(4c) = H 4893 Z = SO₂, R¹ = I, R^(2c) = I, R^(4a) = F, R^(4b) = R^(4c) = H 4894 Z = O, R¹ = F, R^(2c) = CF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4895 Z = O, R¹ = Cl, R^(2c) = CF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4896 Z = O, R¹ = Br, R^(2c) = CF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4897 Z = O, R¹ = I, R^(2c) = CF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4898 Z = S, R¹ = F, R^(2c) = CF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4899 Z = S, R¹ = Cl, R^(2c) = CF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4900 Z = S, R¹ = Br, R^(2c) = CF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4901 Z = S, R¹ = I, R^(2c) = CF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4902 Z = SO, R¹ = F, R^(2c) = CF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4903 Z = SO, R¹ = Cl, R^(2c) = CF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4904 Z = SO, R¹ = Br, R^(2c) = CF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4905 Z = SO, R¹ = I, R^(2c) = CF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4906 Z = SO₂, R¹ = F, R^(2c) = CF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4907 Z = SO₂, R¹ = Cl, R^(2c) = CF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4908 Z = SO₂, R¹ = Br, R^(2c) = CF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4909 Z = SO₂, R¹ = I, R^(2c) = CF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4910 Z = O, R¹ = F, R^(2c) = OTFE, R^(4a) = F, R^(4b) = R^(4c) = H 4911 Z = O, R¹ = Cl, R^(2c) = OTFE, R^(4a) = F, R^(4b) = R^(4c) = H 4912 Z = O, R¹ = Br, R^(2c) = OTFE, R^(4a) = F, R^(4b) = R^(4c) = H 4913 Z = O, R¹ = I, R^(2c) = OTFE, R^(4a) = F, R^(4b) = R^(4c) = H 4914 Z = S, R¹ = F, R^(2c) = OTFE, R^(4a) = F, R^(4b) = R^(4c) = H 4915 Z = S, R¹ = Cl, R^(2c) = OTFE, R^(4a) = F, R^(4b) = R^(4c) = H 4916 Z = S, R¹ = Br, R^(2c) = OTFE, R^(4a) = F, R^(4b) = R^(4c) = H 4917 Z = S, R¹ = I, R^(2c) = OTFE, R^(4a) = F, R^(4b) = R^(4c) = H 4918 Z = SO, R¹ = F, R^(2c) = OTFE, R^(4a) = F, R^(4b) = R^(4c) = H 4919 Z = SO, R¹ = Cl, R^(2c) = OTFE, R^(4a) = F, R^(4b) = R^(4c) = H 4920 Z = SO, R¹ = Br, R^(2c) = OTFE, R^(4a) = F, R^(4b) = R^(4c) = H 4921 Z = SO, R¹ = I, R^(2c) = OTFE, R^(4a) = F, R^(4b) = R^(4c) = H 4922 Z = SO₂, R¹ = F, R^(2c) = OTFE, R^(4a) = F, R^(4b) = R^(4c) = H 4923 Z = SO₂, R¹ = Cl, R^(2c) = OTFE, R^(4a) = F, R^(4b) = R^(4c) = H 4924 Z = SO₂, R¹ = Br, R^(2c) = OTFE, R^(4a) = F, R^(4b) = R^(4c) = H 4925 Z = SO₂, R¹ = I, R^(2c) = OTFE, R^(4a) = F, R^(4b) = R^(4c) = H 4926 Z = O, R¹ = F, R^(2c) = CN, R^(4a) = F, R^(4b) = R^(4c) = H 4927 Z = O, R¹ = Cl, R^(2c) = CN, R^(4a) = F, R^(4b) = R^(4c) = H 4928 Z = O, R¹ = Br, R^(2c) = CN, R^(4a) = F, R^(4b) = R^(4c) = H 4929 Z = O, R¹ = I, R^(2c) = CN, R^(4a) = F, R^(4b) = R^(4c) = H 4930 Z = S, R¹ = F, R^(2c) = CN, R^(4a) = F, R^(4b) = R^(4c) = H 4931 Z = S, R¹ = Cl, R^(2c) = CN, R^(4a) = F, R^(4b) = R^(4c) = H 4932 Z = S, R¹ = Br, R^(2c) = CN, R^(4a) = F, R^(4b) = R^(4c) = H 4933 Z = S, R¹ = I, R^(2c) = CN, R^(4a) = F, R^(4b) = R^(4c) = H 4934 Z = SO, R¹ = F, R^(2c) = CN, R^(4a) = F, R^(4b) = R^(4c) = H 4935 Z = SO, R¹ = Cl, R^(2c) = CN, R^(4a) = F, R^(4b) = R^(4c) = H 4936 Z = SO, R¹ = Br, R^(2c) = CN, R^(4a) = F, R^(4b) = R^(4c) = H 4937 Z = SO, R¹ = I, R^(2c) = CN, R^(4a) = F, R^(4b) = R^(4c) = H 4938 Z = SO₂, R¹ = F, R^(2c) = CN, R^(4a) = F, R^(4b) = R^(4c) = H 4939 Z = SO₂, R¹ = Cl, R^(2c) = CN, R^(4a) = F, R^(4b) = R^(4c) = H 4940 Z = SO₂, R¹ = Br, R^(2c) = CN, R^(4a) = F, R^(4b) = R^(4c) = H 4941 Z = SO₂, R¹ = I, R^(2c) = CN, R^(4a) = F, R^(4b) = R^(4c) = H 4942 Z = O, R¹ = F, R^(2c) = ODFM, R^(4a) = F, R^(4b) = R^(4c) = H 4943 Z = O, R¹ = Cl, R^(2c) = ODFM, R^(4a) = F, R^(4b) = R^(4c) = H 4944 Z = O, R¹ = Br, R^(2c) = ODFM, R^(4a) = F, R^(4b) = R^(4c) = H 4945 Z = O, R¹ = I, R^(2c) = ODFM, R^(4a) = F, R^(4b) = R^(4c) = H 4946 Z = S, R¹ = F, R^(2c) = ODFM, R^(4a) = F, R^(4b) = R^(4c) = H 4947 Z = S, R¹ = Cl, R^(2c) = ODFM, R^(4a) = F, R^(4b) = R^(4c) = H 4948 Z = S, R¹ = Br, R^(2c) = ODFM, R^(4a) = F, R^(4b) = R^(4c) = H 4949 Z = S, R¹ = I, R^(2c) = ODFM, R^(4a) = F, R^(4b) = R^(4c) = H 4950 Z = SO, R¹ = F, R^(2c) = ODFM, R^(4a) = F, R^(4b) = R^(4c) = H 4951 Z = SO, R¹ = Cl, R^(2c) = ODFM, R^(4a) = F, R^(4b) = R^(4c) = H 4952 Z = SO, R¹ = Br, R^(2c) = ODFM, R^(4a) = F, R^(4b) = R^(4c) = H 4953 Z = SO, R¹ = I, R^(2c) = ODFM, R^(4a) = F, R^(4b) = R^(4c) = H 4954 Z = SO₂, R¹ = F, R^(2c) = ODFM, R^(4a) = F, R^(4b) = R^(4c) = H 4955 Z = SO₂, R¹ = Cl, R^(2c) = ODFM, R^(4a) = F, R^(4b) = R^(4c) = H 4956 Z = SO₂, R¹ = Br, R^(2c) = ODFM, R^(4a) = F, R^(4b) = R^(4c) = H 4957 Z = SO₂, R¹ = I, R^(2c) = ODFM, R^(4a) = F, R^(4b) = R^(4c) = H 4958 Z = O, R¹ = F, R^(2c) = OCF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4959 Z = O, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4960 Z = O, R¹ = Br, R^(2c) = OCF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4961 Z = O, R¹ = I, R^(2c) = OCF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4962 Z = S, R¹ = F, R^(2c) = OCF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4963 Z = S, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4964 Z = S, R¹ = Br, R^(2c) = OCF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4965 Z = S, R¹ = I, R^(2c) = OCF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4966 Z = SO, R¹ = F, R^(2c) = OCF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4967 Z = SO, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4968 Z = SO, R¹ = Br, R^(2c) = OCF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4969 Z = SO, R¹ = I, R^(2c) = OCF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4970 Z = SO₂, R¹ = F, R^(2c) = OCF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4971 Z = SO₂, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4972 Z = SO₂, R¹ = Br, R^(2c) = OCF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4973 Z = SO₂, R¹ = I, R^(2c) = OCF₃, R^(4a) = F, R^(4b) = R^(4c) = H 4974 Z = O, R¹ = F, R^(2c) = CF₂H, R^(4a) = F, R^(4b) = R^(4c) = H 4975 Z = O, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = F, R^(4b) = R^(4c) = H 4976 Z = O, R¹ = Br, R^(2c) = CF₂H, R^(4a) = F, R^(4b) = R^(4c) = H 4977 Z = O, R¹ = I, R^(2c) = CF₂H, R^(4a) = F, R^(4b) = R^(4c) = H 4978 Z = S, R¹ = F, R^(2c) = CF₂H, R^(4a) = F, R^(4b) = R^(4c) = H 4979 Z = S, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = F, R^(4b) = R^(4c) = H 4980 Z = S, R¹ = Br, R^(2c) = CF₂H, R^(4a) = F, R^(4b) = R^(4c) = H 4981 Z = S, R¹ = I, R^(2c) = CF₂H, R^(4a) = F, R^(4b) = R^(4c) = H 4982 Z = SO, R¹ = F, R^(2c) = CF₂H, R^(4a) = F, R^(4b) = R^(4c) = H 4983 Z = SO, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = F, R^(4b) = R^(4c) = H 4984 Z = SO, R¹ = Br, R^(2c) = CF₂H, R^(4a) = F, R^(4b) = R^(4c) = H 4985 Z = SO, R¹ = I, R^(2c) = CF₂H, R^(4a) = F, R^(4b) = R^(4c) = H 4986 Z = SO₂, R¹ = F, R^(2c) = CF₂H, R^(4a) = F, R^(4b) = R^(4c) = H 4987 Z = SO₂, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = F, R^(4b) = R^(4c) = H 4988 Z = SO₂, R¹ = Br, R^(2c) = CF₂H, R^(4a) = F, R^(4b) = R^(4c) = H 4989 Z = SO₂, R¹ = I, R^(2c) = CF₂H, R^(4a) = F, R^(4b) = R^(4c) = H 4990 Z = O, R¹ = F, R^(2c) = H, R^(4a) = H, R^(4b) = F R^(4c) = H 4991 Z = O, R¹ = Br, R^(2c) = H, R^(4a) = H, R^(4b) = F R^(4c) = H 4992 Z = O, R¹ = I, R^(2c) = H, R^(4a) = H, R^(4b) = F R^(4c) = H 4993 Z = S, R¹ = F, R^(2c) = H, R^(4a) = H, R^(4b) = F R^(4c) = H 4994 Z = S, R¹ = Cl, R^(2c) = H, R^(4a) = H, R^(4b) = F R^(4c) = H 4995 Z = S, R¹ = Br, R^(2c) = H, R^(4a) = H, R^(4b) = F R^(4c) = H 4996 Z = S, R¹ = I, R^(2c) = H, R^(4a) = H, R^(4b) = F R^(4c) = H 4997 Z = SO, R¹ = F, R^(2c) = H, R^(4a) = H, R^(4b) = F R^(4c) = H 4998 Z = SO, R¹ = Cl, R^(2c) = H, R^(4a) = H, R^(4b) = F R^(4c) = H 4999 Z = SO, R¹ = Br, R^(2c) = H, R^(4a) = H, R^(4b) = F R^(4c) = H 5000 Z = SO, R¹ = I, R^(2c) = H, R^(4a) = H, R^(4b) = F R^(4c) = H 5001 Z = SO₂, R¹ = F, R^(2c) = H, R^(4a) = H, R^(4b) = F R^(4c) = H 5002 Z = SO₂, R¹ = Cl, R^(2c) = H, R^(4a) = H, R^(4b) = F R^(4c) = H 5003 Z = SO₂, R¹ = Br, R^(2c) = H, R^(4a) = H, R^(4b) = F R^(4c) = H 5004 Z = SO₂, R¹ = I, R^(2c) = H, R^(4a) = H, R^(4b) = F R^(4c) = H 5005 Z = O, R¹ = F, R^(2c) = F, R^(4a) = H, R^(4b) = F R^(4c) = H 5006 Z = O, R¹ = Cl, R^(2c) = F, R^(4a) = H, R^(4b) = F R^(4c) = H 5007 Z = O, R¹ = Br, R^(2c) = F, R^(4a) = H, R^(4b) = F R^(4c) = H 5008 Z = O, R¹ = I, R^(2c) = F, R^(4a) = H, R^(4b) = F R^(4c) = H 5009 Z = S, R¹ = F, R^(2c) = F, R^(4a) = H, R^(4b) = F R^(4c) = H 5010 Z = S, R¹ = Cl, R^(2c) = F, R^(4a) = H, R^(4b) = F R^(4c) = H 5011 Z = S, R¹ = Br, R^(2c) = F, R^(4a) = H, R^(4b) = F R^(4c) = H 5012 Z = S, R¹ = I, R^(2c) = F, R^(4a) = H, R^(4b) = F R^(4c) = H 5013 Z = SO, R¹ = F, R^(2c) = F, R^(4a) = H, R^(4b) = F R^(4c) = H 5014 Z = SO, R¹ = Cl, R^(2c) = F, R^(4a) = H, R^(4b) = F R^(4c) = H 5015 Z = SO, R¹ = Br, R^(2c) = F, R^(4a) = H, R^(4b) = F R^(4c) = H 5016 Z = SO, R¹ = I, R^(2c) = F, R^(4a) = H, R^(4b) = F R^(4c) = H 5017 Z = SO₂, R¹ = F, R^(2c) = F, R^(4a) = H, R^(4b) = F R^(4c) = H 5018 Z = SO₂, R¹ = Cl, R^(2c) = F, R^(4a) = H, R^(4b) = F R^(4c) = H 5019 Z = SO₂, R¹ = Br, R^(2c) = F, R^(4a) = H, R^(4b) = F R^(4c) = H 5020 Z = SO₂, R¹ = I, R^(2c) = F, R^(4a) = H, R^(4b) = F R^(4c) = H 5021 Z = O, R¹ = F, R^(2c) = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 5022 Z = O, R¹ = Cl, R^(2c) = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 5023 Z = O, R¹ = Br, R^(2c) = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 5024 Z = O, R¹ = I, R^(2c) = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 5025 Z = S, R¹ = F, R^(2c) = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 5026 Z = S, R¹ = Cl, R^(2c) = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 5027 Z = S, R¹ = Br, R^(2c) = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 5028 Z = S, R¹ = I, R^(2c) = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 5029 Z = SO, R¹ = F, R^(2c) = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 5030 Z = SO, R¹ = Cl, R^(2c) = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 5031 Z = SO, R¹ = Br, R^(2c) = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 5032 Z = SO, R¹ = I, R^(2c) = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 5033 Z = SO₂, R¹ = F, R^(2c) = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 5034 Z = SO₂, R¹ = Cl, R^(2c) = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 5035 Z = SO₂, R¹ = Br, R^(2c) = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 5036 Z = SO₂, R¹ = I, R^(2c) = Cl, R^(4a) = H, R^(4b) = F R^(4c) = H 5037 Z = O, R¹ = F, R^(2c) = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 5038 Z = O, R¹ = Cl, R^(2c) = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 5039 Z = O, R¹ = Br, R^(2c) = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 5040 Z = O, R¹ = I, R^(2c) = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 5041 Z = S, R¹ = F, R^(2c) = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 5042 Z = S, R¹ = Cl, R^(2c) = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 5043 Z = S, R¹ = Br, R^(2c) = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 5044 Z = S, R¹ = I, R^(2c) = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 5045 Z = SO, R¹ = F, R^(2c) = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 5046 Z = SO, R¹ = Cl, R^(2c) = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 5047 Z = SO, R¹ = Br, R^(2c) = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 5048 Z = SO, R¹ = I, R^(2c) = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 5049 Z = SO₂, R¹ = F, R^(2c) = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 5050 Z = SO₂, R¹ = Cl, R^(2c) = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 5051 Z = SO₂, R¹ = Br, R^(2c) = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 5052 Z = SO₂, R¹ = I, R^(2c) = Br, R^(4a) = H, R^(4b) = F R^(4c) = H 5053 Z = O, R¹ = F, R^(2c) = I, R^(4a) = H, R^(4b) = F R^(4c) = H 5054 Z = O, R¹ = Cl, R^(2c) = I, R^(4a) = H, R^(4b) = F R^(4c) = H 5055 Z = O, R¹ = Br, R^(2c) = I, R^(4a) = H, R^(4b) = F R^(4c) = H 5056 Z = O, R¹ = I, R^(2c) = I, R^(4a) = H, R^(4b) = F R^(4c) = H 5057 Z = S, R¹ = F, R^(2c) = I, R^(4a) = H, R^(4b) = F R^(4c) = H 5058 Z = S, R¹ = Cl, R^(2c) = I, R^(4a) = H, R^(4b) = F R^(4c) = H 5059 Z = S, R¹ = Br, R^(2c) = I, R^(4a) = H, R^(4b) = F R^(4c) = H 5060 Z = S, R¹ = I, R^(2c) = I, R^(4a) = H, R^(4b) = F R^(4c) = H 5061 Z = SO, R¹ = F, R^(2c) = I, R^(4a) = H, R^(4b) = F R^(4c) = H 5062 Z = SO, R¹ = Cl, R^(2c) = I, R^(4a) = H, R^(4b) = F R^(4c) = H 5063 Z = SO, R¹ = Br, R^(2c) = I, R^(4a) = H, R^(4b) = F R^(4c) = H 5064 Z = SO, R¹ = I, R^(2c) = I, R^(4a) = H, R^(4b) = F R^(4c) = H 5065 Z = SO₂, R¹ = F, R^(2c) = I, R^(4a) = H, R^(4b) = F R^(4c) = H 5066 Z = SO₂, R¹ = Cl, R^(2c) = I, R^(4a) = H, R^(4b) = F R^(4c) = H 5067 Z = SO₂, R¹ = Br, R^(2c) = I, R^(4a) = H, R^(4b) = F R^(4c) = H 5068 Z = SO₂, R¹ = I, R^(2c) = I, R^(4a) = H, R^(4b) = F R^(4c) = H 5069 Z = O, R¹ = F, R^(2c) = CF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5070 Z = O, R¹ = Cl, R^(2c) = CF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5071 Z = O, R¹ = Br, R^(2c) = CF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5072 Z = O, R¹ = I, R^(2c) = CF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5073 Z = S, R¹ = F, R^(2c) = CF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5074 Z = S, R¹ = Cl, R^(2c) = CF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5075 Z = S, R¹ = Br, R^(2c) = CF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5076 Z = S, R¹ = I, R^(2c) = CF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5077 Z = SO, R¹ = F, R^(2c) = CF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5078 Z = SO, R¹ = Cl, R^(2c) = CF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5079 Z = SO, R¹ = Br, R^(2c) = CF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5080 Z = SO, R¹ = I, R^(2c) = CF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5081 Z = SO₂, R¹ = F, R^(2c) = CF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5082 Z = SO₂, R¹ = Cl, R^(2c) = CF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5083 Z = SO₂, R¹ = Br, R^(2c) = CF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5084 Z = SO₂, R¹ = I, R^(2c) = CF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5085 Z = O, R¹ = F, R^(2c) = OTFE, R^(4a) = H, R^(4b) = F R^(4c) = H 5086 Z = O, R¹ = Cl, R^(2c) = OTFE, R^(4a) = H, R^(4b) = F R^(4c) = H 5087 Z = O, R¹ = Br, R^(2c) = OTFE, R^(4a) = H, R^(4b) = F R^(4c) = H 5088 Z = O, R¹ = I, R^(2c) = OTFE, R^(4a) = H, R^(4b) = F R^(4c) = H 5089 Z = S, R¹ = F, R^(2c) = OTFE, R^(4a) = H, R^(4b) = F R^(4c) = H 5090 Z = S, R¹ = Cl, R^(2c) = OTFE, R^(4a) = H, R^(4b) = F R^(4c) = H 5091 Z = S, R¹ = Br, R^(2c) = OTFE, R^(4a) = H, R^(4b) = F R^(4c) = H 5092 Z = S, R¹ = I, R^(2c) = OTFE, R^(4a) = H, R^(4b) = F R^(4c) = H 5093 Z = SO, R¹ = F, R^(2c) = OTFE, R^(4a) = H, R^(4b) = F R^(4c) = H 5094 Z = SO, R¹ = Cl, R^(2c) = OTFE, R^(4a) = H, R^(4b) = F R^(4c) = H 5095 Z = SO, R¹ = Br, R^(2c) = OTFE, R^(4a) = H, R^(4b) = F R^(4c) = H 5096 Z = SO, R¹ = I, R^(2c) = OTFE, R^(4a) = H, R^(4b) = F R^(4c) = H 5097 Z = SO₂, R¹ = F, R^(2c) = OTFE, R^(4a) = H, R^(4b) = F R^(4c) = H 5098 Z = SO₂, R¹ = Cl, R^(2c) = OTFE, R^(4a) = H, R^(4b) = F R^(4c) = H 5099 Z = SO₂, R¹ = Br, R^(2c) = OTFE, R^(4a) = H, R^(4b) = F R^(4c) = H 5100 Z = SO₂, R¹ = I, R^(2c) = OTFE, R^(4a) = H, R^(4b) = F R^(4c) = H 5101 Z = O, R¹ = F, R^(2c) = CN, R^(4a) = H, R^(4b) = F R^(4c) = H 5102 Z = O, R¹ = Cl, R^(2c) = CN, R^(4a) = H, R^(4b) = F R^(4c) = H 5103 Z = O, R¹ = Br, R^(2c) = CN, R^(4a) = H, R^(4b) = F R^(4c) = H 5104 Z = O, R¹ = I, R^(2c) = CN, R^(4a) = H, R^(4b) = F R^(4c) = H 5105 Z = S, R¹ = F, R^(2c) = CN, R^(4a) = H, R^(4b) = F R^(4c) = H 5106 Z = S, R¹ = Cl, R^(2c) = CN, R^(4a) = H, R^(4b) = F R^(4c) = H 5107 Z = S, R¹ = Br, R^(2c) = CN, R^(4a) = H, R^(4b) = F R^(4c) = H 5108 Z = S, R¹ = I, R^(2c) = CN, R^(4a) = H, R^(4b) = F R^(4c) = H 5109 Z = SO, R¹ = F, R^(2c) = CN, R^(4a) = H, R^(4b) = F R^(4c) = H 5110 Z = SO, R¹ = Cl, R^(2c) = CN, R^(4a) = H, R^(4b) = F R^(4c) = H 5111 Z = SO, R¹ = Br, R^(2c) = CN, R^(4a) = H, R^(4b) = F R^(4c) = H 5112 Z = SO, R¹ = I, R^(2c) = CN, R^(4a) = H, R^(4b) = F R^(4c) = H 5113 Z = SO₂, R¹ = F, R^(2c) = CN, R^(4a) = H, R^(4b) = F R^(4c) = H 5114 Z = SO₂, R¹ = Cl, R^(2c) = CN, R^(4a) = H, R^(4b) = F R^(4c) = H 5115 Z = SO₂, R¹ = Br, R^(2c) = CN, R^(4a) = H, R^(4b) = F R^(4c) = H 5116 Z = SO₂, R¹ = I, R^(2c) = CN, R^(4a) = H, R^(4b) = F R^(4c) = H 5117 Z = O, R¹ = F, R^(2c) = ODFM, R^(4a) = H, R^(4b) = F R^(4c) = H 5118 Z = O, R¹ = Cl, R^(2c) = ODFM, R^(4a) = H, R^(4b) = F R^(4c) = H 5119 Z = O, R¹ = Br, R^(2c) = ODFM, R^(4a) = H, R^(4b) = F R^(4c) = H 5120 Z = O, R¹ = I, R^(2c) = ODFM, R^(4a) = H, R^(4b) = F R^(4c) = H 5121 Z = S, R¹ = F, R^(2c) = ODFM, R^(4a) = H, R^(4b) = F R^(4c) = H 5122 Z = S, R¹ = Cl, R^(2c) = ODFM, R^(4a) = H, R^(4b) = F R^(4c) = H 5123 Z = S, R¹ = Br, R^(2c) = ODFM, R^(4a) = H, R^(4b) = F R^(4c) = H 5124 Z = S, R¹ = I, R^(2c) = ODFM, R^(4a) = H, R^(4b) = F R^(4c) = H 5125 Z = SO, R¹ = F, R^(2c) = ODFM, R^(4a) = H, R^(4b) = F R^(4c) = H 5126 Z = SO, R¹ = Cl, R^(2c) = ODFM, R^(4a) = H, R^(4b) = F R^(4c) = H 5127 Z = SO, R¹ = Br, R^(2c) = ODFM, R^(4a) = H, R^(4b) = F R^(4c) = H 5128 Z = SO, R¹ = I, R^(2c) = ODFM, R^(4a) = H, R^(4b) = F R^(4c) = H 5129 Z = SO₂, R¹ = F, R^(2c) = ODFM, R^(4a) = H, R^(4b) = F R^(4c) = H 5130 Z = SO₂, R¹ = Cl, R^(2c) = ODFM, R^(4a) = H, R^(4b) = F R^(4c) = H 5131 Z = SO₂, R¹ = Br, R^(2c) = ODFM, R^(4a) = H, R^(4b) = F R^(4c) = H 5132 Z = SO₂, R¹ = I, R^(2c) = ODFM, R^(4a) = H, R^(4b) = F R^(4c) = H 5133 Z = O, R¹ = F, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5134 Z = O, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5135 Z = O, R¹ = Br, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5136 Z = O, R¹ = I, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5137 Z = S, R¹ = F, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5138 Z = S, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5139 Z = S, R¹ = Br, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5140 Z = S, R¹ = I, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5141 Z = SO, R¹ = F, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5142 Z = SO, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5143 Z = SO, R¹ = Br, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5144 Z = SO, R¹ = I, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5145 Z = SO₂, R¹ = F, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5146 Z = SO₂, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5147 Z = SO₂, R¹ = Br, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5148 Z = SO₂, R¹ = I, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = F R^(4c) = H 5149 Z = O, R¹ = F, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = F R^(4c) = H 5150 Z = O, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = F R^(4c) = H 5151 Z = O, R¹ = Br, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = F R^(4c) = H 5152 Z = O, R¹ = I, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = F R^(4c) = H 5153 Z = S, R¹ = F, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = F R^(4c) = H 5154 Z = S, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = F R^(4c) = H 5155 Z = S, R¹ = Br, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = F R^(4c) = H 5156 Z = S, R¹ = I, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = F R^(4c) = H 5157 Z = SO, R¹ = F, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = F R^(4c) = H 5158 Z = SO, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = F R^(4c) = H 5159 Z = SO, R¹ = Br, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = F R^(4c) = H 5160 Z = SO, R¹ = I, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = F R^(4c) = H 5161 Z = SO₂, R¹ = F, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = F R^(4c) = H 5162 Z = SO₂, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = F R^(4c) = H 5163 Z = SO₂, R¹ = Br, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = F R^(4c) = H 5164 Z = SO₂, R¹ = I, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = F R^(4c) = H 5165 Z = O, R¹ = F, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = F 5166 Z = O, R¹ = Br, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = F 5167 Z = O, R¹ = I, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = F 5168 Z = S, R¹ = F, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = F 5169 Z = S, R¹ = Cl, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = F 5170 Z = S, R¹ = Br, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = F 5171 Z = S, R¹ = I, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = F 5172 Z = SO, R¹ = F, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = F 5173 Z = SO, R¹ = Cl, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = F 5174 Z = SO, R¹ = Br, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = F 5175 Z = SO, R¹ = I, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = F 5176 Z = SO₂, R¹ = F, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = F 5177 Z = SO₂, R¹ = Cl, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = F 5178 Z = SO₂, R¹ = Br, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = F 5179 Z = SO₂, R¹ = I, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = F 5180 Z = O, R¹ = F, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = F 5181 Z = O, R¹ = Cl, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = F 5182 Z = O, R¹ = Br, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = F 5183 Z = O, R¹ = I, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = F 5184 Z = S, R¹ = F, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = F 5185 Z = S, R¹ = Cl, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = F 5186 Z = S, R¹ = Br, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = F 5187 Z = S, R¹ = I, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = F 5188 Z = SO, R¹ = F, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = F 5189 Z = SO, R¹ = Cl, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = F 5190 Z = SO, R¹ = Br, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = F 5191 Z = SO, R¹ = I, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = F 5192 Z = SO₂, R¹ = F, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = F 5193 Z = SO₂, R¹ = Cl, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = F 5194 Z = SO₂, R¹ = Br, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = F 5195 Z = SO₂, R¹ = I, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = F 5196 Z = O, R¹ = F, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = F 5197 Z = O, R¹ = Cl, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = F 5198 Z = O, R¹ = Br, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = F 5199 Z = O, R¹ = I, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = F 5200 Z = S, R¹ = F, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = F 5201 Z = S, R¹ = Cl, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = F 5202 Z = S, R¹ = Br, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = F 5203 Z = S, R¹ = I, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = F 5204 Z = SO, R¹ = F, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = F 5205 Z = SO, R¹ = Cl, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = F 5206 Z = SO, R¹ = Br, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = F 5207 Z = SO, R¹ = I, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = F 5208 Z = SO₂, R¹ = F, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = F 5209 Z = SO₂, R¹ = Cl, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = F 5210 Z = SO₂, R¹ = Br, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = F 5211 Z = SO₂, R¹ = I, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = F 5212 Z = O, R¹ = F, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = F 5213 Z = O, R¹ = Cl, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = F 5214 Z = O, R¹ = Br, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = F 5215 Z = O, R¹ = I, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = F 5216 Z = S, R¹ = F, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = F 5217 Z = S, R¹ = Cl, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = F 5218 Z = S, R¹ = Br, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = F 5219 Z = S, R¹ = I, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = F 5220 Z = SO, R¹ = F, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = F 5221 Z = SO, R¹ = Cl, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = F 5222 Z = SO, R¹ = Br, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = F 5223 Z = SO, R¹ = I, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = F 5224 Z = SO₂, R¹ = F, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = F 5225 Z = SO₂, R¹ = Cl, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = F 5226 Z = SO₂, R¹ = Br, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = F 5227 Z = SO₂, R¹ = I, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = F 5228 Z = O, R¹ = F, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = F 5229 Z = O, R¹ = Cl, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = F 5230 Z = O, R¹ = Br, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = F 5231 Z = O, R¹ = I, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = F 5232 Z = S, R¹ = F, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = F 5233 Z = S, R¹ = Cl, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = F 5234 Z = S, R¹ = Br, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = F 5235 Z = S, R¹ = I, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = F 5236 Z = SO, R¹ = F, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = F 5237 Z = SO, R¹ = Cl, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = F 5238 Z = SO, R¹ = Br, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = F 5239 Z = SO, R¹ = I, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = F 5240 Z = SO₂, R¹ = F, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = F 5241 Z = SO₂, R¹ = Cl, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = F 5242 Z = SO₂, R¹ = Br, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = F 5243 Z = SO₂, R¹ = I, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = F 5244 Z = O, R¹ = F, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = F 5245 Z = O, R¹ = Cl, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = F 5246 Z = O, R¹ = Br, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = F 5247 Z = O, R¹ = I, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = F 5248 Z = S, R¹ = F, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = F 5249 Z = S, R¹ = Cl, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = F 5250 Z = S, R¹ = Br, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = F 5251 Z = S, R¹ = I, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = F 5252 Z = SO, R¹ = F, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = F 5253 Z = SO, R¹ = Cl, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = F 5254 Z = SO, R¹ = Br, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = F 5255 Z = SO, R¹ = I, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = F 5256 Z = SO₂, R¹ = F, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = F 5257 Z = SO₂, R¹ = Cl, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = F 5258 Z = SO₂, R¹ = Br, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = F 5259 Z = SO₂, R¹ = I, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = F 5260 Z = O, R¹ = F, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = F 5261 Z = O, R¹ = Cl, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = F 5262 Z = O, R¹ = Br, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = F 5263 Z = O, R¹ = I, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = F 5264 Z = S, R¹ = F, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = F 5265 Z = S, R¹ = Cl, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = F 5266 Z = S, R¹ = Br, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = F 5267 Z = S, R¹ = I, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = F 5268 Z = SO, R¹ = F, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = F 5269 Z = SO, R¹ = Cl, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = F 5270 Z = SO, R¹ = Br, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = F 5271 Z = SO, R¹ = I, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = F 5272 Z = SO₂, R¹ = F, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = F 5273 Z = SO₂, R¹ = Cl, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = F 5274 Z = SO₂, R¹ = Br, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = F 5275 Z = SO₂, R¹ = I, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = F 5276 Z = O, R¹ = F, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = F 5277 Z = O, R¹ = Cl, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = F 5278 Z = O, R¹ = Br, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = F 5279 Z = O, R¹ = I, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = F 5280 Z = S, R¹ = F, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = F 5281 Z = S, R¹ = Cl, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = F 5282 Z = S, R¹ = Br, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = F 5283 Z = S, R¹ = I, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = F 5284 Z = SO, R¹ = F, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = F 5285 Z = SO, R¹ = Cl, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = F 5286 Z = SO, R¹ = Br, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = F 5287 Z = SO, R¹ = I, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = F 5288 Z = SO₂, R¹ = F, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = F 5289 Z = SO₂, R¹ = Cl, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = F 5290 Z = SO₂, R¹ = Br, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = F 5291 Z = SO₂, R¹ = I, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = F 5292 Z = O, R¹ = F, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = F 5293 Z = O, R¹ = Cl, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = F 5294 Z = O, R¹ = Br, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = F 5295 Z = O, R¹ = I, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = F 5296 Z = S, R¹ = F, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = F 5297 Z = S, R¹ = Cl, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = F 5298 Z = S, R¹ = Br, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = F 5299 Z = S, R¹ = I, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = F 5300 Z = SO, R¹ = F, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = F 5301 Z = SO, R¹ = Cl, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = F 5302 Z = SO, R¹ = Br, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = F 5303 Z = SO, R¹ = I, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = F 5304 Z = SO₂, R¹ = F, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = F 5305 Z = SO₂, R¹ = Cl, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = F 5306 Z = SO₂, R¹ = Br, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = F 5307 Z = SO₂, R¹ = I, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = F 5308 Z = O, R¹ = F, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = F 5309 Z = O, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = F 5310 Z = O, R¹ = Br, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = F 5311 Z = O, R¹ = I, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = F 5312 Z = S, R¹ = F, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = F 5313 Z = S, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = F 5314 Z = S, R¹ = Br, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = F 5315 Z = S, R¹ = I, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = F 5316 Z = SO, R¹ = F, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = F 5317 Z = SO, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = F 5318 Z = SO, R¹ = Br, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = F 5319 Z = SO, R¹ = I, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = F 5320 Z = SO₂, R¹ = F, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = F 5321 Z = SO₂, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = F 5322 Z = SO₂, R¹ = Br, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = F 5323 Z = SO₂, R¹ = I, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = F 5324 Z = O, R¹ = F, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = F 5325 Z = O, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = F 5326 Z = O, R¹ = Br, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = F 5327 Z = O, R¹ = I, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = F 5328 Z = S, R¹ = F, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = F 5329 Z = S, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = F 5330 Z = S, R¹ = Br, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = F 5331 Z = S, R¹ = I, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = F 5332 Z = SO, R¹ = F, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = F 5333 Z = SO, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = F 5334 Z = SO, R¹ = Br, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = F 5335 Z = SO, R¹ = I, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = F 5336 Z = SO₂, R¹ = F, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = F 5337 Z = SO₂, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = F 5338 Z = SO₂, R¹ = Br, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = F 5339 Z = SO₂, R¹ = I, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = F 5340 Z = O, R¹ = F, R^(2c) = H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5341 Z = O, R¹ = Br, R^(2c) = H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5342 Z = O, R¹ = I, R^(2c) = H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5343 Z = S, R¹ = F, R^(2c) = H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5344 Z = S, R¹ = Cl, R^(2c) = H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5345 Z = S, R¹ = Br, R^(2c) = H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5346 Z = S, R¹ = I, R^(2c) = H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5347 Z = SO, R¹ = F, R^(2c) = H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5348 Z = SO, R¹ = Cl, R^(2c) = H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5349 Z = SO, R¹ = Br, R^(2c) = H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5350 Z = SO, R¹ = I, R^(2c) = H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5351 Z = SO₂, R¹ = F, R^(2c) = H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5352 Z = SO₂, R¹ = Cl, R^(2c) = H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5353 Z = SO₂, R¹ = Br, R^(2c) = H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5354 Z = SO₂, R¹ = I, R^(2c) = H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5355 Z = O, R¹ = F, R^(2c) = F, R^(4a) = Cl, R^(4b) = R^(4c) = H 5356 Z = O, R¹ = Cl, R^(2c) = F, R^(4a) = Cl, R^(4b) = R^(4c) = H 5357 Z = O, R¹ = Br, R^(2c) = F, R^(4a) = Cl, R^(4b) = R^(4c) = H 5358 Z = O, R¹ = I, R^(2c) = F, R^(4a) = Cl, R^(4b) = R^(4c) = H 5359 Z = S, R¹ = F, R^(2c) = F, R^(4a) = Cl, R^(4b) = R^(4c) = H 5360 Z = S, R¹ = Cl, R^(2c) = F, R^(4a) = Cl, R^(4b) = R^(4c) = H 5361 Z = S, R¹ = Br, R^(2c) = F, R^(4a) = Cl, R^(4b) = R^(4c) = H 5362 Z = S, R¹ = I, R^(2c) = F, R^(4a) = Cl, R^(4b) = R^(4c) = H 5363 Z = SO, R¹ = F, R^(2c) = F, R^(4a) = Cl, R^(4b) = R^(4c) = H 5364 Z = SO, R¹ = Cl, R^(2c) = F, R^(4a) = Cl, R^(4b) = R^(4c) = H 5365 Z = SO, R¹ = Br, R^(2c) = F, R^(4a) = Cl, R^(4b) = R^(4c) = H 5366 Z = SO, R¹ = I, R^(2c) = F, R^(4a) = Cl, R^(4b) = R^(4c) = H 5367 Z = SO₂, R¹ = F, R^(2c) = F, R^(4a) = Cl, R^(4b) = R^(4c) = H 5368 Z = SO₂, R¹ = Cl, R^(2c) = F, R^(4a) = Cl, R^(4b) = R^(4c) = H 5369 Z = SO₂, R¹ = Br, R^(2c) = F, R^(4a) = Cl, R^(4b) = R^(4c) = H 5370 Z = SO₂, R¹ = I, R^(2c) = F, R^(4a) = Cl, R^(4b) = R^(4c) = H 5371 Z = O, R¹ = F, R^(2c) = Cl, R^(4a) = Cl, R^(4b) = R^(4c) = H 5372 Z = O, R¹ = Cl, R^(2c) = Cl, R^(4a) = Cl, R^(4b) = R^(4c) = H 5373 Z = O, R¹ = Br, R^(2c) = Cl, R^(4a) = Cl, R^(4b) = R^(4c) = H 5374 Z = O, R¹ = I, R^(2c) = Cl, R^(4a) = Cl, R^(4b) = R^(4c) = H 5375 Z = S, R¹ = F, R^(2c) = Cl, R^(4a) = Cl, R^(4b) = R^(4c) = H 5376 Z = S, R¹ = Cl, R^(2c) = Cl, R^(4a) = Cl, R^(4b) = R^(4c) = H 5377 Z = S, R¹ = Br, R^(2c) = Cl, R^(4a) = Cl, R^(4b) = R^(4c) = H 5378 Z = S, R¹ = I, R^(2c) = Cl, R^(4a) = Cl, R^(4b) = R^(4c) = H 5379 Z = SO, R¹ = F, R^(2c) = Cl, R^(4a) = Cl, R^(4b) = R^(4c) = H 5380 Z = SO, R¹ = Cl, R^(2c) = Cl, R^(4a) = Cl, R^(4b) = R^(4c) = H 5381 Z = SO, R¹ = Br, R^(2c) = Cl, R^(4a) = Cl, R^(4b) = R^(4c) = H 5382 Z = SO, R¹ = I, R^(2c) = Cl, R^(4a) = Cl, R^(4b) = R^(4c) = H 5383 Z = SO₂, R¹ = F, R^(2c) = Cl, R^(4a) = Cl, R^(4b) = R^(4c) = H 5384 Z = SO₂, R¹ = Cl, R^(2c) = Cl, R^(4a) = Cl, R^(4b) = R^(4c) = H 5385 Z = SO₂, R¹ = Br, R^(2c) = Cl, R^(4a) = Cl, R^(4b) = R^(4c) = H 5386 Z = SO₂, R¹ = I, R^(2c) = Cl, R^(4a) = Cl, R^(4b) = R^(4c) = H 5387 Z = O, R¹ = F, R^(2c) = Br, R^(4a) = Cl, R^(4b) = R^(4c) = H 5388 Z = O, R¹ = Cl, R^(2c) = Br, R^(4a) = Cl, R^(4b) = R^(4c) = H 5389 Z = O, R¹ = Br, R^(2c) = Br, R^(4a) = Cl, R^(4b) = R^(4c) = H 5390 Z = O, R¹ = I, R^(2c) = Br, R^(4a) = Cl, R^(4b) = R^(4c) = H 5391 Z = S, R¹ = F, R^(2c) = Br, R^(4a) = Cl, R^(4b) = R^(4c) = H 5392 Z = S, R¹ = Cl, R^(2c) = Br, R^(4a) = Cl, R^(4b) = R^(4c) = H 5393 Z = S, R¹ = Br, R^(2c) = Br, R^(4a) = Cl, R^(4b) = R^(4c) = H 5394 Z = S, R¹ = I, R^(2c) = Br, R^(4a) = Cl, R^(4b) = R^(4c) = H 5395 Z = SO, R¹ = F, R^(2c) = Br, R^(4a) = Cl, R^(4b) = R^(4c) = H 5396 Z = SO, R¹ = Cl, R^(2c) = Br, R^(4a) = Cl, R^(4b) = R^(4c) = H 5397 Z = SO, R¹ = Br, R^(2c) = Br, R^(4a) = Cl, R^(4b) = R^(4c) = H 5398 Z = SO, R¹ = I, R^(2c) = Br, R^(4a) = Cl, R^(4b) = R^(4c) = H 5399 Z = SO₂, R¹ = F, R^(2c) = Br, R^(4a) = Cl, R^(4b) = R^(4c) = H 5400 Z = SO₂, R¹ = Cl, R^(2c) = Br, R^(4a) = Cl, R^(4b) = R^(4c) = H 5401 Z = SO₂, R¹ = Br, R^(2c) = Br, R^(4a) = Cl, R^(4b) = R^(4c) = H 5402 Z = SO₂, R¹ = I, R^(2c) = Br, R^(4a) = Cl, R^(4b) = R^(4c) = H 5403 Z = O, R¹ = F, R^(2c) = I, R^(4a) = Cl, R^(4b) = R^(4c) = H 5404 Z = O, R¹ = Cl, R^(2c) = I, R^(4a) = Cl, R^(4b) = R^(4c) = H 5405 Z = O, R¹ = Br, R^(2c) = I, R^(4a) = Cl, R^(4b) = R^(4c) = H 5406 Z = O, R¹ = I, R^(2c) = I, R^(4a) = Cl, R^(4b) = R^(4c) = H 5407 Z = S, R¹ = F, R^(2c) = I, R^(4a) = Cl, R^(4b) = R^(4c) = H 5408 Z = S, R¹ = Cl, R^(2c) = I, R^(4a) = Cl, R^(4b) = R^(4c) = H 5409 Z = S, R¹ = Br, R^(2c) = I, R^(4a) = Cl, R^(4b) = R^(4c) = H 5410 Z = S, R¹ = I, R^(2c) = I, R^(4a) = Cl, R^(4b) = R^(4c) = H 5411 Z = SO, R¹ = F, R^(2c) = I, R^(4a) = Cl, R^(4b) = R^(4c) = H 5412 Z = SO, R¹ = Cl, R^(2c) = I, R^(4a) = Cl, R^(4b) = R^(4c) = H 5413 Z = SO, R¹ = Br, R^(2c) = I, R^(4a) = Cl, R^(4b) = R^(4c) = H 5414 Z = SO, R¹ = I, R^(2c) = I, R^(4a) = Cl, R^(4b) = R^(4c) = H 5415 Z = SO₂, R¹ = F, R^(2c) = I, R^(4a) = Cl, R^(4b) = R^(4c) = H 5416 Z = SO₂, R¹ = Cl, R^(2c) = I, R^(4a) = Cl, R^(4b) = R^(4c) = H 5417 Z = SO₂, R¹ = Br, R^(2c) = I, R^(4a) = Cl, R^(4b) = R^(4c) = H 5418 Z = SO₂, R¹ = I, R^(2c) = I, R^(4a) = Cl, R^(4b) = R^(4c) = H 5419 Z = O, R¹ = F, R^(2c) = CF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5420 Z = O, R¹ = Cl, R^(2c) = CF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5421 Z = O, R¹ = Br, R^(2c) = CF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5422 Z = O, R¹ = I, R^(2c) = CF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5423 Z = S, R¹ = F, R^(2c) = CF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5424 Z = S, R¹ = Cl, R^(2c) = CF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5425 Z = S, R¹ = Br, R^(2c) = CF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5426 Z = S, R¹ = I, R^(2c) = CF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5427 Z = SO, R¹ = F, R^(2c) = CF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5428 Z = SO, R¹ = Cl, R^(2c) = CF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5429 Z = SO, R¹ = Br, R^(2c) = CF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5430 Z = SO, R¹ = I, R^(2c) = CF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5431 Z = SO₂, R¹ = F, R^(2c) = CF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5432 Z = SO₂, R¹ = Cl, R^(2c) = CF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5433 Z = SO₂, R¹ = Br, R^(2c) = CF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5434 Z = SO₂, R¹ = I, R^(2c) = CF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5435 Z = O, R¹ = F, R^(2c) = OTFE, R^(4a) = Cl, R^(4b) = R^(4c) = H 5436 Z = O, R¹ = Cl, R^(2c) = OTFE, R^(4a) = Cl, R^(4b) = R^(4c) = H 5437 Z = O, R¹ = Br, R^(2c) = OTFE, R^(4a) = Cl, R^(4b) = R^(4c) = H 5438 Z = O, R¹ = I, R^(2c) = OTFE, R^(4a) = Cl, R^(4b) = R^(4c) = H 5439 Z = S, R¹ = F, R^(2c) = OTFE, R^(4a) = Cl, R^(4b) = R^(4c) = H 5440 Z = S, R¹ = Cl, R^(2c) = OTFE, R^(4a) = Cl, R^(4b) = R^(4c) = H 5441 Z = S, R¹ = Br, R^(2c) = OTFE, R^(4a) = Cl, R^(4b) = R^(4c) = H 5442 Z = S, R¹ = I, R^(2c) = OTFE, R^(4a) = Cl, R^(4b) = R^(4c) = H 5443 Z = SO, R¹ = F, R^(2c) = OTFE, R^(4a) = Cl, R^(4b) = R^(4c) = H 5444 Z = SO, R¹ = Cl, R^(2c) = OTFE, R^(4a) = Cl, R^(4b) = R^(4c) = H 5445 Z = SO, R¹ = Br, R^(2c) = OTFE, R^(4a) = Cl, R^(4b) = R^(4c) = H 5446 Z = SO, R¹ = I, R^(2c) = OTFE, R^(4a) = Cl, R^(4b) = R^(4c) = H 5447 Z = SO₂, R¹ = F, R^(2c) = OTFE, R^(4a) = Cl, R^(4b) = R^(4c) = H 5448 Z = SO₂, R¹ = Cl, R^(2c) = OTFE, R^(4a) = Cl, R^(4b) = R^(4c) = H 5449 Z = SO₂, R¹ = Br, R^(2c) = OTFE, R^(4a) = Cl, R^(4b) = R^(4c) = H 5450 Z = SO₂, R¹ = I, R^(2c) = OTFE, R^(4a) = Cl, R^(4b) = R^(4c) = H 5451 Z = O, R¹ = F, R^(2c) = CN, R^(4a) = Cl, R^(4b) = R^(4c) = H 5452 Z = O, R¹ = Cl, R^(2c) = CN, R^(4a) = Cl, R^(4b) = R^(4c) = H 5453 Z = O, R¹ = Br, R^(2c) = CN, R^(4a) = Cl, R^(4b) = R^(4c) = H 5454 Z = O, R¹ = I, R^(2c) = CN, R^(4a) = Cl, R^(4b) = R^(4c) = H 5455 Z = S, R¹ = F, R^(2c) = CN, R^(4a) = Cl, R^(4b) = R^(4c) = H 5456 Z = S, R¹ = Cl, R^(2c) = CN, R^(4a) = Cl, R^(4b) = R^(4c) = H 5457 Z = S, R¹ = Br, R^(2c) = CN, R^(4a) = Cl, R^(4b) = R^(4c) = H 5458 Z = S, R¹ = I, R^(2c) = CN, R^(4a) = Cl, R^(4b) = R^(4c) = H 5459 Z = SO, R¹ = F, R^(2c) = CN, R^(4a) = Cl, R^(4b) = R^(4c) = H 5460 Z = SO, R¹ = Cl, R^(2c) = CN, R^(4a) = Cl, R^(4b) = R^(4c) = H 5461 Z = SO, R¹ = Br, R^(2c) = CN, R^(4a) = Cl, R^(4b) = R^(4c) = H 5462 Z = SO, R¹ = I, R^(2c) = CN, R^(4a) = Cl, R^(4b) = R^(4c) = H 5463 Z = SO₂, R¹ = F, R^(2c) = CN, R^(4a) = Cl, R^(4b) = R^(4c) = H 5464 Z = SO₂, R¹ = Cl, R^(2c) = CN, R^(4a) = Cl, R^(4b) = R^(4c) = H 5465 Z = SO₂, R¹ = Br, R^(2c) = CN, R^(4a) = Cl, R^(4b) = R^(4c) = H 5466 Z = SO₂, R¹ = I, R^(2c) = CN, R^(4a) = Cl, R^(4b) = R^(4c) = H 5467 Z = O, R¹ = F, R^(2c) = ODFM, R^(4a) = Cl, R^(4b) = R^(4c) = H 5468 Z = O, R¹ = Cl, R^(2c) = ODFM, R^(4a) = Cl, R^(4b) = R^(4c) = H 5469 Z = O, R¹ = Br, R^(2c) = ODFM, R^(4a) = Cl, R^(4b) = R^(4c) = H 5470 Z = O, R¹ = I, R^(2c) = ODFM, R^(4a) = Cl, R^(4b) = R^(4c) = H 5471 Z = S, R¹ = F, R^(2c) = ODFM, R^(4a) = Cl, R^(4b) = R^(4c) = H 5472 Z = S, R¹ = Cl, R^(2c) = ODFM, R^(4a) = Cl, R^(4b) = R^(4c) = H 5473 Z = S, R¹ = Br, R^(2c) = ODFM, R^(4a) = Cl, R^(4b) = R^(4c) = H 5474 Z = S, R¹ = I, R^(2c) = ODFM, R^(4a) = Cl, R^(4b) = R^(4c) = H 5475 Z = SO, R¹ = F, R^(2c) = ODFM, R^(4a) = Cl, R^(4b) = R^(4c) = H 5476 Z = SO, R¹ = Cl, R^(2c) = ODFM, R^(4a) = Cl, R^(4b) = R^(4c) = H 5477 Z = SO, R¹ = Br, R^(2c) = ODFM, R^(4a) = Cl, R^(4b) = R^(4c) = H 5478 Z = SO, R¹ = I, R^(2c) = ODFM, R^(4a) = Cl, R^(4b) = R^(4c) = H 5479 Z = SO₂, R¹ = F, R^(2c) = ODFM, R^(4a) = Cl, R^(4b) = R^(4c) = H 5480 Z = SO₂, R¹ = Cl, R^(2c) = ODFM, R^(4a) = Cl, R^(4b) = R^(4c) = H 5481 Z = SO₂, R¹ = Br, R^(2c) = ODFM, R^(4a) = Cl, R^(4b) = R^(4c) = H 5482 Z = SO₂, R¹ = I, R^(2c) = ODFM, R^(4a) = Cl, R^(4b) = R^(4c) = H 5483 Z = O, R¹ = F, R^(2c) = OCF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5484 Z = O, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5485 Z = O, R¹ = Br, R^(2c) = OCF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5486 Z = O, R¹ = I, R^(2c) = OCF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5487 Z = S, R¹ = F, R^(2c) = OCF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5488 Z = S, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5489 Z = S, R¹ = Br, R^(2c) = OCF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5490 Z = S, R¹ = I, R^(2c) = OCF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5491 Z = SO, R¹ = F, R^(2c) = OCF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5492 Z = SO, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5493 Z = SO, R¹ = Br, R^(2c) = OCF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5494 Z = SO, R¹ = I, R^(2c) = OCF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5495 Z = SO₂, R¹ = F, R^(2c) = OCF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5496 Z = SO₂, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5497 Z = SO₂, R¹ = Br, R^(2c) = OCF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5498 Z = SO₂, R¹ = I, R^(2c) = OCF₃, R^(4a) = Cl, R^(4b) = R^(4c) = H 5499 Z = O, R¹ = F, R^(2c) = CF₂H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5500 Z = O, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5501 Z = O, R¹ = Br, R^(2c) = CF₂H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5502 Z = O, R¹ = I, R^(2c) = CF₂H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5503 Z = S, R¹ = F, R^(2c) = CF₂H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5504 Z = S, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5505 Z = S, R¹ = Br, R^(2c) = CF₂H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5506 Z = S, R¹ = I, R^(2c) = CF₂H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5507 Z = SO, R¹ = F, R^(2c) = CF₂H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5508 Z = SO, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5509 Z = SO, R¹ = Br, R^(2c) = CF₂H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5510 Z = SO, R¹ = I, R^(2c) = CF₂H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5511 Z = SO₂, R¹ = F, R^(2c) = CF₂H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5512 Z = SO₂, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5513 Z = SO₂, R¹ = Br, R^(2c) = CF₂H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5514 Z = SO₂, R¹ = I, R^(2c) = CF₂H, R^(4a) = Cl, R^(4b) = R^(4c) = H 5515 Z = O, R¹ = F, R^(2c) = H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5516 Z = O, R¹ = Br, R^(2c) = H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5517 Z = O, R¹ = I, R^(2c) = H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5518 Z = S, R¹ = F, R^(2c) = H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5519 Z = S, R¹ = Cl, R^(2c) = H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5520 Z = S, R¹ = Br, R^(2c) = H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5521 Z = S, R¹ = I, R^(2c) = H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5522 Z = SO, R¹ = F, R^(2c) = H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5523 Z = SO, R¹ = Cl, R^(2c) = H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5524 Z = SO, R¹ = Br, R^(2c) = H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5525 Z = SO, R¹ = I, R^(2c) = H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5526 Z = SO₂, R¹ = F, R^(2c) = H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5527 Z = SO₂, R¹ = Cl, R^(2c) = H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5528 Z = SO₂, R¹ = Br, R^(2c) = H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5529 Z = SO₂, R¹ = I, R^(2c) = H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5530 Z = O, R¹ = F, R^(2c) = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5531 Z = O, R¹ = Cl, R^(2c) = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5532 Z = O, R¹ = Br, R^(2c) = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5533 Z = O, R¹ = I, R^(2c) = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5534 Z = S, R¹ = F, R^(2c) = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5535 Z = S, R¹ = Cl, R^(2c) = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5536 Z = S, R¹ = Br, R^(2c) = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5537 Z = S, R¹ = I, R^(2c) = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5538 Z = SO, R¹ = F, R^(2c) = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5539 Z = SO, R¹ = Cl, R^(2c) = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5540 Z = SO, R¹ = Br, R^(2c) = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5541 Z = SO, R¹ = I, R^(2c) = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5542 Z = SO₂, R¹ = F, R^(2c) = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5543 Z = SO₂, R¹ = Cl, R^(2c) = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5544 Z = SO₂, R¹ = Br, R^(2c) = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5545 Z = SO₂, R¹ = I, R^(2c) = F, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5546 Z = O, R¹ = F, R^(2c) = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5547 Z = O, R¹ = Cl, R^(2c) = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5548 Z = O, R¹ = Br, R^(2c) = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5549 Z = O, R¹ = I, R^(2c) = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5550 Z = S, R¹ = F, R^(2c) = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5551 Z = S, R¹ = Cl, R^(2c) = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5552 Z = S, R¹ = Br, R^(2c) = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5553 Z = S, R¹ = I, R^(2c) = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5554 Z = SO, R¹ = F, R^(2c) = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5555 Z = SO, R¹ = Cl, R^(2c) = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5556 Z = SO, R¹ = Br, R^(2c) = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5557 Z = SO, R¹ = I, R^(2c) = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5558 Z = SO₂, R¹ = F, R^(2c) = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5559 Z = SO₂, R¹ = Cl, R^(2c) = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5560 Z = SO₂, R¹ = Br, R^(2c) = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5561 Z = SO₂, R¹ = I, R^(2c) = Cl, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5562 Z = O, R¹ = F, R^(2c) = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5563 Z = O, R¹ = Cl, R^(2c) = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5564 Z = O, R¹ = Br, R^(2c) = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5565 Z = O, R¹ = I, R^(2c) = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5566 Z = S, R¹ = F, R^(2c) = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5567 Z = S, R¹ = Cl, R^(2c) = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5568 Z = S, R¹ = Br, R^(2c) = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5569 Z = S, R¹ = I, R^(2c) = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5570 Z = SO, R¹ = F, R^(2c) = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5571 Z = SO, R¹ = Cl, R^(2c) = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5572 Z = SO, R¹ = Br, R^(2c) = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5573 Z = SO, R¹ = I, R^(2c) = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5574 Z = SO₂, R¹ = F, R^(2c) = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5575 Z = SO₂, R¹ = Cl, R^(2c) = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5576 Z = SO₂, R¹ = Br, R^(2c) = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5577 Z = SO₂, R¹ = I, R^(2c) = Br, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5578 Z = O, R¹ = F, R^(2c) = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5579 Z = O, R¹ = Cl, R^(2c) = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5580 Z = O, R¹ = Br, R^(2c) = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5581 Z = O, R¹ = I, R^(2c) = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5582 Z = S, R¹ = F, R^(2c) = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5583 Z = S, R¹ = Cl, R^(2c) = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5584 Z = S, R¹ = Br, R^(2c) = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5585 Z = S, R¹ = I, R^(2c) = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5586 Z = SO, R¹ = F, R^(2c) = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5587 Z = SO, R¹ = Cl, R^(2c) = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5588 Z = SO, R¹ = Br, R^(2c) = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5589 Z = SO, R¹ = I, R^(2c) = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5590 Z = SO₂, R¹ = F, R^(2c) = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5591 Z = SO₂, R¹ = Cl, R^(2c) = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5592 Z = SO₂, R¹ = Br, R^(2c) = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5593 Z = SO₂, R¹ = I, R^(2c) = I, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5594 Z = O, R¹ = F, R^(2c) = CF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5595 Z = O, R¹ = Cl, R^(2c) = CF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5596 Z = O, R¹ = Br, R^(2c) = CF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5597 Z = O, R¹ = I, R^(2c) = CF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5598 Z = S, R¹ = F, R^(2c) = CF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5599 Z = S, R¹ = Cl, R^(2c) = CF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5600 Z = S, R¹ = Br, R^(2c) = CF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5601 Z = S, R¹ = I, R^(2c) = CF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5602 Z = SO, R¹ = F, R^(2c) = CF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5603 Z = SO, R¹ = Cl, R^(2c) = CF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5604 Z = SO, R¹ = Br, R^(2c) = CF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5605 Z = SO, R¹ = I, R^(2c) = CF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5606 Z = SO₂, R¹ = F, R^(2c) = CF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5607 Z = SO₂, R¹ = Cl, R^(2c) = CF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5608 Z = SO₂, R¹ = Br, R^(2c) = CF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5609 Z = SO₂, R¹ = I, R^(2c) = CF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5610 Z = O, R¹ = F, R^(2c) = OTFE, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5611 Z = O, R¹ = Cl, R^(2c) = OTFE, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5612 Z = O, R¹ = Br, R^(2c) = OTFE, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5613 Z = O, R¹ = I, R^(2c) = OTFE, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5614 Z = S, R¹ = F, R^(2c) = OTFE, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5615 Z = S, R¹ = Cl, R^(2c) = OTFE, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5616 Z = S, R¹ = Br, R^(2c) = OTFE, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5617 Z = S, R¹ = I, R^(2c) = OTFE, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5618 Z = SO, R¹ = F, R^(2c) = OTFE, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5619 Z = SO, R¹ = Cl, R^(2c) = OTFE, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5620 Z = SO, R¹ = Br, R^(2c) = OTFE, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5621 Z = SO, R¹ = I, R^(2c) = OTFE, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5622 Z = SO₂, R¹ = F, R^(2c) = OTFE, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5623 Z = SO₂, R¹ = Cl, R^(2c) = OTFE, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5624 Z = SO₂, R¹ = Br, R^(2c) = OTFE, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5625 Z = SO₂, R¹ = I, R^(2c) = OTFE, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5626 Z = O, R¹ = F, R^(2c) = CN, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5627 Z = O, R¹ = Cl, R^(2c) = CN, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5628 Z = O, R¹ = Br, R^(2c) = CN, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5629 Z = O, R¹ = I, R^(2c) = CN, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5630 Z = S, R¹ = F, R^(2c) = CN, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5631 Z = S, R¹ = Cl, R^(2c) = CN, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5632 Z = S, R¹ = Br, R^(2c) = CN, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5633 Z = S, R¹ = I, R^(2c) = CN, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5634 Z = SO, R¹ = F, R^(2c) = CN, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5635 Z = SO, R¹ = Cl, R^(2c) = CN, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5636 Z = SO, R¹ = Br, R^(2c) = CN, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5637 Z = SO, R¹ = I, R^(2c) = CN, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5638 Z = SO₂, R¹ = F, R^(2c) = CN, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5639 Z = SO₂, R¹ = Cl, R^(2c) = CN, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5640 Z = SO₂, R¹ = Br, R^(2c) = CN, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5641 Z = SO₂, R¹ = I, R^(2c) = CN, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5642 Z = O, R¹ = F, R^(2c) = ODFM, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5643 Z = O, R¹ = Cl, R^(2c) = ODFM, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5644 Z = O, R¹ = Br, R^(2c) = ODFM, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5645 Z = O, R¹ = I, R^(2c) = ODFM, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5646 Z = S, R¹ = F, R^(2c) = ODFM, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5647 Z = S, R¹ = Cl, R^(2c) = ODFM, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5648 Z = S, R¹ = Br, R^(2c) = ODFM, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5649 Z = S, R¹ = I, R^(2c) = ODFM, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5650 Z = SO, R¹ = F, R^(2c) = ODFM, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5651 Z = SO, R¹ = Cl, R^(2c) = ODFM, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5652 Z = SO, R¹ = Br, R^(2c) = ODFM, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5653 Z = SO, R¹ = I, R^(2c) = ODFM, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5654 Z = SO₂, R¹ = F, R^(2c) = ODFM, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5655 Z = SO₂, R¹ = Cl, R^(2c) = ODFM, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5656 Z = SO₂, R¹ = Br, R^(2c) = ODFM, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5657 Z = SO₂, R¹ = I, R^(2c) = ODFM, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5658 Z = O, R¹ = F, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5659 Z = O, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5660 Z = O, R¹ = Br, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5661 Z = O, R¹ = I, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5662 Z = S, R¹ = F, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5663 Z = S, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5664 Z = S, R¹ = Br, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5665 Z = S, R¹ = I, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5666 Z = SO, R¹ = F, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5667 Z = SO, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5668 Z = SO, R¹ = Br, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5669 Z = SO, R¹ = I, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5670 Z = SO₂, R¹ = F, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5671 Z = SO₂, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5672 Z = SO₂, R¹ = Br, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5673 Z = SO₂, R¹ = I, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5674 Z = O, R¹ = F, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5675 Z = O, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5676 Z = O, R¹ = Br, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5677 Z = O, R¹ = I, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5678 Z = S, R¹ = F, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5679 Z = S, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5680 Z = S, R¹ = Br, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5681 Z = S, R¹ = I, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5682 Z = SO, R¹ = F, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5683 Z = SO, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5684 Z = SO, R¹ = Br, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5685 Z = SO, R¹ = I, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5686 Z = SO₂, R¹ = F, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5687 Z = SO₂, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5688 Z = SO₂, R¹ = Br, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5689 Z = SO₂, R¹ = I, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = Cl R^(4c) = H 5690 Z = O, R¹ = F, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = Cl 5691 Z = O, R¹ = Br, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = Cl 5692 Z = O, R¹ = I, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = Cl 5693 Z = S, R¹ = F, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = Cl 5694 Z = S, R¹ = Cl, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = Cl 5695 Z = S, R¹ = Br, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = Cl 5696 Z = S, R¹ = I, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = Cl 5697 Z = SO, R¹ = F, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = Cl 5698 Z = SO, R¹ = Cl, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = Cl 5699 Z = SO, R¹ = Br, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = Cl 5700 Z = SO, R¹ = I, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = Cl 5701 Z = SO₂, R¹ = F, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = Cl 5702 Z = SO₂, R¹ = Cl, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = Cl 5703 Z = SO₂, R¹ = Br, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = Cl 5704 Z = SO₂, R¹ = I, R^(2c) = H, R^(4a) = R^(4b) = H R^(4c) = Cl 5705 Z = O, R¹ = F, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = Cl 5706 Z = O, R¹ = Cl, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = Cl 5707 Z = O, R¹ = Br, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = Cl 5708 Z = O, R¹ = I, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = Cl 5709 Z = S, R¹ = F, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = Cl 5710 Z = S, R¹ = Cl, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = Cl 5711 Z = S, R¹ = Br, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = Cl 5712 Z = S, R¹ = I, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = Cl 5713 Z = SO, R¹ = F, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = Cl 5714 Z = SO, R¹ = Cl, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = Cl 5715 Z = SO, R¹ = Br, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = Cl 5716 Z = SO, R¹ = I, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = Cl 5717 Z = SO₂, R¹ = F, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = Cl 5718 Z = SO₂, R¹ = Cl, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = Cl 5719 Z = SO₂, R¹ = Br, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = Cl 5720 Z = SO₂, R¹ = I, R^(2c) = F, R^(4a) = R^(4b) = H R^(4c) = Cl 5721 Z = O, R¹ = F, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = Cl 5722 Z = O, R¹ = Cl, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = Cl 5723 Z = O, R¹ = Br, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = Cl 5724 Z = O, R¹ = I, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = Cl 5725 Z = S, R¹ = F, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = Cl 5726 Z = S, R¹ = Cl, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = Cl 5727 Z = S, R¹ = Br, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = Cl 5728 Z = S, R¹ = I, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = Cl 5729 Z = SO, R¹ = F, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = Cl 5730 Z = SO, R¹ = Cl, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = Cl 5731 Z = SO, R¹ = Br, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = Cl 5732 Z = SO, R¹ = I, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = Cl 5733 Z = SO₂, R¹ = F, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = Cl 5734 Z = SO₂, R¹ = Cl, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = Cl 5735 Z = SO₂, R¹ = Br, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = Cl 5736 Z = SO₂, R¹ = I, R^(2c) = Cl, R^(4a) = R^(4b) = H R^(4c) = Cl 5737 Z = O, R¹ = F, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = Cl 5738 Z = O, R¹ = Cl, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = Cl 5739 Z = O, R¹ = Br, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = Cl 5740 Z = O, R¹ = I, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = Cl 5741 Z = S, R¹ = F, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = Cl 5742 Z = S, R¹ = Cl, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = Cl 5743 Z = S, R¹ = Br, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = Cl 5744 Z = S, R¹ = I, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = Cl 5745 Z = SO, R¹ = F, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = Cl 5746 Z = SO, R¹ = Cl, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = Cl 5747 Z = SO, R¹ = Br, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = Cl 5748 Z = SO, R¹ = I, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = Cl 5749 Z = SO₂, R¹ = F, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = Cl 5750 Z = SO₂, R¹ = Cl, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = Cl 5751 Z = SO₂, R¹ = Br, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = Cl 5752 Z = SO₂, R¹ = I, R^(2c) = Br, R^(4a) = R^(4b) = H R^(4c) = Cl 5753 Z = O, R¹ = F, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = Cl 5754 Z = O, R¹ = Cl, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = Cl 5755 Z = O, R¹ = Br, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = Cl 5756 Z = O, R¹ = I, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = Cl 5757 Z = S, R¹ = F, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = Cl 5758 Z = S, R¹ = Cl, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = Cl 5759 Z = S, R¹ = Br, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = Cl 5760 Z = S, R¹ = I, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = Cl 5761 Z = SO, R¹ = F, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = Cl 5762 Z = SO, R¹ = Cl, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = Cl 5763 Z = SO, R¹ = Br, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = Cl 5764 Z = SO, R¹ = I, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = Cl 5765 Z = SO₂, R¹ = F, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = Cl 5766 Z = SO₂, R¹ = Cl, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = Cl 5767 Z = SO₂, R¹ = Br, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = Cl 5768 Z = SO₂, R¹ = I, R^(2c) = I, R^(4a) = R^(4b) = H R^(4c) = Cl 5769 Z = O, R¹ = F, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5770 Z = O, R¹ = Cl, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5771 Z = O, R¹ = Br, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5772 Z = O, R¹ = I, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5773 Z = S, R¹ = F, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5774 Z = S, R¹ = Cl, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5775 Z = S, R¹ = Br, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5776 Z = S, R¹ = I, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5777 Z = SO, R¹ = F, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5778 Z = SO, R¹ = Cl, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5779 Z = SO, R¹ = Br, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5780 Z = SO, R¹ = I, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5781 Z = SO₂, R¹ = F, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5782 Z = SO₂, R¹ = Cl, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5783 Z = SO₂, R¹ = Br, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5784 Z = SO₂, R¹ = I, R^(2c) = CF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5785 Z = O, R¹ = F, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = Cl 5786 Z = O, R¹ = Cl, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = Cl 5787 Z = O, R¹ = Br, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = Cl 5788 Z = O, R¹ = I, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = Cl 5789 Z = S, R¹ = F, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = Cl 5790 Z = S, R¹ = Cl, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = Cl 5791 Z = S, R¹ = Br, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = Cl 5792 Z = S, R¹ = I, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = Cl 5793 Z = SO, R¹ = F, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = Cl 5794 Z = SO, R¹ = Cl, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = Cl 5795 Z = SO, R¹ = Br, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = Cl 5796 Z = SO, R¹ = I, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = Cl 5797 Z = SO₂, R¹ = F, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = Cl 5798 Z = SO₂, R¹ = Cl, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = Cl 5799 Z = SO₂, R¹ = Br, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = Cl 5800 Z = SO₂, R¹ = I, R^(2c) = OTFE, R^(4a) = R^(4b) = H R^(4c) = Cl 5801 Z = O, R¹ = F, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = Cl 5802 Z = O, R¹ = Cl, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = Cl 5803 Z = O, R¹ = Br, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = Cl 5804 Z = O, R¹ = I, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = Cl 5805 Z = S, R¹ = F, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = Cl 5806 Z = S, R¹ = Cl, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = Cl 5807 Z = S, R¹ = Br, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = Cl 5808 Z = S, R¹ = I, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = Cl 5809 Z = SO, R¹ = F, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = Cl 5810 Z = SO, R¹ = Cl, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = Cl 5811 Z = SO, R¹ = Br, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = Cl 5812 Z = SO, R¹ = I, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = Cl 5813 Z = SO₂, R¹ = F, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = Cl 5814 Z = SO₂, R¹ = Cl, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = Cl 5815 Z = SO₂, R¹ = Br, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = Cl 5816 Z = SO₂, R¹ = I, R^(2c) = CN, R^(4a) = R^(4b) = H R^(4c) = Cl 5817 Z = O, R¹ = F, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = Cl 5818 Z = O, R¹ = Cl, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = Cl 5819 Z = O, R¹ = Br, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = Cl 5820 Z = O, R¹ = I, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = Cl 5821 Z = S, R¹ = F, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = Cl 5822 Z = S, R¹ = Cl, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = Cl 5823 Z = S, R¹ = Br, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = Cl 5824 Z = S, R¹ = I, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = Cl 5825 Z = SO, R¹ = F, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = Cl 5826 Z = SO, R¹ = Cl, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = Cl 5827 Z = SO, R¹ = Br, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = Cl 5828 Z = SO, R¹ = I, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = Cl 5829 Z = SO₂, R¹ = F, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = Cl 5830 Z = SO₂, R¹ = Cl, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = Cl 5831 Z = SO₂, R¹ = Br, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = Cl 5832 Z = SO₂, R¹ = I, R^(2c) = ODFM, R^(4a) = R^(4b) = H R^(4c) = Cl 5833 Z = O, R¹ = F, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5834 Z = O, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5835 Z = O, R¹ = Br, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5836 Z = O, R¹ = I, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5837 Z = S, R¹ = F, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5838 Z = S, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5839 Z = S, R¹ = Br, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5840 Z = S, R¹ = I, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5841 Z = SO, R¹ = F, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5842 Z = SO, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5843 Z = SO, R¹ = Br, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5844 Z = SO, R¹ = I, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5845 Z = SO₂, R¹ = F, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5846 Z = SO₂, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5847 Z = SO₂, R¹ = Br, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5848 Z = SO₂, R¹ = I, R^(2c) = OCF₃, R^(4a) = R^(4b) = H R^(4c) = Cl 5849 Z = O, R¹ = F, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = Cl 5850 Z = O, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = Cl 5851 Z = O, R¹ = Br, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = Cl 5852 Z = O, R¹ = I, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = Cl 5853 Z = S, R¹ = F, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = Cl 5854 Z = S, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = Cl 5855 Z = S, R¹ = Br, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = Cl 5856 Z = S, R¹ = I, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = Cl 5857 Z = SO, R¹ = F, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = Cl 5858 Z = SO, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = Cl 5859 Z = SO, R¹ = Br, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = Cl 5860 Z = SO, R¹ = I, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = Cl 5861 Z = SO₂, R¹ = F, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = Cl 5862 Z = SO₂, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = Cl 5863 Z = SO₂, R¹ = Br, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = Cl 5864 Z = SO₂, R¹ = I, R^(2c) = CF₂H, R^(4a) = R^(4b) = H R^(4c) = Cl 5865 Z = O, R¹ = F, R^(2c) = H, R^(4a) = CN, R^(4b) = R^(4c) = H 5866 Z = O, R¹ = Br, R^(2c) = H, R^(4a) = CN, R^(4b) = R^(4c) = H 5867 Z = O, R¹ = I, R^(2c) = H, R^(4a) = CN, R^(4b) = R^(4c) = H 5868 Z = S, R¹ = F, R^(2c) = H, R^(4a) = CN, R^(4b) = R^(4c) = H 5869 Z = S, R¹ = Cl, R^(2c) = H, R^(4a) = CN, R^(4b) = R^(4c) = H 5870 Z = S, R¹ = Br, R^(2c) = H, R^(4a) = CN, R^(4b) = R^(4c) = H 5871 Z = S, R¹ = I, R^(2c) = H, R^(4a) = CN, R^(4b) = R^(4c) = H 5872 Z = SO, R¹ = F, R^(2c) = H, R^(4a) = CN, R^(4b) = R^(4c) = H 5873 Z = SO, R¹ = Cl, R^(2c) = H, R^(4a) = CN, R^(4b) = R^(4c) = H 5874 Z = SO, R¹ = Br, R^(2c) = H, R^(4a) = CN, R^(4b) = R^(4c) = H 5875 Z = SO, R¹ = I, R^(2c) = H, R^(4a) = CN, R^(4b) = R^(4c) = H 5876 Z = SO₂, R¹ = F, R^(2c) = H, R^(4a) = CN, R^(4b) = R^(4c) = H 5877 Z = SO₂, R¹ = Cl, R^(2c) = H, R^(4a) = CN, R^(4b) = R^(4c) = H 5878 Z = SO₂, R¹ = Br, R^(2c) = H, R^(4a) = CN, R^(4b) = R^(4c) = H 5879 Z = SO₂, R¹ = I, R^(2c) = H, R^(4a) = CN, R^(4b) = R^(4c) = H 5880 Z = O, R¹ = F, R^(2c) = F, R^(4a) = CN, R^(4b) = R^(4c) = H 5881 Z = O, R¹ = Cl, R^(2c) = F, R^(4a) = CN, R^(4b) = R^(4c) = H 5882 Z = O, R¹ = Br, R^(2c) = F, R^(4a) = CN, R^(4b) = R^(4c) = H 5883 Z = O, R¹ = I, R^(2c) = F, R^(4a) = CN, R^(4b) = R^(4c) = H 5884 Z = S, R¹ = F, R^(2c) = F, R^(4a) = CN, R^(4b) = R^(4c) = H 5885 Z = S, R¹ = Cl, R^(2c) = F, R^(4a) = CN, R^(4b) = R^(4c) = H 5886 Z = S, R¹ = Br, R^(2c) = F, R^(4a) = CN, R^(4b) = R^(4c) = H 5887 Z = S, R¹ = I, R^(2c) = F, R^(4a) = CN, R^(4b) = R^(4c) = H 5888 Z = SO, R¹ = F, R^(2c) = F, R^(4a) = CN, R^(4b) = R^(4c) = H 5889 Z = SO, R¹ = Cl, R^(2c) = F, R^(4a) = CN, R^(4b) = R^(4c) = H 5890 Z = SO, R¹ = Br, R^(2c) = F, R^(4a) = CN, R^(4b) = R^(4c) = H 5891 Z = SO, R¹ = I, R^(2c) = F, R^(4a) = CN, R^(4b) = R^(4c) = H 5892 Z = SO₂, R¹ = F, R^(2c) = F, R^(4a) = CN, R^(4b) = R^(4c) = H 5893 Z = SO₂, R¹ = Cl, R^(2c) = F, R^(4a) = CN, R^(4b) = R^(4c) = H 5894 Z = SO₂, R¹ = Br, R^(2c) = F, R^(4a) = CN, R^(4b) = R^(4c) = H 5895 Z = SO₂, R¹ = I, R^(2c) = F, R^(4a) = CN, R^(4b) = R^(4c) = H 5896 Z = O, R¹ = F, R^(2c) = Cl, R^(4a) = CN, R^(4b) = R^(4c) = H 5897 Z = O, R¹ = Cl, R^(2c) = Cl, R^(4a) = CN, R^(4b) = R^(4c) = H 5898 Z = O, R¹ = Br, R^(2c) = Cl, R^(4a) = CN, R^(4b) = R^(4c) = H 5899 Z = O, R¹ = I, R^(2c) = Cl, R^(4a) = CN, R^(4b) = R^(4c) = H 5900 Z = S, R¹ = F, R^(2c) = Cl, R^(4a) = CN, R^(4b) = R^(4c) = H 5901 Z = S, R¹ = Cl, R^(2c) = Cl, R^(4a) = CN, R^(4b) = R^(4c) = H 5902 Z = S, R¹ = Br, R^(2c) = Cl, R^(4a) = CN, R^(4b) = R^(4c) = H 5903 Z = S, R¹ = I, R^(2c) = Cl, R^(4a) = CN, R^(4b) = R^(4c) = H 5904 Z = SO, R¹ = F, R^(2c) = Cl, R^(4a) = CN, R^(4b) = R^(4c) = H 5905 Z = SO, R¹ = Cl, R^(2c) = Cl, R^(4a) = CN, R^(4b) = R^(4c) = H 5906 Z = SO, R¹ = Br, R^(2c) = Cl, R^(4a) = CN, R^(4b) = R^(4c) = H 5907 Z = SO, R¹ = I, R^(2c) = Cl, R^(4a) = CN, R^(4b) = R^(4c) = H 5908 Z = SO₂, R¹ = F, R^(2c) = Cl, R^(4a) = CN, R^(4b) = R^(4c) = H 5909 Z = SO₂, R¹ = Cl, R^(2c) = Cl, R^(4a) = CN, R^(4b) = R^(4c) = H 5910 Z = SO₂, R¹ = Br, R^(2c) = Cl, R^(4a) = CN, R^(4b) = R^(4c) = H 5911 Z = SO₂, R¹ = I, R^(2c) = Cl, R^(4a) = CN, R^(4b) = R^(4c) = H 5912 Z = O, R¹ = F, R^(2c) = Br, R^(4a) = CN, R^(4b) = R^(4c) = H 5913 Z = O, R¹ = Cl, R^(2c) = Br, R^(4a) = CN, R^(4b) = R^(4c) = H 5914 Z = O, R¹ = Br, R^(2c) = Br, R^(4a) = CN, R^(4b) = R^(4c) = H 5915 Z = O, R¹ = I, R^(2c) = Br, R^(4a) = CN, R^(4b) = R^(4c) = H 5916 Z = S, R¹ = F, R^(2c) = Br, R^(4a) = CN, R^(4b) = R^(4c) = H 5917 Z = S, R¹ = Cl, R^(2c) = Br, R^(4a) = CN, R^(4b) = R^(4c) = H 5918 Z = S, R¹ = Br, R^(2c) = Br, R^(4a) = CN, R^(4b) = R^(4c) = H 5919 Z = S, R¹ = I, R^(2c) = Br, R^(4a) = CN, R^(4b) = R^(4c) = H 5920 Z = SO, R¹ = F, R^(2c) = Br, R^(4a) = CN, R^(4b) = R^(4c) = H 5921 Z = SO, R¹ = Cl, R^(2c) = Br, R^(4a) = CN, R^(4b) = R^(4c) = H 5922 Z = SO, R¹ = Br, R^(2c) = Br, R^(4a) = CN, R^(4b) = R^(4c) = H 5923 Z = SO, R¹ = I, R^(2c) = Br, R^(4a) = CN, R^(4b) = R^(4c) = H 5924 Z = SO₂, R¹ = F, R^(2c) = Br, R^(4a) = CN, R^(4b) = R^(4c) = H 5925 Z = SO₂, R¹ = Cl, R^(2c) = Br, R^(4a) = CN, R^(4b) = R^(4c) = H 5926 Z = SO₂, R¹ = Br, R^(2c) = Br, R^(4a) = CN, R^(4b) = R^(4c) = H 5927 Z = SO₂, R¹ = I, R^(2c) = Br, R^(4a) = CN, R^(4b) = R^(4c) = H 5928 Z = O, R¹ = F, R^(2c) = I, R^(4a) = CN, R^(4b) = R^(4c) = H 5929 Z = O, R¹ = Cl, R^(2c) = I, R^(4a) = CN, R^(4b) = R^(4c) = H 5930 Z = O, R¹ = Br, R^(2c) = I, R^(4a) = CN, R^(4b) = R^(4c) = H 5931 Z = O, R¹ = I, R^(2c) = I, R^(4a) = CN, R^(4b) = R^(4c) = H 5932 Z = S, R¹ = F, R^(2c) = I, R^(4a) = CN, R^(4b) = R^(4c) = H 5933 Z = S, R¹ = Cl, R^(2c) = I, R^(4a) = CN, R^(4b) = R^(4c) = H 5934 Z = S, R¹ = Br, R^(2c) = I, R^(4a) = CN, R^(4b) = R^(4c) = H 5935 Z = S, R¹ = I, R^(2c) = I, R^(4a) = CN, R^(4b) = R^(4c) = H 5936 Z = SO, R¹ = F, R^(2c) = I, R^(4a) = CN, R^(4b) = R^(4c) = H 5937 Z = SO, R¹ = Cl, R^(2c) = I, R^(4a) = CN, R^(4b) = R^(4c) = H 5938 Z = SO, R¹ = Br, R^(2c) = I, R^(4a) = CN, R^(4b) = R^(4c) = H 5939 Z = SO, R¹ = I, R^(2c) = I, R^(4a) = CN, R^(4b) = R^(4c) = H 5940 Z = SO₂, R¹ = F, R^(2c) = I, R^(4a) = CN, R^(4b) = R^(4c) = H 5941 Z = SO₂, R¹ = Cl, R^(2c) = I, R^(4a) = CN, R^(4b) = R^(4c) = H 5942 Z = SO₂, R¹ = Br, R^(2c) = I, R^(4a) = CN, R^(4b) = R^(4c) = H 5943 Z = SO₂, R¹ = I, R^(2c) = I, R^(4a) = CN, R^(4b) = R^(4c) = H 5944 Z = O, R¹ = F, R^(2c) = CF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 5945 Z = O, R¹ = Cl, R^(2c) = CF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 5946 Z = O, R¹ = Br, R^(2c) = CF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 5947 Z = O, R¹ = I, R^(2c) = CF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 5948 Z = S, R¹ = F, R^(2c) = CF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 5949 Z = S, R¹ = Cl, R^(2c) = CF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 5950 Z = S, R¹ = Br, R^(2c) = CF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 5951 Z = S, R¹ = I, R^(2c) = CF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 5952 Z = SO, R¹ = F, R^(2c) = CF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 5953 Z = SO, R¹ = Cl, R^(2c) = CF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 5954 Z = SO, R¹ = Br, R^(2c) = CF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 5955 Z = SO, R¹ = I, R^(2c) = CF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 5956 Z = SO₂, R¹ = F, R^(2c) = CF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 5957 Z = SO₂, R¹ = Cl, R^(2c) = CF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 5958 Z = SO₂, R¹ = Br, R^(2c) = CF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 5959 Z = SO₂, R¹ = I, R^(2c) = CF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 5960 Z = O, R¹ = F, R^(2c) = OTFE, R^(4a) = CN, R^(4b) = R^(4c) = H 5961 Z = O, R¹ = Cl, R^(2c) = OTFE, R^(4a) = CN, R^(4b) = R^(4c) = H 5962 Z = O, R¹ = Br, R^(2c) = OTFE, R^(4a) = CN, R^(4b) = R^(4c) = H 5963 Z = O, R¹ = I, R^(2c) = OTFE, R^(4a) = CN, R^(4b) = R^(4c) = H 5964 Z = S, R¹ = F, R^(2c) = OTFE, R^(4a) = CN, R^(4b) = R^(4c) = H 5965 Z = S, R¹ = Cl, R^(2c) = OTFE, R^(4a) = CN, R^(4b) = R^(4c) = H 5966 Z = S, R¹ = Br, R^(2c) = OTFE, R^(4a) = CN, R^(4b) = R^(4c) = H 5967 Z = S, R¹ = I, R^(2c) = OTFE, R^(4a) = CN, R^(4b) = R^(4c) = H 5968 Z = SO, R¹ = F, R^(2c) = OTFE, R^(4a) = CN, R^(4b) = R^(4c) = H 5969 Z = SO, R¹ = Cl, R^(2c) = OTFE, R^(4a) = CN, R^(4b) = R^(4c) = H 5970 Z = SO, R¹ = Br, R^(2c) = OTFE, R^(4a) = CN, R^(4b) = R^(4c) = H 5971 Z = SO, R¹ = I, R^(2c) = OTFE, R^(4a) = CN, R^(4b) = R^(4c) = H 5972 Z = SO₂, R¹ = F, R^(2c) = OTFE, R^(4a) = CN, R^(4b) = R^(4c) = H 5973 Z = SO₂, R¹ = Cl, R^(2c) = OTFE, R^(4a) = CN, R^(4b) = R^(4c) = H 5974 Z = SO₂, R¹ = Br, R^(2c) = OTFE, R^(4a) = CN, R^(4b) = R^(4c) = H 5975 Z = SO₂, R¹ = I, R^(2c) = OTFE, R^(4a) = CN, R^(4b) = R^(4c) = H 5976 Z = O, R¹ = F, R^(2c) = CN, R^(4a) = CN, R^(4b) = R^(4c) = H 5977 Z = O, R¹ = Cl, R^(2c) = CN, R^(4a) = CN, R^(4b) = R^(4c) = H 5978 Z = O, R¹ = Br, R^(2c) = CN, R^(4a) = CN, R^(4b) = R^(4c) = H 5979 Z = O, R¹ = I, R^(2c) = CN, R^(4a) = CN, R^(4b) = R^(4c) = H 5980 Z = S, R¹ = F, R^(2c) = CN, R^(4a) = CN, R^(4b) = R^(4c) = H 5981 Z = S, R¹ = Cl, R^(2c) = CN, R^(4a) = CN, R^(4b) = R^(4c) = H 5982 Z = S, R¹ = Br, R^(2c) = CN, R^(4a) = CN, R^(4b) = R^(4c) = H 5983 Z = S, R¹ = I, R^(2c) = CN, R^(4a) = CN, R^(4b) = R^(4c) = H 5984 Z = SO, R¹ = F, R^(2c) = CN, R^(4a) = CN, R^(4b) = R^(4c) = H 5985 Z = SO, R¹ = Cl, R^(2c) = CN, R^(4a) = CN, R^(4b) = R^(4c) = H 5986 Z = SO, R¹ = Br, R^(2c) = CN, R^(4a) = CN, R^(4b) = R^(4c) = H 5987 Z = SO, R¹ = I, R^(2c) = CN, R^(4a) = CN, R^(4b) = R^(4c) = H 5988 Z = SO₂, R¹ = F, R^(2c) = CN, R^(4a) = CN, R^(4b) = R^(4c) = H 5989 Z = SO₂, R¹ = Cl, R^(2c) = CN, R^(4a) = CN, R^(4b) = R^(4c) = H 5990 Z = SO₂, R¹ = Br, R^(2c) = CN, R^(4a) = CN, R^(4b) = R^(4c) = H 5991 Z = SO₂, R¹ = I, R^(2c) = CN, R^(4a) = CN, R^(4b) = R^(4c) = H 5992 Z = O, R¹ = F, R^(2c) = ODFM, R^(4a) = CN, R^(4b) = R^(4c) = H 5993 Z = O, R¹ = Cl, R^(2c) = ODFM, R^(4a) = CN, R^(4b) = R^(4c) = H 5994 Z = O, R¹ = Br, R^(2c) = ODFM, R^(4a) = CN, R^(4b) = R^(4c) = H 5995 Z = O, R¹ = I, R^(2c) = ODFM, R^(4a) = CN, R^(4b) = R^(4c) = H 5996 Z = S, R¹ = F, R^(2c) = ODFM, R^(4a) = CN, R^(4b) = R^(4c) = H 5997 Z = S, R¹ = Cl, R^(2c) = ODFM, R^(4a) = CN, R^(4b) = R^(4c) = H 5998 Z = S, R¹ = Br, R^(2c) = ODFM, R^(4a) = CN, R^(4b) = R^(4c) = H 5999 Z = S, R¹ = I, R^(2c) = ODFM, R^(4a) = CN, R^(4b) = R^(4c) = H 6000 Z = SO, R¹ = F, R^(2c) = ODFM, R^(4a) = CN, R^(4b) = R^(4c) = H 6001 Z = SO, R¹ = Cl, R^(2c) = ODFM, R^(4a) = CN, R^(4b) = R^(4c) = H 6002 Z = SO, R¹ = Br, R^(2c) = ODFM, R^(4a) = CN, R^(4b) = R^(4c) = H 6003 Z = SO, R¹ = I, R^(2c) = ODFM, R^(4a) = CN, R^(4b) = R^(4c) = H 6004 Z = SO₂, R¹ = F, R^(2c) = ODFM, R^(4a) = CN, R^(4b) = R^(4c) = H 6005 Z = SO₂, R¹ = Cl, R^(2c) = ODFM, R^(4a) = CN, R^(4b) = R^(4c) = H 6006 Z = SO₂, R¹ = Br, R^(2c) = ODFM, R^(4a) = CN, R^(4b) = R^(4c) = H 6007 Z = SO₂, R¹ = I, R^(2c) = ODFM, R^(4a) = CN, R^(4b) = R^(4c) = H 6008 Z = O, R¹ = F, R^(2c) = OCF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 6009 Z = O, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 6010 Z = O, R¹ = Br, R^(2c) = OCF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 6011 Z = O, R¹ = I, R^(2c) = OCF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 6012 Z = S, R¹ = F, R^(2c) = OCF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 6013 Z = S, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 6014 Z = S, R¹ = Br, R^(2c) = OCF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 6015 Z = S, R¹ = I, R^(2c) = OCF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 6016 Z = SO, R¹ = F, R^(2c) = OCF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 6017 Z = SO, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 6018 Z = SO, R¹ = Br, R^(2c) = OCF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 6019 Z = SO, R¹ = I, R^(2c) = OCF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 6020 Z = SO₂, R¹ = F, R^(2c) = OCF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 6021 Z = SO₂, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 6022 Z = SO₂, R¹ = Br, R^(2c) = OCF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 6023 Z = SO₂, R¹ = I, R^(2c) = OCF₃, R^(4a) = CN, R^(4b) = R^(4c) = H 6024 Z = O, R¹ = F, R^(2c) = CF₂H, R^(4a) = CN, R^(4b) = R^(4c) = H 6025 Z = O, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = CN, R^(4b) = R^(4c) = H 6026 Z = O, R¹ = Br, R^(2c) = CF₂H, R^(4a) = CN, R^(4b) = R^(4c) = H 6027 Z = O, R¹ = I, R^(2c) = CF₂H, R^(4a) = CN, R^(4b) = R^(4c) = H 6028 Z = S, R¹ = F, R^(2c) = CF₂H, R^(4a) = CN, R^(4b) = R^(4c) = H 6029 Z = S, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = CN, R^(4b) = R^(4c) = H 6030 Z = S, R¹ = Br, R^(2c) = CF₂H, R^(4a) = CN, R^(4b) = R^(4c) = H 6031 Z = S, R¹ = I, R^(2c) = CF₂H, R^(4a) = CN, R^(4b) = R^(4c) = H 6032 Z = SO, R¹ = F, R^(2c) = CF₂H, R^(4a) = CN, R^(4b) = R^(4c) = H 6033 Z = SO, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = CN, R^(4b) = R^(4c) = H 6034 Z = SO, R¹ = Br, R^(2c) = CF₂H, R^(4a) = CN, R^(4b) = R^(4c) = H 6035 Z = SO, R¹ = I, R^(2c) = CF₂H, R^(4a) = CN, R^(4b) = R^(4c) = H 6036 Z = SO₂, R¹ = F, R^(2c) = CF₂H, R^(4a) = CN, R^(4b) = R^(4c) = H 6037 Z = SO₂, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = CN, R^(4b) = R^(4c) = H 6038 Z = SO₂, R¹ = Br, R^(2c) = CF₂H, R^(4a) = CN, R^(4b) = R^(4c) = H 6039 Z = SO₂, R¹ = I, R^(2c) = CF₂H, R^(4a) = CN, R^(4b) = R^(4c) = H 6040 Z = O, R¹ = F, R^(2c) = H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6041 Z = O, R¹ = Br, R^(2c) = H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6042 Z = O, R¹ = I, R^(2c) = H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6043 Z = S, R¹ = F, R^(2c) = H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6044 Z = S, R¹ = Cl, R^(2c) = H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6045 Z = S, R¹ = Br, R^(2c) = H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6046 Z = S, R¹ = I, R^(2c) = H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6047 Z = SO, R¹ = F, R^(2c) = H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6048 Z = SO, R¹ = Cl, R^(2c) = H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6049 Z = SO, R¹ = Br, R^(2c) = H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6050 Z = SO, R¹ = I, R^(2c) = H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6051 Z = SO₂, R¹ = F, R^(2c) = H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6052 Z = SO₂, R¹ = Cl, R^(2c) = H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6053 Z = SO₂, R¹ = Br, R^(2c) = H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6054 Z = SO₂, R¹ = I, R^(2c) = H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6055 Z = O, R¹ = F, R^(2c) = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 6056 Z = O, R¹ = Cl, R^(2c) = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 6057 Z = O, R¹ = Br, R^(2c) = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 6058 Z = O, R¹ = I, R^(2c) = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 6059 Z = S, R¹ = F, R^(2c) = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 6060 Z = S, R¹ = Cl, R^(2c) = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 6061 Z = S, R¹ = Br, R^(2c) = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 6062 Z = S, R¹ = I, R^(2c) = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 6063 Z = SO, R¹ = F, R^(2c) = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 6064 Z = SO, R¹ = Cl, R^(2c) = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 6065 Z = SO, R¹ = Br, R^(2c) = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 6066 Z = SO, R¹ = I, R^(2c) = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 6067 Z = SO₂, R¹ = F, R^(2c) = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 6068 Z = SO₂, R¹ = Cl, R^(2c) = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 6069 Z = SO₂, R¹ = Br, R^(2c) = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 6070 Z = SO₂, R¹ = I, R^(2c) = F, R^(4a) = H, R^(4b) = CN R^(4c) = H 6071 Z = O, R¹ = F, R^(2c) = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 6072 Z = O, R¹ = Cl, R^(2c) = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 6073 Z = O, R¹ = Br, R^(2c) = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 6074 Z = O, R¹ = I, R^(2c) = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 6075 Z = S, R¹ = F, R^(2c) = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 6076 Z = S, R¹ = Cl, R^(2c) = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 6077 Z = S, R¹ = Br, R^(2c) = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 6078 Z = S, R¹ = I, R^(2c) = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 6079 Z = SO, R¹ = F, R^(2c) = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 6080 Z = SO, R¹ = Cl, R^(2c) = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 6081 Z = SO, R¹ = Br, R^(2c) = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 6082 Z = SO, R¹ = I, R^(2c) = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 6083 Z = SO₂, R¹ = F, R^(2c) = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 6084 Z = SO₂, R¹ = Cl, R^(2c) = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 6085 Z = SO₂, R¹ = Br, R^(2c) = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 6086 Z = SO₂, R¹ = I, R^(2c) = Cl, R^(4a) = H, R^(4b) = CN R^(4c) = H 6087 Z = O, R¹ = F, R^(2c) = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 6088 Z = O, R¹ = Cl, R^(2c) = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 6089 Z = O, R¹ = Br, R^(2c) = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 6090 Z = O, R¹ = I, R^(2c) = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 6091 Z = S, R¹ = F, R^(2c) = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 6092 Z = S, R¹ = Cl, R^(2c) = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 6093 Z = S, R¹ = Br, R^(2c) = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 6094 Z = S, R¹ = I, R^(2c) = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 6095 Z = SO, R¹ = F, R^(2c) = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 6096 Z = SO, R¹ = Cl, R^(2c) = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 6097 Z = SO, R¹ = Br, R^(2c) = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 6098 Z = SO, R¹ = I, R^(2c) = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 6099 Z = SO₂, R¹ = F, R^(2c) = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 6100 Z = SO₂, R¹ = Cl, R^(2c) = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 6101 Z = SO₂, R¹ = Br, R^(2c) = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 6102 Z = SO₂, R¹ = I, R^(2c) = Br, R^(4a) = H, R^(4b) = CN R^(4c) = H 6103 Z = O, R¹ = F, R^(2c) = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 6104 Z = O, R¹ = Cl, R^(2c) = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 6105 Z = O, R¹ = Br, R^(2c) = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 6106 Z = O, R¹ = I, R^(2c) = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 6107 Z = S, R¹ = F, R^(2c) = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 6108 Z = S, R¹ = Cl, R^(2c) = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 6109 Z = S, R¹ = Br, R^(2c) = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 6110 Z = S, R¹ = I, R^(2c) = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 6111 Z = SO, R¹ = F, R^(2c) = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 6112 Z = SO, R¹ = Cl, R^(2c) = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 6113 Z = SO, R¹ = Br, R^(2c) = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 6114 Z = SO, R¹ = I, R^(2c) = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 6115 Z = SO₂, R¹ = F, R^(2c) = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 6116 Z = SO₂, R¹ = Cl, R^(2c) = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 6117 Z = SO₂, R¹ = Br, R^(2c) = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 6118 Z = SO₂, R¹ = I, R^(2c) = I, R^(4a) = H, R^(4b) = CN R^(4c) = H 6119 Z = O, R¹ = F, R^(2c) = CF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6120 Z = O, R¹ = Cl, R^(2c) = CF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6121 Z = O, R¹ = Br, R^(2c) = CF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6122 Z = O, R¹ = I, R^(2c) = CF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6123 Z = S, R¹ = F, R^(2c) = CF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6124 Z = S, R¹ = Cl, R^(2c) = CF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6125 Z = S, R¹ = Br, R^(2c) = CF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6126 Z = S, R¹ = I, R^(2c) = CF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6127 Z = SO, R¹ = F, R^(2c) = CF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6128 Z = SO, R¹ = Cl, R^(2c) = CF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6129 Z = SO, R¹ = Br, R^(2c) = CF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6130 Z = SO, R¹ = I, R^(2c) = CF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6131 Z = SO₂, R¹ = F, R^(2c) = CF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6132 Z = SO₂, R¹ = Cl, R^(2c) = CF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6133 Z = SO₂, R¹ = Br, R^(2c) = CF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6134 Z = SO₂, R¹ = I, R^(2c) = CF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6135 Z = O, R¹ = F, R^(2c) = OTFE, R^(4a) = H, R^(4b) = CN R^(4c) = H 6136 Z = O, R¹ = Cl, R^(2c) = OTFE, R^(4a) = H, R^(4b) = CN R^(4c) = H 6137 Z = O, R¹ = Br, R^(2c) = OTFE, R^(4a) = H, R^(4b) = CN R^(4c) = H 6138 Z = O, R¹ = I, R^(2c) = OTFE, R^(4a) = H, R^(4b) = CN R^(4c) = H 6139 Z = S, R¹ = F, R^(2c) = OTFE, R^(4a) = H, R^(4b) = CN R^(4c) = H 6140 Z = S, R¹ = Cl, R^(2c) = OTFE, R^(4a) = H, R^(4b) = CN R^(4c) = H 6141 Z = S, R¹ = Br, R^(2c) = OTFE, R^(4a) = H, R^(4b) = CN R^(4c) = H 6142 Z = S, R¹ = I, R^(2c) = OTFE, R^(4a) = H, R^(4b) = CN R^(4c) = H 6143 Z = SO, R¹ = F, R^(2c) = OTFE, R^(4a) = H, R^(4b) = CN R^(4c) = H 6144 Z = SO, R¹ = Cl, R^(2c) = OTFE, R^(4a) = H, R^(4b) = CN R^(4c) = H 6145 Z = SO, R¹ = Br, R^(2c) = OTFE, R^(4a) = H, R^(4b) = CN R^(4c) = H 6146 Z = SO, R¹ = I, R^(2c) = OTFE, R^(4a) = H, R^(4b) = CN R^(4c) = H 6147 Z = SO₂, R¹ = F, R^(2c) = OTFE, R^(4a) = H, R^(4b) = CN R^(4c) = H 6148 Z = SO₂, R¹ = Cl, R^(2c) = OTFE, R^(4a) = H, R^(4b) = CN R^(4c) = H 6149 Z = SO₂, R¹ = Br, R^(2c) = OTFE, R^(4a) = H, R^(4b) = CN R^(4c) = H 6150 Z = SO₂, R¹ = I, R^(2c) = OTFE, R^(4a) = H, R^(4b) = CN R^(4c) = H 6151 Z = O, R¹ = F, R^(2c) = CN, R^(4a) = H, R^(4b) = CN R^(4c) = H 6152 Z = O, R¹ = Cl, R^(2c) = CN, R^(4a) = H, R^(4b) = CN R^(4c) = H 6153 Z = O, R¹ = Br, R^(2c) = CN, R^(4a) = H, R^(4b) = CN R^(4c) = H 6154 Z = O, R¹ = I, R^(2c) = CN, R^(4a) = H, R^(4b) = CN R^(4c) = H 6155 Z = S, R¹ = F, R^(2c) = CN, R^(4a) = H, R^(4b) = CN R^(4c) = H 6156 Z = S, R¹ = Cl, R^(2c) = CN, R^(4a) = H, R^(4b) = CN R^(4c) = H 6157 Z = S, R¹ = Br, R^(2c) = CN, R^(4a) = H, R^(4b) = CN R^(4c) = H 6158 Z = S, R¹ = I, R^(2c) = CN, R^(4a) = H, R^(4b) = CN R^(4c) = H 6159 Z = SO, R¹ = F, R^(2c) = CN, R^(4a) = H, R^(4b) = CN R^(4c) = H 6160 Z = SO, R¹ = Cl, R^(2c) = CN, R^(4a) = H, R^(4b) = CN R^(4c) = H 6161 Z = SO, R¹ = Br, R^(2c) = CN, R^(4a) = H, R^(4b) = CN R^(4c) = H 6162 Z = SO, R¹ = I, R^(2c) = CN, R^(4a) = H, R^(4b) = CN R^(4c) = H 6163 Z = SO₂, R¹ = F, R^(2c) = CN, R^(4a) = H, R^(4b) = CN R^(4c) = H 6164 Z = SO₂, R¹ = Cl, R^(2c) = CN, R^(4a) = H, R^(4b) = CN R^(4c) = H 6165 Z = SO₂, R¹ = Br, R^(2c) = CN, R^(4a) = H, R^(4b) = CN R^(4c) = H 6166 Z = SO₂, R¹ = I, R^(2c) = CN, R^(4a) = H, R^(4b) = CN R^(4c) = H 6167 Z = O, R¹ = F, R^(2c) = ODFM, R^(4a) = H, R^(4b) = CN R^(4c) = H 6168 Z = O, R¹ = Cl, R^(2c) = ODFM, R^(4a) = H, R^(4b) = CN R^(4c) = H 6169 Z = O, R¹ = Br, R^(2c) = ODFM, R^(4a) = H, R^(4b) = CN R^(4c) = H 6170 Z = O, R¹ = I, R^(2c) = ODFM, R^(4a) = H, R^(4b) = CN R^(4c) = H 6171 Z = S, R¹ = F, R^(2c) = ODFM, R^(4a) = H, R^(4b) = CN R^(4c) = H 6172 Z = S, R¹ = Cl, R^(2c) = ODFM, R^(4a) = H, R^(4b) = CN R^(4c) = H 6173 Z = S, R¹ = Br, R^(2c) = ODFM, R^(4a) = H, R^(4b) = CN R^(4c) = H 6174 Z = S, R¹ = I, R^(2c) = ODFM, R^(4a) = H, R^(4b) = CN R^(4c) = H 6175 Z = SO, R¹ = F, R^(2c) = ODFM, R^(4a) = H, R^(4b) = CN R^(4c) = H 6176 Z = SO, R¹ = Cl, R^(2c) = ODFM, R^(4a) = H, R^(4b) = CN R^(4c) = H 6177 Z = SO, R¹ = Br, R^(2c) = ODFM, R^(4a) = H, R^(4b) = CN R^(4c) = H 6178 Z = SO, R¹ = I, R^(2c) = ODFM, R^(4a) = H, R^(4b) = CN R^(4c) = H 6179 Z = SO₂, R¹ = F, R^(2c) = ODFM, R^(4a) = H, R^(4b) = CN R^(4c) = H 6180 Z = SO₂, R¹ = Cl, R^(2c) = ODFM, R^(4a) = H, R^(4b) = CN R^(4c) = H 6181 Z = SO₂, R¹ = Br, R^(2c) = ODFM, R^(4a) = H, R^(4b) = CN R^(4c) = H 6182 Z = SO₂, R¹ = I, R^(2c) = ODFM, R^(4a) = H, R^(4b) = CN R^(4c) = H 6183 Z = O, R¹ = F, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6184 Z = O, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6185 Z = O, R¹ = Br, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6186 Z = O, R¹ = I, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6187 Z = S, R¹ = F, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6188 Z = S, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6189 Z = S, R¹ = Br, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6190 Z = S, R¹ = I, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6191 Z = SO, R¹ = F, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6192 Z = SO, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6193 Z = SO, R¹ = Br, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6194 Z = SO, R¹ = I, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6195 Z = SO₂, R¹ = F, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6196 Z = SO₂, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6197 Z = SO₂, R¹ = Br, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6198 Z = SO₂, R¹ = I, R^(2c) = OCF₃, R^(4a) = H, R^(4b) = CN R^(4c) = H 6199 Z = O, R¹ = F, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6200 Z = O, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6201 Z = O, R¹ = Br, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6202 Z = O, R¹ = I, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6203 Z = S, R¹ = F, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6204 Z = S, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6205 Z = S, R¹ = Br, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6206 Z = S, R¹ = I, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6207 Z = SO, R¹ = F, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6208 Z = SO, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6209 Z = SO, R¹ = Br, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6210 Z = SO, R¹ = I, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6211 Z = SO₂, R¹ = F, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6212 Z = SO₂, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6213 Z = SO₂, R¹ = Br, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6214 Z = SO₂, R¹ = I, R^(2c) = CF₂H, R^(4a) = H, R^(4b) = CN R^(4c) = H 6215 Z = O, R¹ = F, R^(2c) = H, R^(4a) = R^(4b) = H, R^(4c) = CN 6216 Z = O, R¹ = Br, R^(2c) = H, R^(4a) = R^(4b) = H, R^(4c) = CN 6217 Z = O, R¹ = I, R^(2c) = H, R^(4a) = R^(4b) = H, R^(4c) = CN 6218 Z = S, R¹ = F, R^(2c) = H, R^(4a) = R^(4b) = H, R^(4c) = CN 6219 Z = S, R¹ = Cl, R^(2c) = H, R^(4a) = R^(4b) = H, R^(4c) = CN 6220 Z = S, R¹ = Br, R^(2c) = H, R^(4a) = R^(4b) = H, R^(4c) = CN 6221 Z = S, R¹ = I, R^(2c) = H, R^(4a) = R^(4b) = H, R^(4c) = CN 6222 Z = SO, R¹ = F, R^(2c) = H, R^(4a) = R^(4b) = H, R^(4c) = CN 6223 Z = SO, R¹ = Cl, R^(2c) = H, R^(4a) = R^(4b) = H, R^(4c) = CN 6224 Z = SO, R¹ = Br, R^(2c) = H, R^(4a) = R^(4b) = H, R^(4c) = CN 6225 Z = SO, R¹ = I, R^(2c) = H, R^(4a) = R^(4b) = H, R^(4c) = CN 6226 Z = SO₂, R¹ = F, R^(2c) = H, R^(4a) = R^(4b) = H, R^(4c) = CN 6227 Z = SO₂, R¹ = Cl, R^(2c) = H, R^(4a) = R^(4b) = H, R^(4c) = CN 6228 Z = SO₂, R¹ = Br, R^(2c) = H, R^(4a) = R^(4b) = H, R^(4c) = CN 6229 Z = SO₂, R¹ = I, R^(2c) = H, R^(4a) = R^(4b) = H, R^(4c) = CN 6230 Z = O, R¹ = F, R^(2c) = F, R^(4a) = R^(4b) = H, R^(4c) = CN 6231 Z = O, R¹ = Cl, R^(2c) = F, R^(4a) = R^(4b) = H, R^(4c) = CN 6232 Z = O, R¹ = Br, R^(2c) = F, R^(4a) = R^(4b) = H, R^(4c) = CN 6233 Z = O, R¹ = I, R^(2c) = F, R^(4a) = R^(4b) = H, R^(4c) = CN 6234 Z = S, R¹ = F, R^(2c) = F, R^(4a) = R^(4b) = H, R^(4c) = CN 6235 Z = S, R¹ = Cl, R^(2c) = F, R^(4a) = R^(4b) = H, R^(4c) = CN 6236 Z = S, R¹ = Br, R^(2c) = F, R^(4a) = R^(4b) = H, R^(4c) = CN 6237 Z = S, R¹ = I, R^(2c) = F, R^(4a) = R^(4b) = H, R^(4c) = CN 6238 Z = SO, R¹ = F, R^(2c) = F, R^(4a) = R^(4b) = H, R^(4c) = CN 6239 Z = SO, R¹ = Cl, R^(2c) = F, R^(4a) = R^(4b) = H, R^(4c) = CN 6240 Z = SO, R¹ = Br, R^(2c) = F, R^(4a) = R^(4b) = H, R^(4c) = CN 6241 Z = SO, R¹ = I, R^(2c) = F, R^(4a) = R^(4b) = H, R^(4c) = CN 6242 Z = SO₂, R¹ = F, R^(2c) = F, R^(4a) = R^(4b) = H, R^(4c) = CN 6243 Z = SO₂, R¹ = Cl, R^(2c) = F, R^(4a) = R^(4b) = H, R^(4c) = CN 6244 Z = SO₂, R¹ = Br, R^(2c) = F, R^(4a) = R^(4b) = H, R^(4c) = CN 6245 Z = SO₂, R¹ = I, R^(2c) = F, R^(4a) = R^(4b) = H, R^(4c) = CN 6246 Z = O, R¹ = F, R^(2c) = Cl, R^(4a) = R^(4b) = H, R^(4c) = CN 6247 Z = O, R¹ = Cl, R^(2c) = Cl, R^(4a) = R^(4b) = H, R^(4c) = CN 6248 Z = O, R¹ = Br, R^(2c) = Cl, R^(4a) = R^(4b) = H, R^(4c) = CN 6249 Z = O, R¹ = I, R^(2c) = Cl, R^(4a) = R^(4b) = H, R^(4c) = CN 6250 Z = S, R¹ = F, R^(2c) = Cl, R^(4a) = R^(4b) = H, R^(4c) = CN 6251 Z = S, R¹ = Cl, R^(2c) = Cl, R^(4a) = R^(4b) = H, R^(4c) = CN 6252 Z = S, R¹ = Br, R^(2c) = Cl, R^(4a) = R^(4b) = H, R^(4c) = CN 6253 Z = S, R¹ = I, R^(2c) = Cl, R^(4a) = R^(4b) = H, R^(4c) = CN 6254 Z = SO, R¹ = F, R^(2c) = Cl, R^(4a) = R^(4b) = H, R^(4c) = CN 6255 Z = SO, R¹ = Cl, R^(2c) = Cl, R^(4a) = R^(4b) = H, R^(4c) = CN 6256 Z = SO, R¹ = Br, R^(2c) = Cl, R^(4a) = R^(4b) = H, R^(4c) = CN 6257 Z = SO, R¹ = I, R^(2c) = Cl, R^(4a) = R^(4b) = H, R^(4c) = CN 6258 Z = SO₂, R¹ = F, R^(2c) = Cl, R^(4a) = R^(4b) = H, R^(4c) = CN 6259 Z = SO₂, R¹ = Cl, R^(2c) = Cl, R^(4a) = R^(4b) = H, R^(4c) = CN 6260 Z = SO₂, R¹ = Br, R^(2c) = Cl, R^(4a) = R^(4b) = H, R^(4c) = CN 6261 Z = SO₂, R¹ = I, R^(2c) = Cl, R^(4a) = R^(4b) = H, R^(4c) = CN 6262 Z = O, R¹ = F, R^(2c) = Br, R^(4a) = R^(4b) = H, R^(4c) = CN 6263 Z = O, R¹ = Cl, R^(2c) = Br, R^(4a) = R^(4b) = H, R^(4c) = CN 6264 Z = O, R¹ = Br, R^(2c) = Br, R^(4a) = R^(4b) = H, R^(4c) = CN 6265 Z = O, R¹ = I, R^(2c) = Br, R^(4a) = R^(4b) = H, R^(4c) = CN 6266 Z = S, R¹ = F, R^(2c) = Br, R^(4a) = R^(4b) = H, R^(4c) = CN 6267 Z = S, R¹ = Cl, R^(2c) = Br, R^(4a) = R^(4b) = H, R^(4c) = CN 6268 Z = S, R¹ = Br, R^(2c) = Br, R^(4a) = R^(4b) = H, R^(4c) = CN 6269 Z = S, R¹ = I, R^(2c) = Br, R^(4a) = R^(4b) = H, R^(4c) = CN 6270 Z = SO, R¹ = F, R^(2c) = Br, R^(4a) = R^(4b) = H, R^(4c) = CN 6271 Z = SO, R¹ = Cl, R^(2c) = Br, R^(4a) = R^(4b) = H, R^(4c) = CN 6272 Z = SO, R¹ = Br, R^(2c) = Br, R^(4a) = R^(4b) = H, R^(4c) = CN 6273 Z = SO, R¹ = I, R^(2c) = Br, R^(4a) = R^(4b) = H, R^(4c) = CN 6274 Z = SO₂, R¹ = F, R^(2c) = Br, R^(4a) = R^(4b) = H, R^(4c) = CN 6275 Z = SO₂, R¹ = Cl, R^(2c) = Br, R^(4a) = R^(4b) = H, R^(4c) = CN 6276 Z = SO₂, R¹ = Br, R^(2c) = Br, R^(4a) = R^(4b) = H, R^(4c) = CN 6277 Z = SO₂, R¹ = I, R^(2c) = Br, R^(4a) = R^(4b) = H, R^(4c) = CN 6278 Z = O, R¹ = F, R^(2c) = I, R^(4a) = R^(4b) = H, R^(4c) = CN 6279 Z = O, R¹ = Cl, R^(2c) = I, R^(4a) = R^(4b) = H, R^(4c) = CN 6280 Z = O, R¹ = Br, R^(2c) = I, R^(4a) = R^(4b) = H, R^(4c) = CN 6281 Z = O, R¹ = I, R^(2c) = I, R^(4a) = R^(4b) = H, R^(4c) = CN 6282 Z = S, R¹ = F, R^(2c) = I, R^(4a) = R^(4b) = H, R^(4c) = CN 6283 Z = S, R¹ = Cl, R^(2c) = I, R^(4a) = R^(4b) = H, R^(4c) = CN 6284 Z = S, R¹ = Br, R^(2c) = I, R^(4a) = R^(4b) = H, R^(4c) = CN 6285 Z = S, R¹ = I, R^(2c) = I, R^(4a) = R^(4b) = H, R^(4c) = CN 6286 Z = SO, R¹ = F, R^(2c) = I, R^(4a) = R^(4b) = H, R^(4c) = CN 6287 Z = SO, R¹ = Cl, R^(2c) = I, R^(4a) = R^(4b) = H, R^(4c) = CN 6288 Z = SO, R¹ = Br, R^(2c) = I, R^(4a) = R^(4b) = H, R^(4c) = CN 6289 Z = SO, R¹ = I, R^(2c) = I, R^(4a) = R^(4b) = H, R^(4c) = CN 6290 Z = SO₂, R¹ = F, R^(2c) = I, R^(4a) = R^(4b) = H, R^(4c) = CN 6291 Z = SO₂, R¹ = Cl, R^(2c) = I, R^(4a) = R^(4b) = H, R^(4c) = CN 6292 Z = SO₂, R¹ = Br, R^(2c) = I, R^(4a) = R^(4b) = H, R^(4c) = CN 6293 Z = SO₂, R¹ = I, R^(2c) = I, R^(4a) = R^(4b) = H, R^(4c) = CN 6294 Z = O, R¹ = F, R^(2c) = CF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6295 Z = O, R¹ = Cl, R^(2c) = CF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6296 Z = O, R¹ = Br, R^(2c) = CF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6297 Z = O, R¹ = I, R^(2c) = CF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6298 Z = S, R¹ = F, R^(2c) = CF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6299 Z = S, R¹ = Cl, R^(2c) = CF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6300 Z = S, R¹ = Br, R^(2c) = CF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6301 Z = S, R¹ = I, R^(2c) = CF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6302 Z = SO, R¹ = F, R^(2c) = CF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6303 Z = SO, R¹ = Cl, R^(2c) = CF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6304 Z = SO, R¹ = Br, R^(2c) = CF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6305 Z = SO, R¹ = I, R^(2c) = CF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6306 Z = SO₂, R¹ = F, R^(2c) = CF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6307 Z = SO₂, R¹ = Cl, R^(2c) = CF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6308 Z = SO₂, R¹ = Br, R^(2c) = CF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6309 Z = SO₂, R¹ = I, R^(2c) = CF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6310 Z = O, R¹ = F, R^(2c) = OTFE, R^(4a) = R^(4b) = H, R^(4c) = CN 6311 Z = O, R¹ = Cl, R^(2c) = OTFE, R^(4a) = R^(4b) = H, R^(4c) = CN 6312 Z = O, R¹ = Br, R^(2c) = OTFE, R^(4a) = R^(4b) = H, R^(4c) = CN 6313 Z = O, R¹ = I, R^(2c) = OTFE, R^(4a) = R^(4b) = H, R^(4c) = CN 6314 Z = S, R¹ = F, R^(2c) = OTFE, R^(4a) = R^(4b) = H, R^(4c) = CN 6315 Z = S, R¹ = Cl, R^(2c) = OTFE, R^(4a) = R^(4b) = H, R^(4c) = CN 6316 Z = S, R¹ = Br, R^(2c) = OTFE, R^(4a) = R^(4b) = H, R^(4c) = CN 6317 Z = S, R¹ = I, R^(2c) = OTFE, R^(4a) = R^(4b) = H, R^(4c) = CN 6318 Z = SO, R¹ = F, R^(2c) = OTFE, R^(4a) = R^(4b) = H, R^(4c) = CN 6319 Z = SO, R¹ = Cl, R^(2c) = OTFE, R^(4a) = R^(4b) = H, R^(4c) = CN 6320 Z = SO, R¹ = Br, R^(2c) = OTFE, R^(4a) = R^(4b) = H, R^(4c) = CN 6321 Z = SO, R¹ = I, R^(2c) = OTFE, R^(4a) = R^(4b) = H, R^(4c) = CN 6322 Z = SO₂, R¹ = F, R^(2c) = OTFE, R^(4a) = R^(4b) = H, R^(4c) = CN 6323 Z = SO₂, R¹ = Cl, R^(2c) = OTFE, R^(4a) = R^(4b) = H, R^(4c) = CN 6324 Z = SO₂, R¹ = Br, R^(2c) = OTFE, R^(4a) = R^(4b) = H, R^(4c) = CN 6325 Z = SO₂, R¹ = I, R^(2c) = OTFE, R^(4a) = R^(4b) = H, R^(4c) = CN 6326 Z = O, R¹ = F, R^(2c) = CN, R^(4a) = R^(4b) = H, R^(4c) = CN 6327 Z = O, R¹ = Cl, R^(2c) = CN, R^(4a) = R^(4b) = H, R^(4c) = CN 6328 Z = O, R¹ = Br, R^(2c) = CN, R^(4a) = R^(4b) = H, R^(4c) = CN 6329 Z = O, R¹ = I, R^(2c) = CN, R^(4a) = R^(4b) = H, R^(4c) = CN 6330 Z = S, R¹ = F, R^(2c) = CN, R^(4a) = R^(4b) = H, R^(4c) = CN 6331 Z = S, R¹ = Cl, R^(2c) = CN, R^(4a) = R^(4b) = H, R^(4c) = CN 6332 Z = S, R¹ = Br, R^(2c) = CN, R^(4a) = R^(4b) = H, R^(4c) = CN 6333 Z = S, R¹ = I, R^(2c) = CN, R^(4a) = R^(4b) = H, R^(4c) = CN 6334 Z = SO, R¹ = F, R^(2c) = CN, R^(4a) = R^(4b) = H, R^(4c) = CN 6335 Z = SO, R¹ = Cl, R^(2c) = CN, R^(4a) = R^(4b) = H, R^(4c) = CN 6336 Z = SO, R¹ = Br, R^(2c) = CN, R^(4a) = R^(4b) = H, R^(4c) = CN 6337 Z = SO, R¹ = I, R^(2c) = CN, R^(4a) = R^(4b) = H, R^(4c) = CN 6338 Z = SO₂, R¹ = F, R^(2c) = CN, R^(4a) = R^(4b) = H, R^(4c) = CN 6339 Z = SO₂, R¹ = Cl, R^(2c) = CN, R^(4a) = R^(4b) = H, R^(4c) = CN 6340 Z = SO₂, R¹ = Br, R^(2c) = CN, R^(4a) = R^(4b) = H, R^(4c) = CN 6341 Z = SO₂, R¹ = I, R^(2c) = CN, R^(4a) = R^(4b) = H, R^(4c) = CN 6342 Z = O, R¹ = F, R^(2c) = ODFM, R^(4a) = R^(4b) = H, R^(4c) = CN 6343 Z = O, R¹ = Cl, R^(2c) = ODFM, R^(4a) = R^(4b) = H, R^(4c) = CN 6344 Z = O, R¹ = Br, R^(2c) = ODFM, R^(4a) = R^(4b) = H, R^(4c) = CN 6345 Z = O, R¹ = I, R^(2c) = ODFM, R^(4a) = R^(4b) = H, R^(4c) = CN 6346 Z = S, R¹ = F, R^(2c) = ODFM, R^(4a) = R^(4b) = H, R^(4c) = CN 6347 Z = S, R¹ = Cl, R^(2c) = ODFM, R^(4a) = R^(4b) = H, R^(4c) = CN 6348 Z = S, R¹ = Br, R^(2c) = ODFM, R^(4a) = R^(4b) = H, R^(4c) = CN 6349 Z = S, R¹ = I, R^(2c) = ODFM, R^(4a) = R^(4b) = H, R^(4c) = CN 6350 Z = SO, R¹ = F, R^(2c) = ODFM, R^(4a) = R^(4b) = H, R^(4c) = CN 6351 Z = SO, R¹ = Cl, R^(2c) = ODFM, R^(4a) = R^(4b) = H, R^(4c) = CN 6352 Z = SO, R¹ = Br, R^(2c) = ODFM, R^(4a) = R^(4b) = H, R^(4c) = CN 6353 Z = SO, R¹ = I, R^(2c) = ODFM, R^(4a) = R^(4b) = H, R^(4c) = CN 6354 Z = SO₂, R¹ = F, R^(2c) = ODFM, R^(4a) = R^(4b) = H, R^(4c) = CN 6355 Z = SO₂, R¹ = Cl, R^(2c) = ODFM, R^(4a) = R^(4b) = H, R^(4c) = CN 6356 Z = SO₂, R¹ = Br, R^(2c) = ODFM, R^(4a) = R^(4b) = H, R^(4c) = CN 6357 Z = SO₂, R¹ = I, R^(2c) = ODFM, R^(4a) = R^(4b) = H, R^(4c) = CN 6358 Z = O, R¹ = F, R^(2c) = OCF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6359 Z = O, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6360 Z = O, R¹ = Br, R^(2c) = OCF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6361 Z = O, R¹ = I, R^(2c) = OCF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6362 Z = S, R¹ = F, R^(2c) = OCF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6363 Z = S, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6364 Z = S, R¹ = Br, R^(2c) = OCF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6365 Z = S, R¹ = I, R^(2c) = OCF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6366 Z = SO, R¹ = F, R^(2c) = OCF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6367 Z = SO, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6368 Z = SO, R¹ = Br, R^(2c) = OCF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6369 Z = SO, R¹ = I, R^(2c) = OCF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6370 Z = SO₂, R¹ = F, R^(2c) = OCF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6371 Z = SO₂, R¹ = Cl, R^(2c) = OCF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6372 Z = SO₂, R¹ = Br, R^(2c) = OCF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6373 Z = SO₂, R¹ = I, R^(2c) = OCF₃, R^(4a) = R^(4b) = H, R^(4c) = CN 6374 Z = O, R¹ = F, R^(2c) = CF₂H, R^(4a) = R^(4b) = H, R^(4c) = CN 6375 Z = O, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = R^(4b) = H, R^(4c) = CN 6376 Z = O, R¹ = Br, R^(2c) = CF₂H, R^(4a) = R^(4b) = H, R^(4c) = CN 6377 Z = O, R¹ = I, R^(2c) = CF₂H, R^(4a) = R^(4b) = H, R^(4c) = CN 6378 Z = S, R¹ = F, R^(2c) = CF₂H, R^(4a) = R^(4b) = H, R^(4c) = CN 6379 Z = S, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = R^(4b) = H, R^(4c) = CN 6380 Z = S, R¹ = Br, R^(2c) = CF₂H, R^(4a) = R^(4b) = H, R^(4c) = CN 6381 Z = S, R¹ = I, R^(2c) = CF₂H, R^(4a) = R^(4b) = H, R^(4c) = CN 6382 Z = SO, R¹ = F, R^(2c) = CF₂H, R^(4a) = R^(4b) = H, R^(4c) = CN 6383 Z = SO, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = R^(4b) = H, R^(4c) = CN 6384 Z = SO, R¹ = Br, R^(2c) = CF₂H, R^(4a) = R^(4b) = H, R^(4c) = CN 6385 Z = SO, R¹ = I, R^(2c) = CF₂H, R^(4a) = R^(4b) = H, R^(4c) = CN 6386 Z = SO₂, R¹ = F, R^(2c) = CF₂H, R^(4a) = R^(4b) = H, R^(4c) = CN 6387 Z = SO₂, R¹ = Cl, R^(2c) = CF₂H, R^(4a) = R^(4b) = H, R^(4c) = CN 6388 Z = SO₂, R¹ = Br, R^(2c) = CF₂H, R^(4a) = R^(4b) = H, R^(4c) = CN 6389 Z = SO₂, R¹ = I, R^(2c) = CF₂H, R^(4a) = R^(4b) = H, R^(4c) = CN

Table 6390

Table 6390 is constructed the same way as Table 4639 except that the structure is replaced with the structure below.

The disclosure also includes Tables 6391-8140 which are constructed the same as Table 6390 except that the header row is replaced with the header row shown in Tables 4640-6389.

TABLE 8141

R^(2a) R^(2b) R^(2d) R^(2a) R^(2b) R^(2d) R^(2a) R^(2b) R^(2d) H H H CF₃ F H CF₂H Cl H F H H OTFE F H H Br H Cl H H CN F H F Br H Br H H ODFM F H Cl Br H I H H OCF₃ F H Br Br H CF₃ H H CF₂H F H I Br H OTFE H H H Cl H CF₃ Br H CN H H F Cl H OTFE Br H ODFM H H Cl Cl H CN Br H OCF₃ H H Br Cl H ODFM Br H CF₂H H H I Cl H OCF₃ Br H H F H CF₃ Cl H CF₂H Br H F F H OTFE Cl H H I H Cl F H CN Cl H F I H Br F H ODFM Cl H Cl I H I F H OCF₃ Cl H Br I H I I H ODFM CN H F H F CF₃ I H OCF₃ CN H Cl H F OTFE I H CF₂H CN H Br H F CN I H H ODFM H I H F ODFM I H F ODFM H CF₃ H F OCF₃ I H Cl ODFM H OTFE H F CF₂H I H Br ODFM H CN H F H CF₃ H I ODFM H ODFM H F F CF₃ H CF₃ ODFM H OCF₃ H F Cl CF₃ H OTFE ODFM H CF₂H H F Br CF₃ H CN ODFM H H F F I CF₃ H ODFM ODFM H F F F CF₃ CF₃ H OCF₃ ODFM H Cl F F OTFE CF₃ H CF₂H ODFM H Br F F CN CF₃ H H OCF₃ H I F F ODFM CF₃ H F OCF₃ H CF₃ F F OCF₃ CF₃ H Cl OCF₃ H OTFE F F CF₂H CF₃ H Br OCF₃ H CN F F H OTFE H I OCF₃ H ODFM F F F OTFE H CF₃ OCF₃ H OCF₃ F F Cl OTFE H OTFE OCF₃ H CF₂H F F Br OTFE H CN OCF₃ H H Cl F I OTFE H ODFM OCF₃ H F Cl F CF₃ OTFE H OCF₃ OCF₃ H Cl Cl F OTFE OTFE H CF₂H OCF₃ H Br Cl F CN OTFE H H CF₂H H I Cl F ODFM OTFE H F CF₂H H CF₃ Cl F OCF₃ OTFE H Cl CF₂H H OTFE Cl F CF₂H OTFE H Br CF₂H H CN Cl F H CN H I CF₂H H ODFM Cl F F CN H CF₃ CF₂H H OCF₃ Cl F Cl CN H OTFE CF₂H H CF₂H Cl F Br CN H CN CF₂H H H Br F I CN H ODFM CF₂H H F Br F CF₃ CN H OCF₃ CF₂H H Cl Br F OTFE CN H CF₂H CF₂H H Br Br F CN CN H H H F I Br F CF₃ Br F OCF₃ OTFE F Cl CF₂H F OTFE Br F CF₂H OTFE F Br CF₂H F CN Br F H CN F I CF₂H F ODFM Br F F CN F CF₃ CF₂H F OCF₃ Br F Cl CN F OTFE CF₂H F CF₂H Br F Br CN F CN CF₂H F H I F I CN F ODFM CF₂H F F I F CF₃ CN F OCF₃ CF₂H F Cl I F OTFE CN F CF₂H CF₂H F Br I F CN CN F H H Cl I I F ODFM CN F F H Cl CF₃ I F OCF₃ CN F Cl H Cl OTFE I F CF₂H CN F Br H Cl CN I F H ODFM F I H Cl ODFM I F F ODFM F CF₃ H Cl OCF₃ I F Cl ODFM F OTFE H Cl CF₂H I F Br ODFM F CN H Cl H CF₃ F I ODFM F ODFM H Cl F CF₃ F CF₃ ODFM F OCF₃ H Cl Cl CF₃ F OTFE ODFM F CF₂H H Cl Br CF₃ F CN ODFM F H F Cl I CF₃ F ODFM ODFM F F F Cl CF₃ CF₃ F OCF₃ ODFM F Cl F Cl OTFE CF₃ F CF₂H ODFM F Br F Cl CN CF₃ F H OCF₃ F I F Cl ODFM CF₃ F F OCF₃ F CF₃ F Cl OCF₃ CF₃ F Cl OCF₃ F OTFE F Cl CF₂H CF₃ F Br OCF₃ F CN F Cl H OTFE F I OCF₃ F ODFM F Cl F OTFE F CF₃ OCF₃ F OCF₃ F Cl Cl OTFE F OTFE OCF₃ F CF₂H F Cl Br OTFE F CN OCF₃ F H Cl Cl I OTFE F ODFM OCF₃ F F Cl Cl CF₃ OTFE F OCF₃ OCF₃ F Cl Cl Cl OTFE OTFE F CF₂H OCF₃ F Br Cl Cl CN OTFE F H CF₂H F I Cl Cl ODFM OTFE F F CF₂H F CF₃ Cl Cl OTFE Cl Cl CF₂H CF₃ Cl Br OCF₃ Cl CN Cl Cl H OTFE Cl I OCF₃ Cl ODFM Cl Cl F OTFE Cl CF₃ OCF₃ Cl OCF₃ Cl Cl Cl OTFE Cl OTFE OCF₃ Cl CF₂H Cl Cl Br OTFE Cl CN OCF₃ Cl H Br Cl I OTFE Cl ODFM OCF₃ Cl F Br Cl CF₃ OTFE Cl OCF₃ OCF₃ Cl Cl Br Cl OTFE OTFE Cl CF₂H OCF₃ Cl Br Br Cl CN OTFE Cl H CF₂H Cl I Br Cl ODFM OTFE Cl F CF₂H Cl CF₃ Br Cl OCF₃ OTFE Cl Cl CF2H Cl OTFE Br Cl CF₂H OTFE Cl Br CF₂H Cl CN Br Cl H CN Cl I CF2H Cl ODFM Br Cl F CN Cl CF₃ CF₂H Cl OCF₃ Br Cl Cl CN Cl OTFE CF₂H Cl CF₂H Br Cl Br CN Cl CN CF₂H Cl H I Cl I CN Cl ODFM CF₂H Cl F I Cl CF₃ CN Cl OCF₃ CF₂H Cl Cl I Cl OTFE CN Cl CF₂H CF₂H Cl Br I Cl CN CN Cl H H Br I I Cl ODFM CN Cl F H Br CF₃ I Cl OCF₃ CN Cl Cl H Br OTFE I Cl CF₂H CN Cl Br H Br CN I Cl H ODFM Cl I H Br ODFM I Cl F ODFM Cl CF₃ H Br OCF₃ I Cl Cl ODFM Cl OTFE H Br CF₂H I Cl Br ODFM Cl CN H Br H CF₃ Cl I ODFM Cl ODFM H Br F CF₃ Cl CF₃ ODFM Cl OCF₃ H Br Cl CF₃ Cl OTFE ODFM Cl CF₂H H Br Br CF₃ Cl CN ODFM Cl H F Br I CF₃ Cl ODFM ODFM Cl F F Br CF₃ CF₃ Cl OCF₃ ODFM Cl Cl F Br OTFE CF₃ Cl CF₂H ODFM Cl Br F Br CN CF₃ Cl H OCF₃ Cl I F Br ODFM CF₃ Cl F OCF₃ Cl CF₃ F Br OCF₃ CF₃ Cl Cl OCF₃ Cl OTFE F Br CN F Br H CF₃ Br I ODFM Br ODFM F Br F CF₃ Br CF₃ ODFM Br OCF₃ F Br Cl CF₃ Br OTFE ODFM Br CF₂H F Br Br CF₃ Br CN ODFM Br H Cl Br I CF₃ Br ODFM ODFM Br F Cl Br CF₃ CF₃ Br OCF₃ ODFM Br Cl Cl Br OTFE CF₃ Br CF₂H ODFM Br Br Cl Br CN CF₃ Br H OCF₃ Br I Cl Br ODFM CF₃ Br F OCF₃ Br CF₃ Cl Br OCF₃ CF₃ Br Cl OCF₃ Br OTFE Cl Br CF₂H CF₃ Br Br OCF₃ Br CN Cl Br H OTFE Br I OCF₃ Br ODFM Cl Br F OTFE Br CF₃ OCF₃ Br OCF₃ Cl Br Cl OTFE Br OTFE OCF₃ Br CF₂H Cl Br Br OTFE Br CN OCF₃ Br H Br Br I OTFE Br ODFM OCF₃ Br F Br Br CF₃ OTFE Br OCF₃ OCF₃ Br Cl Br Br OTFE OTFE Br CF₂H OCF₃ Br Br Br Br CN OTFE Br H CF₂H Br I Br Br ODFM OTFE Br F CF₂H Br CF₃ Br Br OCF₃ OTFE Br Cl CF₂H Br OTFE Br Br CF₂H OTFE Br Br CF₂H Br CN Br Br H CN Br I CF₂H Br ODFM Br Br F CN Br CF₃ CF₂H Br OCF₃ Br Br Cl CN Br OTFE CF₂H Br CF₂H Br Br Br CN Br CN CF₂H Br H I Br I CN Br ODFM CF₂H Br F I Br CF₃ CN Br OCF₃ CF₂H Br Cl I Br OTFE CN Br CF₂H CF₂H Br Br I Br CN CN Br H H Br I I Br ODFM CN Br F H Br CF₃ I Br OCF₃ CN Br Cl H Br OTFE I Br CF₂H CN Br Br H Br CN I Br H ODFM Br I H Br ODFM I Br F ODFM Br CF₃ H Br OCF₃ I Br Cl ODFM Br OTFE H Br CF₂H I Br Br ODFM Br CN H Br ODFM H Br F I Br CF₃ CN Br OCF₃ H Br Cl I Br OTFE CN Br CF₂H H Br Br I Br CN CN Br H F Br I I Br ODFM CN Br F F Br CF₃ I Br OCF₃ CN Br Cl F Br OTFE I Br CF₂H CN Br Br F Br CN I Br H ODFM Br I F Br ODFM I Br F ODFM Br CF₃ F Br OCF₃ I Br Cl ODFM Br OTFE F Br CF₂H I Br Br ODFM Br CN F Br H CF₃ Br I ODFM Br ODFM F Br F CF₃ Br CF₃ ODFM Br OCF₃ F Br Cl CF₃ Br OTFE ODFM Br CF₂H F Br Br CF₃ Br CN ODFM Br H Cl Br I CF₃ Br ODFM ODFM Br F Cl Br CF₃ CF₃ Br OCF₃ ODFM Br Cl Cl Br OTFE CF₃ Br CF₂H ODFM Br Br Cl Br CN CF₃ Br H OCF₃ Br I Cl Br ODFM CF₃ Br F OCF₃ Br CF₃ Cl Br OCF₃ CF₃ Br Cl OCF₃ Br OTFE Cl Br CF₂H CF₃ Br Br OCF₃ Br CN Cl Br H OTFE Br I OCF₃ Br ODFM Cl Br F OTFE Br CF₃ OCF₃ Br OCF₃ Cl Br Cl OTFE Br OTFE OCF₃ Br CF₂H Cl Br Br OTFE Br CN OCF₃ Br H Br Br I OTFE Br ODFM OCF₃ Br F Br Br CF₃ OTFE Br OCF₃ OCF₃ Br Cl Br Br OTFE OTFE Br CF₂H OCF₃ Br Br Br Br CN OTFE Br H CF₂H Br I Br Br ODFM OTFE Br F CF₂H Br CF₃ Br Br OCF₃ OTFE Br Cl CF₂H Br OTFE Br Br CF₂H OTFE Br Br CF₂H Br CN Br Br H CN Br I CF₂H Br ODFM Br Br F CN Br CF₃ CF₂H Br OCF₃ Br Br Cl CN Br OTFE CF₂H Br CF₂H Br Br Br CN Br CN CF₂H Br H I Br I CN Br ODFM CF₂H Br OCF₃ CF₂H Br Cl Br I OTFE OTFE I CF₂H CF₂H Br Br Br I CN OTFE I H H I I Br I ODFM OTFE I F H I CF₃ Br I OCF₃ OTFE I Cl H I OTFE Br I CF₂H OTFE I Br H I CN Br I H CN I I H I ODFM Br I F CN I CF₃ H I OCF₃ Br I Cl CN I OTFE H I CF₂H Br I Br CN I CN H I H I I I CN I ODFM H I F I I CF₃ CN I OCF₃ H I Cl I I OTFE CN I CF₂H H I Br I I CN CN I H F I I I I ODFM CN I F F I CF₃ I I OCF₃ CN I Cl F I OTFE I I CF₂H CN I Br F I CN I I H ODFM I I F I ODFM I I F ODFM I CF₃ F I OCF₃ I I Cl ODFM I OTFE F I CF₂H I I Br ODFM I CN F I H CF₃ I I ODFM I ODFM F I F CF₃ I CF₃ ODFM I OCF₃ F I Cl CF₃ I OTFE ODFM I CF₂H F I Br CF₃ I CN ODFM I H Cl I I CF₃ I ODFM ODFM I F Cl I CF₃ CF₃ I OCF₃ ODFM I Cl Cl I OTFE CF₃ I CF₂H ODFM I Br Cl I CN CF₃ I H OCF₃ I I Cl I ODFM CF₃ I F OCF₃ I CF₃ Cl I OCF₃ CF₃ I Cl OCF₃ I OTFE Cl I CF₂H CF₃ I Br OCF₃ I CN Cl I H OTFE I I OCF₃ I ODFM Cl I F OTFE I CF₃ OCF₃ I OCF₃ Cl I Cl OTFE I OTFE OCF₃ I CF₂H Cl I Br OTFE I CN OCF₃ I H Br I I OTFE I ODFM OCF₃ I F Br I CF₃ OTFE I OCF₃ OCF₃ I CF₂H OCF₃ I Br Cl I CN CF₃ I H CF₂H I I Cl I ODFM CF₃ I F CF₂H I CF₃ Cl I OCF₃ CF₃ I Cl CF₂H I OTFE Cl I CF₂H CF₃ I Br CF₂H I CN Cl I H OTFE I I CF₂H I ODFM Cl I F OTFE I CF₃ CF₂H I OCF₃ Cl I Cl OTFE I OTFE CF₂H I CF₂H Cl I Br OTFE I CN CF₂H I H Br I I OTFE I ODFM CF₂H I F Br I CF₃ OTFE I OCF₃ CF₂H I Cl Br I OTFE OTFE I CF₂H CF₂H I Br Br I CN OTFE I H H I I Br I ODFM OTFE I F H I CF₃ Br I OCF₃ OTFE I Cl H I OTFE Br I CF₂H OTFE I Br H I CN Br I H CN I I H I ODFM Br I F CN I CF₃ H I OCF₃ Br I Cl CN I OTFE H I CF₂H Br I Br CN I CN H I H I I I CN I ODFM H I F I I CF₃ CN I OCF₃ H I Cl I I OTFE CN I CF₂H H I Br I I CN CN I H F I I I I ODFM CN I F F I CF₃ I I OCF₃ CN I Cl F I OTFE I I CF₂H CN I Br F I CN I I H ODFM I I F I ODFM I I F ODFM I CF₃ F I OCF₃ I I Cl ODFM I OTFE F I CF₂H I I Br ODFM I CN F I H CF₃ I I ODFM I ODFM F I F CF₃ I CF₃ ODFM I OCF₃ F I Cl CF₃ I OTFE ODFM I CF₂H F I Br CF₃ I CN ODFM I H Cl I I CF₃ I ODFM ODFM I F Cl I CF₃ CF₃ I OCF₃ ODFM I Cl Cl I OTFE CF₃ I CF₂H ODFM I H OCF₃ I I F CF₃ ODFM I CF₃ F OCF₃ I CF₃ F CF₃ OCF₃ I CF₃ Cl OCF₃ I OTFE F CF₃ CF₂H I CF₃ Br OCF₃ I CN F CF₃ H CF₃ CF₃ I OCF₃ I ODFM F CF₃ F CF₃ CF₃ CF₃ OCF₃ I OCF₃ F CF₃ Cl CF₃ CF₃ OTFE OCF₃ I CF₂H F CF₃ Br CF₃ CF₃ CN OCF₃ I H Cl CF₃ I CF₃ CF₃ ODFM OCF₃ I F Cl CF₃ CF₃ CF₃ CF₃ OCF₃ OCF₃ I Cl Cl CF₃ OTFE CF₃ CF₃ CF₂H OCF₃ I Br Cl CF₃ CN CF₃ CF₃ H CF₂H I I Cl CF₃ ODFM CF₃ CF₃ F CF₂H I CF₃ Cl CF₃ OCF₃ CF₃ CF₃ Cl CF₂H I OTFE Cl CF₃ CF₂H CF₃ CF₃ Br CF₂H I CN Cl CF₃ H OTFE CF₃ I CF₂H I ODFM Cl CF₃ F OTFE CF₃ CF₃ CF₂H I OCF₃ Cl CF₃ Cl OTFE CF₃ OTFE CF₂H I CF₂H Cl CF₃ Br OTFE CF₃ CN CF₂H I H Br CF₃ I OTFE CF₃ ODFM CF₂H I F Br CF₃ CF₃ OTFE CF₃ OCF₃ CF₂H I Cl Br CF₃ OTFE OTFE CF₃ CF₂H CF₂H I Br Br CF₃ CN OTFE CF₃ H H CF₃ I Br CF₃ ODFM OTFE CF₃ F H CF₃ CF₃ Br CF₃ OCF₃ OTFE CF₃ Cl H CF₃ OTFE Br CF₃ CF₂H OTFE CF₃ Br H CF₃ CN Br CF₃ H CN CF₃ I H CF₃ ODFM Br CF₃ F CN CF₃ CF₃ H CF₃ OCF₃ Br CF₃ Cl CN CF₃ OTFE H CF₃ CF₂H Br CF₃ Br CN CF₃ CN H CF₃ H I CF₃ I CN CF₃ ODFM H CF₃ F I CF₃ CF₃ CN CF₃ OCF₃ H CF₃ Cl I CF₃ OTFE CN CF₃ CF₂H H CF₃ Br I CF₃ CN CN CF₃ H F CF₃ I I CF₃ ODFM CN CF₃ F F CF₃ CF₃ I CF₃ OCF₃ CN CF₃ Cl F CF₃ OTFE I CF₃ CF₂H CN CF₃ Br F CF₃ CN I CF₃ H ODFM CF₃ F ODFM CF₃ CF₃ H CF₃ OCF₃ Br CF₃ Cl ODFM CF₃ OTFE H CF₃ CF₂H Br CF₃ Br ODFM CF₃ CN H CF₃ H I CF₃ I ODFM CF₃ ODFM H CF₃ F I CF₃ CF₃ ODFM CF₃ OCF₃ H CF₃ Cl I CF₃ OTFE ODFM CF₃ CF₂H H CF₃ Br I CF₃ CN ODFM CF₃ H F CF₃ I I CF₃ ODFM ODFM CF₃ F F CF₃ CF₃ I CF₃ OCF₃ ODFM CF₃ Cl F CF₃ OTFE I CF₃ CF₂H ODFM CF₃ Br F CF₃ CN I CF₃ H OCF₃ CF₃ I F CF₃ ODFM I CF₃ F OCF₃ CF₃ CF₃ F CF₃ OCF₃ I CF₃ Cl OCF₃ CF₃ OTFE F CF₃ CF₂H I CF₃ Br OCF₃ CF₃ CN F CF₃ H CF₃ CF₃ I OCF₃ CF₃ ODFM F CF₃ F CF₃ CF₃ CF₃ OCF₃ CF₃ OCF₃ F CF₃ Cl CF₃ CF₃ OTFE OCF₃ CF₃ CF₂H F CF₃ Br CF₃ CF₃ CN OCF₃ CF₃ H Cl CF₃ I CF₃ CF₃ ODFM OCF₃ CF₃ F Cl CF₃ CF₃ CF₃ CF₃ OCF₃ OCF₃ CF₃ Cl Cl CF₃ OTFE CF₃ CF₃ CF₂H OCF₃ CF₃ Br Cl CF₃ CN CF₃ CF₃ H CF₂H CF₃ I Cl CF₃ ODFM CF₃ CF₃ F CF₂H CF₃ CF₃ Cl CF₃ OCF₃ CF₃ CF₃ Cl CF₂H CF₃ OTFE Cl CF₃ CF₂H CF₃ CF₃ Br CF₂H CF₃ CN Cl CF₃ H OTFE CF₃ I CF₂H CF₃ ODFM Cl CF₃ F OTFE CF₃ CF₃ CF₂H CF₃ OCF₃ Cl CF₃ Cl OTFE CF₃ OTFE CF₂H CF₃ CF₂H Cl CF₃ Br OTFE CF₃ CN CF₂H CF₃ H Br CF₃ I OTFE CF₃ ODFM CF₂H CF₃ F Br CF₃ CF₃ OTFE CF₃ OCF₃ CF₂H CF₃ Cl Br CF₃ OTFE OTFE CF₃ CF₂H CF₂H CF₃ Br Br CF₃ CN OTFE CF₃ H H CF₃ I Br CF₃ ODFM OTFE CF₃ F H CF₃ CF₃ Br CF₃ OCF₃ OTFE CF₃ Cl H CF₃ OTFE Br CF₃ CF₂H OTFE CF₃ Br H CF₃ CN Br CF₃ H CN CF₃ I H CF₃ ODFM Br CF₃ F CN CF₃ Cl CN CF₃ OTFE CF₂H CF₃ CF₂H Cl OTFE Br CN CF₃ CN CF₂H CF₃ H Br OTFE I CN CF₃ ODFM CF₂H CF₃ F Br OTFE CF₃ CN CF₃ OCF₃ CF₂H CF₃ Cl Br OTFE OTFE CN CF₃ CF₂H CF₂H CF₃ Br Br OTFE CN CN CF₃ H H OTFE I Br OTFE ODFM CN CF₃ F H OTFE CF₃ Br OTFE OCF₃ CN CF₃ Cl H OTFE OTFE Br OTFE CF₂H CN CF₃ Br H OTFE CN Br OTFE H ODFM CF₃ I H OTFE ODFM Br OTFE F ODFM CF₃ CF₃ H OTFE OCF₃ Br OTFE Cl ODFM CF₃ OTFE H OTFE CF₂H Br OTFE Br ODFM CF₃ CN H OTFE H I OTFE I ODFM CF₃ ODFM H OTFE F I OTFE CF₃ ODFM CF₃ OCF₃ H OTFE Cl I OTFE OTFE ODFM CF₃ CF₂H H OTFE Br I OTFE CN ODFM CF₃ H F OTFE I I OTFE ODFM ODFM CF₃ F F OTFE CF₃ I OTFE OCF₃ ODFM CF₃ Cl F OTFE OTFE I OTFE CF₂H ODFM CF₃ Br F OTFE CN I OTFE H OCF₃ CF₃ I F OTFE ODFM I OTFE F OCF₃ CF₃ CF₃ F OTFE OCF₃ I OTFE Cl OCF₃ CF₃ OTFE F OTFE CF₂H I OTFE Br OCF₃ CF₃ CN F OTFE H CF₃ OTFE I OCF₃ CF₃ ODFM F OTFE F CF₃ OTFE CF₃ OCF₃ CF₃ OCF₃ F OTFE Cl CF₃ OTFE OTFE OCF₃ CF₃ CF₂H F OTFE Br CF₃ OTFE CN OCF₃ CF₃ H Cl OTFE I CF₃ OTFE ODFM OCF₃ CF₃ F Cl OTFE CF₃ CF₃ OTFE OCF₃ OCF₃ CF₃ Cl Cl OTFE OTFE CF₃ OTFE CF₂H OCF₃ CF₃ Br Cl OTFE CN CF₃ OTFE H CF₂H CF₃ I Cl OTFE ODFM CF₃ OTFE F CF₂H CF₃ CF₃ Cl OTFE OCF₃ CF₃ OTFE Cl CF₂H CF₃ OTFE Cl OTFE CF₂H CF₃ OTFE Br CF₂H CF₃ CN Cl OTFE H OTFE OTFE I CF₂H CF₃ ODFM Cl OTFE F OTFE OTFE CF₃ CF₂H CF₃ OCF₃ Cl OTFE Cl OTFE OTFE Br OTFE OTFE CN OCF₃ OTFE H Cl CN I OTFE OTFE ODFM OCF₃ OTFE F Cl CN CF₃ OTFE OTFE OCF₃ OCF₃ OTFE Cl Cl CN OTFE OTFE OTFE CF₂H OCF₃ OTFE Br Cl CN CN OTFE OTFE H CF₂H OTFE I Cl CN ODFM OTFE OTFE F CF₂H OTFE CF₃ Cl CN OCF₃ OTFE OTFE Cl CF₂H OTFE OTFE Cl CN CF₂H OTFE OTFE Br CF₂H OTFE CN Cl CN H CN OTFE I CF2H OTFE ODFM Cl CN F CN OTFE CF₃ CF₂H OTFE OCF₃ Cl CN Cl CN OTFE OTFE CF₂H OTFE CF₂H Cl CN Br CN OTFE CN CF₂H OTFE H Br CN I CN OTFE ODFM CF₂H OTFE F Br CN CF₃ CN OTFE OCF₃ CF₂H OTFE Cl Br CN OTFE CN OTFE CF₂H CF₂H OTFE Br Br CN CN CN OTFE H H CN I Br CN ODFM CN OTFE F H CN CF₃ Br CN OCF₃ CN OTFE Cl H CN OTFE Br CN CF₂H CN OTFE Br H CN CN Br CN H ODFM OTFE I H CN ODFM Br CN F ODFM OTFE CF₃ H CN OCF₃ Br CN Cl ODFM OTFE OTFE H CN CF₂H Br CN Br ODFM OTFE CN H CN H I CN I ODFM OTFE ODFM H CN F I CN CF₃ ODFM OTFE OCF₃ H CN Cl I CN OTFE ODFM OTFE CF₂H H CN Br I CN CN ODFM OTFE H F CN I I CN ODFM ODFM OTFE F F CN CF₃ I CN OCF₃ ODFM OTFE Cl F CN OTFE I CN CF₂H ODFM OTFE Br F CN CN I CN H OCF₃ OTFE I F CN ODFM I CN F OCF₃ OTFE CF₃ F CN OCF₃ I CN Cl OCF₃ OTFE OTFE F CN CF₂H I CN Br OCF₃ OTFE CN F CN H CF₃ CN I OCF₃ OTFE ODFM F CN F CF₃ CN CF₃ OCF₃ OTFE OCF₃ F CN Cl CF₃ CN OTFE OCF₃ OTFE CF₂H F CN Br CF₃ CN I CF₃ CN ODFM ODFM CN F F ODFM CF₃ CF₃ CN OCF₃ ODFM CN Cl F ODFM OTFE CF₃ CN CF₂H ODFM CN Br F ODFM CN CF₃ CN H OCF₃ CN I F ODFM ODFM CF₃ CN F OCF₃ CN CF₃ F ODFM OCF₃ CF₃ CN Cl OCF₃ CN OTFE F ODFM CF₂H CF₃ CN Br OCF₃ CN CN F ODFM H OTFE CN I OCF₃ CN ODFM F ODFM F OTFE CN CF₃ OCF₃ CN OCF₃ F ODFM Cl OTFE CN OTFE OCF₃ CN CF₂H F ODFM Br OTFE CN CN OCF₃ CN H Cl ODFM I OTFE CN ODFM OCF₃ CN F Cl ODFM CF₃ OTFE CN OCF₃ OCF₃ CN Cl Cl ODFM OTFE OTFE CN CF₂H OCF₃ CN Br Cl ODFM CN OTFE CN H CF₂H CN I Cl ODFM ODFM OTFE CN F CF₂H CN CF₃ Cl ODFM OCF₃ OTFE CN Cl CF₂H CN OTFE Cl ODFM CF₂H OTFE CN Br CF₂H CN CN Cl ODFM H CN CN I CF2H CN ODFM Cl ODFM F CN CN CF₃ CF₂H CN OCF₃ Cl ODFM Cl CN CN OTFE CF₂H CN CF₂H Cl ODFM Br CN CN CN CF₂H CN H Br ODFM I CN CN ODFM CF₂H CN F Br ODFM CF₃ CN CN OCF₃ CF₂H CN Cl Br ODFM OTFE CN CN CF₂H CF₂H CN Br Br ODFM CN CN CN H H ODFM I Br ODFM ODFM CN CN F H ODFM CF₃ Br ODFM OCF₃ CN CN Cl H ODFM OTFE Br ODFM CF₂H CN CN Br H ODFM CN Br ODFM H ODFM CN I H ODFM ODFM Br ODFM F ODFM CN CF₃ H ODFM OCF₃ Br ODFM Cl ODFM CN OTFE H ODFM CF₂H Br ODFM Br ODFM CN CN H ODFM H I ODFM I ODFM CN ODFM H ODFM F I ODFM CF₃ ODFM CN OCF₃ H ODFM Cl I ODFM OTFE ODFM CN CF₂H H ODFM Br I ODFM CN ODFM CN H F ODFM I I ODFM CF₃ I ODFM OCF₃ CN ODFM Cl H OCF₃ OTFE I ODFM CF₂H CN ODFM Br H OCF₃ CN I ODFM H ODFM ODFM I H OCF₃ ODFM I ODFM F ODFM ODFM CF₃ H OCF₃ OCF₃ I ODFM Cl ODFM ODFM OTFE H OCF₃ CF₂H I ODFM Br ODFM ODFM CN H OCF₃ H CF₃ ODFM I ODFM ODFM ODFM H OCF₃ F CF₃ ODFM CF₃ ODFM ODFM OCF₃ H OCF₃ Cl CF₃ ODFM OTFE ODFM ODFM CF₂H H OCF₃ Br CF₃ ODFM CN ODFM ODFM H F OCF₃ I CF₃ ODFM ODFM ODFM ODFM F F OCF₃ CF₃ CF₃ ODFM OCF₃ ODFM ODFM Cl F OCF₃ OTFE CF₃ ODFM CF₂H ODFM ODFM Br F OCF₃ CN CF₃ ODFM H OCF₃ ODFM I F OCF₃ ODFM CF₃ ODFM F OCF₃ ODFM CF₃ F OCF₃ OCF₃ CF₃ ODFM Cl OCF₃ ODFM OTFE F OCF₃ CF₂H CF₃ ODFM Br OCF₃ ODFM CN F OCF₃ H OTFE ODFM I OCF₃ ODFM ODFM F OCF₃ F OTFE ODFM CF₃ OCF₃ ODFM OCF₃ F OCF₃ Cl OTFE ODFM OTFE OCF₃ ODFM CF₂H F OCF₃ Br OTFE ODFM CN OCF₃ ODFM H Cl OCF₃ I OTFE ODFM ODFM OCF₃ ODFM F Cl OCF₃ CF₃ OTFE ODFM OCF₃ OCF₃ ODFM Cl Cl OCF₃ OTFE OTFE ODFM CF₂H OCF₃ ODFM Br Cl OCF₃ CN OTFE ODFM H CF₂H ODFM I Cl OCF₃ ODFM OTFE ODFM F CF₂H ODFM CF₃ Cl OCF₃ OCF₃ OTFE ODFM Cl CF₂H ODFM OTFE Cl OCF₃ CF₂H OTFE ODFM Br CF₂H ODFM CN Cl OCF₃ H CN ODFM I CF2H ODFM ODFM Cl OCF₃ F CN ODFM CF₃ CF₂H ODFM OCF₃ Cl OCF₃ Cl CN ODFM OTFE CF₂H ODFM CF₂H Cl OCF₃ Br CN ODFM CN CF₂H ODFM H Br OCF₃ I CN ODFM ODFM CF₂H ODFM F Br OCF₃ CF₃ CN ODFM OCF₃ CF₂H ODFM Cl Br OCF₃ OTFE CN ODFM CF₂H CF₂H ODFM Br Br OCF₃ CN CN ODFM H H OCF₃ I Br OCF₃ ODFM CN ODFM F H OCF₃ CF₃ Br OCF₃ OTFE Br OCF₃ CF₂H OTFE OCF₃ Br CF₂H OCF₃ CN Br OCF₃ H CN OCF₃ I CF2H OCF₃ ODFM Br OCF₃ F CN OCF₃ CF₃ CF₂H OCF₃ OCF₃ Br OCF₃ Cl CN OCF₃ OTFE CF₂H OCF₃ CF₂H Br OCF₃ Br CN OCF₃ CN CF₂H OCF₃ H I OCF₃ I CN OCF₃ ODFM CF₂H OCF₃ F I OCF₃ CF₃ CN OCF₃ OCF₃ CF₂H OCF₃ Cl I OCF₃ OTFE CN OCF₃ CF₂H CF₂H OCF₃ Br I OCF₃ CN CN OCF₃ H H CF₂H I I OCF₃ ODFM CN OCF₃ F H CF₂H CF₃ I OCF₃ OCF₃ CN OCF₃ Cl H CF₂H OTFE I OCF₃ CF₂H CN OCF₃ Br H CF₂H CN I OCF₃ H ODFM OCF₃ I H CF₂H ODFM I OCF₃ F ODFM OCF₃ CF₃ H CF₂H OCF₃ I OCF₃ Cl ODFM OCF₃ OTFE H CF₂H CF₂H I OCF₃ Br ODFM OCF₃ CN H CF₂H H CF₃ OCF₃ I ODFM OCF₃ ODFM H CF₂H F CF₃ OCF₃ CF₃ ODFM OCF₃ OCF₃ H CF₂H Cl CF₃ OCF₃ OTFE ODFM OCF₃ CF₂H H CF₂H Br CF₃ OCF₃ CN ODFM OCF₃ H F CF₂H I CF₃ OCF₃ ODFM ODFM OCF₃ F F CF₂H CF₃ CF₃ OCF₃ OCF₃ ODFM OCF₃ Cl F CF₂H OTFE CF₃ OCF₃ CF₂H ODFM OCF₃ Br F CF₂H CN CF₃ OCF₃ H OCF₃ OCF₃ I F CF₂H ODFM CF₃ OCF₃ F OCF₃ OCF₃ CF₃ F CF₂H OCF₃ CF₃ OCF₃ Cl OCF₃ OCF₃ OTFE F CF₂H CF₂H CF₃ OCF₃ Br OCF₃ OCF₃ CN F CF₂H H OTFE OCF₃ I OCF₃ OCF₃ ODFM F CF₂H F OTFE OCF₃ CF₃ OCF₃ OCF₃ OCF₃ F CF₂H Cl OTFE OCF₃ OTFE OCF₃ OCF₃ CF₂H F CF₂H Br OTFE OCF₃ CN OCF₃ OCF₃ H Cl CF₂H I OTFE OCF₃ ODFM OCF₃ OCF₃ F Cl CF₂H CF₃ OTFE OCF₃ OCF₃ OCF₃ OCF₃ Cl Cl CF₂H OTFE OTFE OCF₃ CF₂H OCF₃ OCF₃ Br Cl CF₂H CN OTFE OCF₃ H CF₂H OCF₃ I Cl CF₂H ODFM OTFE OCF₃ F CF₂H OCF₃ CF₃ Cl CF₂H OCF₃ OTFE OCF₃ Cl CF₂H OCF₃ OTFE Cl CF₂H CN Cl CF₂H CF₃ CF₃ CF₂H Br ODFM CF₂H ODFM Cl CF₂H OTFE CF₃ CF₂H I ODFM CF₂H OCF₃ Cl CF₂H CN CF₃ CF₂H CF₃ ODFM CF₂H CF₂H Cl CF₂H ODFM CF₃ CF₂H OTFE ODFM CF₂H H Br CF₂H OCF₃ CF₃ CF₂H CN ODFM CF₂H F Br CF₂H CF₂H CF₃ CF₂H ODFM ODFM CF₂H Cl Br CF₂H H OTFE CF₂H OCF₃ ODFM CF₂H Br Br CF₂H F OTFE CF₂H CF₂H ODFM CF₂H I Br CF₂H Cl OTFE CF₂H H OCF₃ CF₂H CF₃ Br CF₂H Br OTFE CF₂H F OCF₃ CF₂H OTFE Br CF₂H I OTFE CF2H Cl OCF₃ CF₂H CN Br CF₂H CF₃ OTFE CF₂H Br OCF₃ CF₂H ODFM Br CF₂H OTFE OTFE CF₂H I OCF₃ CF₂H OCF₃ Br CF₂H CN OTFE CF₂H CF₃ OCF₃ CF₂H CF₂H Br CF₂H ODFM OTFE CF₂H OTFE OCF₃ CF₂H H I CF₂H OCF₃ OTFE CF₂H CN OCF₃ CF₂H F I CF₂H CF₂H OTFE CF₂H ODFM OCF₃ CF₂H Cl I CF₂H H CN CF₂H OCF₃ OCF₃ CF₂H Br I CF₂H F CN CF₂H CF₂H OCF₃ CF₂H I I CF₂H Cl CN CF₂H H CF₂H CF₂H CF₃ I CF₂H Br CN CF₂H F CF₂H CF₂H OTFE I CF2H I CN CF₂H Cl CF₂H CF₂H CN I CF₂H CF₃ CN CF₂H Br CF₂H CF₂H ODFM I CF2H OTFE CN CF₂H I CF2H CF₂H OCF₃ I CF₂H CN CN CF₂H CF₃ CF₂H CF₂H CF₂H I CF₂H ODFM CN CF₂H OTFE CF₂H CF₂H H CF₃ CF₂H OCF₃ CN CF₂H CN CF₂H CF₂H F CF₃ CF₂H CF₂H CN CF₂H ODFM CF₂H CF₂H Cl CF₃ CF₂H H ODFM CF₂H OCF₃ CF₂H CF₂H Br CF₃ CF₂H F ODFM CF₂H CF₂H CF₂H CF₂H I CF₃ CF₂H Cl ODFM CF₂H

The disclosure also includes Tables 8142-9891 which are constructed the same as Table 8141 except that the header row is replaced with the header row shown in Tables 4640-6389.

Table 9892

Table 9892 is constructed the same way as Table 4639 except that the structure is replaced with the structure below.

The disclosure also includes Tables 9893-11642 which are constructed the same as Table 9892 except that the header row is replaced with the header row shown in Tables 4640-6389.

Table 11643

Table 11643 is constructed the same way as Table 4639 except that the structure is replaced with the structure below.

The disclosure also includes Tables 11644-13393 which are constructed the same as Table 11643 except that the header row is replaced with the header row shown in Tables 4640-6389.

TABLE 13394

R^(2a) R^(2b) R^(2c) R^(2d) R^(2e) R^(2a) R^(2b) R^(2c) R^(2d) R^(2e) H H H H H F OCF₃ H H H F H H H H Br F H H H Cl H H H H Br Br H H H Br H H H H Br CF₃ H H H I H H H H Br CN H H H CF₃ H H H H Br OCF₃ H H H OTFE H H H H CF₃ F H H H CN H H H H CF₃ Br H H H ODFM H H H H CF₃ CF₃ H H H OCF₃ H H H H CF₃ CN H H H CF₂H H H H H CF₃ OCF₃ H H H H H H H H CN F H H H H F H H H CN Br H H H H Cl H H H CN CF₃ H H H H Br H H H CN CN H H H H I H H H CN OCF₃ H H H H CF₃ H H H OCF₃ F H H H H OTFE H H H OCF₃ Br H H H H CN H H H OCF₃ CF₃ H H H H ODFM H H H OCF₃ CN H H H H OCF₃ H H H OCF₃ OCF₃ H H H H CF₂H H H H F H F H H H H H H H F H Br H H H H F H H F H CF₃ H H H H Cl H H F H CN H H H H Br H H F H OCF₃ H H H H I H H Br H F H H H H CF₃ H H Br H Br H H H H OTFE H H Br H CF₃ H H H H CN H H Br H CN H H H H ODFM H H Br H OCF₃ H H H H OCF₃ H H CF₃ H F H H H H CF₂H H H CF₃ H Br H H F F H H H CF₃ H CF₃ H H F Br H H H CF₃ H CN H H F CF₃ H H H CF₃ H OCF₃ H H F CN H H H CN H F H H CN H Br H H F H H H CN CN H CF₃ H H F H H H OCF₃ CN H CN H H Br H H H F CN H OCF₃ H H Br H H H Br OCF₃ H F H H Br H H H CF₃ OCF₃ H Br H H Br H H H CN OCF₃ H CF₃ H H Br H H H OCF₃ OCF₃ H CN H H CF₃ H H H F OCF₃ H OCF₃ H H CF₃ H H H Br F H H F H CF₃ H H H CF₃ F H H Br H CF₃ H H H CN F H H CF₃ H CF₃ H H H OCF₃ F H H CN H CN H H H F F H H OCF₃ H CN H H H Br Br H H F H CN H H H CF₃ Br H H Br H CN H H H CN Br H H CF₃ H CN H H H OCF₃ Br H H CN H OCF₃ H H H F Br H H OCF₃ H OCF₃ H H H Br CF₃ H H F H OCF₃ H H H CF₃ CF₃ H H Br H OCF₃ H H H CN CF₃ H H CF₃ H OCF₃ H H H OCF₃ CF₃ H H CN H H F F H H CF₃ H H OCF₃ H H F Br H H CN H H F H H F CF₃ H H CN H H Br H H F CN H H CN H H CF₃ H H F OCF₃ H H CN H H CN H H Br F H H CN H H OCF₃ H H Br Br H H OCF₃ H H F H H Br CF₃ H H OCF₃ H H Br H H Br CN H H OCF₃ H H CF₃ H H Br OCF₃ H H OCF₃ H H CN H H CF₃ F H H OCF₃ H H OCF₃ H H CF₃ Br H H F H H H F H CF₃ CF₃ H H F H H H Br H CF₃ CN H H F H H H CF₃ H CF₃ OCF₃ H H H CN F H H H F CF₃ F H H CN Br H H H F CN F H H CN CF₃ H H H F OCF₃ F H H CN CN H H H Br F F H H CN OCF₃ H H H Br Br F H H OCF₃ F H H H Br CF₃ F H H OCF₃ Br H H H Br CN F H H OCF₃ CF₃ H H H Br OCF₃ F H H OCF₃ CN H H H CF₃ F F H H OCF₃ OCF₃ H H H CF₃ Br F H H F H F H H CF₃ CF₃ F H H F H Br H H CF₃ CN F H H F H CF₃ H H CF₃ OCF₃ F H H F H CN H H CN F F H H F H OCF₃ H H CN Br F H H Br H F H H CN CF₃ F H H Br H Br H H CN CN F H H Br H CF₃ H H CN OCF₃ F H H Br H CN H H OCF₃ F F H H Br H OCF₃ H H OCF₃ Br F H H CF₃ H F H H OCF₃ CF₃ F H H CF₃ H Br H H OCF₃ CN F H H CF₃ H CF₃ H H OCF₃ OCF₃ F H H CF₃ H CN H H Br F Br H H CF₃ H OCF₃ H H Br Br Br H H CN H F H H Br CF₃ Br H H CN H Br H H Br CN Br H H CN H CF₃ H H Br OCF₃ Br H H CN H CN H H CF₃ F Br H H CN H OCF₃ H H CF₃ Br Br H H OCF₃ H F H H CF₃ CF₃ Br H H OCF₃ H Br H H CF₃ CN Br H H OCF₃ H CF₃ H H CF₃ OCF₃ Br H H OCF₃ H CN H H CN F Br H H OCF₃ H OCF₃ H H CN Br Br H H F F F H H CN CF₃ Br H H F Br F H H CN CN Br H H CN OCF₃ Br H F H Br F H H OCF₃ F Br H F H CF₃ F H H OCF₃ Br Br H F H CN F H H OCF₃ CF₃ Br H F H OCF₃ F H H OCF₃ CN Br H Br H F F H H OCF₃ OCF₃ Br H Br H Br F H H CF₃ F CF₃ H Br H CF₃ F H H CF₃ Br CF₃ H Br H CN F H H CF₃ CF₃ CF₃ H Br H OCF₃ F H H CF₃ CN CF₃ H CF₃ H F F H H CF₃ OCF₃ CF₃ H CF₃ H Br F H H CN F CF₃ H CF₃ H CF₃ F H H CN Br CF₃ H CF₃ H CN F H H CN CF₃ CF₃ H CF₃ H OCF₃ F H H CN CN CF₃ H CN H F F H H CN OCF₃ CF₃ H CN H Br F H H OCF₃ F CF₃ H CN H CF₃ F H H OCF₃ Br CF₃ H CN H CN F H H OCF₃ CF₃ CF₃ H CN H OCF₃ F H H OCF₃ CN CF₃ H OCF₃ H F F H H OCF₃ OCF₃ CF₃ H OCF₃ H Br F H H CN F CN H OCF₃ H CF₃ F H H CN Br CN H OCF₃ H CN F H H CN CF₃ CN H OCF₃ H OCF₃ F H H CN CN CN H F H F Br H H CN OCF₃ CN H F H Br Br H H OCF₃ F CN H F H CF₃ Br H H OCF₃ Br CN H F H CN Br H H OCF₃ CF₃ CN H F H OCF₃ Br H H OCF₃ CN CN H Br H F Br H H OCF₃ OCF₃ CN H Br H Br Br H H OCF₃ F OCF₃ H Br H CF₃ Br H H OCF₃ Br OCF₃ H Br H CN Br H H OCF₃ CF₃ OCF₃ H Br H OCF₃ Br H H OCF₃ CN OCF₃ H CF₃ H F Br H H OCF₃ OCF₃ OCF₃ H CF₃ H Br Br H F H F F H CF₃ H CF₃ Br H CF₃ H CN Br H F H F CN H CF₃ H OCF₃ Br H F H Br CN H CN H F Br H F H CF₃ CN H CN H Br Br H F H CN CN H CN H CF₃ Br H F H OCF₃ CN H CN H CN Br H Br H F CN H CN H OCF₃ Br H Br H Br CN H OCF₃ H F Br H Br H CF₃ CN H OCF₃ H Br Br H Br H CN CN H OCF₃ H CF₃ Br H Br H OCF₃ CN H OCF₃ H CN Br H CF₃ H F CN H OCF₃ H OCF₃ Br H CF₃ H Br CN H F H F CF₃ H CF₃ H CF₃ CN H F H Br CF₃ H CF₃ H CN CN H F H CF₃ CF₃ H CF₃ H OCF₃ CN H F H CN CF₃ H CN H F CN H F H OCF₃ CF₃ H CN H Br CN H Br H F CF₃ H CN H CF₃ CN H Br H Br CF₃ H CN H CN CN H Br H CF₃ CF₃ H CN H OCF₃ CN H Br H CN CF₃ H OCF₃ H F CN H Br H OCF₃ CF₃ H OCF₃ H Br CN H CF₃ H F CF₃ H OCF₃ H CF₃ CN H CF₃ H Br CF₃ H OCF₃ H CN CN H CF₃ H CF₃ CF₃ H OCF₃ H OCF₃ OCF₃ H CF₃ H CN CF₃ H F H F OCF₃ H CF₃ H OCF₃ CF₃ H F H Br OCF₃ H CN H F CF₃ H F H CF₃ OCF₃ H CN H Br CF₃ H F H CN OCF₃ H CN H CF₃ CF₃ H F H OCF₃ OCF₃ H CN H CN CF₃ H Br H F OCF₃ H CN H OCF₃ CF₃ H Br H Br OCF₃ H OCF₃ H F CF₃ H Br H CF₃ OCF₃ H OCF₃ H Br CF₃ H Br H CN OCF₃ H OCF₃ H CF₃ CF₃ H Br H OCF₃ OCF₃ H OCF₃ H CN CF₃ H CF₃ H F OCF₃ H OCF₃ H OCF₃ CF₃ H CF₃ H Br OCF₃ H CF₃ H CF₃ OCF₃ H OCF₃ F OCF₃ H H CF₃ H CN OCF₃ H F Br F H H CF₃ H OCF₃ OCF₃ H F Br Br H H CN H F OCF₃ H F Br CF₃ H H CN H Br OCF₃ H F Br CN H H CN H CF₃ OCF₃ H F Br OCF₃ H H CN H CN OCF₃ H Br Br F H H CN H OCF₃ OCF₃ H Br Br Br H H OCF₃ H F OCF₃ H Br Br CF₃ H H OCF₃ H Br OCF₃ H Br Br CN H H OCF₃ H CF₃ OCF₃ H Br Br OCF₃ H H OCF₃ H CN OCF₃ H CF₃ Br F H H OCF₃ H OCF₃ OCF₃ H CF₃ Br Br H H F F F H H CF₃ Br CF₃ H H F F Br H H CF₃ Br CN H H F F CF₃ H H CF₃ Br OCF₃ H H F F CN H H CN Br F H H F F OCF₃ H H CN Br Br H H Br F F H H CN Br CF₃ H H Br F Br H H CN Br CN H H Br F CF₃ H H CN Br OCF₃ H H Br F CN H H OCF₃ Br F H H Br F OCF₃ H H OCF₃ Br Br H H CF₃ F F H H OCF₃ Br CF₃ H H CF₃ F Br H H OCF₃ Br CN H H CF₃ F CF₃ H H OCF₃ Br OCF₃ H H CF₃ F CN H H F CF₃ F H H CF₃ F OCF₃ H H F CF₃ Br H H CN F F H H F CF₃ CF₃ H H CN F Br H H F CF₃ CN H H CN F CF₃ H H F CF₃ OCF₃ H H CN F CN H H Br CF₃ F H H CN F OCF₃ H H Br CF₃ Br H H OCF₃ F F H H Br CF₃ CF₃ H H OCF₃ F Br H H Br CF₃ CN H H OCF₃ F CF₃ H H Br CF₃ OCF₃ H H OCF₃ F CN H H CF₃ CF₃ F H H CF₃ CF₃ Br H H CN CN CN H H CF₃ CF₃ CF₃ H H CN CN OCF₃ H H CF₃ CF₃ CN H H OCF₃ CN F H H CF₃ CF₃ OCF₃ H H OCF₃ CN Br H H CN CF₃ F H H OCF₃ CN CF₃ H H CN CF₃ Br H H OCF₃ CN CN H H CN CF₃ CF₃ H H OCF₃ OCF₃ OCF₃ H H CN CF₃ CN H H F OCF₃ F H H CN CF₃ OCF₃ H H F OCF₃ Br H H OCF₃ CF₃ F H H F OCF₃ CF₃ H H OCF₃ CF₃ Br H H F OCF₃ CN H H OCF₃ CF₃ CF₃ H H F OCF₃ OCF₃ H H OCF₃ CF₃ CN H H Br OCF₃ F H H OCF₃ CF₃ OCF₃ H H Br OCF₃ Br H H F CN F H H Br OCF₃ CF₃ H H F CN Br H H Br OCF₃ CN H H F CN CF₃ H H Br OCF₃ OCF₃ H H F CN CN H H CF₃ OCF₃ F H H F CN OCF₃ H H CF₃ OCF₃ Br H H Br CN F H H CF₃ OCF₃ CF₃ H H Br CN Br H H CF₃ OCF₃ CN H H Br CN CF₃ H H CF₃ OCF₃ OCF₃ H H Br CN CN H H CN OCF₃ F H H Br CN OCF₃ H H CN OCF₃ Br H H CF₃ CN F H H CN OCF₃ CF₃ H H CF₃ CN Br H H CN OCF₃ CN H H CF₃ CN CF₃ H H CN OCF₃ OCF₃ H H CF₃ CN CN H H OCF₃ OCF₃ F H H CF₃ CN OCF₃ H H OCF₃ OCF₃ Br H H CN CN F H H OCF₃ OCF₃ CF₃ H H CN CN Br H H OCF₃ OCF₃ CN H H CN CN CF₃ H H OCF₃ OCF₃ OCF₃ H H

The disclosure also includes Tables 13395-13712 which are constructed the same as Table 13394 except that the header row is replaced with the header row shown in Tables 2-319.

Formulation/Utility

A compound of this invention will generally be used as a herbicidal active ingredient in a composition, i.e. formulation, with at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents, which serves as a carrier. The formulation or composition ingredients are selected to be consistent with the physical properties of the active ingredient, mode of application and environmental factors such as soil type, moisture and temperature.

Useful formulations include both liquid and solid compositions. Liquid compositions include solutions (including emulsifiable concentrates), suspensions, emulsions (including microemulsions, oil-in-water emulsions, flowable concentrates and/or suspoemulsions) and the like, which optionally can be thickened into gels. The general types of aqueous liquid compositions are soluble concentrate, suspension concentrate, capsule suspension, concentrated emulsion, microemulsion, oil-in-water emulsion, flowable concentrate and suspo-emulsion. The general types of nonaqueous liquid compositions are emulsifiable concentrate, microemulsifiable concentrate, dispersible concentrate and oil dispersion.

The general types of solid compositions are dusts, powders, granules, pellets, prills, pastilles, tablets, filled films (including seed coatings) and the like, which can be water-dispersible (“wettable”) or water-soluble. Films and coatings formed from film-forming solutions or flowable suspensions are particularly useful for seed treatment. Active ingredient can be (micro)encapsulated and further formed into a suspension or solid formulation; alternatively the entire formulation of active ingredient can be encapsulated (or “overcoated”). Encapsulation can control or delay release of the active ingredient. An emulsifiable granule combines the advantages of both an emulsifiable concentrate formulation and a dry granular formulation. High-strength compositions are primarily used as intermediates for further formulation.

Sprayable formulations are typically extended in a suitable medium before spraying. Such liquid and solid formulations are formulated to be readily diluted in the spray medium, usually water, but occasionally another suitable medium like an aromatic or paraffinic hydrocarbon or vegetable oil. Spray volumes can range from about from about one to several thousand liters per hectare, but more typically are in the range from about ten to several hundred liters per hectare. Sprayable formulations can be tank mixed with water or another suitable medium for foliar treatment by aerial or ground application, or for application to the growing medium of the plant. Liquid and dry formulations can be metered directly into drip irrigation systems or metered into the furrow during planting.

The formulations will typically contain effective amounts of active ingredient, diluent and surfactant within the following approximate ranges which add up to 100 percent by weight.

Weight Percent Active Ingredient Diluent Surfactant Water-Dispersible and Water- 0.001-90 0-99.999 0-15 soluble Granules, Tablets and Powders Oil Dispersions, Suspensions,    1-50 40-99    0-50 Emulsions, Solutions (including Emulsifiable Concentrates) Dusts    1-25 70-99    0-5  Granules and Pellets 0.001-99 5-99.999 0-15 High Strength Compositions   90-99 0-10    0-2 

Solid diluents include, for example, clays such as bentonite, montmorillonite, attapulgite and kaolin, gypsum, cellulose, titanium dioxide, zinc oxide, starch, dextrin, sugars (e.g., lactose, sucrose), silica, talc, mica, diatomaceous earth, urea, calcium carbonate, sodium carbonate and bicarbonate, and sodium sulfate. Typical solid diluents are described in Watkins et al., Handbook of Insecticide Dust Diluents and Carriers, 2nd Ed., Dorland Books, Caldwell, N.J.

Liquid diluents include, for example, water, N,N-dimethylalkanamides (e.g., N,N-dimethylformamide), limonene, dimethyl sulfoxide, N-alkylpyrrolidones (e.g., N-methylpyrrolidinone), alkyl phosphates (e.g., triethyl phosphate), ethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, propylene carbonate, butylene carbonate, paraffins (e.g., white mineral oils, normal paraffins, isoparaffins), alkylbenzenes, alkylnaphthalenes, glycerine, glycerol triacetate, sorbitol, aromatic hydrocarbons, dearomatized aliphatics, alkylbenzenes, alkylnaphthalenes, ketones such as cyclohexanone, 2-heptanone, isophorone and 4-hydroxy-4-methyl-2-pentanone, acetates such as isoamyl acetate, hexyl acetate, heptyl acetate, octyl acetate, nonyl acetate, tridecyl acetate and isobornyl acetate, other esters such as alkylated lactate esters, dibasic esters, alkyl and aryl benzoates and γ-butyrolactone, and alcohols, which can be linear, branched, saturated or unsaturated, such as methanol, ethanol, n-propanol, isopropyl alcohol, n-butanol, isobutyl alcohol, n-hexanol, 2-ethylhexanol, n-octanol, decanol, isodecyl alcohol, isooctadecanol, cetyl alcohol, lauryl alcohol, tridecyl alcohol, oleyl alcohol, cyclohexanol, tetrahydrofurfuryl alcohol, diacetone alcohol, cresol and benzyl alcohol. Liquid diluents also include glycerol esters of saturated and unsaturated fatty acids (typically C₆-C₂₂), such as plant seed and fruit oils (e.g., oils of olive, castor, linseed, sesame, corn (maize), peanut, sunflower, grapeseed, safflower, cottonseed, soybean, rapeseed, coconut and palm kernel), animal-sourced fats (e.g., beef tallow, pork tallow, lard, cod liver oil, fish oil), and mixtures thereof. Liquid diluents also include alkylated fatty acids (e.g., methylated, ethylated, butylated) wherein the fatty acids may be obtained by hydrolysis of glycerol esters from plant and animal sources, and can be purified by distillation. Typical liquid diluents are described in Marsden, Solvents Guide, 2nd Ed., Interscience, New York, 1950.

The solid and liquid compositions of the present invention often include one or more surfactants. When added to a liquid, surfactants (also known as “surface-active agents”) generally modify, most often reduce, the surface tension of the liquid. Depending on the nature of the hydrophilic and lipophilic groups in a surfactant molecule, surfactants can be useful as wetting agents, dispersants, emulsifiers or defoaming agents.

Surfactants can be classified as nonionic, anionic or cationic. Nonionic surfactants useful for the present compositions include, but are not limited to: alcohol alkoxylates such as alcohol alkoxylates based on natural and synthetic alcohols (which may be branched or linear) and prepared from the alcohols and ethylene oxide, propylene oxide, butylene oxide or mixtures thereof; amine ethoxylates, alkanolamides and ethoxylated alkanolamides; alkoxylated triglycerides such as ethoxylated soybean, castor and rapeseed oils; alkylphenol alkoxylates such as octylphenol ethoxylates, nonylphenol ethoxylates, dinonyl phenol ethoxylates and dodecyl phenol ethoxylates (prepared from the phenols and ethylene oxide, propylene oxide, butylene oxide or mixtures thereof); block polymers prepared from ethylene oxide or propylene oxide and reverse block polymers where the terminal blocks are prepared from propylene oxide; ethoxylated fatty acids; ethoxylated fatty esters and oils; ethoxylated methyl esters; ethoxylated tristyrylphenol (including those prepared from ethylene oxide, propylene oxide, butylene oxide or mixtures thereof); fatty acid esters, glycerol esters, lanolin-based derivatives, polyethoxylate esters such as polyethoxylated sorbitan fatty acid esters, polyethoxylated sorbitol fatty acid esters and polyethoxylated glycerol fatty acid esters; other sorbitan derivatives such as sorbitan esters; polymeric surfactants such as random copolymers, block copolymers, alkyd peg (polyethylene glycol) resins, graft or comb polymers and star polymers; polyethylene glycols (pegs); polyethylene glycol fatty acid esters; silicone-based surfactants; and sugar-derivatives such as sucrose esters, alkyl polyglycosides and alkyl polysaccharides.

Useful anionic surfactants include, but are not limited to: alkylaryl sulfonic acids and their salts; carboxylated alcohol or alkylphenol ethoxylates; diphenyl sulfonate derivatives; lignin and lignin derivatives such as lignosulfonates; maleic or succinic acids or their anhydrides; olefin sulfonates; phosphate esters such as phosphate esters of alcohol alkoxylates, phosphate esters of alkylphenol alkoxylates and phosphate esters of styryl phenol ethoxylates; protein-based surfactants; sarcosine derivatives; styryl phenol ether sulfate; sulfates and sulfonates of oils and fatty acids; sulfates and sulfonates of ethoxylated alkylphenols; sulfates of alcohols; sulfates of ethoxylated alcohols; sulfonates of amines and amides such as N,N-alkyltaurates; sulfonates of benzene, cumene, toluene, xylene, and dodecyl and tridecylbenzenes; sulfonates of condensed naphthalenes; sulfonates of naphthalene and alkyl naphthalene; sulfonates of fractionated petroleum; sulfosuccinamates; and sulfosuccinates and their derivatives such as dialkyl sulfosuccinate salts.

Useful cationic surfactants include, but are not limited to: amides and ethoxylated amides; amines such as N-alkyl propanediamines, tripropylenetriamines and dipropylenetetramines, and ethoxylated amines, ethoxylated diamines and propoxylated amines (prepared from the amines and ethylene oxide, propylene oxide, butylene oxide or mixtures thereof); amine salts such as amine acetates and diamine salts; quaternary ammonium salts such as quaternary salts, ethoxylated quaternary salts and diquaternary salts; and amine oxides such as alkyldimethylamine oxides and bis-(2-hydroxyethyl)-alkylamine oxides.

Also useful for the present compositions are mixtures of nonionic and anionic surfactants or mixtures of nonionic and cationic surfactants. Nonionic, anionic and cationic surfactants and their recommended uses are disclosed in a variety of published references including McCutcheon's Emulsifiers and Detergents, annual American and International Editions published by McCutcheon's Division, The Manufacturing Confectioner Publishing Co.; Sisely and Wood, Encyclopedia of Surface Active Agents, Chemical Publ. Co., Inc., New York, 1964; and A. S. Davidson and B. Milwidsky, Synthetic Detergents, Seventh Edition, John Wiley and Sons, New York, 1987.

Compositions of this invention may also contain formulation auxiliaries and additives, known to those skilled in the art as formulation aids (some of which may be considered to also function as solid diluents, liquid diluents or surfactants). Such formulation auxiliaries and additives may control: pH (buffers), foaming during processing (antifoams such polyorganosiloxanes), sedimentation of active ingredients (suspending agents), viscosity (thixotropic thickeners), in-container microbial growth (antimicrobials), product freezing (antifreezes), color (dyes/pigment dispersions), wash-off (film formers or stickers), evaporation (evaporation retardants), and other formulation attributes. Film formers include, for example, polyvinyl acetates, polyvinyl acetate copolymers, polyvinylpyrrolidone-vinyl acetate copolymer, polyvinyl alcohols, polyvinyl alcohol copolymers and waxes. Examples of formulation auxiliaries and additives include those listed in McCutcheon's Volume 2: Functional Materials, annual International and North American editions published by McCutcheon's Division, The Manufacturing Confectioner Publishing Co.; and PCT Publication WO 03/024222.

The compound of Formula 1 and any other active ingredients are typically incorporated into the present compositions by dissolving the active ingredient in a solvent or by grinding in a liquid or dry diluent. Solutions, including emulsifiable concentrates, can be prepared by simply mixing the ingredients. If the solvent of a liquid composition intended for use as an emulsifiable concentrate is water-immiscible, an emulsifier is typically added to emulsify the active-containing solvent upon dilution with water. Active ingredient slurries, with particle diameters of up to 2,000 μm can be wet milled using media mills to obtain particles with average diameters below 3 μm. Aqueous slurries can be made into finished suspension concentrates (see, for example, U.S. Pat. No. 3,060,084) or further processed by spray drying to form water-dispersible granules. Dry formulations usually require dry milling processes, which produce average particle diameters in the 2 to 10 μm range. Dusts and powders can be prepared by blending and usually grinding (such as with a hammer mill or fluid-energy mill). Granules and pellets can be prepared by spraying the active material upon preformed granular carriers or by agglomeration techniques. See Browning, “Agglomeration”, Chemical Engineering, Dec. 4, 1967, pp 147-48, Perry's Chemical Engineer's Handbook, 4th Ed., McGraw-Hill, New York, 1963, pages 8-57 and following, and WO 91/13546. Pellets can be prepared as described in U.S. Pat. No. 4,172,714. Water-dispersible and water-soluble granules can be prepared as taught in U.S. Pat. No. 4,144,050, U.S. Pat. No. 3,920,442 and DE 3,246,493. Tablets can be prepared as taught in U.S. Pat. No. 5,180,587, U.S. Pat. No. 5,232,701 and U.S. Pat. No. 5,208,030. Films can be prepared as taught in GB 2,095,558 and U.S. Pat. No. 3,299,566.

For further information regarding the art of formulation, see T. S. Woods, “The Formulator's Toolbox—Product Forms for Modern Agriculture” in Pesticide Chemistry and Bioscience, The Food—Environment Challenge, T. Brooks and T. R. Roberts, Eds., Proceedings of the 9th International Congress on Pesticide Chemistry, The Royal Society of Chemistry, Cambridge, 1999, pp. 120-133. See also U.S. Pat. No. 3,235,361, Col. 6, line 16 through Col. 7, line 19 and Examples 10-41; U.S. Pat. No. 3,309,192, Col. 5, line 43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58, 132, 138-140, 162-164, 166, 167 and 169-182; U.S. Pat. No. 2,891,855, Col. 3, line 66 through Col. 5, line 17 and Examples 1-4; Klingman, Weed Control as a Science, John Wiley and Sons, Inc., New York, 1961, pp 81-96; Hance et al., Weed Control Handbook, 8th Ed., Blackwell Scientific Publications, Oxford, 1989; and Developments in formulation technology, PJB Publications, Richmond, UK, 2000.

In the following Examples, all percentages are by weight and all formulations are prepared in conventional ways. Compound numbers refer to compounds in Index Tables A. Without further elaboration, it is believed that one skilled in the art using the preceding description can utilize the present invention to its fullest extent. The following Examples are, therefore, to be construed as merely illustrative, and not limiting of the disclosure in any way whatsoever. Percentages are by weight except where otherwise indicated.

Example A

High Strength Concentrate

Compound 1 98.5% silica aerogel 0.5% synthetic amorphous fine silica 1.0%

Example B

Wettable Powder

Compound 2 65.0% dodecylphenol polyethylene glycol ether 2.0% sodium ligninsulfonate 4.0% sodium silicoaluminate 6.0% montmorillonite (calcined) 23.0%

Example C

(i) Granule

Compound 3 10.0% attapulgite granules (low volatile matter, 0.71/0.30 mm; 90.0% U.S.S. No. 25-50 sieves)

Example D

Extruded Pellet

Compound 1 25.0% anhydrous sodium sulfate 10.0% crude calcium ligninsulfonate 5.0% sodium alkylnaphthalenesulfonate 1.0% calcium/magnesium bentonite 59.0%

Example E

Emulsifiable Concentrate

Compound 2 10.0% polyoxyethylene sorbitol hexoleate 20.0% C₆-C₁₀ fatty acid methyl ester 70.0%

Example F

Microemulsion

Compound 3 5.0% polyvinylpyrrolidone-vinyl acetate copolymer 30.0% alkylpolyglycoside 30.0% glyceryl monooleate 15.0% water 20.0%

Example G

Suspension Concentrate

Compound 1  35% butyl polyoxyethylene/polypropylene block copolymer 4.0% stearic acid/polyethylene glycol copolymer 1.0% styrene acrylic polymer 1.0% xanthan gum 0.1% propylene glycol 5.0% silicone based defoamer 0.1% 1,2-benzisothiazolin-3-one 0.1% water 53.7% 

Example H

Emulsion in Water

Compound 2 10.0% butyl polyoxyethylene/polypropylene block copolymer 4.0% stearic acid/polyethylene glycol copolymer 1.0% styrene acrylic polymer 1.0% xanthan gum 0.1% propylene glycol 5.0% silicone based defoamer 0.1% 1,2-benzisothiazolin-3-one 0.1% aromatic petroleum based hydrocarbon 20.0 water 58.7%

Example I

Oil Dispersion

Compound 3 25% polyoxyethylene sorbitol hexaoleate 15% organically modified bentonite clay 2.5%  fatty acid methyl ester 57.5%  

Test results indicate that the compounds of the present invention are highly active preemergent and/or postemergent herbicides and/or plant growth regulants. The compounds of the inention generally show highest activity for postemergence weed control (i.e. applied after weed seedlings emerge from the soil) and preemergence weed control (i.e. applied before weed seedlings emerge from the soil). Many of them have utility for broad-spectrum pre- and/or postemergence weed control in areas where complete control of all vegetation is desired such as around fuel storage tanks, industrial storage areas, parking lots, drive-in theaters, air fields, river banks, irrigation and other waterways, around billboards and highway and railroad structures. Many of the compounds of this invention, by virtue of selective metabolism in crops versus weeds, or by selective activity at the locus of physiological inhibition in crops and weeds, or by selective placement on or within the environment of a mixture of crops and weeds, are useful for the selective control of grass and broadleaf weeds within a crop/weed mixture. One skilled in the art will recognize that the preferred combination of these selectivity factors within a compound or group of compounds can readily be determined by performing routine biological and/or biochemical assays. Compounds of this invention may show tolerance to important agronomic crops including, but is not limited to, alfalfa, barley, cotton, wheat, rape, sugar beets, corn (maize), sorghum, soybeans, rice, oats, peanuts, vegetables, tomato, potato, perennial plantation crops including coffee, cocoa, oil palm, rubber, sugarcane, citrus, grapes, fruit trees, nut trees, banana, plantain, pineapple, hops, tea and forests such as eucalyptus and conifers (e.g., loblolly pine), and turf species (e.g., Kentucky bluegrass, St. Augustine grass, Kentucky fescue and Bermuda grass). Compounds of this invention can be used in crops genetically transformed or bred to incorporate resistance to herbicides, express proteins toxic to invertebrate pests (such as Bacillus thuringiensis toxin), and/or express other useful traits. Those skilled in the art will appreciate that not all compounds are equally effective against all weeds. Alternatively, the subject compounds are useful to modify plant growth.

As the compounds of the invention have (both preemergent and postemergent herbicidal) activity, to control undesired vegetation by killing or injuring the vegetation or reducing its growth, the compounds can be usefully applied by a variety of methods involving contacting a herbicidally effective amount of a compound of the invention, or a composition comprising said compound and at least one of a surfactant, a solid diluent or a liquid diluent, to the foliage or other part of the undesired vegetation or to the environment of the undesired vegetation such as the soil or water in which the undesired vegetation is growing or which surrounds the seed or other propagule of the undesired vegetation.

A herbicidally effective amount of the compounds of this invention is determined by a number of factors. These factors include: formulation selected, method of application, amount and type of vegetation present, growing conditions, etc. In general, a herbicidally effective amount of compounds of this invention is about 0.001 to 20 kg/ha with a preferred range of about 0.004 to 1 kg/ha. One skilled in the art can easily determine the herbicidally effective amount necessary for the desired level of weed control.

In one common embodiment, a compound of the invention is applied, typically in a formulated composition, to a locus comprising desired vegetation (e.g., crops) and undesired vegetation (i.e. weeds), both of which may be seeds, seedlings and/or larger plants, in contact with a growth medium (e.g., soil). In this locus, a composition comprising a compound of the invention can be directly applied to a plant or a part thereof, particularly of the undesired vegetation, and/or to the growth medium in contact with the plant.

Compounds of the invention are useful in treating all plants and plant parts. Plant varieties and cultivars can be obtained by conventional propagation and breeding methods or by genetic engineering methods. Genetically modified plants (transgenic plants) are those in which a heterologous gene (transgene) has been stably integrated into the plant's genome. A transgene that is defined by its particular location in the plant genome is called a transformation or transgenic event.

Genetically modified plant cultivars which can be treated according to the invention include those that are resistant against one or more biotic stresses (pests such as nematodes, insects, mites, fungi, etc.) or abiotic stresses (drought, cold temperature, soil salinity, etc.), or that contain other desirable characteristics. Plants can be genetically modified to exhibit traits of, for example, herbicide tolerance, insect-resistance, modified oil profiles or drought tolerance. Useful genetically modified plants containing single gene transformation events or combinations of transformation events are listed in Exhibit C. Additional information for the genetic modifications listed in Exhibit C can be obtained from publicly available databases maintained, for example, by the U.S. Department of Agriculture.

The following abbreviations, T1 through T37, are used in Exhibit C for traits. A “-” means the entry is not available. “tol.” means tolerance.

Trait Description T1 Glyphosate tolerance T2 High lauric acid oil T3 Glufosinate tolerance T4 Phytate breakdown T5 Oxynil tol. T6 Disease resistance T7 Insect resistance T9 Modified flower color T11 ALS Herbicide Tol. T12 Dicamba tol. T13 Anti-allergy T14 Salt tolerance T15 Cold tol. T16 Imidazolinone herb. tol. T17 Modified alpha-amylase T18 Pollination control T19 2,4-D tol. T20 Increased lysine T21 Drought tol. T22 Delayed ripening/senescence T23 Modified product quality T24 High cellulose T25 Modified starch/carbohydrate T26 Insect & disease resist. T27 High tryptophan T28 Erect leaves semidwarf T29 Semidwarf T30 Low iron tol. T31 Modified oil/fatty acid T32 HPPD tol. T33 High oil T34 Aryloxyalkanoate tol. T35 Mesotrione tol. T36 Reduced nicotine T37 Modified product

Exhibit C Crop Event Name Event Code Trait(s) Gene(s) Alfalfa J101 MON-00101-8 T1 cp4 epsps (aroA:CP4) Alfalfa J163 MON-ØØ163-7 T1 cp4 epsps (aroA:CP4) Canola* 23-18-17 (Event 18) CGN-89465-2 T2 te Canola* 23-198 (Event 23) CGN-89465-2 T2 te Canola* 61061 DP-Ø61Ø61-7 T1 gat4621 Canola* 73496 DP-Ø73496-4 T1 gat4621 Canola* GT200 (RT200) MON-89249-2 T1 cp4 epsps (aroA:CP4); goxv247 Canola* GT73 (RT73) MON-ØØØ73-7 T1 cp4 epsps (aroA:CP4); goxv247 Canola* HCN10 (Topas 19/2) — T3 bar Canola* HCN28 (T45) ACS-BNØØ8-2 T3 pat (syn) Canola* HCN92 (Topas 19/2) ACS-BNØØ7-1 T3 bar Canola* MON88302 MON-883Ø2-9 T1 cp4 epsps (aroA:CP4) Canola* MPS961 — T4 phyA Canola* MPS962 — T4 phyA Canola* MPS963 — T4 phyA Canola* MPS964 — T4 phyA Canola* MPS965 — T4 phyA Canola* MS1 (B91-4) ACS-BNØØ4-7 T3 bar Canola* MS8 ACS-BNØØ5-8 T3 bar Canola* OXY-235 ACS-BNØ11-5 T5 bxn Canola* PHY14 — T3 bar Canola* PHY23 — T3 bar Canola* PHY35 — T3 bar Canola* PHY36 — T3 bar Canola* RF1 (B93-101) ACS-BNØØ1-4 T3 bar Canola* RF2 (B94-2) ACS-BNØØ2-5 T3 bar Canola* RF3 ACS-BNØØ3-6 T3 bar Bean EMBRAPA 5.1 EMB-PV051-1 T6 ac1 (sense and antisense) Brinjal # EE-1 — T7 cry1Ac Cotton 19-51a DD-Ø1951A-7 T11 S4-HrA Cotton 281-24-236 DAS-24236-5 T3, T7 pat (syn); cry1F Cotton 3006-210-23 DAS-21Ø23-5 T3, T7 pat (syn); cry1Ac Cotton 31707 — T5, T7 bxn; cry1Ac Cotton 31803 — T5, T7 bxn; cry1Ac Cotton 31807 — T5, T7 bxn; cry1Ac Cotton 31808 — T5, T7 bxn; cry1Ac Cotton 42317 — T5, T7 bxn; cry1Ac Cotton BNLA-601 — T7 cry1Ac Cotton BXN10211 BXN10211-9 T5 bxn; cry1Ac Cotton BXN10215 BXN10215-4 T5 bxn; cry1Ac Cotton BXN10222 BXN10222-2 T5 bxn; cry1Ac Cotton BXN10224 BXN10224-4 T5 bxn; cry1Ac Cotton COT102 SYN-IR102-7 T7 vip3A(a) Cotton COT67B SYN-IR67B-1 T7 cry1Ab Cotton COT202 — T7 vip3A Cotton Event 1 — T7 cry1Ac Cotton GMF Cry1A GTL- T7 cry1Ab-Ac GMF311-7 Cotton GHB119 BCS-GH005-8 T7 cry2Ae Cotton GHB614 BCS-GH002-5 T1 2mepsps Cotton GK12 — T7 cry1Ab-Ac Cotton LLCotton25 ACS-GH001-3 T3 bar Cotton MLS 9124 — T7 cry1C Cotton MON1076 MON-89924-2 T7 cry1Ac Cotton MON1445 MON-01445-2 T1 cp4 epsps (aroA:CP4) Cotton MON15985 MON-15985-7 T7 cry1Ac; cry2Ab2 Cotton MON1698 MON-89383-1 T7 cp4 epsps (aroA:CP4) Cotton MON531 MON-00531-6 T7 cry1Ac Cotton MON757 MON-00757-7 T7 cry1Ac Cotton MON88913 MON-88913-8 T1 cp4 epsps (aroA:CP4) Cotton Nqwe Chi 6 Bt — T7 — Cotton SKG321 — T7 cry1A; CpTI Cotton T303-3 BCS-GH003-6 T3, T7 cry1Ab; bar Cotton T304-40 BCS-GH004-7 T3, T7 cry1Ab; bar Cotton CE43-67B — T7 cry1Ab Cotton CE46-02A — T7 cry1Ab Cotton CE44-69D — T7 cry1Ab Cotton 1143-14A — T7 cry1Ab Cotton 1143-51B — T7 cry1Ab Cotton T342-142 — T7 cry1Ab Cotton PV-GHGT07 (1445) — T1 cp4 epsps (aroA:CP4) Cotton EE-GH3 — T1 mepsps Cotton EE-GH5 — T7 cry1Ab Cotton MON88701 MON-88701-3 T3, T12 Modified dmo; bar Cotton OsCr11 — T13 Modified Cry j Flax FP967 CDC-FL001-2 T11 als Lentil RH44 — T16 als Maize 3272 SYN-E3272-5 T17 amy797E Maize 5307 SYN-05307-1 T7 ecry3.1Ab Maize 59122 DAS-59122-7 T3, T7 cry34Ab1; cry35Ab1; pat Maize 676 PH-000676-7 T3, T18 pat; dam Maize 678 PH-000678-9 T3, T18 pat; dam Maize 680 PH-000680-2 T3, T18 pat; dam Maize 98140 DP-098140-6 T1, T11 gat4621; zm-hra Maize Bt10 — T3, T7 cry1Ab; pat Maize Bt176 (176) SYN-EV176-9 T3, T7 cry1Ab; bar Maize BVLA430101 — T4 phyA2 Maize CBH-351 ACS-ZM004-3 T3, T7 cry9C; bar Maize DAS40278-9 DAS40278-9 T19 aad-1 Maize DBT418 DKB-89614-9 T3, T7 cry1Ac; pinII; bar Maize DLL25 (B16) DKB-89790-5 T3 bar Maize GA21 MON-00021-9 T1 mepsps Maize GG25 — T1 mepsps Maize GJ11 — T1 mepsps Maize Fl117 — T1 mepsps Maize GAT-ZM1 — T3 pat Maize LY038 REN-00038-3 T20 cordapA Maize MIR162 SYN-IR162-4 T7 vip3Aa20 Maize MIR604 SYN-IR604-5 T7 mcry3A Maize MON801 (MON80100) MON801 T1, T7 cry1Ab; cp4 epsps (aroA:CP4); goxv247 Maize MON802 MON-80200-7 T1, T7 cry1Ab; cp4 epsps (aroA:CP4); goxv247 Maize MON809 PH-MON-809-2 T1, T7 cry1Ab; cp4 epsps (aroA:CP4); goxv247 Maize MON810 MON-00810-6 T1, T7 cry1Ab; cp4 epsps (aroA:CP4); goxv247 Maize MON832 — T1 cp4 epsps (aroA:CP4); goxv247 Maize MON863 MON-00863-5 T7 cry3Bb1 Maize MON87427 MON-87427-7 T1 cp4 epsps (aroA:CP4) Maize MON87460 MON-87460-4 T21 cspB Maize MON88017 MON-88017-3 T1, T7 cry3Bb1; cp4 epsps (aroA:CP4) Maize MON89034 MON-89034-3 T7 cry2Ab2; cry1A.105 Maize MS3 ACS-ZM001-9 T3, T18 bar; barnase Maize MS6 ACS-ZM005-4 T3, T18 bar; barnase Maize NK603 MON-00603-6 T1 cp4 epsps (aroA:CP4) Maize T14 ACS-ZM002-1 T3 pat (syn) Maize T25 ACS-ZM003-2 T3 pat (syn) Maize TC1507 DAS-01507-1 T3, T7 cry1Fa2; pat Maize TC6275 DAS-06275-8 T3, T7 mocry1F; bar Maize VIP1034 — T3, T7 vip3A; pat Maize 43A47 DP-043A47-3 T3, T7 cry1F; cry34Ab1; cry35Ab1; pat Maize 40416 DP-040416-8 T3, T7 cry1F; cry34Ab1; cry35Ab1; pat Maize 32316 DP-032316-8 T3, T7 cry1F; cry34Ab1; cry35Ab1; pat Maize 4114 DP-004114-3 T3, T7 cry1F; cry34Ab1; cry35Ab1; pat Melon Melon A — T22 sam-k Melon Melon B — T22 sam-k Papaya 55-1 CUH-CP551-8 T6 prsv cp Papaya 63-1 CUH-CP631-7 T6 prsv cp Papaya Huanong No. 1 — T6 prsv rep Papaya X17-2 UFL-X17CP-6 T6 prsv cp Plum C-5 ARS-PLMC5-6 T6 ppv cp Canola** ZSR500 — T1 cp4 epsps (aroA:CP4); goxv247 Canola** ZSR502 — T1 cp4 epsps (aroA:CP4); goxv247 Canola** ZSR503 — T1 cp4 epsps (aroA:CP4); goxv247 Rice 7Crp#242-95-7 — T13 7crp Rice 7Crp#10 — T13 7crp Rice GM Shanyou 63 — T7 cry1Ab; cry1Ac Rice Huahui-1/TT51-1 — T7 cry1Ab; cry1Ac Rice LLRICE06 ACS-OS001-4 T3 bar Rice LLRICE601 BCS-OS003-7 T3 bar Rice LLRICE62 ACS-OS002-5 T3 bar Rice Tarom molaii + cry1Ab — T7 cry1Ab (truncated) Rice GAT-OS2 — T3 bar Rice GAT-OS3 — T3 bar Rice PE-7 — T7 Cry1Ac Rice 7Crp#10 — T13 7crp Rice KPD627-8 — T27 OASA1D Rice KPD722-4 — T27 OASA1D Rice KA317 — T27 OASA1D Rice HW5 — T27 OASA1D Rice HW1 — T27 OASA1D Rice B-4-1-18 — T28 Δ OsBRI1 Rice G-3-3-22 — T29 OSGA2ox1 Rice AD77 — T6 DEF Rice AD51 — T6 DEF Rice AD48 — T6 DEF Rice AD41 — T6 DEF Rice 13pNasNa800725atAprt1 — T30 HvNAS1; HvNAAT-A; APRT Rice 13pAprt1 — T30 APRT Rice gHvNAS1-gHvNAAT-1 — T30 HvNAS1; HvNAAT-A; HvNAAT-B Rice gHvIDS3-1 — T30 HvIDS3 Rice gHvNAAT1 — T30 HvNAAT-A; HvNAAT-B Rice gHvNAS1-1 — T30 HvNAS1 Rice NIA-OS006-4 — T6 WRKY45 Rice NIA-OS005-3 — T6 WRKY45 Rice NIA-OS004-2 — T6 WRKY45 Rice NIA-OS003-1 — T6 WRKY45 Rice NIA-OS002-9 — T6 WRKY45 Rice NIA-OS001-8 — T6 WRKY45 Rice OsCr11 — T13 Modified Cry j Rice 17053 — T1 cp4 epsps (aroA:CP4) Rice 17314 — T1 cp4 epsps (aroA:CP4) Rose WKS82/130-4-1 IFD-52401-4 T9 5AT; bp40 (f3′5′h) Rose WKS92/130-9-1 IFD-52901-9 T9 5AT; bp40 (f3′5′h) Soybean 260-05 (G94-1, G94-19, — T9 gm-fad2-1 (silencing locus) G168) Soybean A2704-12 ACS-GM005-3 T3 pat Soybean A2704-21 ACS-GM004-2 T3 pat Soybean A5547-127 ACS-GM006-4 T3 pat Soybean A5547-35 ACS-GM008-6 T3 pat Soybean CV127 BPS-CV127-9 T16 csr1-2 Soybean DAS68416-4 DAS68416-4 T3 pat Soybean DP305423 DP-305423-1 T11, T31 gm-fad2-1 (silencing locus); gm-hra Soybean DP356043 DP-356043-5 T1, T31 gm-fad2-1 (silencing locus); gat4601 Soybean FG72 MST-FG072-3 T32, T1 2mepsps; hppdPF W336 Soybean GTS 40-3-2 (40-3-2) MON-04032-6 T1 cp4 epsps (aroA:CP4) Soybean GU262 ACS-GM003-1 T3 pat Soybean MON87701 MON-87701-2 T7 cry1Ac Soybean MON87705 MON-87705-6 T1, T31 fatb1-A (sense & antisense); fad2- 1A (sense & antisense); cp4 epsps (aroA:CP4) Soybean MON87708 MON-87708-9 T1, T12 dmo; cp4 epsps (aroA:CP4) Soybean MON87769 MON-87769-7 T1, T31 Pj.D6D; Nc.Fad3; cp4 epsps (aroA:CP4) Soybean MON89788 MON-89788-1 T1 cp4 epsps (aroA:CP4) Soybean W62 ACS-GM002-9 T3 bar Soybean W98 ACS-GM001-8 T3 bar Soybean MON87754 MON-87754-1 T33 dgat2A Soybean DAS21606 DAS-21606 T34, T3 Modified aad-12; pat Soybean DAS44406 DAS-44406-6 T1, T3, T34 Modified aad-12; 2mepsps; pat Soybean SYHT04R SYN-0004R-8 T35 Modified avhppd Soybean 9582.814.19.1 — T3, T7 cry1Ac, cry1F, PAT Squash CZW3 SEM-ØCZW3-2 T6 cmv cp, zymv cp, wmv cp Squash ZW20 SEM-0ZW20-7 T6 zymv cp, wmv cp Sugar Beet GTSB77 (T9100152) SY-GTSB77-8 T1 cp4 epsps (aroA:CP4); goxv247 Sugar Beet H7-1 KM-000H71-4 T1 cp4 epsps (aroA:CP4) Sugar Beet T120-7 ACS-BV001-3 T3 pat Sugar Beet T227-1 — T1 cp4 epsps (aroA:CP4) Sugarcane NXI-1T — T21 EcbetA Sunflower X81359 — T16 als Pepper PK-SP01 — T6 cmv cp Tobacco C/F/93/08-02 — T5 bxn Tobacco Vector 21-41 — T36 NtQPT1 (antisense) Sunflower X81359 — T16 als Wheat MON71800 MON-718ØØ-3 T1 cp4 epsps (aroA:CP4) *Argentine (Brassica napus), **Polish (B. rapa), # Eggplant

Although most typically, compounds of the invention are used to control undesired vegetation, contact of desired vegetation in the treated locus with compounds of the invention may result in super-additive or synergistic effects with genetic traits in the desired vegetation, including traits incorporated through genetic modification. For example, resistance to phytophagous insect pests or plant diseases, tolerance to biotic/abiotic stresses or storage stability may be greater than expected from the genetic traits in the desired vegetation.

Compounds of this invention can also be mixed with one or more other biologically active compounds or agents including herbicides, herbicide safeners, fungicides, insecticides, nematocides, bactericides, acaricides, growth regulators such as insect molting inhibitors and rooting stimulants, chemosterilants, semiochemicals, repellents, attractants, pheromones, feeding stimulants, plant nutrients, other biologically active compounds or entomopathogenic bacteria, virus or fungi to form a multi-component pesticide giving an even broader spectrum of agricultural protection. Mixtures of the compounds of the invention with other herbicides can broaden the spectrum of activity against additional weed species, and suppress the proliferation of any resistant biotypes. Thus the present invention also pertains to a composition comprising a compound of Formula 1 (in a herbicidally effective amount) and at least one additional biologically active compound or agent (in a biologically effective amount) and can further comprise at least one of a surfactant, a solid diluent or a liquid diluent. The other biologically active compounds or agents can be formulated in compositions comprising at least one of a surfactant, solid or liquid diluent. For mixtures of the present invention, one or more other biologically active compounds or agents can be formulated together with a compound of Formula 1, to form a premix, or one or more other biologically active compounds or agents can be formulated separately from the compound of Formula 1, and the formulations combined together before application (e.g., in a spray tank) or, alternatively, applied in succession.

A mixture of one or more of the following herbicides with a compound of this invention may be particularly useful for weed control: acetochlor, acifluorfen and its sodium salt, aclonifen, acrolein (2-propenal), alachlor, alloxydim, ametryn, amicarbazone, amidosulfuron, aminocyclopyrachlor and its esters (e.g., methyl, ethyl) and salts (e.g., sodium, potassium), aminopyralid, amitrole, ammonium sulfamate, anilofos, asulam, atrazine, azimsulfuron, beflubutamid, benazolin, benazolin-ethyl, bencarbazone, benfluralin, benfuresate, bensulfuron-methyl, bensulide, bentazone, benzobicyclon, benzofenap, bicyclopyrone, bifenox, bilanafos, bispyribac and its sodium salt, bromacil, bromobutide, bromofenoxim, bromoxynil, bromoxynil octanoate, butachlor, butafenacil, butamifos, butralin, butroxydim, butylate, cafenstrole, carbetamide, carfentrazone-ethyl, catechin, chlomethoxyfen, chloramben, chlorbromuron, chlorflurenol-methyl, chloridazon, chlorimuron-ethyl, chlorotoluron, chlorpropham, chlorsulfuron, chlorthal-dimethyl, chlorthiamid, cinidon-ethyl, cinmethylin, cinosulfuron, clacyfos, clefoxydim, clethodim, clodinafop-propargyl, clomazone, clomeprop, clopyralid, clopyralid-olamine, cloransulam-methyl, cumyluron, cyanazine, cycloate, cyclopyrimorate, cyclosulfamuron, cycloxydim, cyhalofop-butyl, 2,4-D and its butotyl, butyl, isoctyl and isopropyl esters and its dimethylammonium, diolamine and trolamine salts, daimuron, dalapon, dalapon-sodium, dazomet, 2,4-DB and its dimethylammonium, potassium and sodium salts, desmedipham, desmetryn, dicamba and its diglycolammonium, dimethylammonium, potassium and sodium salts, dichlobenil, dichlorprop, diclofop-methyl, diclosulam, difenzoquat metilsulfate, diflufenican, diflufenzopyr, dimefuron, dimepiperate, dimethachlor, dimethametryn, dimethenamid, dimethenamid-P, dimethipin, dimethylarsinic acid and its sodium salt, dinitramine, dinoterb, diphenamid, diquat dibromide, dithiopyr, diuron, DNOC, endothal, EPTC, esprocarb, ethalfluralin, ethametsulfuron-methyl, ethiozin, ethofumesate, ethoxyfen, ethoxysulfuron, etobenzanid, fenoxaprop-ethyl, fenoxaprop-P-ethyl, fenoxasulfone, fenquinotrione, fentrazamide, fenuron, fenuron-TCA, flamprop-methyl, flamprop-M-i sopropyl, flamprop-M-methyl, flazasulfuron, florasulam, fluazifop-butyl, fluazifop-P-butyl, fluazolate, flucarbazone, flucetosulfuron, fluchloralin, flufenacet, flufenpyr, flufenpyr-ethyl, flumetsulam, flumiclorac-pentyl, flumioxazin, fluometuron, fluoroglycofen-ethyl, flupoxam, flupyrsulfuron-methyl and its sodium salt, flurenol, flurenol-butyl, fluridone, flurochloridone, fluroxypyr, flurtamone, fluthiacet-methyl, fomesafen, foramsulfuron, fosamine-ammonium, glufosinate, glufosinate-ammonium, glufosinate-P, glyphosate and its salts such as ammonium, isopropylammonium, potassium, sodium (including sesquisodium) and trimesium (alternatively named sulfosate), halauxifen, halauxifen-methyl, halosulfuron-methyl, haloxyfop-etotyl, haloxyfop-methyl, hexazinone, imazamethabenz-methyl, imazamox, imazapic, imazapyr, imazaquin, imazaquin-ammonium, imazethapyr, imazethapyr-ammonium, imazosulfuron, indanofan, indaziflam, iofensulfuron, iodosulfuron-methyl, ioxynil, ioxynil octanoate, ioxynil-sodium, ipfencarbazone, isoproturon, isouron, isoxaben, isoxaflutole, isoxachlortole, lactofen, lenacil, linuron, maleic hydrazide, MCPA and its salts (e.g., MCPA-dimethylammonium, MCPA-potassium and MCPA-sodium, esters (e.g., MCPA-2-ethylhexyl, MCPA-butotyl) and thioesters (e.g., MCPA-thioethyl), MCPB and its salts (e.g., MCPB-sodium) and esters (e.g., MCPB-ethyl), mecoprop, mecoprop-P, mefenacet, mefluidide, mesosulfuron-methyl, mesotrione, metam-sodium, metamifop, metamitron, metazachlor, metazosulfuron, methabenzthiazuron, methylarsonic acid and its calcium, monoammonium, monosodium and disodium salts, methyldymron, metobenzuron, metobromuron, metolachlor, S-metolachlor, metosulam, metoxuron, metribuzin, metsulfuron-methyl, molinate, monolinuron, naproanilide, napropamide, napropamide-M, naptalam, neburon, nicosulfuron, norflurazon, orbencarb, orthosulfamuron, oryzalin, oxadiargyl, oxadiazon, oxasulfuron, oxaziclomefone, oxyfluorfen, paraquat dichloride, pebulate, pelargonic acid, pendimethalin, penoxsulam, pentanochlor, pentoxazone, perfluidone, pethoxamid, pethoxyamid, phenmedipham, picloram, picloram-potassium, picolinafen, pinoxaden, piperophos, pretilachlor, primisulfuron-methyl, prodiamine, profoxydim, prometon, prometryn, propachlor, propanil, propaquizafop, propazine, propham, propisochlor, propoxycarbazone, propyrisulfuron, propyzamide, prosulfocarb, prosulfuron, pyraclonil, pyraflufen-ethyl, pyrasulfotole, pyrazogyl, pyrazolynate, pyrazoxyfen, pyrazosulfuron-ethyl, pyribenzoxim, pyributicarb, pyridate, pyriftalid, pyriminobac-methyl, pyrimisulfan, pyrithiobac, pyrithiobac-sodium, pyroxasulfone, pyroxsulam, quinclorac, quinmerac, quinoclamine, quizalofop-ethyl, quizalofop-P-ethyl, quizalofop-P-tefuryl, rimsulfuron, saflufenacil, sethoxydim, siduron, simazine, simetryn, sulcotrione, sulfentrazone, sulfometuron-methyl, sulfosulfuron, 2,3,6-TBA, TCA, TCA-sodium, tebutam, tebuthiuron, tefuryltrione, tembotrione, tepraloxydim, terbacil, terbumeton, terbuthylazine, terbutryn, thenylchlor, thiazopyr, thiencarbazone, thifensulfuron-methyl, thiobencarb, tiafenacil, tiocarbazil, topramezone, tralkoxydim, tri-allate, triafamone, triasulfuron, triaziflam, tribenuron-methyl, triclopyr, triclopyr-butotyl, triclopyr-triethylammonium, tridiphane, trietazine, trifloxysulfuron, trifluralin, triflusulfuron-methyl, tritosulfuron, vernolate, 3-(2-chloro-3,6-difluorophenyl)-4-hydroxy-1-methyl-1,5-naphthyridin-2(1H)-one, 5-chloro-3-[(2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl]-1-(4-methoxyphenyl)-2(1H)-quinoxalinone, 2-chloro-N-(1-methyl-1H-tetrazol-5-yl)-6-(trifluoromethyl)-3-pyridinecarboxamide, 7-(3,5-dichloro-4-pyridinyl)-5-(2,2-difluoroethyl)-8-hydroxypyrido[2,3-b]pyrazin-6(5H)-one), 4-(2,6-diethyl-4-methylphenyl)-5-hydroxy-2,6-dimethyl-3 (2H)-pyridazinone), 5-[[(2, 6-difluorophenyl)methoxy]methyl]-4,5-dihydro-5-methyl-3-(3-methyl-2-thienyl)isoxazole (previously methioxolin), 3-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propyn-1-yl)-2H-1,4-benzoxazin-6-yl]dihydro-1,5-dimethyl-6-thioxo-1,3,5-triazine-2,4(1H,3H)-dione, 4-(4-fluorophenyl)-6-[(2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl]-2-methyl-1,2,4-triazine-3,5(2H,4H)-dione, methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-2-pyridinecarboxylate, 2-methyl-3-(methylsulfonyl)-N-(1-methyl-1H-tetrazol-5-yl)-4-(trifluoromethyl)benzamide and 2-methyl-N-(4-methyl-1,2,5-oxadiazol-3-yl)-3-(methylsulfinyl)-4-(trifluoromethyl)benzamide. Other herbicides also include bioherbicides such as Alternaria destruens Simmons, Colletotrichum gloeosporiodes (Penz.) Penz. & Sacc., Drechsiera monoceras (MTB-951), Myrothecium verrucaria (Albertini & Schweinitz) Ditmar: Fries, Phytophthora palmivora (Butl.) Butl. and Puccinia thlaspeos Schub.

Compounds of this invention can also be used in combination with plant growth regulators such as aviglycine, N-(phenylmethyl)-1H-purin-6-amine, epocholeone, gibberellic acid, gibberellin A₄ and A₇, harpin protein, mepiquat chloride, prohexadione calcium, prohydrojasmon, sodium nitrophenolate and trinexapac-methyl, and plant growth modifying organisms such as Bacillus cereus strain BP01.

General references for agricultural protectants (i.e. herbicides, herbicide safeners, insecticides, fungicides, nematocides, acaricides and biological agents) include The Pesticide Manual, 13th Edition, C. D. S. Tomlin, Ed., British Crop Protection Council, Farnham, Surrey, U. K., 2003 and The BioPesticide Manual, 2nd Edition, L. G. Copping, Ed., British Crop Protection Council, Farnham, Surrey, U. K., 2001.

For embodiments where one or more of these various mixing partners are used, the weight ratio of these various mixing partners (in total) to the compound of Formula 1 is typically between about 1:3000 and about 3000:1. Of note are weight ratios between about 1:300 and about 300:1 (for example ratios between about 1:30 and about 30:1). One skilled in the art can easily determine through simple experimentation the biologically effective amounts of active ingredients necessary for the desired spectrum of biological activity. It will be evident that including these additional components may expand the spectrum of weeds controlled beyond the spectrum controlled by the compound of Formula 1 alone.

In certain instances, combinations of a compound of this invention with other biologically active (particularly herbicidal) compounds or agents (i.e. active ingredients) can result in a greater-than-additive (i.e. synergistic) effect on weeds and/or a less-than-additive effect (i.e. safening) on crops or other desirable plants. Reducing the quantity of active ingredients released in the environment while ensuring effective pest control is always desirable. Ability to use greater amounts of active ingredients to provide more effective weed control without excessive crop injury is also desirable. When synergism of herbicidal active ingredients occurs on weeds at application rates giving agronomically satisfactory levels of weed control, such combinations can be advantageous for reducing crop production cost and decreasing environmental load. When safening of herbicidal active ingredients occurs on crops, such combinations can be advantageous for increasing crop protection by reducing weed competition.

Of note is a combination of a compound of the invention with at least one other herbicidal active ingredient. Of particular note is such a combination where the other herbicidal active ingredient has different site of action from the compound of the invention. In certain instances, a combination with at least one other herbicidal active ingredient having a similar spectrum of control but a different site of action will be particularly advantageous for resistance management. Thus, a composition of the present invention can further comprise (in a herbicidally effective amount) at least one additional herbicidal active ingredient having a similar spectrum of control but a different site of action.

Compounds of this invention can also be used in combination with herbicide safeners such as allidochlor, benoxacor, cloquintocet-mexyl, cumyluron, cyometrinil, cyprosulfonamide, daimuron, dichlormid, dicyclonon, dietholate, dimepiperate, fenchlorazole-ethyl, fenclorim, flurazole, fluxofenim, furilazole, isoxadifen-ethyl, mefenpyr-diethyl, mephenate, methoxyphenone naphthalic anhydride (1,8-naphthalic anhydride), oxabetrinil, N-(aminocarbonyl)-2-methylbenzenesulfonamide, N-(aminocarbonyl)-2-fluorobenzenesulfonamide, 1-bromo-4-[(chloromethyl)sulfonyl]benzene (BCS), 4-(dichloroacetyl)-1-oxa-4-azospiro[4.5]decane (MON 4660), 2-(dichloromethyl)-2-methyl-1,3-dioxolane (MG 191), ethyl 1, 6-dihydro-1-(2-methoxyphenyl)-6-oxo-2-phenyl-5-pyrimidinecarboxylate, 2-hydroxy-N,N-dimethyl-6-(trifluoromethyl)pyridine-3-carboxamide, and 3-oxo-1-cyclohexen-1-yl 1-(3,4-dimethylphenyl)-1,6-dihydro-6-oxo-2-phenyl-5-pyrimidinecarboxylate to increase safety to certain crops. Antidotally effective amounts of the herbicide safeners can be applied at the same time as the compounds of this invention, or applied as seed treatments. Therefore an aspect of the present invention relates to a herbicidal mixture comprising a compound of this invention and an antidotally effective amount of a herbicide safener. Seed treatment is particularly useful for selective weed control, because it physically restricts antidoting to the crop plants. Therefore a particularly useful embodiment of the present invention is a method for selectively controlling the growth of undesired vegetation in a crop comprising contacting the locus of the crop with a herbicidally effective amount of a compound of this invention wherein seed from which the crop is grown is treated with an antidotally effective amount of safener. Antidotally effective amounts of safeners can be easily determined by one skilled in the art through simple experimentation.

Of note is a composition comprising a compound of the invention (in a herbicidally effective amount), at least one additional active ingredient selected from the group consisting of other herbicides and herbicide safeners (in an effective amount), and at least one component selected from the group consisting of surfactants, solid diluents and liquid diluents.

Table A1 lists specific combinations of a Component (a) with Component (b) illustrative of the mixtures, compositions and methods of the present invention. Compound No. (Compound Number) (i.e. Compound 1) in the Component (a) column is identified in Index Table A. The second column of Table A1 lists the specific Component (b) compound (e.g., “2,4-D” in the first line). The third, fourth and fifth columns of Table A1 lists ranges of weight ratios for rates at which the Component (a) compound is typically applied to a field-grown crop relative to Component (b) (i.e. (a):(b)). Thus, for example, the first line of Table A1 specifically discloses the combination of Component (a) (i.e. Compound 1 in Index Table A) with 2,4-D is typically applied in a weight ratio between 1:192-6:1. The remaining lines of Table A1 are to be construed similarly.

TABLE A1 Component (a) Typical More Typical Most Typical (Compound No.) Component (b) Weight Ratio Weight Ratio Weight Ratio 1 2,4-D 1:192-6:1  1:64-2:1  1:24-1:3  1 Acetochlor 1:768-2:1  1:256-1:2  1:96-1:11 1 Acifluorfen 1:96-12:1 1:32-4:1  1:12-1:2  1 Aclonifen 1:857-2:1  1:285-1:3  1:107-1:12  1 Alachlor 1:768-2:1  1:256-1:2  1:96-1:11 1 Ametryn 1:384-3:1  1:128-1:1  1:48-1:6  1 Amicarbazone 1:192-6:1  1:64-2:1  1:24-1:3  1 Amidosulfuron  1:6-168:1  1:2-56:1  1:1-11:1 1 Aminocyclopyrachlor 1:48-24:1 1:16-8:1  1:6-2:1 1 Aminopyralid 1:20-56:1  1:6-19:1 1:2-4:1 1 Amitrole 1:768-2:1  1:256-1:2  1:96-1:11 1 Anilofos 1:96-12:1 1:32-4:1  1:12-1:2  1 Asulam 1:960-2:1  1:320-1:3  1:120-1:14  1 Atrazine 1:192-6:1  1:64-2:1  1:24-1:3  1 Azimsulfuron  1:6-168:1  1:2-56:1  1:1-11:1 1 Beflubutamid 1:342-4:1  1:114-2:1  1:42-1:5  1 Benfuresate 1:617-2:1  1:205-1:2  1:77-1:9  1 Bensulfuron-methyl 1:25-45:1  1:8-15:1 1:3-3:1 1 Bentazone 1:192-6:1  1:64-2:1  1:24-1:3  1 Benzobicyclon 1:85-14:1 1:28-5:1  1:10-1:2  1 Benzofenap 1:257-5:1  1:85-2:1  1:32-1:4  1 Bicyclopyrone 1:42-27:1 1:14-9:1  1:5-2:1 1 Bifenox 1:257-5:1  1:85-2:1  1:32-1:4  1 Bispyribac-sodium  1:10-112:1  1:3-38:1 1:1-7:1 1 Bromacil 1:384-3:1  1:128-1:1  1:48-1:6  1 Bromobutide 1:384-3:1  1:128-1:1  1:48-1:6  1 Bromoxynil 1:96-12:1 1:32-4:1  1:12-1:2  1 Butachlor 1:768-2:1  1:256-1:2  1:96-1:11 1 Butafenacil 1:42-27:1 1:14-9:1  1:5-2:1 1 Butylate 1:1542-1:2   1:514-1:5  1:192-1:22  1 Carfenstrole 1:192-6:1  1:64-2:1  1:24-1:3  1 Carfentrazone-ethyl 1:128-9:1  1:42-3:1  1:16-1:2  1 Chlorimuron-ethyl  1:8-135:1  1:2-45:1 1:1-9:1 1 Chlorotoluron 1:768-2:1  1:256-1:2  1:96-1:11 1 Chlorsulfuron  1:6-168:1  1:2-56:1  1:1-11:1 1 Cincosulfuron 1:17-68:1  1:5-23:1 1:2-5:1 1 Cinidon-ethyl 1:384-3:1  1:128-1:1  1:48-1:6  1 Cinmethylin 1:34-34:1 1:11-12:1 1:4-3:1 1 Clacyfos 1:192-6:1  1:64-2:1  1:24-1:3  1 Clethodim 1:48-24:1 1:16-8:1  1:6-2:1 1 Clodinafop-propargyl 1:20-56:1  1:6-19:1 1:2-4:1 1 Clomazone 1:384-3:1  1:128-1:1  1:48-1:6  1 Clomeprop 1:171-7:1  1:57-3:1  1:21-1:3  1 Clopyralid 1:192-6:1  1:64-2:1  1:24-1:3  1 Cloransulam-methyl 1:12-96:1  1:4-32:1 1:1-6:1 1 Cumyluron 1:384-3:1  1:128-1:1  1:48-1:6  1 Cyanazine 1:384-3:1  1:128-1:1  1:48-1:6  1 Cyclopyrimorate 1:17-68:1  1:5-23:1 1:2-5:1 1 Cyclosulfamuron 1:17-68:1  1:5-23:1 1:2-5:1 1 Cycloxydim 1:96-12:1 1:32-4:1  1:12-1:2  1 Cyhalofop 1:25-45:1  1:8-15:1 1:3-3:1 1 Daimuron 1:192-6:1  1:64-2:1  1:24-1:3  1 Desmedipham 1:322-4:1  1:107-2:1  1:40-1:5  1 Dicamba 1:192-6:1  1:64-2:1  1:24-1:3  1 Dichlobenil 1:1371-1:2   1:457-1:4  1:171-1:20  1 Dichlorprop 1:925-2:1  1:308-1:3  1:115-1:13  1 Diclofop-methyl 1:384-3:1  1:128-1:1  1:48-1:6  1 Diclosulam  1:10-112:1  1:3-38:1 1:1-7:1 1 Difenzoquat 1:288-4:1  1:96-2:1  1:36-1:4  1 Diflufenican 1:857-2:1  1:285-1:3  1:107-1:12  1 Diflufenzopyr 1:12-96:1  1:4-32:1 1:1-6:1 1 Dimethachlor 1:768-2:1  1:256-1:2  1:96-1:11 1 Dimethametryn 1:192-6:1  1:64-2:1  1:24-1:3  1 Dimethenamid-P 1:384-3:1  1:128-1:1  1:48-1:6  1 Dithiopyr 1:192-6:1  1:64-2:1  1:24-1:3  1 Diuron 1:384-3:1  1:128-1:1  1:48-1:6  1 EPTC 1:768-2:1  1:256-1:2  1:96-1:11 1 Esprocarb 1:1371-1:2   1:457-1:4  1:171-1:20  1 Ethalfluralin 1:384-3:1  1:128-1:1  1:48-1:6  1 Ethametsulfuron-methyl 1:17-68:1  1:5-23:1 1:2-5:1 1 Ethoxyfen  1:8-135:1  1:2-45:1 1:1-9:1 1 Ethoxysulfuron 1:20-56:1  1:6-19:1 1:2-4:1 1 Etobenzanid 1:257-5:1  1:85-2:1  1:32-1:4  1 Fenoxaprop-ethyl 1:120-10:1  1:40-4:1  1:15-1:2  1 Fenoxasulfone 1:85-14:1 1:28-5:1  1:10-1:2  1 Fenquinotrione 1:42-27:1 1:14-9:1  1:5-2:1 1 Fentrazamide 1:17-68:1  1:5-23:1 1:2-5:1 1 Flazasulfuron 1:17-68:1  1:5-23:1 1:2-5:1 1 Florasulam  1:2-420:1  1:1-140:1  2:1-27:1 1 Fluazifop-butyl 1:192-6:1  1:64-2:1  1:24-1:3  1 Flucarbazone  1:8-135:1  1:2-45:1 1:1-9:1 1 Flucetosulfuron  1:8-135:1  1:2-45:1 1:1-9:1 1 Flufenacet 1:257-5:1  1:85-2:1  1:32-1:4  1 Flumetsulam 1:24-48:1  1:8-16:1 1:3-3:1 1 Flumiclorac-pentyl  1:10-112:1  1:3-38:1 1:1-7:1 1 Flumioxazin 1:25-45:1  1:8-15:1 1:3-3:1 1 Fluometuron 1:384-3:1  1:128-1:1  1:48-1:6  1 Flupyrsulfuron-methyl  1:3-336:1  1:1-112:1  2:1-21:1 1 Fluridone 1:384-3:1  1:128-1:1  1:48-1:6  1 Fluroxypyr 1:96-12:1 1:32-4:1  1:12-1:2  1 Flurtamone 1:857-2:1  1:285-1:3  1:107-1:12  1 Fluthiacet-methyl 1:48-42:1 1:16-14:1 1:3-3:1 1 Fomesafen 1:96-12:1 1:32-4:1  1:12-1:2  1 Foramsulfuron 1:13-84:1  1:4-28:1 1:1-6:1 1 Glufosinate 1:288-4:1  1:96-2:1  1:36-1:4  1 Glyphosate 1:288-4:1  1:96-2:1  1:36-1:4  1 Halosulfuron-methyl 1:17-68:1  1:5-23:1 1:2-5:1 1 Halauxifen 1:20-56:1  1:6-19:1 1:2-4:1 1 Halauxifen-methyl 1:20-56:1  1:6-19:1 1:2-4:1 1 Haloxyfop-methyl 1:34-34:1 1:11-12:1 1:4-3:1 1 Hexazinone 1:192-6:1  1:64-2:1  1:24-1:3  1 Imazamox 1:13-84:1  1:4-28:1 1:1-6:1 1 Imazapic 1:20-56:1  1:6-19:1 1:2-4:1 1 Imazapyr 1:85-14:1 1:28-5:1  1:10-1:2  1 Imazaquin 1:34-34:1 1:11-12:1 1:4-3:1 1 Imazethabenz-methyl 1:171-7:1  1:57-3:1  1:21-1:3  1 Imazethapyr 1:24-48:1  1:8-16:1 1:3-3:1 1 Imazosulfuron 1:27-42:1  1:9-14:1 1:3-3:1 1 Indanofan 1:342-4:1  1:114-2:1  1:42-1:5  1 Indaziflam 1:25-45:1  1:8-15:1 1:3-3:1 1 Iodosulfuron-methyl  1:3-336:1  1:1-112:1  2:1-21:1 1 Ioxynil 1:192-6:1  1:64-2:1  1:24-1:3  1 Ipfencarbazone 1:85-14:1 1:28-5:1  1:10-1:2  1 Isoproturon 1:384-3:1  1:128-1:1  1:48-1:6  1 Isoxaben 1:288-4:1  1:96-2:1  1:36-1:4  1 Isoxaflutole 1:60-20:1 1:20-7:1  1:7-2:1 1 Lactofen 1:42-27:1 1:14-9:1  1:5-2:1 1 Lenacil 1:384-3:1  1:128-1:1  1:48-1:6  1 Linuron 1:384-3:1  1:128-1:1  1:48-1:6  1 MCPA 1:192-6:1  1:64-2:1  1:24-1:3  1 MCPB 1:288-4:1  1:96-2:1  1:36-1:4  1 Mecoprop 1:768-2:1  1:256-1:2  1:96-1:11 1 Mefenacet 1:384-3:1  1:128-1:1  1:48-1:6  1 Mefluidide 1:192-6:1  1:64-2:1  1:24-1:3  1 Mesosulfuron-methyl  1:5-224:1  1:1-75:1  1:1-14:1 1 Mesotrione 1:42-27:1 1:14-9:1  1:5-2:1 1 Metamifop 1:42-27:1 1:14-9:1  1:5-2:1 1 Metazachlor 1:384-3:1  1:128-1:1  1:48-1:6  1 Metazosulfuron 1:25-45:1  1:8-15:1 1:3-3:1 1 Methabenzthiazuron 1:768-2:1  1:256-1:2  1:96-1:11 1 Metolachlor 1:768-2:1  1:256-1:2  1:96-1:11 1 Metosulam  1:8-135:1  1:2-45:1 1:1-9:1 1 Metribuzin 1:192-6:1  1:64-2:1  1:24-1:3  1 Metsulfuron-methyl  1:2-560:1  1:1-187:1  3:1-35:1 1 Molinate 1:1028-2:1   1:342-1:3  1:128-1:15  1 Napropamide 1:384-3:1  1:128-1:1  1:48-1:6  1 Napropamide-M 1:192-6:1  1:64-2:1  1:24-1:3  1 Naptalam 1:192-6:1  1:64-2:1  1:24-1:3  1 Nicosulfuron 1:12-96:1  1:4-32:1 1:1-6:1 1 Norflurazon 1:1152-1:1   1:384-1:3  1:144-1:16  1 Orbencarb 1:1371-1:2   1:457-1:4  1:171-1:20  1 Orthosulfamuron 1:20-56:1  1:6-19:1 1:2-4:1 1 Oryzalin 1:514-3:1  1:171-1:2  1:64-1:8  1 Oxadiargyl 1:384-3:1  1:128-1:1  1:48-1:6  1 Oxadiazon 1:548-3:1  1:182-1:2  1:68-1:8  1 Oxasulfuron 1:27-42:1  1:9-14:1 1:3-3:1 1 Oxaziclomefone 1:42-27:1 1:14-9:1  1:5-2:1 1 Oxyfluorfen 1:384-3:1  1:128-1:1  1:48-1:6  1 Paraquat 1:192-6:1  1:64-2:1  1:24-1:3  1 Pendimethalin 1:384-3:1  1:128-1:1  1:48-1:6  1 Penoxsulam  1:10-112:1  1:3-38:1 1:1-7:1 1 Penthoxamid 1:384-3:1  1:128-1:1  1:48-1:6  1 Pentoxazone 1:102-12:1  1:34-4:1  1:12-1:2  1 Phenmedipham 1:102-12:1  1:34-4:1  1:12-1:2  1 Picloram 1:96-12:1 1:32-4:1  1:12-1:2  1 Picolinafen 1:34-34:1 1:11-12:1 1:4-3:1 1 Pinoxaden 1:25-45:1  1:8-15:1 1:3-3:1 1 Pretilachlor 1:192-6:1  1:64-2:1  1:24-1:3  1 Primisulfuron-methyl  1:8-135:1  1:2-45:1 1:1-9:1 1 Prodiamine 1:384-3:1  1:128-1:1  1:48-1:6  1 Profoxydim 1:42-27:1 1:14-9:1  1:5-2:1 1 Prometryn 1:384-3:1  1:128-1:1  1:48-1:6  1 Propachlor 1:1152-1:1   1:384-1:3  1:144-1:16  1 Propanil 1:384-3:1  1:128-1:1  1:48-1:6  1 Propaquizafop 1:48-24:1 1:16-8:1  1:6-2:1 1 Propoxycarbazone 1:17-68:1  1:5-23:1 1:2-5:1 1 Propyrisulfuron 1:17-68:1  1:5-23:1 1:2-5:1 1 Propyzamide 1:384-3:1  1:128-1:1  1:48-1:6  1 Prosulfocarb 1:1200-1:2   1:400-1:4  1:150-1:17  1 Prosulfuron  1:6-168:1  1:2-56:1  1:1-11:1 1 Pyraclonil 1:42-27:1 1:14-9:1  1:5-2:1 1 Pyraflufen-ethyl  1:5-224:1  1:1-75:1  1:1-14:1 1 Pyrasulfotole 1:13-84:1  1:4-28:1 1:1-6:1 1 Pyrazolynate 1:857-2:1  1:285-1:3  1:107-1:12  1 Pyrazosulfuron-ethyl  1:10-112:1  1:3-38:1 1:1-7:1 1 Pyrazoxyfen  1:5-224:1  1:1-75:1  1:1-14:1 1 Pyribenzoxim  1:10-112:1  1:3-38:1 1:1-7:1 1 Pyributicarb 1:384-3:1  1:128-1:1  1:48-1:6  1 Pyridate 1:288-4:1  1:96-2:1  1:36-1:4  1 Pyriftalid  1:10-112:1  1:3-38:1 1:1-7:1 1 Pyriminobac-methyl 1:20-56:1  1:6-19:1 1:2-4:1 1 Pyrimisulfan 1:17-68:1  1:5-23:1 1:2-5:1 1 Pyrithiobac 1:24-48:1  1:8-16:1 1:3-3:1 1 Pyroxasulfone 1:85-14:1 1:28-5:1  1:10-1:2  1 Pyroxsulam  1:5-224:1  1:1-75:1  1:1-14:1 1 Quinclorac 1:192-6:1  1:64-2:1  1:24-1:3  1 Quizalofop-ethyl 1:42-27:1 1:14-9:1  1:5-2:1 1 Rimsulfuron 1:13-84:1  1:4-28:1 1:1-6:1 1 Saflufenacil 1:25-45:1  1:8-15:1 1:3-3:1 1 Sethoxydim 1:96-12:1 1:32-4:1  1:12-1:2  1 Simazine 1:384-3:1  1:128-1:1  1:48-1:6  1 Sulcotrione 1:120-10:1  1:40-4:1  1:15-1:2  1 Sulfentrazone 1:147-8:1  1:49-3:1  1:18-1:3  1 Sulfometuron-methyl 1:34-34:1 1:11-12:1 1:4-3:1 1 Sulfosulfuron  1:8-135:1  1:2-45:1 1:1-9:1 1 Tebuthiuron 1:384-3:1  1:128-1:1  1:48-1:6  1 Tefuryltrione 1:42-27:1 1:14-9:1  1:5-2:1 1 Tembotrione 1:31-37:1 1:10-13:1 1:3-3:1 1 Tepraloxydim 1:25-45:1  1:8-15:1 1:3-3:1 1 Terbacil 1:288-4:1  1:96-2:1  1:36-1:4  1 Terbuthylazine 1:857-2:1  1:285-1:3  1:107-1:12  1 Terbutryn 1:192-6:1  1:64-2:1  1:24-1:3  1 Thenylchlor 1:85-14:1 1:28-5:1  1:10-1:2  1 Thiazopyr 1:384-3:1  1:128-1:1  1:48-1:6  1 Thiencarbazone  1:3-336:1  1:1-112:1  2:1-21:1 1 Thifensulfuron-methyl  1:5-224:1  1:1-75:1  1:1-14:1 1 Tiafenacil 1:42-27:1 1:14-9:1  1:5-2:1 1 Thiobencarb 1:768-2:1  1:256-1:2  1:96-1:11 1 Topramzone  1:6-168:1  1:2-56:1  1:1-11:1 1 Tralkoxydim 1:68-17:1 1:22-6:1  1:8-2:1 1 Triallate 1:768-2:1  1:256-1:2  1:96-1:11 1 Triasulfuron  1:5-224:1  1:1-75:1  1:1-14:1 1 Triaziflam 1:171-7:1  1:57-3:1  1:21-1:3  1 Tribenuron-methyl  1:3-336:1  1:1-112:1  2:1-21:1 1 Triclopyr 1:192-6:1  1:64-2:1  1:24-1:3  1 Trifloxysulfuron  1:2-420:1  1:1-140:1  2:1-27:1 1 Trifluralin 1:288-4:1  1:96-2:1  1:36-1:4  1 Triflusulfuron-methyl 1:17-68:1  1:5-23:1 1:2-5:1 1 Tritosulfuron 1:13-84:1  1:4-28:1 1:1-6:1

Table A2 is constructed the same as Table A1 above except that entries below the “Component (a)” column heading are replaced with the respective Component (a) Column Entry shown below. Compound No. in the Component (a) column is identified in Index Table A. Thus, for example, in Table A2 the entries below the “Component (a)” column heading all recite “Compound 2” (i.e. Compound 2 identified in Index Table A), and the first line below the column headings in Table A2 specifically discloses a mixture of Compound 2 with 2,4-D. Table A3 is constructed similarly.

Table Number Component (a) Column Entries A2 Compound 2 A3 Compound 3 A4 Compound 4 A5 Compound 5 A6 Compound 6 A7 Compound 7 A8 Compound 8 A9 Compound 9 A10 Compound 10

Preferred for better control of undesired vegetation (e.g., lower use rate such as from synergism, broader spectrum of weeds controlled, or enhanced crop safety) or for preventing the development of resistant weeds are mixtures of a compound of this invention with a herbicide selected from the group consisting of aminocyclopyrachlor, chlorimuron-ethyl, diuron, hexazinone, mesotrione, S-metolachlor, metsulfuron-methyl, nicosulfuron, thifensulfuron-methyl and tribenuron-methyl.

The following Tests demonstrate the control efficacy of the compounds of this invention against specific weeds. The weed control afforded by the compounds is not limited, however, to these species. See Index Table A for compound descriptions. The following abbreviations are used in the Index Table which follow: Ph is phenyl, CF₃ is trifluoromethyl and OCF₃ is trifluoromethoxy. The abbreviation “Ex.” stands for “Example” and is followed by a number indicating in which example the compound is prepared.

INDEX TABLE A

Cmpd. M.S.(AP+) No. (R⁴)_(q) R¹ A or m.p. 1 H (q is 0) Cl 4-Cl-phenyl 72-74 2 H (q is 0) Cl 3-CF₃-phenyl 368 3 H (q is 0) Cl 3-OCF₃-phenyl 384 4 H (q is 0) Cl 5-F-2-pyrimidinyl 90-93 5 H (q is 0) Cl 5-(CF₃)-2-pyrimidinyl 120-123 6 H (q is 0) Cl 5-Cl-2-pyrimidinyl 147-150 7 H (q is 0) Cl 5-(CF₃)-2-pyridinyl 369 8 H (q is 0) Cl 5-Cl-2-pyridinyl 335 9 H (q is 0) Cl 5-F-2-pyridinyl 319 10 H (q is 0) Cl 4-CF₃-phenyl 84-88

BIOLOGICAL EXAMPLES OF THE INVENTION

Test A

Seeds of plant species selected from barnyardgrass (Echinochloa crus-galli), kochia (Kochia scoparia), ragweed (common ragweed, Ambrosia elatior), Italian ryegrass (Lolium multiflorum), giant foxtail (Setaria faberii), and pigweed (Amaranthus retroflexus) were planted into a blend of loam soil and sand and treated preemergence with a directed soil spray using test chemicals formulated in a non-phytotoxic solvent mixture which included a surfactant.

At the same time, plants selected from these weed species and also wheat (Triticum aestivum), corn (Zea mays), blackgrass (Alopecurus myosuroides), and galium (catchweed bedstraw, Galium aparine) were planted in pots containing the same blend of loam soil and sand and treated with postemergence applications of test chemicals formulated in the same manner. Plants ranged in height from 2 to 10 cm and were in the one- to two-leaf stage for the postemergence treatment. Treated plants and untreated controls were maintained in a greenhouse for approximately 10 days, after which time all treated plants were compared to untreated controls and visually evaluated for injury. Plant response ratings, summarized in Table A, are based on a 0 to 100 scale where 0 is no effect and 100 is complete control. A dash (-) response means no test result.

TABLE A Compound 1000 g ai/ha 3 500 g ai/ha 1 2 Postemergence Barnyardgrass 70 Barnyardgrass 100 0 Blackgrass 40 Blackgrass 90 0 Corn 20 Corn 30 20 Foxtail, Giant 100 Foxtail, Giant 100 60 Galium 100 Galium 100 60 Kochia 90 Kochia 100 90 Pigweed 90 Pigweed 100 80 Ragweed 30 Ragweed 20 0 Ryegrass, Italian 30 Ryegrass, Italian 70 0 Wheat 30 Wheat 40 20 Compounds 125 g ai/ha 1 2 4 5 6 7 8 9 10 Postemergence Barnyardgrass 20 0 0 20 30 50 30 10 90 Blackgrass 20 0 20 50 50 30 20 10 50 Corn 30 0 10 10 20 20 20 10 30 Foxtail, Giant 70 0 0 80 60 50 70 20 90 Galium 50 20 50 90 90 90 70 60 80 Kochia 90 30 80 60 90 90 90 90 90 Pigweed 100 30 70 90 90 90 90 80 90 Ragweed 20 0 20 80 50 60 70 40 20 Ryegrass, Italian 0 0 0 30 20 20 20 20 60 Wheat 30 0 0 0 0 20 0 0 10 Compounds 31 g ai/ha 4 5 6 7 8 9 10 Postemergence Barnyardgrass 0 0 10 20 10 0 40 Blackgrass 20 30 10 10 10 0 30 Corn 0 0 0 10 10 10 20 Foxtail, Giant 0 10 10 20 20 0 50 Galium 30 50 60 50 60 30 30 Kochia 40 40 80 80 70 70 80 Pigweed 50 70 80 70 80 50 70 Ragweed 10 30 30 30 30 20 10 Ryegrass, Italian 0 0 0 0 10 0 0 Wheat 0 0 0 0 0 0 0 Compound Compounds 1000 g ai/ha 3 500 g ai/ha 1 2 Preemergence Barnyardgrass 80 Barnyardgrass 100 0 Foxtail, Giant 100 Foxtail, Giant 100 90 Kochia 40 Kochia 100 30 Pigweed 70 Pigweed 100 20 Ragweed 20 Ragweed 20 0 Ryegrass, Italian 50 Ryegrass, Italian 20 0 Compounds 125 g ai/ha 1 2 4 5 6 7 8 9 10 Preemergence Barnyardgrass 30 0 0 80 70 70 30 0 90 Foxtail, Giant 90 0 20 100 100 100 80 70 100 Kochia 40 0 70 100 100 70 100 50 60 Pigweed 40 0 70 100 100 100 100 80 100 Ragweed 0 0 0 80 80 70 20 70 10 Ryegrass, Italian 0 0 0 0 10 60 10 0 50 Compounds 31 g ai/ha 4 5 6 7 8 9 10 Preemergence Barnyardgrass 0 0 20 20 0 0 50 Foxtail, Giant 0 70 60 60 40 10 70 Kochia 0 0 60 30 30 20 30 Pigweed 70 90 80 100 70 50 50 Ragweed 0 0 70 10 0 — 0 Ryegrass, Italian 0 0 0 10 0 0 10 Test B

Plant species in the flooded paddy test selected from rice (Oryza sativa), sedge, umbrella (small-flower umbrella sedge, Cyperus difformis), ducksalad (Heteranthera limosa), and barnyardgrass (Echinochloa crus-galli) were grown to the 2-leaf stage for testing. At time of treatment, test pots were flooded to 3 cm above the soil surface, treated by application of test compounds directly to the paddy water, and then maintained at that water depth for the duration of the test. Treated plants and controls were maintained in a greenhouse for 13 to 15 days, after which time all species were compared to controls and visually evaluated. Plant response ratings, summarized in Table B, are based on a scale of 0 to 100 where 0 is no effect and 100 is complete control. A dash (-) response means no test result.

TABLE B Compounds 250 g ai/ha 1 2 3 4 5 6 7 8 9 10 Flood Barnyardgrass 20 0 0 0 0 0 0 0 0 30 Ducksalad 45 0 0 0 85 80 100 75 60 65 Rice 10 0 0 0 0 0 0 0 0 20 Sedge, Umbrella 65 0 0 0 75 85 90 65 40 90 Test C

Seeds of plant species selected from blackgrass (Alopecurus myosuroides), Italian ryegrass (Lolium multiflorum), winter wheat (Triticum aestivum), galium (catchweed bedstraw, Galium aparine), corn (Zea mays), large (Lg) crabgrass (Digitaria sanguinalis), giant foxtail (Setaria faberii), johnsongrass (Sorghum halepense), lambsquarters (Chenopodium album), morningglory (Ipomoea coccinea), yellow nutsedge (Cyperus esculentus), pigweed (Amaranthus retroflexus), ragweed (common ragweed, Ambrosia elatior), soybean (Glycine max), barnyardgrass (Echinochloa crus-galli), oilseed rape (Brassica napus), waterhemp (common waterhemp, Amaranthus rudis), and velvetleaf (Abutilon theophrasti) were planted into a blend of loam soil and sand and treated preemergence with test chemicals formulated in a non-phytotoxic solvent mixture which included a surfactant.

At the same time, plants selected from these crop and weed species and also chickweed (common chickweed, Stellaria media), kochia (Kochia scoparia), and wild oat (Avena fatua), were planted in pots containing Sunshine Redi-Earth® planting medium comprising spaghnum peat moss, vermiculite, starter nutrients and dolomitic limestone and treated with postemergence applications of test chemicals formulated in the same manner. Plants ranged in height from 2 to 18 cm (1- to 4-leaf stage) for postemergence treatments. Treated plants and controls were maintained in a greenhouse for 13 to 15 days, after which time all species were compared to controls and visually evaluated. Plant response ratings, summarized in Table C, are based on a scale of 0 to 100 where 0 is no effect and 100 is complete control. A dash (-) response means no test result.

TABLE C Compounds Compounds 125 g ai/ha 1 6 7 10 62 g ai/ha 1 6 7 10 Postemergence Barnyardgrass 10 10 10 65 Barnyardgrass 10 5 5 25 Blackgrass 5 5 20 25 Blackgrass 5 5 10 30 Chickweed 65 55 55 80 Chickweed 50 60 35 70 Corn 10 20 15 25 Corn 10 10 20 25 Crabgrass, Large 20 20 15 80 Crabgrass, Large 15 5 15 60 Foxtail, Giant 10 10 20 20 Foxtail, Giant 10 5 15 10 Galium 85 80 75 80 Galium 80 60 60 75 Johnsongrass 5 5 10 25 Johnsongrass 5 5 10 10 Kochia 95 85 85 95 Kochia 95 80 70 90 Lambsquarters 55 70 75 90 Lambsquarters 45 65 65 75 Morningglory 60 80 45 75 Morningglory 40 65 40 70 Nutsedge, Yellow 10 5 10 20 Nutsedge, Yellow 5 5 5 15 Oat, Wild 10 0 5 25 Oat, Wild 5 0 5 15 Oilseed Rape 80 10 35 80 Oilseed Rape 70 20 40 80 Pigweed 80 85 80 90 Pigweed 60 75 85 80 Ragweed 40 70 55 65 Ragweed 35 40 35 60 Ryegrass, Italian 10 0 10 20 Ryegrass, Italian 5 0 5 10 Soybean 70 70 55 55 Soybean 30 60 50 65 Velvetleaf 25 75 65 65 Velvetleaf 20 75 40 60 Waterhemp 90 70 85 98 Waterhemp 70 70 85 98 Wheat 10 0 0 10 Wheat 5 0 0 10 Compounds Compounds 31 g ai/ha 1 6 7 10 16 g ai/ha 1 6 7 10 Postemergence Barnyardgrass 5 5 5 10 Barnyardgrass 5 5 5 5 Blackgrass 5 0 5 10 Blackgrass 5 0 5 10 Chickweed 10 55 20 30 Chickweed 10 50 0 70 Corn 5 10 10 15 Corn 5 5 10 20 Crabgrass, Large 15 15 10 35 Crabgrass, Large 10 5 10 25 Foxtail, Giant 10 5 10 15 Foxtail, Giant 5 5 10 10 Galium 45 60 50 50 Galium 40 50 45 45 Johnsongrass 5 5 5 10 Johnsongrass 0 0 5 5 Kochia 90 60 50 90 Kochia 90 50 10 85 Lambsquarters 15 35 65 75 Lambsquarters 15 20 25 65 Morningglory 40 75 35 55 Morningglory 10 50 20 50 Nutsedge, Yellow 5 5 5 10 Nutsedge, Yellow 5 0 0 5 Oat, Wild 5 0 0 5 Oat, Wild 5 0 0 0 Oilseed Rape 30 15 35 25 Oilseed Rape 10 5 20 5 Pigweed 95 70 65 90 Pigweed 35 70 70 70 Ragweed 70 45 30 25 Ragweed 10 25 25 25 Ryegrass, Italian 5 0 5 5 Ryegrass, Italian 5 0 0 5 Soybean 35 45 40 40 Soybean 15 40 50 40 Velvetleaf 10 65 35 35 Velvetleaf 10 50 25 15 Waterhemp 80 75 70 80 Waterhemp 25 60 60 75 Wheat 5 0 0 5 Wheat 0 0 0 0 Compounds Compounds 125 g ai/ha 1 6 7 10 62 g ai/ha 1 6 7 10 Preemergence Barnyardgrass 75 40 75 98 Barnyardgrass 40 10 35 75 Blackgrass 85 5 85 95 Blackgrass 25 5 30 95 Corn 0 5 10 5 Corn 0 0 10 10 Crabgrass, Large 100 100 100 100 Crabgrass, Large 98 90 95 100 Foxtail, Giant 100 100 98 100 Foxtail, Giant 90 70 85 100 Galium 40 90 100 98 Galium 0 90 98 60 Johnsongrass 15 10 20 70 Johnsongrass 5 5 10 35 Lambsquarters 60 85 75 75 Lambsquarters 45 65 75 35 Morningglory 15 55 25 55 Morningglory 0 20 10 15 Nutsedge, Yellow 5 5 15 0 Nutsedge, Yellow 0 0 0 0 Oilseed Rape 60 98 95 80 Oilseed Rape 10 98 85 70 Pigweed 100 100 100 100 Pigweed 75 90 100 100 Ragweed 0 85 40 65 Ragweed 10 70 50 25 Ryegrass, Italian 60 5 30 85 Ryegrass, Italian 5 5 10 90 Soybean — 75 50 — Soybean 10 — 15 — Velvetleaf 10 80 55 55 Velvetleaf 5 40 35 40 Waterhemp 100 100 100 100 Waterhemp 100 100 100 100 Wheat 0 0 0 5 Wheat 0 5 0 5 Compounds Compounds 31 g ai/ha 1 6 7 10 16 g ai/ha 1 6 7 10 Preemergence Barnyardgrass 20 5 10 55 Barnyardgrass 5 0 5 15 Blackgrass 20 0 0 60 Blackgrass 0 0 0 15 Corn 0 5 0 0 Corn 0 0 0 0 Crabgrass, Large 70 50 60 98 Crabgrass, Large 5 5 5 75 Foxtail, Giant 55 5 60 90 Foxtail, Giant 10 0 25 55 Galium 0 90 50 80 Galium 90 80 0 0 Johnsongrass 0 0 0 5 Johnsongrass 0 0 0 0 Lambsquarters 20 30 40 25 Lambsquarters 30 40 15 35 Morningglory 0 5 0 0 Morningglory 0 5 0 0 Nutsedge, Yellow 0 0 0 0 Nutsedge, Yellow 0 0 0 0 Oilseed Rape 0 90 35 10 Oilseed Rape 0 30 5 0 Pigweed 65 75 100 65 Pigweed 25 55 20 55 Ragweed 0 25 45 25 Ragweed 0 25 35 35 Ryegrass, Italian 0 5 0 10 Ryegrass, Italian 0 0 0 0 Soybean 10 20 — 20 Soybean 0 10 10 — Velvetleaf 0 25 10 20 Velvetleaf 0 10 5 0 Waterhemp 65 90 85 95 Waterhemp 20 75 85 70 Wheat 0 0 0 0 Wheat 0 0 0 0 

What is claimed is:
 1. A compound selected from Formula 1, and salts thereof,

wherein A is phenyl optionally substituted with up to 4 R²; or a 5- or 6-membered heteroaromatic ring, the ring bonded to the remainder of Formula 1 through a ring carbon atom, and optionally substituted with up to 4 R²; Z is 0 or SO_(m); R¹ is halogen, cyano, nitro, C₁-C₄ alkoxy, C₁-C₄ alkyl, C₂-C₆ alkenyl, C₂-C₆ alkynyl, SO_(n)R³ or C₁-C₄ haloalkyl; each R² is halogen, cyano, CHO, nitro, C₁-C₄ alkyl, C₂-C₄ alkenyl, C₂-C₄ alkynyl, C₁-C₄ alkoxy, C₃-C₄ alkenyloxy, C₃-C₄ alkynyloxy, C₁-C₄ haloalkyl, C₁-C₄ haloalkoxy, C₂-C₄ alkoxyalkyl, C₂-C₄ alkylthioalkyl, SO_(n)R³, C₂-C₆ dialkylamino, C₁-C₄ cyanoalkyl, C₁-C₄ hydroxyalkyl, CH(═NOH), C₃-C₆ cycloalkyl, phenyl or pyridyl; each R³ is independently C₁-C₄ alkyl, C₁-C₄ haloalkyl, C₁-C₄ alkylamino or C₂-C₆ dialkylamino; each R⁴ is independently halogen, cyano, hydroxy, nitro, amino, CHO, C₁-C₄ alkyl, C₂-C₄ alkenyl, C₂-C₄ alkynyl, C(═O)N(R^(4A))(R^(4B)), C(═NOR^(4C))H, C(═N)(R^(4D))H, C₁-C₄ alkoxy, C₂-C₄ cyanoalkoxy, C₂-C₄ alkylcarbonyl, C₂-C₄ alkoxycarbonyl, C₂-C₄ alkylcarbonyloxy, C₂-C₄ alkoxyalkyl, C₁-C₄ haloalkyl, C₁-C₄ haloalkoxy, SO_(n)R³ or C₃-C₆ cycloalkyl; or phenyl optionally substituted with cyano, halogen or C₁-C₄ alkyl; R^(4A) is C₁-C₄ alkyl or C₁-C₄ haloalkyl; R^(4B) is H, C₁-C₄ alkyl or C₁-C₄ haloalkyl; R^(4C) is H or C₁-C₄ alkyl; R^(4D) is H or C₁-C₄ alkyl; q is 0, 1, 2 or 3; m is 0, 1 or 2; and each n is independently 0, 1 or
 2. 2. The compound of claim 1 wherein A is a 5- or 6-membered nitrogen-containing heteroaromatic ring, the ring bonded to the remainder of Formula 1 through a ring carbon atom, and optionally substituted with up to 3 R²; or A is phenyl optionally substituted with up to 3 R².
 3. The compound of claim 2 wherein A is selected from A-1 through A-20; Z is 0; R¹ is halogen, C₁-C₄ alkyl or C₁-C₄ haloalkyl; each R² is independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, C₁-C₄ haloalkyl or C₁-C₄ haloalkoxy; q is 0, 1 or 2; and each R⁴ is independently halogen, cyano, amino, C₁-C₄ alkyl, C₂-C₄ alkenyl, C₂-C₄ alkynyl, C₁-C₄ alkoxy, C₂-C₄ alkoxycarbonyl, C₂-C₄ alkylcarbonyloxy, C₂-C₄ alkoxyalkyl or C₁-C₄ haloalkyl; wherein A-1 through A-20 are


4. The compound of claim 3 wherein A is selected from A-1 through A-13; R¹ is halogen; each R² is independently Cl, CF₃ or OCF₃; q is 0 or 1; and R⁴ is halogen, cyano, amino or C₁-C₄ alkyl.
 5. The compound of claim 4 wherein R² is halogen; q is 0; and A is selected from


6. The compound of claim 2 wherein A is phenyl optionally substituted with up to 2 R²; Z is O; R¹ is halogen, C₁-C₄ alkyl or C₁-C₄ haloalkyl; each R² is independently halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, C₁-C₄ haloalkyl or C₁-C₄ haloalkoxy; q is 0, 1 or 2; and each R⁴ is independently halogen, cyano, amino, C₁-C₄ alkyl, C₂-C₄ alkenyl, C₂-C₄ alkynyl, C₁-C₄ alkoxy, C₂-C₄ alkoxycarbonyl, C₂-C₄ alkylcarbonyloxy, C₂-C₄ alkoxyalkyl or C₁-C₄ haloalkyl.
 7. The compound of claim 6 wherein A is phenyl optionally substituted with one R²; R¹ is halogen; R² is independently Cl, CF₃ or OCF₃; and q is O.
 8. The compound of claim 7 wherein R¹ is chlorine.
 9. A compound of claim 1 selected from the group consisting of 1-(4-chlorophenyl)-6-[(5-chloro-2-pyrimidinyl)oxy]-2(1H)-pyridinone; 6-[(5-chloro-2-pyrimidinyl)oxy]-1-[3-(trifluoromethyl)phenyl]-2(1H)-pyridinone; and 6-[(5-chloro-2-pyrimidinyl)oxy]-1-[3-(trifluoromethoxy)phenyl]-2(1H)-pyridinone.
 10. A herbicidal composition comprising a compound of claim 1 and at least one component selected from the group consisting of surfactants, solid diluents and liquid diluents.
 11. A herbicidal mixture comprising (a) a compound of claim 1, and (b) at least one additional active ingredient selected from (b1) through (b16) and salts of compounds of (b1) through (b16): (b1) photosystem II inhibitors; (b2) acetohydroxy acid synthase (AHAS) inhibitors; (b3) acetyl-CoA carboxylase (ACCase) inhibitors; (b4) auxin mimics; (b5) 5-enol-pyruvylshikimate-3-phosphate (EPSP) synthase inhibitors; (b6) photosystem I electron diverters; (b7) protoporphyrinogen oxidase (PPO) inhibitors; (b8) glutamine synthetase (GS) inhibitors; (b9) very long chain fatty acid (VLCFA) elongase inhibitors; (b10) auxin transport inhibitors; (b11) phytoene desaturase (PDS) inhibitors; (b12) 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) inhibitors; (b13) homogentisate solenesyltransererase (HST) inhibitors; (b14) cellulose biosynthesis inhibitors; (b15) other herbicides including mitotic disruptors, organic arsenicals, asulam, bromobutide, cinmethylin, cumyluron, dazomet, difenzoquat, dymron, etobenzanid, flurenol, fosamine, fosamine-ammonium, metam, methyldymron, oleic acid, oxaziclomefone, pelargonic acid and pyributicarb; and (b16) herbicide safeners.
 12. A herbicidal mixture comprising (a) a compound of claim 1, and (b) at least one additional active ingredient selected from (b1) photosystem II inhibitors, (b2) acetohydroxy acid synthase (AHAS) inhibitors, (b4) auxin mimics, (b5) 5-enol-pyruvylshikimate-3-phosphate (EPSP) synthase inhibitors, (b7) protoporphyrinogen oxidase (PPO) inhibitors, (b9) very long chain fatty acid (VLCFA) elongase inhibitors and (b12) 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) inhibitors.
 13. A herbicidal mixture comprising (a) a compound of claim 1, and (b) at least one additional active ingredient selected from the group consisting of 2,4-D, acetochlor, alachlor, atrazine, bromoxynil, bentazon, bicyclopyrone, carfentrazone-ethyl, cloransulam-methyl, dicamba, dimethenamid-p, florasulam, flufenacet, flumioxazin, flupyrsulfuron-methyl, fluroxypyr-meptyl, glyphosate, halauxifen-methyl, isoxaflutole, MCPA, mesotrione, metolachlor, metsulfuron-methyl, nicosulfuron, pyrasulfotole, pyroxasulfone, pyroxsulam, rimsulfuron, saflufenacil, tembotrione, thifensulfuron-methyl, topramazone and tribenuron.
 14. A method for controlling the growth of undesired vegetation comprising contacting the vegetation or its environment with a herbicidally effective amount of a compound of claim
 1. 15. A method for controlling the growth of undesired vegetation in genetically modified plants that exhibit traits of glyphosate tolerance, glufosinate tolerance, ALS herbicide tolerance, dicamba tolerance, imidazolinone herbicide tolerance, 2,4-D tolerance, HPPD tolerance and mesotrione tolerance, comprising contacting the vegetation or its environment with a herbicidally effective amount of a compound of claim
 1. 